Sakata Daiji 坂田大治

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SAKATA Daiji 坂田大治

SAKATA DAIJI 坂田大治

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Researcher Number	70456870
Other IDs
Affiliation (Current)	2026: 鹿児島大学, 医歯学域医学系, 講師
Affiliation (based on the past Project Information) *help	2026: 鹿児島大学, 医歯学域医学系, 講師 2021 – 2023: 鹿児島大学, 医歯学域医学系, 講師 2020: 九州大学, 生体防御医学研究所, 助教 2016 – 2017: 九州大学, 生体防御医学研究所, 助教 2015: 東京大学, 医学(系)研究科(研究院), 助教 … More 2012: 京都大学, 医学研究科, 研究員 2011: 京都大学, 医学(系)研究科(研究院), 研究員 2010: 京都大学, 医学研究科, 助教 2008 – 2009: Kyoto University, 医学研究科, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology / Tumor immunology Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator 神経免疫 / 痒み / アルツハイマー / 免疫 / 神経免疫反応 / DOCK２ / 炎症反応 / 自閉症 / DOCK2 / 妊娠免疫 … More / アルツハイマーモデル / MIA / ミクログリア / 末梢神経 / サイトカイン / IL-27 / AIM / 免疫炎症 / 異物除去 / 病態モデル / DOCK8 / DOCKファミリー分子 / 病態モデルマウス / DOCKファミリー / IL-31 / アトピー性皮膚炎 / アトピー / 神経変性疾患 / 神経免疫炎症 / 炎症 / 脂質メディエーター / プロスタノイド / アレルギー / 細胞骨格 / 細胞遊走 / 遺伝子欠損マウス / リンパ球 / アクチン / mDia … More Except Principal Investigator 呼吸器 / 線維化 / 炎症 / 難治性肺疾患 / mDia Less

痒み感覚におけるIL-27の生理的意義とその作用Principal Investigator
- Principal Investigator
  
  坂田大治
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kagoshima University
抑制性サイトカインIL-27による痒み抑制メカニズムの解明Principal Investigator
- Principal Investigator
  
  坂田大治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kagoshima University
Microglia based analysis of DOCK2 in longitudinal neuro-immune response through life spanPrincipal Investigator
- Principal Investigator
  
  SAKATA Daiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kagoshima University
  Kyushu University
The role of AIM in immuno-inflammationPrincipal Investigator
- Principal Investigator
  
  SAKATA DAIJI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
  The University of Tokyo
Analysis of the roles of mDia in refractory pulmonary diseases
- Principal Investigator
  
  OGA Toru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyoto University
腫瘍免疫におけるプロスタノイド受容体の役割の解析Principal Investigator
- Principal Investigator
  
  坂田大治
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Tumor immunology
- Research Institution
  Kyoto University
Comprehensive analysis of function of mDia family proteins in lymphocytesPrincipal Investigator
- Principal Investigator
  
  SAKATA Daiji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2022 2021 2018 2017 2010 2009 2008

All Journal Article Presentation

[Journal Article] Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells2022
- Author(s)
  Tatsuguchi T., Uruno T., Sugiura Y., Sakata D., Izumi Y., Sakurai T., Hattori Y., Oki E., Kubota N., Nishimoto K., Oyama M., Kunimura K., Ohki T., Bamba T., Tahara H., Sakamoto M., Nakamura M., Suematsu M., Fukui Y.
- Journal Title
  
  Int. Immunol.
  
  Volume: － Issue: 5 Pages: 277-289
- DOI
  10.1093/intimm/dxac002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06304, KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-21H02430, KAKENHI-PROJECT-20K07540
[Journal Article] 2.論文標題 DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells.2021
- Author(s)
  Matsubara K, Kunimura K, Yamane N, Aihara R, Sakurai T, Sakata D, Uruno T, Fukui Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 559 Pages: 135-140
- DOI
  10.1016/j.bbrc.2021.04.094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-21H02430, KAKENHI-PROJECT-20K07540
[Journal Article] Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.2021
- Author(s)
  Kamikaseda Y, Uruno T, Kunimura K, Harada A, Saiki K, Oisaki K, Sakata D, Nakahara T, Kido-Nakahara M, Kanai M, Nakamura S, Ohkawa Y, Furue M, Fukui Y.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 148 Issue: 2 Pages: 633-638
- DOI
  10.1016/j.jaci.2021.03.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21398, KAKENHI-PUBLICLY-20H04846, KAKENHI-PUBLICLY-20H05368, KAKENHI-PUBLICLY-21H00232, KAKENHI-PUBLICLY-21H00430, KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-19H03211, KAKENHI-PROJECT-21H02430, KAKENHI-PROJECT-18H02406, KAKENHI-PROJECT-20K07540
[Journal Article] DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activation Rac1P29S mutation.2018
- Author(s)
  Tomino T, Tajiri H, Tatsuguchi T, Shirai T, Oisaki K, Matsunaga S, Sanematsu F, Sakata D, Yoshizumi T, Maehara Y, Kanai M, Cote JF, Fukui Y, Uruno T
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 497 Issue: 1 Pages: 298-304
- DOI
  10.1016/j.bbrc.2018.02.073
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-16K15620, KAKENHI-PROJECT-18H02406, KAKENHI-PROJECT-16K08627, KAKENHI-PROJECT-15K08525
[Journal Article] The Rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production.2018
- Author(s)
  Ushijima M, Uruno T, Nishikimi A, Sanematsu F, Kamikaseda Y, Kunimura K, Sakata D, Okada T, Fukui Y
- Journal Title
  
  Front Immunol.
  
  Volume: 9 Pages: 243-243
- DOI
  10.3389/fimmu.2018.00243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-18H02406, KAKENHI-PROJECT-16K08627, KAKENHI-PROJECT-15K08525
[Journal Article] DOCK8 Regulates Macrophage Migration through Cdc42 Activation and LRAP35a Interaction.2017
- Author(s)
  Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 292 Issue: 6 Pages: 2191-2202
- DOI
  10.1074/jbc.m116.736306
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-15K08525, KAKENHI-PROJECT-16K08627
[Journal Article] Emerging roles of prostanoids in T cell-mediated immunity.2010
- Author(s)
  Sakata, D., et al
- Journal Title
  
  IUBMB Life
  
  Volume: 62 Pages: 591-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22680062
[Journal Article] Prostaglandin E2, An immunoactivator2010
- Author(s)
  Sakata D., Yao C., Narumiya S.
- Journal Title
  
  J. Pharm. Sci. 112巻
  
  Pages: 1-5
- NAID
  130000148448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790372
[Journal Article] Prostaglandin E2, An immunoactivator2010
- Author(s)
  Sakata D., Tao C., Narumiya S.
- Journal Title
  
  J.Pharm.Sci. 112
  
  Pages: 1-5
- NAID
  130000148448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790372
[Journal Article] Prostaglandin F2α-FP signaling facilitates bleomycin-induced pulmonary fibrosis independently TGF-β2009
- Author(s)
  Oga T., Matsuoka T., Yao C., Nonomura K., Kitaoka S., Sakata D., Kita Y., Tanizawa K., Taguchi Y., Chin K., Mishima M., Shimizu T., Narumiya S.
- Journal Title
  
  Nature Medicine 15
  
  Pages: 1426-1430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790372
[Journal Article] Prostaglandin F2α-FP signaling facilitates bleomycin-induced pulmonary fibrosis independently of TGF-β2009
- Author(s)
  Oga T., Matsuoka T., Yao C., Nonomura K., Kitaoka S., Sakata D., Kita Y., Tanizawa K., Taguchi Y., Chin K., Mishima M., Shimizu T., Narumiya S.
- Journal Title
  
  Nat. Med. 15巻
  
  Pages: 1426-1430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790372
[Journal Article] Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 expansion2009
- Author(s)
  Yao C., Sakata D., Esaki Y., Li Y., Matsuoka T., Kuroiwa K., Sugimoto Y., Narumiya S.
- Journal Title
  
  Nature Medicine 15
  
  Pages: 633-640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790372
[Journal Article] Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 expansion2009
- Author(s)
  Yao C., Sakata D., Esaki Y., Li Y., Matsuoka T., Kuroiwa K., Sugimoto Y., Narumiya S.
- Journal Title
  
  Nat. Med. 15巻
  
  Pages: 633-640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790372
[Journal Article] T細胞の遊走とアクチン再編成2008
- Author(s)
  坂田大治
- Journal Title
  
  臨床免疫・アレルギー科 50巻
  
  Pages: 265-270
- Data Source
  KAKENHI-PROJECT-20790372
[Journal Article] T細胞の遊走とアクチン再編成2008
- Author(s)
  坂田大治
- Journal Title
  
  臨床免疫・アレルギー科 50
  
  Pages: 265-270
- Data Source
  KAKENHI-PROJECT-20790372
[Presentation] Dual role of the PGE2-EP4 signaling in mouse EAE model2010
- Author(s)
  坂田大治
- Organizer
  第83回日本薬理学会
- Place of Presentation
  大阪グランキューブ
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-20790372
[Presentation] Dual role of the PGE_2-EP4 signaling in mouse EAE model2010
- Author(s)
  坂田大治
- Organizer
  第83回日本薬理学会
- Place of Presentation
  大阪グランキユーブ
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-20790372
[Presentation] Prostaglandin E2-EP4 signaling facilitates bleomycin-induced pulmonary fibrosis independently of TGF-β2009
- Author(s)
  Daiji Sakata
- Organizer
  The 9th world congress on inflammation
- Place of Presentation
  Keio Plaza Hotel, Tokyo
- Data Source
  KAKENHI-PROJECT-20790372
[Presentation] ProstaglandinE2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion2009
- Author(s)
  Daiji Sakata
- Organizer
  The 9th world congress on inflammation
- Place of Presentation
  Keio Plaza Hotel Tokyo
- Data Source
  KAKENHI-PROJECT-20790372

1. OGA Toru (90378670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. OHKAWA Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 福井宣規

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
4. 宇留野武人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 馬場健史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 和泉自泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakata Daiji 坂田 大治

SAKATA Daiji 坂田 大治

SAKATA DAIJI 坂田 大治

Research Projects

Research Products

Co-Researchers

痒み感覚におけるIL-27の生理的意義とその作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抑制性サイトカインIL-27による痒み抑制メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Microglia based analysis of DOCK2 in longitudinal neuro-immune response through life spanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of AIM in immuno-inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the roles of mDia in refractory pulmonary diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍免疫におけるプロスタノイド受容体の役割の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analysis of function of mDia family proteins in lymphocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2.論文標題 DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activation Rac1P29S mutation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DOCK8 Regulates Macrophage Migration through Cdc42 Activation and LRAP35a Interaction.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Emerging roles of prostanoids in T cell-mediated immunity.2010

Author(s)

Sakata Daiji 坂田大治

SAKATA Daiji 坂田大治

SAKATA DAIJI 坂田大治