TOTSUKA Teruji 戸塚輝治

Researcher Number	70447465
Affiliation (based on the past Project Information) *help	2010 – 2011: 東京医科歯科大学, 医学部, 非常勤講師 2007 – 2009: Tokyo Medical and Dental University, 医学部附属病院, 助教 2008: 東京医科歯科大学, 医学部・附属病院, 助教
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / CD4^+CD45RB^<high>T細胞移入大腸炎モデル / CD4^+CD45RB^<high> T細胞移入大腸炎モデ / 抑制性CD4+CD25+T細胞 / 腸管局所療法 / 注腸療法 / 抑制性T細胞 / 加齢化免疫記憶T細胞 / マウス大腸炎モデル / 腸炎惹起生免疫記憶T細胞 … More / 制御性T細胞 / 老化CD4+T細胞 / 新規治療法 / マウスモデル / 加齢化免疫記憶CD4^+T細胞 … More Except Principal Investigator 免疫記憶細胞 / 骨髄 / マウスモデル / 大腸炎 / 免疫記憶T細胞 / 腸炎責任CD4 T細胞 / 慢性大腸炎モデル / IL-7 / 免疫記憶T 細胞 / 腸炎責任CD4 T 細胞 / 炎症性腸疾患 Less

Injection therapy of regulatory T cells into intestinal lumenPrincipal Investigator
- Principal Investigator
  
  TOTSUKA Teruji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Circulating colitogenic CD4+ memory T cells between bone marrow and intestine may be targets for the treatment of inflammatory bowel diseases
- Principal Investigator
  
  KANAI Takanori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
  Tokyo Medical and Dental University
Immunosenescent colitogenic CD4^+ T cells convert to regulatory cells and suppress colitisPrincipal Investigator
- Principal Investigator
  
  TOTUKA Teruji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] 消化器疾患における自然免疫・獲得免疫のクロストーク慢性大腸炎の発症と維持におけるIL-7の役割2009
- Author(s)
  戸塚輝治、金井隆典、渡辺守
- Data Source
  KAKENHI-PROJECT-21590804
[Book] サイトカインと炎症性腸疾患・自己免疫疾患その病態における役割と治療展開炎症性腸疾患(解説)2009
- Author(s)
  戸塚輝治、渡辺守
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] The development of colitogenic CD4+T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012
- Author(s)
  Yamaji O, Totsuka T
- Journal Title
  
  J Immunol
  
  Volume: 188 Pages: 2524-2536
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012
- Author(s)
  Yamaji O, Totsuka T
- Journal Title
  
  J Immunol
  
  Volume: 188 Issue: 6 Pages: 2524-2536
- DOI
  10.4049/jimmunol.1100371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23390112, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659223, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PLANNED-23102003
[Journal Article] Upregulated IL-7 Receptor{ alpha} Expression on Colitogenic Memory CD4+T Cells May Participate in the Development and Persistence of Chronic Colitis2011
- Author(s)
  Shinohara T, Nemoto Y, Totsuka T, et al
- Journal Title
  
  Eur J Immunol
  
  Volume: 186 Pages: 2623-2632
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] Upregulated IL-7 Receptor {alpha} Expression on Colitogenic Memory CD4+ T Cells May Participate in the Development and Persistence of Chronic Colitis.2010
- Author(s)
  Shinohara T, Nemoto Y, Totsuka T, et al
- Journal Title
  
  J Immunol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] IL-2 is positively involved in the development of colitogenic CD4+IL-7R alpha high memory T cells in chronic colitis2010
- Author(s)
  Kameyama K, Totsuka T, Watanabe M, et al
- Volume
  183
- Pages
  2423-2436
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] IL-2 is positively involved in the development of co litogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.2010
- Author(s)
  Kameyama K, Totsuka T, Watanabe M, et al
- Journal Title
  
  Eur J Immunol
  
  Volume: 183 Pages: 2423-2436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population2010
- Author(s)
  Nagahori M, Hyun SB, Totsuka T, et al
- Journal Title
  
  J Gastroenterol
  
  Volume: 45 Pages: 1008-1013
- NAID
  10027699223
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] Prevalence of metabolic syndrome is comparable between inflam matory bowel disease patients and the general population.2010
- Author(s)
  Nagahori M, Hyun SB, TotsukaT, et al
- Journal Title
  
  J Gastroenterol.
  
  Volume: 45 Pages: 1008-1013
- NAID
  10027699223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+regulatory T cells in chronic colitis2009
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, et al
- Journal Title
  
  J Immunol
  
  Volume: 182 Pages: 6079-6087
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directoly involved in colitis-associated carcinogenesis2009
- Author(s)
  Onizawa M, Nagaishi T, Totsuka T, et al
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 296 Pages: 850-859
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis2009
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M.
- Journal Title
  
  J Immunol 182
  
  Pages: 6079-6087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] RANK-RANKL signaling pathway Is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.2009
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, et al
- Journal Title
  
  J Immunol. 182
  
  Pages: 6079-6087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article]2009
- Author(s)
  戸塚輝治、金井隆典、渡辺守
- Journal Title
  
  消化器と免疫 45号消化器疾患における自然免疫・獲得免疫のクロストーク慢性大腸炎の発症と維持におけるIL-7の役割(日本消化器免疫学会)
  
  Pages: 47-51
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] RANKL2009
- Author(s)
  Totsuka T, Kanai T, Watanabe M.
- Journal Title
  
  J Immunol in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Signaling pathway via TNF-{alpha}/NF-{kappa} B in intestinal epithelial cells may be directly involved in Colitis-associated carcinogenesis.2009
- Author(s)
  Oni zawa M, Nagaishi T, Kanai T, Nagano K, 0shima S, Kemoto Y, Yoshi oka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis.2009
- Author(s)
  Nemoto Y, Kanai T, Totsuka T, et al
- Journal Title
  
  J Immunol 183
  
  Pages: 5059-5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] Persistent retention of Colitogenic CD4(+)memory T cells causes inflammatory bowel diseases to become intractable.2009
- Author(s)
  kanai T, Nemoto Y, Tomita T, Totsuka T, Watanabe M, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Long-lived colitogenic CD4+momory T cells residing outside the intestine participate in the perpetuation of chronic colitis2009
- Author(s)
  Nemoto Y, Kanai T, Totsuka T, et al
- Journal Title
  
  J Immunol
  
  Volume: 183 Pages: 5059-5068
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009
- Author(s)
  Onizawa M, Nagaishi T, Totsuka T, et al
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 296
  
  Pages: 850-859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease2009
- Author(s)
  Kanai T, Nemoto Y, Kamada N, Totsuka T, Hisamatsu T, Watanabe M, Hibi T.
- Journal Title
  
  Curr Opin GastroenterolEpub ahead of print(Curr Opin Gastroenterol)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article]2009
- Author(s)
  戸塚輝治、渡辺守
- Journal Title
  
  炎症と免疫(Vol.17 no.3)サイトカインと炎症性疾患・自己免疫疾患その病態における役割と治療展開炎症性腸疾患(解説)(先端医学社)
  
  Pages: 327-334
- Data Source
  KAKENHI-PROJECT-21590804
[Journal Article] Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable2009
- Author(s)
  Kanai T, Nemoto Y, Tomita T, Totsuka T, Watanabe M, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis. 15
  
  Pages: 926-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis2009
- Author(s)
  Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 296
  
  Pages: 850-859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Immunosenescent colitogenic CD4^+ T cells convert to regulatory cells and suppress colitis.2008
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M.
- Journal Title
  
  Eur J Immunol. 38
  
  Pages: 1275-1286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow2008
- Author(s)
  Fujii T, Tomita T, Kanai T, Nemoto Y, Totsuka T, Sakamoto N, Nakamura T, Tsuchiya K, Okamoto R, Watanabe M.
- Journal Title
  
  Eur J Immunol 38
  
  Pages: 3290-3303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M.
- Journal Title
  
  J Immunol 180
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.2008
- Author(s)
  Ito Y, Totsuka T
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 294(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+Tcell-mediated colitis.2008
- Author(s)
  Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, Okumura K, Yagita H, Watanabe M
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 294(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M
- Journal Title
  
  J Immunol 180(1)
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Colitogenic CD4^+ effector-memory T cells actively recirculate in chronic colitic mice.2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Fujii T, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M.
- Journal Title
  
  Inflamm Bowel Dis. 14
  
  Pages: 1630-1640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Blockade of NKG2D signaling prevents the development of marine CD4^+ T cell-mediated colitis.2008
- Author(s)
  Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, Okumura K, Yagita H, Watanabe M
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+T cells in chronic colitis.2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M
- Journal Title
  
  J Immunol. 180(8)
  
  Pages: 5291-5299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Colitogenic CD4+effector-memory T cells actively recirculate in chroniccolitic mice.2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Fujii T, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 14(12)
  
  Pages: 1630-1640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Negative feedback regulation of colitogenic CD4(+) T cells by increased granulopoiesis2008
- Author(s)
  Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 14(11)
  
  Pages: 1491-1503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Immunosenescent colitogenic CD4(+)T cells convert to regulatory cell sand suppress colitis.2008
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M
- Journal Title
  
  Eur J Immunol. 38(5)
  
  Pages: 1275-1286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Continuous generation of colitogenic CD4^+ T cells in persistent colitis.2008
- Author(s)
  Toraita T, Kanai T, Fujii T, Nemoto Y, Okaraoto R, Tsuchiya K, Totsuka T, Sakamoto N, Watanabe M.
- Journal Title
  
  Eur J Immunol. 38
  
  Pages: 1264-1274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Systemic, but not intestinal. IL-7 is essential for the persistence of chroniccolitis.2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M
- Journal Title
  
  J Immunol. 180(1)
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis.2008
- Author(s)
  Totsuka T, Kanai T, et. al.
- Journal Title
  
  European Journal of Immunology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M.
- Journal Title
  
  J Immunol 180
  
  Pages: 5291-5299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Continuous generation of colitogenic CD4(+) Tcells in persistent colitis2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Watanabe M
- Journal Title
  
  Eur J Immunol 38(5)
  
  Pages: 1264-1274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Continuous generation of colitogenic CD4(+) T cells in persistent colitis2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Watanabe M.
- Journal Title
  
  Eur J Immunol 38
  
  Pages: 1264-1274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Continuous generation of colitogenic CD4(+)T cells in persistent colitis.2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Watanabe M
- Journal Title
  
  Eur J Immunol. 38(5)
  
  Pages: 1264-1274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.2008
- Author(s)
  Tomita T, Totsuka T
- Journal Title
  
  Journal of immunology 180(1)
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis2008
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R,Watanabe M
- Journal Title
  
  Eur J Immunol 38(5)
  
  Pages: 1275-1286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis2008
- Author(s)
  Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, Okumura K, Yagita H, Watanabe M
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 294(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M.
- Journal Title
  
  J Immunol 180
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4^+ T cells in chronic colitis.2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M.
- Journal Title
  
  J Immunol. 180
  
  Pages: 5291-5299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Negative feedback regulation of colitogenic CD4(+)T cells by increased granulopoiesis.2008
- Author(s)
  Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 14(11)
  
  Pages: 1491-1503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Colitogenic CD4+ effector-memory T cells actively recirculate in chronic coliti0c mice2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Fujii T, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 14(12)
  
  Pages: 1630-1640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M
- Journal Title
  
  J Immunol 180(8)
  
  Pages: 5291-5299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] FTY720 suppresses the development of colitis in lyinphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.2008
- Author(s)
  Fujii T, Tomita T, Kanai T, Nemoto Y, Totsuka T, Sakamoto N, Nakamura T, Tsuchiya K, Okamoto R, Watanabe M.
- Journal Title
  
  Eur J Immunol. 38
  
  Pages: 3290-3303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis2008
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M.
- Journal Title
  
  Eur J Immunol 38
  
  Pages: 1275-1286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Fujii T, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M.
- Journal Title
  
  Inflamm Bowel Dis. 14
  
  Pages: 1630-1640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis2008
- Author(s)
  Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis. 14
  
  Pages: 1491-1503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis2008
- Author(s)
  Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, Okumura K, Yagita H, Watanabe M.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 294
  
  Pages: 199-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Journal Article] Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation2007
- Author(s)
  Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M
- Journal Title
  
  J Immunol 178(8)
  
  Pages: 4937-4946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Extracorporeal elimination of TNF-alpha-producing CD14(dull)CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis2007
- Author(s)
  Kanai T, Makita S, Kawamura T, Nemoto Y, Kubota D, Nagayama K, Totsuka T, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 13(3)
  
  Pages: 284-290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] IL-7 Is essential for the development and the persistence of chronic colitis.2007
- Author(s)
  Totsuka T
- Journal Title
  
  Journal of immunology 178(8)
  
  Pages: 4737-4748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis2007
- Author(s)
  Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Takeda K, Watanabe M
- Journal Title
  
  Gastroenterology 132(1)
  
  Pages: 176-189
- NAID
  40015644486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.2007
- Author(s)
  Makita S, Totsuka T
- Journal Title
  
  Journal of immunology 178(8)
  
  Pages: 4937-4946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] IL-7 Is essential for the development and the persistence of chronic colitis2007
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M
- Journal Title
  
  J Immunol 178(8)
  
  Pages: 4737-4748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590718
[Journal Article] IL-7 is essential for the development and the persistence of chronic colitis.2007
- Author(s)
  Totsuka T, Kanai T, et. al.
- Journal Title
  
  Journal of Immunology 178
  
  Pages: 4737-4748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390197
[Presentation] Systemic, but not intersinal, IL-7 is essential for the development and persistence of Chronic Colitis.2009
- Author(s)
  戸塚輝治
- Organizer
  DDW2009
- Place of Presentation
  シカゴ
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-21590804
[Presentation] Systemic, but not intersinal, IL-7 is essential for the development and persistence of Chronic Colitis2009
- Author(s)
  Totsuka T
- Organizer
  DDW2009
- Place of Presentation
  Chicago
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-21590804
[Presentation] 腸炎惹起性CD4^+IL-7Rα^<high>メモリーT細胞分化機構におけるIL-2の重要性2009
- Author(s)
  石黒佳織、金井隆典、戸塚輝治, ほか
- Organizer
  第51回日本消化器病学会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590804
[Presentation] 腸炎惹起性CD4^+IL-7Rα^<high>メモリーT細胞分化機構におけるIL-2の重要性2009
- Author(s)
  石黒佳織、金井隆典、戸塚輝治, 他
- Organizer
  第51回日本消化器病学会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590804
[Presentation] 炎症性腸疾患の発症/持続にはCD4^+T細胞におけるIL-7Rαが必須である2009
- Author(s)
  篠原玉子、金井隆典、戸塚輝治, ほか
- Organizer
  第51回日本消化器病学会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590804
[Presentation] 炎症性腸疾患の発症/持続にはCD4^+T細胞におけるIL-7Rαが必須である2009
- Author(s)
  篠原玉子、金井隆典、戸塚輝治, 他
- Organizer
  第51回日本消化器病学会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590804
[Presentation] Colitogenic CD4+ T Cells convert to regulatory cells to suppress colitis in the process of the immunosenescence2008
- Author(s)
  Totsuka T, Kanai T Nemoto Y, Tomita T, Watanabe M
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] Colitogenic CD4+ T Cells convert to regulatory cells to suppress colitis in the process of the immunosenescence.2008
- Author(s)
  Totsuka T, Kanai T Nemoto Y, Tomita T, Watanabe M
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis2007
- Author(s)
  Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Watanabe M
- Organizer
  DDW 2007
- Place of Presentation
  Washington.D.C
- Year and Date
  2007-05-22
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] Uniqueness of colitogenic lamina propria CD4+ T cells for the perpetuation of colitis2007
- Author(s)
  Kanai T, Nemoto Y, Shinohara T, Fujii T, Ito Y, Tomita T, Okamoto R, Tsuchiya K, Totsuka T, Watanabe M
- Organizer
  ICMI2007
- Place of Presentation
  東京
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] Blockade of TNF-α inhibits tumor progression in colitis-associated cancer2007
- Author(s)
  Onizawa M, Kanai T, Nemoto Y, Oshima S, Makita S, Okamoto R, Totsuka T, Yagita H, Watanabe M
- Organizer
  DDW 2007
- Place of Presentation
  Washington.D.C
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] IL-7 is essential for the development and the persistence of chronic colitis2007
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Tomita T, Makita S, Watanabe M
- Organizer
  ICMI2007
- Place of Presentation
  東京
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] IL-7 is essential for the development and persistence of chronic colitis2007
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Tomita T, Makita S, Totsuka T, Watanabe M
- Organizer
  DDW 2007
- Place of Presentation
  Washington.D.C
- Year and Date
  2007-05-22
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] Bone marrow is a reservoir for persistent colitogenic CD + TEM cells in IL-7 dependent manner2007
- Author(s)
  Nemoto Y, Kanai T, Makita S, Totsuka T, Watanabe M
- Organizer
  ICMI2007
- Place of Presentation
  東京
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis2007
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Fujii T,Shinohara T, Kameyama K, Totsuka T, Watanabe M
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] Ameliorating effect of anti-NKG2D in CD4+ cell-mediated murine model of chronic colitis2007
- Author(s)
  Ito Y, Kanai T, Fujii Y, Nemoto Y, Makita S, Totsuka T, Tsuchiya K, Yagita H, Watanabe M
- Organizer
  DDW 2007
- Place of Presentation
  Washington.D.C
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19590718
[Presentation] Continuous recirculation of colitogenic CD4+ T cells may be required for perpetuation of chronic colitis2007
- Author(s)
  Tomita T, Kanai T, Fujii Y, Nemoto Y, Makita S, Totsuka T, Watanabe M
- Organizer
  DDW 2007
- Place of Presentation
  Washington.D.C
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19590718

1. WATANABE Manabu (10175127)

# of Collaborated Projects: 4 results

# of Collaborated Products: 57 results
2. KANAI Takanori (40245478)

# of Collaborated Projects: 3 results

# of Collaborated Products: 53 results
3. ARAKI Akihiro (80361690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAGAISHI Takashi (60447464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 永石宇治

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

TOTSUKA Teruji 戸塚 輝治

Research Projects

Research Products

Co-Researchers

Injection therapy of regulatory T cells into intestinal lumenPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Circulating colitogenic CD4+ memory T cells between bone marrow and intestine may be targets for the treatment of inflammatory bowel diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunosenescent colitogenic CD4^+ T cells convert to regulatory cells and suppress colitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 消化器疾患における自然免疫・獲得免疫のクロストーク慢性大腸炎の発症と維持におけるIL-7の役割2009

Author(s)

Data Source

[Book] サイトカインと炎症性腸疾患・自己免疫疾患その病態における役割と治療展開炎症性腸疾患(解説)2009

Author(s)

Data Source

[Journal Article] The development of colitogenic CD4+T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012

Author(s)

Journal Title

Data Source

[Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulated IL-7 Receptor{ alpha} Expression on Colitogenic Memory CD4+T Cells May Participate in the Development and Persistence of Chronic Colitis2011

Author(s)

Journal Title

Data Source

[Journal Article] Upregulated IL-7 Receptor {alpha} Expression on Colitogenic Memory CD4+ T Cells May Participate in the Development and Persistence of Chronic Colitis.2010

Author(s)

Journal Title

Data Source

[Journal Article] IL-2 is positively involved in the development of colitogenic CD4+IL-7R alpha high memory T cells in chronic colitis2010

Author(s)

Volume

Pages

Data Source

[Journal Article] IL-2 is positively involved in the development of co litogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.2010

Author(s)

Journal Title

Data Source

[Journal Article] Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Prevalence of metabolic syndrome is comparable between inflam matory bowel disease patients and the general population.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+regulatory T cells in chronic colitis2009

Author(s)

Journal Title

Data Source

[Journal Article] Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directoly involved in colitis-associated carcinogenesis2009

Author(s)

Journal Title

Data Source

[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis2009

Author(s)

Journal Title

Data Source

[Journal Article] RANK-RANKL signaling pathway Is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.2009

Author(s)

Journal Title

Data Source

TOTSUKA Teruji 戸塚輝治