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Okuno Hironobu  奥野 博庸

ORCIDConnect your ORCID iD *help
Researcher Number 70445310
Other IDs
Affiliation (Current) 2025: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2023 – 2024: 東京医科大学, 医学部, 講師
2016 – 2023: 慶應義塾大学, 医学部(信濃町), 助教
2019: 慶應義塾大学, 医学部, 助教
2017: 慶應義塾大学, 医学部, 助教
2015: 慶應義塾大学, 医学部, 助教
2014: 慶應義塾大学, 医学部, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatric surgery
Keywords
Principal Investigator
iPS細胞 / PDGFRb / 疾患モデリング / 脳血液関門 / 患者由来iPS細胞 / PDGFRb / migration assay / pericyte / Gain of function / 小崎過成長症候群 … More / PDGFRB / プラダー・ウィリー症候群 / プラダーウィリー症候群 / MeCP2 / MeCP2結合領域 / Prader-Willi sydrome / インプリンティング / メチル化維持機能 / Prader-Willi症候群 / 視床下部 / 方向性 / 神経堤細胞 / 遊走 / CHD7 / 神経堤 / CHARGE症候群 … More
Except Principal Investigator
iPS細胞 / 神経堤 / CDC42 / 血管障害 / 白質病変 / 小崎過成長症候群 / 血小板由来成長因子受容体 / 脳動脈瘤 / 冠状動脈瘤 / 動脈瘤 / 過成長 / 過成長症候群 / 血小板由来成長因子 / 疾患モデル動物 / 頭蓋縫合早期癒合症 / PDGFRB / 乳歯幹細胞 / ヒルシュスプルング病類縁疾患 / ヒルシュスプルング病 / 指定難病 / 組織工学 / 細胞移植 / 乳歯幹細胞学 / 再生医療学 / 小児外科学 / 歯学 / 細胞・組織 / 再生医学 / 移植・再生医療 / 腸管蠕動不全 / 再生医療 / 幹細胞 Less
  • Research Projects

    (6 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (23 People)
  •  CDC42異常症患者iPS細胞由来神経堤および神経細胞を用いた病態解明

    • Principal Investigator
      中山 俊宏
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Tokyo Medical University
  •  小崎過成長症候群患者iPS細胞由来脳血液関門モデルを用いた疾患メカニズムの解明Principal Investigator

    • Principal Investigator
      奥野 博庸
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Tokyo Medical University
      Keio University
  •  PDGFRB異常による新規過成長症候群の病態解明と治療法開発

    • Principal Investigator
      武内 俊樹
    • Project Period (FY)
      2019 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Keio University
  •  Elucidation of the mechanism of methylation maintenance of imprinting region using iPS cellsPrincipal Investigator

    • Principal Investigator
      OKUNO HIronobu
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Keio University
  •  Elucidation of the etiology and development of the novel therapy using stem cells from human exfoliated deciduous teeth for Hirschsprung's disease and its allied disorders

    • Principal Investigator
      TAGUCHI Tomoaki
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatric surgery
    • Research Institution
      Kyushu University
  •  Neural crest disease model using iPS cells and elucidation of pathophysiology for drug discoveryPrincipal Investigator

    • Principal Investigator
      Okuno Hironobu
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Keio University

All 2023 2021 2019 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Kosaki overgrowth syndrome: A newly identified entity caused by pathogenic variants in platelet‐derived growth factor receptor‐beta2019

    • Author(s)
      Takenouchi Toshiki、Okuno Hironobu、Kosaki Kenjiro
    • Journal Title

      American Journal of Medical Genetics Part C: Seminars in Medical Genetics

      Volume: 181 Issue: 4 Pages: 650-657

    • DOI

      10.1002/ajmg.c.31755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08329
  • [Journal Article] CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations2017

    • Author(s)
      Okuno H, Renault Mihara F, Ohta S, Fukuda K, Kurosawa K, Akamatsu W, Sanosaka T, Kohyama J, Hayashi K, Nakajima K, Takahashi T, Wysocka J, Kosaki K, Okano H.
    • Journal Title

      elife

      Volume: 6 Pages: 23-24

    • DOI

      10.7554/elife.21114

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07115, KAKENHI-PROJECT-26860823, KAKENHI-PROJECT-16K21360, KAKENHI-PLANNED-16H06482
  • [Presentation] Disease modeling using induced pluripotent stem cellsfrom patients with Kosaki overgrowth syndrome revealsabnormal migration of myofibroblasts2023

    • Author(s)
      Hironobu Okuno, Miki Sato, Naoko Yamamoto Toshiki Takenouchi, Kenjiro Kosaki, Hideyuki Okano
    • Organizer
      Human Genetics Asia 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07922
  • [Presentation] Modeling Prader-Willi syndrome using hypothalamic neurons from patient-derived induced pluripotent stem cells2021

    • Author(s)
      Akisa Nemoto, Hironobu Okuno, Hideyuki Okano
    • Organizer
      第64回神経化学会
    • Data Source
      KAKENHI-PROJECT-18K15686
  • [Presentation] Generation of Hypothalamic Cell Model of Prader-Willi Syndrome Using Patient-derived induced Pluripotent Stem Cells2021

    • Author(s)
      Akisa Nemoto, Hironobu Okuno, Hideyuki Okano
    • Organizer
      The 2021 Tokyo International Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15686
  • [Presentation] In vitro and in vivo cell dynamics analysis of iPSC-derived neural crest cells harboring CHD7 mutations reveals defective migration of CHARGE syndrome2017

    • Author(s)
      Hironobu Okuno
    • Organizer
      Society for Neuroscience (SfN) 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860823
  • [Presentation] CHARGE症候群患者iPS細胞由来神経堤細胞を用いた病態解析2017

    • Author(s)
      奥野博庸
    • Organizer
      第一回慶應ライフサイエンスシンポジウム
    • Data Source
      KAKENHI-PROJECT-26860823
  • [Presentation] Differentiation of iPS cells into cranial neural crest cells to model congenital disorder that arises from defects in cranial neural crest cell development.2016

    • Author(s)
      Hironobu Okuno, Francois Renault Mihara, Shigeki Ohta, Kenji Kurosawa, Wado Akamatsu, Kenjiro Kosaki, Takao Takahashi, Hideyuki Okano
    • Organizer
      The 13 th International Congress of Human Genetics
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860823
  • [Presentation] Differentiation of iPS cells into cranial neural crest cells to model congenital disorder that arises from defects in the development of the embryonic cranial neural crest cell lineage.2016

    • Author(s)
      奥野 博庸
    • Organizer
      The 13th International Congress of human Genetics
    • Place of Presentation
      国立京都国際会館(京都府京都市左京区)
    • Year and Date
      2016-04-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860823
  • [Presentation] Modeling for abnormal neural crest cells migration in CHARGE syndrome using patient-iPSCs derived neural crest cells2015

    • Author(s)
      奥野博庸
    • Organizer
      The 55th Annual Meeting of the Japanese Teratology Society, The 38th Annual Meeting of the Japan Society of Pediatric Genetics
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市中央区)
    • Year and Date
      2015-07-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860823
  • 1.  TAGUCHI Tomoaki (20197247)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  松浦 俊治 (10532856)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  吉丸 耕一朗 (60711190)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  桐野 浩輔 (00621707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  山座 孝義 (80304814)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  山座 治義 (30336151)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  尾崎 正雄 (10152472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  岡 暁子 (60452778)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  孝橋 賢一 (10529879)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  梶岡 俊一 (90274472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  大賀 正一 (60233053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  黒田 達夫 (60170130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  増本 幸二 (20343329)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  田尻 達郎 (80304806)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  家入 里志 (00363359)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  木下 義晶 (80345529)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  柳 佑典 (30596664)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  野中 和明 (90128067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  高田 英俊 (70294931)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  中畑 龍俊 (20110744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  武内 俊樹 (60383741)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  中山 俊宏 (00991928)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  OHTA Shigeki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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