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KUROSAKI Hajime  黒崎 創

ORCIDConnect your ORCID iD *help
Researcher Number 70464295
Other IDs
Affiliation (Current) 2025: 鳥取大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2025: 鳥取大学, 医学部, 講師
2023: 鳥取大学, 医学部, 講師
2020: 鳥取大学, 医学部, 助教
2012 – 2019: 鳥取大学, 医学(系)研究科(研究院), 助教
2011: 鳥取大学, 大学院・医学系研究科, 助教
2009: Tottori University, 大学院・医学系研究科, 助教
2008: Tottori University, 医学系研究科, 助教
Review Section/Research Field
Principal Investigator
Hematology / Basic Section 56040:Obstetrics and gynecology-related
Except Principal Investigator
Hematology
Keywords
Principal Investigator
血友病 / 細胞補充 / iPS細胞 / 遺伝子治療 / 遺伝子改変 / 抗腫瘍性増強 / がんウイルス療法 / 腫瘍溶解性ウイルス / 人工染色体ベクター / 再生医療 … More / 幹細胞 / 血栓・止血 / 第8因子 / 移植・再生医療 / 再生医学 / 遺伝子 / ヒト人工染色体ベクター / 染色体 … More
Except Principal Investigator
凝固第VIII因子 / 血液凝固因子 / 凝固因子 / 第VIII因子 / 血液凝固 / 血小板 / ヒト人工染色体 / iPS細胞 / 人工染色体 / 組換えタンパク質 / ゲノム / 遺伝子 / 移植・再生医療 / 細胞工学 / 遺伝子工学 / 血友病 / 組換えタンパク / 遺伝子治療 / 分子血栓止血学 Less
  • Research Projects

    (7 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (2 People)
  •  卵巣癌に対する遠隔感染能強化型腫瘍溶解性ワクシニアウイルス有効性の検証Principal Investigator

    • Principal Investigator
      黒崎 創
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Tottori University
  •  Development of oncolytic vaccinia virus with enhanced remote infection capability for ovarian cancerPrincipal Investigator

    • Principal Investigator
      KUROSAKI Hajime
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Tottori University
  •  Development of cell replacement therapy for hemophilia using a novel artificial chromosome vectorPrincipal Investigator

    • Principal Investigator
      KUROSAKI Hajime
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tottori University
  •  Correction model of hemophilia A mice with multicopy of reprogramming factors and factor VIII gene using ACPrincipal Investigator

    • Principal Investigator
      Kurosaki Hajime
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Tottori University
  •  Correction model of hemophilia A mice with multicopy of reprogramming factors and factor VIII gene using HACPrincipal Investigator

    • Principal Investigator
      KUROSAKI Hajime
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Tottori University
  •  Human arterial chromosomes for new hemophilia therapy

    • Principal Investigator
      TAKETA Hiroyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Sojo University
      Tottori University
  •  Human FVIII expression using a HAC vector toward stem cell-mediated gene therapy for hemophilia APrincipal Investigator

    • Principal Investigator
      KUROSAKI Hajime
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Hematology
    • Research Institution
      Tottori University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

  • [Book] 幹細胞研究の最近の進歩 幹細胞へのヒト人工染色体導入-医学・薬学への応用-2009

    • Author(s)
      黒崎 創
    • Publisher
      最新医学社
    • Data Source
      KAKENHI-PROJECT-20890130
  • [Book] 幹細胞研究の最近の進歩幹細胞へのヒト人工染色体導入-医学・薬学への応用-2009

    • Author(s)
      黒崎創
    • Publisher
      最新医学社
    • Data Source
      KAKENHI-PROJECT-20890130
  • [Journal Article] Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome2015

    • Author(s)
      Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, Takehara S, Osaki M, Kazuki Y, Kurosawa Y, Nakamura T, Katoh M, Oshimura M
    • Journal Title

      BMC Biotechnol.

      Volume: 15 Issue: 1 Pages: 58-58

    • DOI

      10.1186/s12896-015-0142-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K01291, KAKENHI-PROJECT-26460275, KAKENHI-PROJECT-26860733, KAKENHI-PROJECT-25221308
  • [Journal Article] An induced pluripotent stem cell-mediated and integration-free factor VIII expression system.2013

    • Author(s)
      Yakura y, et. al.
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 431 Issue: 2 Pages: 336-341

    • DOI

      10.1016/j.bbrc.2012.12.096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00264, KAKENHI-PROJECT-23591407, KAKENHI-PROJECT-23659040, KAKENHI-PROJECT-24659469, KAKENHI-PROJECT-24790974
  • [Journal Article] An induced pluripotent stem cell-mediated and integration-free factor VIII expression system2013

    • Author(s)
      Yakura Y, Ishihara C, Kurosaki H, Kazuki Y, Komatsu N, Okada Y, Doi T, Takeya H, Oshimura M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 431(2) Pages: 336-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Journal Article] Integration-free and stable expression of FVIII using a human artificial chromosome2011

    • Author(s)
      Kurosaki H, et.al.
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Issue: 10 Pages: 727-733

    • DOI

      10.1038/jhg.2011.88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00264, KAKENHI-PROJECT-21659238, KAKENHI-PROJECT-22590301, KAKENHI-PROJECT-23591426
  • [Journal Article] Effects of Tritrichomonas muris on the Mouse Intestine: A Proteomic Analysis.2009

    • Author(s)
      Kashiwagi A, Kurosaki H, Luo H, Yamamoto H, Oshimura M, Shibahara T.
    • Journal Title

      Experimental Animals Vol.58,No.5

      Pages: 537-542

    • NAID

      130000122265

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890130
  • [Presentation] Pharmacological and toxicological evaluation in mouse and cynomolgus monkey with tumor-targeted and armed oncolytic vaccinia virus2019

    • Author(s)
      黒崎 創
    • Organizer
      2019年度 若手支援「技術講習会」
    • Data Source
      KAKENHI-PROJECT-16K09828
  • [Presentation] Novel Approach for Systemic Cancer Therapy with Oncolytic Vaccinia Virus through Evading the Host Immune Response2018

    • Author(s)
      Motomu Nakatake, Hajime Kurosaki, Takafumi Nakamura
    • Organizer
      ASGCT 21th Annual Meeting, Chicago, IL, 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09828
  • [Presentation] Preclinical toxicological evaluation in cynomolgus monkey with tumor-targeted and armed oncolytic vaccinia virus purified through manufacturing process2018

    • Author(s)
      Hajime Kurosaki, Tomotaka Okamura, Mai Itoh, Motomu Nakatake, Nozomi Kuwano, Kosuke Horita, Kenta Ishii, Hiromichi Kohno, Yasuhiro Yasutomi, and Takafumi Nakamura
    • Organizer
      The 24rd Annual Meeting of Japan Society of Gene Therapy, Tokyo, 2018
    • Data Source
      KAKENHI-PROJECT-16K09828
  • [Presentation] Novel approach for systemic cancer therapy with oncolytic vaccnia virus through evading the host immune response2018

    • Author(s)
      Motomu Nakatake, Hajime Kurosaki and Takafumi Nakamura
    • Organizer
      The 24rd Annual Meeting of Japan Society of Gene Therapy, Tokyo, 2018
    • Data Source
      KAKENHI-PROJECT-16K09828
  • [Presentation] Predictive biomarkers for cancer virotherapy with oncolytic vaccinia virus2018

    • Author(s)
      Kosuke Horita, Hajime Kurosaki, Motomu Nakatake, Nozomi Kuwano, Kenta Ishii, Hiromichi Kohno, Mai Itoh, Hiroaki Itamochi, Tetsuro Oishi, Tasuku Harada and Takafumi Nakamura
    • Organizer
      The 24rd Annual Meeting of Japan Society of Gene Therapy, Tokyo, 2018
    • Data Source
      KAKENHI-PROJECT-16K09828
  • [Presentation] Preclinical Study of Tumor-Targeted and Armed Oncolytic Vaccinia Virus for Systemic Cancer Virotherapy2017

    • Author(s)
      Motomu Nakatake, Hajime Kurosaki, Kosuke Horita, Nozomi Kuwano, Kenta Ishii, Miyuki Nomura, Teruhisa Sakamoto, Tomotaka Okamura, Yasuhiro Yasutomi, Takafumi Nakamura
    • Organizer
      ASGCT 20th Annual Meeting, May 10 - 13, 2017, Washington, DC
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09828
  • [Presentation] Preclinical study for tumor-targeted and armed oncolytic vaccinia virus for systemic cancer virotherapy2016

    • Author(s)
      Motomu Nakatake, Hajime Kurosaki, Kosuke Horita, Kenta Ishii, Nozomi kuwano, Kosei Hasegawa, Keiichi Fujiwara, Miyuki Nomura and Takafumi Nakamura
    • Organizer
      The 22st Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Toranomon Hills forum, Tokyo, Japan
    • Year and Date
      2016-07-29
    • Data Source
      KAKENHI-PROJECT-16K09828
  • [Presentation] Upregulated lncRNA-UCA1 enhances therapeutic effect of oncolytic vaccinia virus in paclitaxel resistant ovarian cancer2016

    • Author(s)
      Kosuke Horita, Hajime Kurosaki, Motomu Nakatake, Nozomi kuwano, Kenta Ishii, Miyuki Nomura, Hiroaki Itamochi, Tetsuro Oishi, Tasuku Harada and Takafumi Nakamura
    • Organizer
      The 22st Annual Meeting of Japan Society of Gene Therapy, Tokyo, 2016
    • Place of Presentation
      Toranomon Hills forum, Tokyo, Japan
    • Year and Date
      2016-07-29
    • Data Source
      KAKENHI-PROJECT-26860733
  • [Presentation] Identification of host factors required for enhancing replication and spread of oncolytic vaccinia virus2015

    • Author(s)
      Horita K., Nakatake M., Goto I., Yamane M., Okazaki M., Rarada R., Kurosaki H., Nakamura T.
    • Organizer
      The 21st Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Osaka International Convention Center, Nakanoshima, Kita-ku, Osaka, Japan
    • Year and Date
      2015-07-25
    • Data Source
      KAKENHI-PROJECT-26860733
  • [Presentation] Engineered integration-free iPS cells using artifidcial chromosome vectors for hemophilia A therapy2015

    • Author(s)
      Kurosaki H, Yakura Y, Hiratsuka M, Takehara S, Yoshino T, Kazuki Y, Nakamura T, Oshimura M
    • Organizer
      The 21st Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Osaka International Convention Center, Nakanoshima, Kita-ku, Osaka, Japan
    • Year and Date
      2015-07-24
    • Data Source
      KAKENHI-PROJECT-26860733
  • [Presentation] Enhancing tumor specificity and therapeutic index of oncolytic vaccinia virus through deletions of both VGF and O1 protein genes2015

    • Author(s)
      Nakatake M, Yamane M, Parada R, Horita K, Okazaki M, Hasegawa K, Miyara A, Fujiwara K, Kurosaki H, Nakamura T
    • Organizer
      The 21st Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Osaka International Convention Center, Nakanoshima, Kita-ku, Osaka, Japan
    • Year and Date
      2015-07-25
    • Data Source
      KAKENHI-PROJECT-26860733
  • [Presentation] ENGINEERED INTEGRATION-FREE iPS CELLS USING ARTIFICIAL CHROMOSOME VECTORS FOR HEMOPHILIA A THERAPY2014

    • Author(s)
      Hajime Kurosaki, Kana Ueda, Teruhiko Suzuki, Yuwna Yakura, Sayaka Fukuhara, Masaharu Hiratsuka, Shoko Takehara, Toko Yoshino, Yasuhiro Kazuki, Takafumi Nakamura and Mitsuo Oshimura
    • Organizer
      The 20th annual meeting JSGT 2014
    • Place of Presentation
      The Jikei University School of Medicine, Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Presentation] Toward safe and effective gene- and cell-therapies using human artificial chromosomes and stem cells2013

    • Author(s)
      Narumi Uno, Kana Ueda, Yuichi Iida, Yuna Yakura, Hajime Kurosaki, Katsuhiro Uno, Mitsuhiko Osaki, Tetsuya Ohbayashi, Yasuhiro Kazuki, Masaharu Hiratuka and Mitsuo Oshimura
    • Organizer
      International Conference on Genetic Engineering & Genetically Modified Organisms
    • Place of Presentation
      DoubleTree by Hilton, Raleigh, NC, USA
    • Year and Date
      2013-08-13
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Presentation] Systemic cancer virotherapy with MDVV, a combined miRNA-regulated and thymidine kinase-deleted oncolytic vaccinia virus2013

    • Author(s)
      Nitta N., Okada N., Goto I., Yamane M., Nakatake M., Kurosaki H., Nakamura T
    • Organizer
      The 19th annual meeting JSGT 2013
    • Place of Presentation
      OKAYAMA CONVENTION CENTER, Okayama, Japan
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Presentation] Toward safe and effective gene- and cell-therapies using human artificial chromosomes and stem cells.2013

    • Author(s)
      Narumi Uno, Kana Ueda, Yuichi Iida, Yuna Yakura, Hajime Kurosaki, Katsuhiro Uno,Mitsuhiko Osaki, Tetsuya Ohbayashi, Yasuhiro Kazuki, Masaharu Hiratuka, Mitsuo Oshimura.
    • Organizer
      CiRA International Symposium 2013 Raising the Next Generation of Stem Cell Research
    • Place of Presentation
      Kyoto University Clock Tower Hall, Japan
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Presentation] Systemic cancer virotherapy with MDVV, a combined miRNA-regulated and thymidine kinase-deleted oncolytic vaccinia virus2013

    • Author(s)
      Nitta N., Okada N., Goto I., Yamane M., Nakatake M., Kurosaki H., Nakamura T
    • Organizer
      The 19th annual meeting JSGT2013
    • Place of Presentation
      CONVENTION CENTER
    • Year and Date
      2013-07-04
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Presentation] Human artificial chromosomes for gene delivery2012

    • Author(s)
      Oshimura M , Kazuki Y , Hiratsuka M , Ohbayashi T, Iida Y, Uno N, Ueno E, Ueda K, Ohira T, Kurosaki H, Abe S, Kugoh H
    • Organizer
      Pep Talk
    • Place of Presentation
      USA
    • Year and Date
      2012-01-09
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Presentation] ヒト人工染色体を用いた血小板特異的FVIII 発現iPS細胞の作製-新規治療法確立へ向けて2012

    • Author(s)
      矢倉裕奈, 黒崎創, 石原千恵, 香月康宏, 土井健史, 武谷浩之, 押村光雄
    • Organizer
      第34回日本血栓止血学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-09
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Presentation] 人工染色体ベクターを用いた新規血友病A 遺伝子治療法の開発2012

    • Author(s)
      矢倉裕奈, 黒崎創, 石原千恵, 香月康宏, 土井健史, 松下正, 武谷浩之, 押村光雄
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-14
    • Data Source
      KAKENHI-PROJECT-24790974
  • [Presentation] ヒト人工染色体を用いた血小板特異的FVIII発現iPS細胞の作製-新規治療法確立へ向けて2012

    • Author(s)
      矢倉裕奈、黒崎創、石原千恵、香月康宏、土井健史、武谷浩之、押村光雄
    • Organizer
      第34回日本血栓止血学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-09
    • Data Source
      KAKENHI-PROJECT-21659238
  • [Presentation] 人工染色体ベクターを用いた新規血友病A遺伝子治療法の開発2012

    • Author(s)
      矢倉裕奈、黒崎創、石原千恵、香月康宏、土井健史、松下正、武谷浩之、押村光雄
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-14
    • Data Source
      KAKENHI-PROJECT-21659238
  • [Presentation] ヒト人工染色体とiPS細胞を用いた新規血友病遺伝子治療法2011

    • Author(s)
      矢倉裕奈、石原千恵、藤井昂洸、香月康宏、黒崎創、土井健史、小松則夫、押村光雄、武谷浩之
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-21659238
  • [Presentation] 血友病A型細胞補充療法を目指したヒト第VIII因子発現HACベクターの有用性の検討2010

    • Author(s)
      黒崎創
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      国際会議場(広島)
    • Year and Date
      2010-03-18
    • Data Source
      KAKENHI-PROJECT-20890130
  • [Presentation] Human FVIII expression using a HAC vector toward stem cell-mediated gene therapy for hemophilia A2009

    • Author(s)
      Hajime Kurosaki
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2009-10-22
    • Data Source
      KAKENHI-PROJECT-20890130
  • [Presentation] ヒト人工染色体を用いた血小板特異的な第VIII因子発現系の確立2009

    • Author(s)
      矢倉裕奈、石原千恵、林輝、松井俊樹、松本幸子、黒崎創、押村光雄、土井健史、小松則夫、武谷浩之
    • Organizer
      第32回日本血栓止血学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21659238
  • [Presentation] Development of human artificial chromosome vectors for gene therapy of hemophilia A2009

    • Author(s)
      Yakura Y, Ishihara C, Hayashi A, Matsui T, Matsumoto S, Kurosaki H, Oshimura M, Doi T, Komatsu N, and Takeya H
    • Organizer
      XXIIst Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Boston
    • Year and Date
      2009-07-16
    • Data Source
      KAKENHI-PROJECT-21659238
  • [Presentation] Human FVIII Expression Using a HAC Vector Toward Gene Therapy for Hemophilia A2008

    • Author(s)
      Hajime Kurosaki
    • Organizer
      American Society of Gene Therapy 11t h Annual Meeting
    • Place of Presentation
      Boston, Massachusetts in USA
    • Year and Date
      2008-05-31
    • Data Source
      KAKENHI-PROJECT-20890130
  • [Presentation] Human FVIII Expression Using a HAC Vector Toward Gene Therapy for Hemophilia A2008

    • Author(s)
      Hajime Kurosaki
    • Organizer
      American Society of Gene Therapy 11^<th> Annua1 Meeting
    • Place of Presentation
      Boston, Massachusetts in USA
    • Year and Date
      2008-05-31
    • Data Source
      KAKENHI-PROJECT-20890130
  • [Presentation] ENGINEERED INTEGRATION-FREE iPS CELLS USING ARTIFICIAL CHROMOSOME VECTORS FOR HEMOPHILIA A THERAPY

    • Author(s)
      Hajime Kurosaki, Kana Ueda, Teruhiko Suzuki, Yuwna Yakura, Sayaka Fukuhara, Masaharu Hiratsuka, Shoko Takehara, Toko Yoshino, Yasuhiro Kazuki, Takafumi Nakamura and Mitsuo Oshimura
    • Organizer
      20th Annual Meeting of JSGT 2014
    • Place of Presentation
      Jikei University School of Medicine (Daigaku Ichigou-kan), 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan
    • Year and Date
      2014-08-06 – 2014-08-08
    • Data Source
      KAKENHI-PROJECT-26860733
  • [Presentation] DELETIONS OF BOTH VACCINIA GROWTH FACTOR AND O1 PROTEIN GENES ENHANCE THERAPEUTIC INDEX OF ONCOLYTIC VACCINIA VIRUS

    • Author(s)
      Naoyoshi Nitta, Ikumi Goto, Motomu Nakatake, Masato Yamane, Kosuke Horita, Hajime Kurosaki and Takafumi Nakamura
    • Organizer
      20th Annual Meeting of JSGT 2014
    • Place of Presentation
      Jikei University School of Medicine (Daigaku Ichigou-kan), 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan
    • Year and Date
      2014-08-06 – 2014-08-08
    • Data Source
      KAKENHI-PROJECT-26860733
  • 1.  TAKETA Hiroyuki (60222105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  加藤 基伸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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