nagata naoto 長田直人

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NAGATA Naoto 長田直人

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Researcher Number	70456408
Other IDs	https://orcid.org/0000-0002-2389-2334
Affiliation (Current)	2025: 金沢大学, 医学系, 講師
Affiliation (based on the past Project Information) *help	2025: 金沢大学, 医学系, 講師 2017 – 2023: 金沢大学, 医学系, 講師 2016: 金沢大学, 医学系, 助教 2013 – 2015: 金沢大学, 脳・肝インターフェースメディシン研究センター, 特任助教 2008 – 2009: Kanazawa University, 薬学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Eating habits / Gastroenterology / Medical pharmacy
Keywords	Principal Investigator 肥満 / 酸化ストレス / 転写因子 / エネルギー代謝 / 脂肪肝炎 / 酸化ストレス応答 / 脂肪吸収 / 褐色脂肪細胞 / 熱産生 / 食品機能性因子 … More / ブロッコリースプラウト / 慢性炎症 / 腸内細菌叢 / 機能性食品因子 / 過栄養 / チロシンフォスファターゼ / 脂肪酸酸化 / 線維化 / 炎症 / AMPキナーゼ / マクロファージ / プロバイオティクス / 腸内細菌 / 脂肪酸β酸化 / 酪酸 / 単鎖脂肪酸 / 脂質代謝 / 薬物療法 Less

Nrf2活性化による熱産生増加メカニズムの解明と肥満抑制への応用Principal Investigator
- Principal Investigator
  
  長田直人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kanazawa University
Nrf2による腸管からの脂肪吸収抑制機構の解明と肥満治療への応用に向けた基礎研究Principal Investigator
- Principal Investigator
  
  長田直人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kanazawa University
Nrf2 Regulates Energy Metabolism in MicePrincipal Investigator
- Principal Investigator
  
  NAGATA NAOTO
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kanazawa University
Regulation of inflammation and energy metabolism by broccoli sprout extractPrincipal Investigator
- Principal Investigator
  
  Nagata Naoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Kanazawa University
Impacts of protein tyrosine phosphatase Shp2 on liver inflammationPrincipal Investigator
- Principal Investigator
  
  NAGATA Naoto
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Development of new therapy of steatohepatitis by Clostridium ButyricumPrincipal Investigator
- Principal Investigator
  
  NAGATA Naoto
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University

All 2023 2021 2019 2018 2017 2016 2015 2013 2009

All Journal Article Presentation Patent

[Journal Article] A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation.2023
- Author(s)
  Suratsawadee Promsuwan, Kazuki Sawamoto,Liang Xu,Mayumi Nagashimada,Naoto Nagata, Yumi Takiyama
- Journal Title
  
  Diabetology International
  
  Volume: 15 Issue: 1 Pages: 86-89
- DOI
  10.1007/s13340-023-00658-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08301, KAKENHI-PROJECT-22K08621, KAKENHI-PROJECT-23K24787
[Journal Article] Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction2019
- Author(s)
  Xu L、Nagata N、Ota T
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 23 Pages: 5920-5920
- DOI
  10.3390/ijms20235920
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04047, KAKENHI-PROJECT-18K08506
[Journal Article] Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors2019
- Author(s)
  Fuke Nobuo、Nagata Naoto、Suganuma Hiroyuki、Ota Tsuguhito
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 10 Pages: 2277-2277
- DOI
  10.3390/nu11102277
- NAID
  120006728440
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04047, KAKENHI-PROJECT-18K08506
[Journal Article] Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance2018
- Author(s)
  Xu Liang、Nagata Naoto、Ota Tsuguhito
- Journal Title
  
  Adipocyte
  
  Volume: 7 Issue: 3 Pages: 218-225
- DOI
  10.1080/21623945.2018.1474669
- NAID
  120006226752
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08506, KAKENHI-PROJECT-16H03035
[Journal Article] Glucoraphanin: A broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance2018
- Author(s)
  Xu Liang、Nagata Naoto、Ota Tsuguhito
- Journal Title
  
  Adipocyte
  
  Volume: 印刷中
- NAID
  120006226752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00813
[Journal Article] Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice.2017
- Author(s)
  Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S and Ota T.
- Journal Title
  
  Diabetes
  
  Volume: 印刷中 Issue: 5 Pages: 1222-1236
- DOI
  10.2337/db16-0662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-26290037, KAKENHI-PROJECT-15K00813, KAKENHI-PROJECT-17K19586, KAKENHI-PROJECT-17K14992, KAKENHI-PUBLICLY-17H05615, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-17H03576
[Patent] ＬＰＳ産生抑制剤、及びＬＰＳ産生抑制用の食品組成物2016
- Inventor(s)
  太田　嗣人、長田　直人、牛田　悠介、青木　雄大、梅田　涼平
- Industrial Property Rights Holder
  太田　嗣人、長田　直人、牛田　悠介、青木　雄大、梅田　涼平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-065168
- Filing Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] Glucoraphanin has the therapeutic potential of resolving hepatic steatosis in a murine model of diet-induced obesity2021
- Author(s)
  Suratsawadee Promsuwan, Kazuki Sawamoto, Liang Xu, Naoto Nagata, Yumi Takiyama
- Organizer
  IDF2021
- Data Source
  KAKENHI-PROJECT-18K08506
[Presentation] Nrf2 activation by glucoraphanin alleviates high-fat diet-induced obesity and insulin resistance through adipose tissue browning.2019
- Author(s)
  Naoto Nagata, Guanliang Chen, Tsuguhito OTA, Hitoshi Ando
- Organizer
  Enviromental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08506
[Presentation] スルフォラファンによる転写因子 Nrf2 活性化を介したエネルギー代謝調節機構の検討2017
- Author(s)
  太田嗣人、牛田悠介、菅沼大行、長田直人
- Organizer
  第71回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及び脂肪肝抑制機構の検討　Sulforaphane-mediated Nrf2 activation ameliorates obesity and fatty liver disease in obese mice2017
- Author(s)
  Naoto Nagata, Tsuguhito Ota, Hitoshi Ando
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017)
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及びNAFLD抑制機構の検討2016
- Author(s)
  長田直人,牛田悠介, 菅沼大行, Xu Liang, Zhuge Fen, 金子周一, 太田嗣人
- Organizer
  第3回肝臓と糖尿病・代謝研究会
- Place of Presentation
  石川県立音楽堂邦楽ホール、石川県金沢市
- Year and Date
  2016-07-16
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] Nrf2 activation improves high fat diet-induced inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status in liver2016
- Author(s)
  Naoto Nagata, Yusuke Ushida, Yudai Aoki, Liang Xu, Fen Zhuge, Hiroyuki Suganuma, Shuichi Kaneko, Tsuguhito Ota
- Organizer
  76th Scientific Sessions | American Diabetes Association
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及び代謝異常抑制機構の解析2016
- Author(s)
  長田直人 ,牛田悠介 ,菅沼大行 ,Xu Liang ,Zhuge Fen ,太田嗣人
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館、京都府京都市
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及びNAFLD抑制機構の検討2016
- Author(s)
  長田直人,牛田悠介, 菅沼大行, Xu Liang, Zhuge Fen, 金子周一, 太田嗣人
- Organizer
  第28回分子糖尿病学シンポジウム
- Place of Presentation
  タワー１１１、富山県富山市
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] Nrf2 activation by glucoraphanin alleviates obesity and insulin resistance through increased energy expenditure and alternative activation of macrophages2016
- Author(s)
  NAOTO NAGATA, YUSUKE USHIDA, YUDAI AOKI, LIANG XU, FEN ZHUGE, HIROYUKI SUGANUMA, SHUICHI KANEKO, TSUGUHITO OTA
- Organizer
  2016 Keystone Symposia Conference
- Place of Presentation
  La Jolla, California, USA
- Year and Date
  2016-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] Nrf2 Activation by Glucoraphanin Relieves Obesity and Insulin Resistance through Increased Energy Expenditure and Alternative Activation of Macrophages2016
- Author(s)
  NAOTO NAGATA, YUSUKE USHIDA, YUDAI AOKI, LIANG XU, FEN ZHUGE, HIROYUKI SUGANUMA, SHUICHI KANEKO, TSUGUHITO OTA
- Organizer
  第76回アメリカ糖尿病学会
- Place of Presentation
  ニューオリンズ、アメリカ合衆国
- Year and Date
  2016-06-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] Glucoraphanin-mediated Nrf2 activation reduces obesity and insulin resistance by increasing energy expenditure and limiting endotoxemia-related chronic inflammation2016
- Author(s)
  Ota T, Ushida Y, Aoki Y, Xu L, Zhuge F, Suganuma H, Kaneko S, Nagata N
- Organizer
  EASD2016
- Place of Presentation
  ミュンヘン、ドイツ
- Year and Date
  2016-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] Broccoli sprouts improve high fat diet-induced inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status in liver2015
- Author(s)
  Naoto Nagata, Yusuke Ushida, Yudai Aoki, Ryohei Umeda, Satoshi Sunabori, Liang Xu, Fen Zhuge, Yuriko Sakai, Hiroyuki Suganuma, Tsuguhito Ota
- Organizer
  第12回アジア栄養学会議
- Place of Presentation
  横浜
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00813
[Presentation] 肝臓のタンパク質チロシンホスファターゼShp2による糖脂質代謝調節機構の解析2013
- Author(s)
  長田直人 Graham James　太田嗣人　Haj Fawaz
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本ホテルキャッスル
- Data Source
  KAKENHI-PROJECT-25860526
[Presentation] Astaxanthin ameliorates hepatic insulin resistance and inhibits the progression of lipotoxic model of nonalcoholic steatohepatitis2013
- Author(s)
  Naoto Nagata, Y. Ni, M. Nagashimada, F. Zhuge, S. Kaneko, T. Ota
- Organizer
  国際糖尿病学会議(IDF2013)
- Place of Presentation
  メルボルン、オーストラリア
- Data Source
  KAKENHI-PROJECT-25860526
[Presentation] 腸内細菌由来の生理活性物質である短鎖脂肪酸はAMPキナーゼを活性化させる、中川ゆうみ2009
- Author(s)
  長田直人, 澤本一樹, 太田嗣人, 横山将嘉, 高山浩昭, 熊崎雅史, 野田浩代, 北出紘規, 松本優香子, 御簾博文, 篁俊成, 金子周一, 宮本謙一
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  ホテルNCB、大阪
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20790131

1. Iida Noriho (40705604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. OTA Tsuguhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 滝山由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 高橋智聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

nagata naoto 長田 直人

NAGATA Naoto 長田 直人

Research Projects

Research Products

Co-Researchers

Nrf2活性化による熱産生増加メカニズムの解明と肥満抑制への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nrf2による腸管からの脂肪吸収抑制機構の解明と肥満治療への応用に向けた基礎研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nrf2 Regulates Energy Metabolism in MicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of inflammation and energy metabolism by broccoli sprout extractPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Impacts of protein tyrosine phosphatase Shp2 on liver inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapy of steatohepatitis by Clostridium ButyricumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Glucoraphanin: A broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice.2017

Author(s)

Journal Title

DOI

Data Source

[Patent] ＬＰＳ産生抑制剤、及びＬＰＳ産生抑制用の食品組成物2016

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

nagata naoto 長田直人

NAGATA Naoto 長田直人

[Presentation] スルフォラファンによる転写因子 Nrf2 活性化を介したエネルギー代謝調節機構の検討2017

[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及び脂肪肝抑制機構の検討　Sulforaphane-mediated Nrf2 activation ameliorates obesity and fatty liver disease in obese mice2017