KAJIWARA Naoki 梶原直樹

Researcher Number	70453917
Affiliation (Current)	2025: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2020 – 2021: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主任研究員 2012 – 2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 2012: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2011: 東京農工大学, 生物システム応用科学府, 助教 … More 2009: Juntendo University, 医学研究科, 研究員 2009: National Research Institute for Child Health and Development, 大学院・医学研究科, 博士研究員 2008: National Research Institute for Child Health and Development, 免疫アレルギー研究部, 共同研究員 Less
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / Environmental and hygienic pharmacy Except Principal Investigator Laboratory medicine
Keywords	Principal Investigator シアル酸 / ヘマグルチニン / 高病原性 / H5N1 / インフルエンザ / 感染 / アレルギー / 感染機構 / 抗体 / エピトープ … More / 鳥インフルエンザウイルス / 中和抗体 / H5 / インフルエンザウイルス / 肺炎 / サイトカイン / インターロイキン-16 / 炎症 / PAF / 血小板活性化因子 / アレルギー・ぜんそく / 脱顆粒 / ヒスタミン / 血小板活性化因子受容体 / マスト細胞 … More Except Principal Investigator PCR / リハビリ / 神経筋疾患 / 加齢 / バイオマーカー / 骨格筋 / イムノPCR / 高感度測定 / 加齢性筋萎縮症 / 診断 / サルコペニア / 筋萎縮 Less

Sialic acid-independent infection mechanism of H5N1 highly pathogenic avian influenza virusesPrincipal Investigator
- Principal Investigator
  
  KAJIWARA Naoki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  Tokyo Metropolitan Institute of Medical Science
Identification of novel receptor in the sialic acid-independent infection of H5N1 highly pathogenic avian influenza virusPrincipal Investigator
- Principal Investigator
  
  KAJIWARA Naoki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of rapid qRT-PCR for applying to the gene diagnosis
- Principal Investigator
  
  OBOKI Keisuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Trial of severe pneumonia treatment by unraveling novel infection route of highly pathogenic avian influenza virusPrincipal Investigator
- Principal Investigator
  
  KAJIWARA Naoki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of Diagnostics for Sarcopenia with Secretary Neurosynaptic markers
- Principal Investigator
  
  SHIBASKI Futoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Inhibitory effect of IL-16 on allergic diseasesPrincipal Investigator
- Principal Investigator
  
  KAJIWARA Naoki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  公益財団法人東京都医学総合研究所
   Tokyo University of Agriculture and Technology
Involvement of human lung mast cell activation through PAF receptor in severe asthmaPrincipal Investigator
- Principal Investigator
  
  KAJIWARA Naoki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  National Research Institute for Child Health and Development

All 2021 2020 2019 2018 2017 2016 2013 2012 2011 2010 2008 Other

All Journal Article Presentation Book

[Book] 医薬品モダリティの特許戦略と技術開発動向2019
- Author(s)
  梶原直樹、芝崎太
- Total Pages
  676
- Publisher
  株式会社技術情報協会
- ISBN
  9784861047497
- Data Source
  KAKENHI-PROJECT-17K10043
[Journal Article] Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus2020
- Author(s)
  Kajiwara Naoki、Nomura Namiko、Ukaji Masako、Yamamoto Naoki、Kohara Michinori、Yasui Fumihiko、Sakoda Yoshihiro、Kida Hiroshi、Shibasaki Futoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 18008-18008
- DOI
  10.1038/s41598-020-74604-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08854, KAKENHI-PROJECT-17K10043
[Journal Article] Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells2013
- Author(s)
  Ohmori K, Nishikawa S, Oku K, Oida K, Amagai Y, Kajiwara N, Jung K, Matsuda A, Tanaka A, Matsuda H
- Journal Title
  
  Vet. J. 2013
  
  Volume: (in press) Issue: 3 Pages: 402-407
- DOI
  10.1016/j.tvjl.2012.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658260, KAKENHI-PROJECT-23688040, KAKENHI-PROJECT-23880009, KAKENHI-PROJECT-24658267, KAKENHI-PROJECT-25670281
[Journal Article] Cell-penetrating peptide2013
- Author(s)
  Kajiwara N, Shibasaki F.
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 141 Issue: 4 Pages: 220-221
- DOI
  10.1254/fpj.141.220
- NAID
  10031165479
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670066
[Journal Article] Daily intake of Jeju groundwater improves the skin condition of the model mouse for human atopic dermatitis.2013
- Author(s)
  Tanaka A, Jung K, Matsuda A, Jang H, Kajiwara N, Amagai Y, Oida K, Ahn G, Ohmori K, Kang KG, Matsuda H
- Journal Title
  
  Journal of Dermatology
  
  Volume: 40 Issue: 3 Pages: 193-200
- DOI
  10.1111/1346-8138.12055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01098, KAKENHI-PROJECT-13F03905, KAKENHI-PROJECT-23658260, KAKENHI-PROJECT-23688040, KAKENHI-PROJECT-23880009, KAKENHI-PROJECT-24248055, KAKENHI-PROJECT-24658267, KAKENHI-PROJECT-25670281
[Journal Article] Activation of human mast cells through the platelet-activating factor receptor2010
- Author(s)
  Kajiwara N, Sasaki T, Bradding P, Cruse G, Sagara H, Ohmori K, Saito H, Ra C, Okayama Y.
- Journal Title
  
  J Allergy Clin Immunol 125(5)
  
  Pages: 1137-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790700
[Presentation] H5N1高病原性鳥インフルエンザウイルスの膜透過性ペプチドを介した細胞侵入機構2021
- Author(s)
  梶原直樹、山本直樹、小原道法、安井文彦、迫田義博、喜田宏、芝崎太
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-17K10043
[Presentation] H5N1高病原性鳥インフルエンザウイルスの膜透過性ペプチドを介した細胞侵入機構2021
- Author(s)
  梶原直樹、山本直樹、小原道法、安井文彦、迫田義博、喜田宏、芝崎太
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K08854
[Presentation] H5N1高病原性鳥インフルエンザウイルスのシアル酸非依存的な細胞侵入機構の解析2020
- Author(s)
  梶原直樹、山本直樹、小原道法、安井文彦、芝崎太
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K10043
[Presentation] H5N1高病原性鳥インフルエンザウイルスのシアル酸非依存的な細胞侵入機構2018
- Author(s)
  梶原直樹、山本直樹、小原道法、安井文彦、迫田義博、喜田宏、芝崎太
- Organizer
  Conference for BioSignal and Medicine 2018
- Data Source
  KAKENHI-PROJECT-17K10043
[Presentation] H5N1高病原性鳥インフルエンザウイルスのシアル酸非依存的な細胞侵入経路の解析2018
- Author(s)
  梶原直樹、山本直樹、小原道法、安井文彦、迫田義博、喜田宏、芝崎太
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K10043
[Presentation] 高病原性トリインフルエンザウイルスH5N1のシアル酸非依存的感染機構2017
- Author(s)
  梶原直樹、野村奈美子、宇梶麻紗子、貞任大地、小原道法、安井文彦、芝崎太
- Organizer
  Conference for BioSignal and Medicine 2017
- Data Source
  KAKENHI-PROJECT-17K10043
[Presentation] H5N1高病原性鳥インフルエンザウイルスのシアル酸非依存的な細胞侵入経路の解析2017
- Author(s)
  梶原直樹、野村奈美子、宇梶麻紗子、貞任大地、山本直樹、小原道法、安井文彦、迫田義博、喜田宏、芝崎太
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K10043
[Presentation] 高病原性トリインフルエンザウイルスH5N1のシアル酸非依存的感染機構2016
- Author(s)
  梶原直樹、野村奈美子、宇梶麻紗子、貞任大地、小原道法、芝崎太
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25670066
[Presentation] 高病原性トリインフルエンザウイルスH5N1の新規感染機構2016
- Author(s)
  梶原直樹、野村奈美子、宇梶麻紗子、貞任大地、小原道法、芝崎太
- Organizer
  Conference for BioSignal and Medicine 2016
- Place of Presentation
  亀山亭ホテル(大分県日田市)
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-25670066
[Presentation] ITCによる接触皮膚炎におけるIL-16の役割2012
- Author(s)
  梶原直樹, 大保木啓介, Hardy Kornfeld, 奥村康, 斎藤博久, 中江進, 芝崎太
- Organizer
  Conference for BioSignal and Medicine (CBSM)2012
- Place of Presentation
  ホテル近鉄アクアヴィラ伊勢志摩
- Data Source
  KAKENHI-PROJECT-23791129
[Presentation] FITCによる接触皮膚炎におけるIL-16の役割2012
- Author(s)
  梶原直樹
- Organizer
  Conference for BioSignal and Medicine (CBSM) 2012
- Place of Presentation
  三重県伊勢市
- Data Source
  KAKENHI-PROJECT-23791129
[Presentation] FITCによる接触皮膚炎におけるIL-16の役割2011
- Author(s)
  梶原直樹, 大保木啓介, 森田英明, Hardy Kornfeld, 奥村康, 斎藤博久, 中江進, 大森啓太郎, 田中あかね, 松田浩珍
- Organizer
  Conference for BioSignal and Medicine (CBSM)2011
- Place of Presentation
  軽井沢プリンスホテルウエスト
- Data Source
  KAKENHI-PROJECT-23791129
[Presentation] PAF causes degranulation via PLC・2 activation in human mast cells2008
- Author(s)
  Okayama Y, Kajiwara N, Ono Y, Saito H, Ra C.
- Organizer
  第58回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2008-11-27
- Data Source
  KAKENHI-PROJECT-20790700
[Presentation] ヒトマスト細胞のGαiに結合したPAF受容体の活性化はPLCβ2の活性化を介て脱顆粒を惹起する2008
- Author(s)
  岡山吉道、梶原直樹、斎藤博久、羅智靖
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20790700
[Presentation] Activation of platelet-activating factor receptor-coupled G・i leads to degranulation via phospholipase C・2 activation in human mast cells2008
- Author(s)
  Okayama Y, Kajiwara N, Saito H, Ra C.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20790700
[Presentation] インフルエンザの迅速・高感度診断を可能にした蛍光イムノクロマトグラフ法の開発
- Author(s)
  梶原直樹、櫻井陽、野村奈美子、橋本麻紗子、芝崎太
- Organizer
  Conference for BioSignal and Medicine 2014
- Place of Presentation
  静岡県伊豆市　ラフォーレ修善寺
- Year and Date
  2014-11-22 – 2014-11-23
- Data Source
  KAKENHI-PROJECT-25670281
[Presentation] FITCによる接触皮膚炎におけるIL-16の役割
- Author(s)
  梶原直樹
- Organizer
  Conference for BioSignal and Medicine (CBSM2011)
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-23791129
[Presentation] Pathogenic role of IL-33 in murine asthma model (JP-1)
- Author(s)
  Oboki K, Kajiwara N, Nakae S, Saito H, and Shibasaki F
- Organizer
  YONSEII BK21PLUS - CBSM International Joint Symposium
- Place of Presentation
  Andon , Korea
- Year and Date
  2014-06-21 – 2014-06-22
- Data Source
  KAKENHI-PROJECT-25670281
[Presentation] R&D of Innovative Devices for Self-Care Monitoring and OTC Diagnosis Based on Industry-Academia Cooperation
- Author(s)
  Shibasaki F, Oboki. K, Nomura N, Migita T, Ogawa M, Ohishi T, Kajiwara, N, Sadato D, and Koide T.
- Organizer
  YONSEII BK21PLUS - CBSM International Joint Symposium
- Place of Presentation
  Andon , Korea
- Year and Date
  2014-06-21 – 2014-06-22
- Data Source
  KAKENHI-PROJECT-25670281

1. SHIBASAKI Futoshi (90300954)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. NOMURA Namiko (50599694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. OBOKI Keisuke (80415108)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OKAYAMA Yoshimichi (80292605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. ENDO Fumiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AZUMA Hitomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OGAWA Mina

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OYA Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Daichi Sadato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAUCHI Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. AKAGI Yoshinori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. INUI Nobuhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OHMORI Keitaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. AHN Ginnae

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. AHN Ginae

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAJIWARA Naoki 梶原 直樹

Research Projects

Research Products

Co-Researchers

Sialic acid-independent infection mechanism of H5N1 highly pathogenic avian influenza virusesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel receptor in the sialic acid-independent infection of H5N1 highly pathogenic avian influenza virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of rapid qRT-PCR for applying to the gene diagnosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Trial of severe pneumonia treatment by unraveling novel infection route of highly pathogenic avian influenza virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Diagnostics for Sarcopenia with Secretary Neurosynaptic markers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibitory effect of IL-16 on allergic diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of human lung mast cell activation through PAF receptor in severe asthmaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医薬品モダリティの特許戦略と技術開発動向2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-penetrating peptide2013

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Daily intake of Jeju groundwater improves the skin condition of the model mouse for human atopic dermatitis.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of human mast cells through the platelet-activating factor receptor2010

Author(s)

Journal Title

Data Source

[Presentation] H5N1高病原性鳥インフルエンザウイルスの膜透過性ペプチドを介した細胞侵入機構2021

KAJIWARA Naoki 梶原直樹

[Presentation] ヒトマスト細胞のGαiに結合したPAF受容体の活性化はPLCβ2の活性化を介て脱顆粒を惹起する2008