Kawahara Manabu 川原学

… Alternative Names

Researcher Number	70468700
Other IDs
External Links
Affiliation (Current)	2022: 北海道大学, 農学研究院, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 北海道大学, 農学研究院, 准教授 2012 – 2016: 北海道大学, (連合)農学研究科(研究院), 准教授 2008 – 2009: Saga University, 農学部, 准教授
Review Section/Research Field	Principal Investigator Applied animal science / Basic Section 42010:Animal production science-related / Laboratory animal science Except Principal Investigator Animal production science / Basic Section 42010:Animal production science-related
Keywords	Principal Investigator 哺乳類 / ウシ / ゲノムインプリンティング / 核移植 / 卵子ゲノム / 個体発生 / マウス / 初期胚発生 / 胚盤胞期胚 / 栄養膜細胞 … More Except Principal Investigator ウシ / 乳腺上皮細胞 / TRPチャネル / 乳分泌 / 乳腺発達 / 子宮内膜 / スフェロイド / 胚性分泌因子 / RNAseq / LC/MS/MS / 胚性シグナル応答遺伝子 / 着床 / 妊娠認識 / オートファジー・リソソーム / インターフェロンτ / ウシ子宮 / カテプシン / 妊娠 / アポトーシス / ピロトーシス / IFNτ / 妊娠応答 / IFNtau / IFNAR / 畜産学 / 子宮 / 泌乳期 / 形態形成 / 暑熱ストレス / 乳腺 / 寒冷ストレス / ヒートショックプロテイン / 乳分泌培養モデル / 熱ショックタンパク質 / 物理化学的刺激 Less

初期胚分化制御機構の解明に基づくウシガラス化保存胚の発生能改善Principal Investigator
- Principal Investigator
  
  川原学
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hokkaido University
物理化学的刺激を感知するTRPチャネルが乳腺組織の形態形成と乳分泌を制御する機構
- Principal Investigator
  
  小林謙
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hokkaido University
乳腺上皮細胞の温度応答性分子群が乳腺組織の形態形成と機能発現を制御する機構の解明
- Principal Investigator
  
  小林謙
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hokkaido University
Trophectoderm regeneration to support full-term development in the inner cell mass isolated from bovine blastocystPrincipal Investigator
- Principal Investigator
  
  Kawahara Manabu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hokkaido University
The role of nuclear-mitochondrial interaction in mouse embryo implantationPrincipal Investigator
- Principal Investigator
  
  Kawahara Manabu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Hokkaido University
Role of autophagy-lysosomal related responses on uterine modulation at the time of maternal-fetal recogntion
- Principal Investigator
  
  Takahashi Masashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  Hokkaido University
Elucidation of embryonic secretory factors using bovine endometrial spheroids
- Principal Investigator
  
  Yamauchi Nobuhiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  Kyushu University
Exploring novel paternally methylated imprinted genes using bi-maternal mouse fetusesPrincipal Investigator
- Principal Investigator
  
  KAWAHARA manabu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  Hokkaido University
Determination of paternally methylated imprinted regions in mouse genomePrincipal Investigator
- Principal Investigator
  
  KAWAHARA Manabu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  Saga University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2010 2009 2008 Other

All Journal Article Presentation Patent

[Journal Article] Lipopolysaccharide and lipoteichoic acid influence milk production ability via different early responses in bovine mammary epithelial cells2021
- Author(s)
  Tsugami Y, Wakasa H, Kawahara M, Nishimura T, Kobayashi K
- Journal Title
  
  Experimental Cell Research
  
  Volume: 15 Pages: 112472-112472
- DOI
  10.1016/j.yexcr.2021.112472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320, KAKENHI-PROJECT-18H02321, KAKENHI-PROJECT-19J10189
[Journal Article] Requirement for expression of WW domain containing transcription regulator 1 in bovine trophectoderm development2021
- Author(s)
  Saito Shun, Yamamura Shota, Kohri Nanami, Bai Hanako, Takahashi Masashi, Kawahara Manabu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 555 Pages: 140-146
- DOI
  10.1016/j.bbrc.2021.03.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15644, KAKENHI-PROJECT-18H02321
[Journal Article] Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells2021
- Author(s)
  Tsugami Y, Wakasa H, Kawahara M, Watanabe A, Suzuki T, Nishimura T, Kobayashi K
- Journal Title
  
  Cell and Tissue Research
  
  Volume: ahead of print
- DOI
  10.1007/s00441-020-03344-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320, KAKENHI-PROJECT-18H02321, KAKENHI-PROJECT-19J10189
[Journal Article] Establishment of an in vitro culture model to study milk production and the blood?milk barrier with bovine mammary epithelial cells2020
- Author(s)
  Tsugami Y, Suzuki N, Kawahara M, Suzuki T, Nishimura T, Kobayashi K
- Journal Title
  
  Animal Science Journal
  
  Volume: 91 Pages: 1-12
- DOI
  10.1111/asj.13355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02320, KAKENHI-PROJECT-19J10189
[Journal Article] Vitrification-induced activation of lysosomal cathepsin B perturbs spindle assembly checkpoint function in mouse oocytes2020
- Author(s)
  Balboula Ahmed Z、Schindler Karen、Kotani Tomoya、Kawahara Manabu、Takahashi Masashi
- Journal Title
  
  Molecular Human Reproduction
  
  Volume: 26 Pages: 689-701
- DOI
  10.1093/molehr/gaaa051
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02321
[Journal Article] Effect of summer heat stress on gene expression in bovine uterine endometrial tissues2020
- Author(s)
  Bai Hanako, Ukita Haruka, Kawahara Manabu, Mitani Tomohiro, Furukawa Eri, Yanagawa Yojiro, Yabuuchi Naoto, Kim Heejin, Takahashi Masashi
- Journal Title
  
  Animal Science Journal
  
  Volume: 91
- DOI
  10.1111/asj.13474
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15644, KAKENHI-PROJECT-18H02321
[Journal Article] The role of RHOA signaling in trophectoderm cell-fate decision in cattle2020
- Author(s)
  Kohri Nanam, Akizawa Hiroki, Iisaka Sakie, Bai Hanako, Takahashi Masashi, Kawahara Manabu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 528 Pages: 713-718
- DOI
  10.1016/j.bbrc.2020.05.210
- NAID
  120007126837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15644, KAKENHI-PROJECT-18H02321
[Journal Article] Yes-associated protein 1 translocation through actin cytoskeleton organization in trophectoderm cells2020
- Author(s)
  Yamamura Shota, Goda Nanami, Akizawa Hiroki, Kohri Nanami, Balboula Ahmed Z, Kobayashi Ken, Bai Hanako, Takahashi Masashi, Kawahara Manabu
- Journal Title
  
  Developmental Biology
  
  Volume: 468 Pages: 14-25
- DOI
  10.1016/j.ydbio.2020.09.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15644, KAKENHI-PROJECT-18H02321
[Journal Article] Trophectoderm regeneration to support full-term development in the inner cell mass isolated from bovine blastocyst2019
- Author(s)
  Kohri Nanami、Akizawa Hiroki、Iisaka Sakie、Bai Hanako、Yanagawa Yojiro、Takahashi Masashi、Komatsu Masaya、Kawai Masahito、Nagano Masashi、Kawahara Manabu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Pages: 19209-19223
- DOI
  10.1074/jbc.ra119.010746
- NAID
  120006940625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02321
[Journal Article] Effects of use of conventional and sexed semen on the conception rate in heifers: A comparison study2019
- Author(s)
  Oikawa Kohei、Yamazaki Takeshi、Yamaguchi Satoshi、Abe Hayato、Bai Hanako、Takahashi Masashi、Kawahara Manabu
- Journal Title
  
  Theriogenology
  
  Volume: 135 Pages: 33-37
- DOI
  10.1016/j.theriogenology.2019.06.012
- NAID
  120006882075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02321
[Journal Article] Significance of CCN2 expression in bovine preimplantation development.2019
- Author(s)
  Akizawa Hiroki、Yanagawa Yojiro、Nagano Masashi、Bai Hanako、Takahashi Masashi、Kawahara Manabu
- Journal Title
  
  Animal Science Journal
  
  Volume: 90 Pages: 49-54
- DOI
  10.1111/asj.13126
- NAID
  120006776818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17J01122, KAKENHI-PROJECT-17K15357, KAKENHI-PROJECT-18H02321
[Journal Article] Overgrowth of mice generated from postovulatory aged oocyte spindles.2019
- Author(s)
  Shiina K, Komatsu M, Yokoi F, Bai H, Takahashi T, Kawahara M.
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 印刷中 Pages: 1-11
- DOI
  10.1096/fba.2019-00005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15357, KAKENHI-PROJECT-18H02321
[Journal Article] Evaluating the electrical impedance and mucus-related gene expression of uterine endometrial tissues in mares2018
- Author(s)
  Kikuchi K, Kozai K, Hojo T, Sakatani M, Okuda K, Bai H, Kawahara M, Takahashi M.
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 64 Issue: 2 Pages: 193-197
- DOI
  10.1262/jrd.2017-128
- NAID
  130006699687
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15357, KAKENHI-PROJECT-26292136, KAKENHI-PROJECT-16K14587
[Journal Article] Reciprocal regulation of TEAD4 and CCN2 for the trophectoderm development of the bovine blastocyst2018
- Author(s)
  Akizawa H., Kobayashi K., Bai H., Takahashi M., Kagawa S., Nagatomo H. and Kawahara M.
- Journal Title
  
  Reproduction
  
  Volume: IN PRESS Pages: 563-571
- DOI
  10.1530/rep-18-0043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14587, KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-17J01122, KAKENHI-PROJECT-17K15357
[Journal Article] インターフェロン-τ化学合成ペプチドによるウシ子宮内膜細胞活性リガンド領域の探索2018
- Author(s)
  鈴木惇文・木村康二・唄花子・川原学・高橋昌志
- Journal Title
  
  北海道畜産草地学会報
  
  Volume: 印刷中
- NAID
  130007730561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04579
[Journal Article] Identification and expression analysis of cDNA encoding insulin-like growth factor 2 in horses2018
- Author(s)
  Kikuchi K, Sasaki K, Akizawa H, Tsukahara H, Bai H, Takahashi M, Nambo Y, Hata H, Kawahara M.
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 64 Issue: 1 Pages: 57-64
- DOI
  10.1262/jrd.2017-124
- NAID
  130006405024
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15357, KAKENHI-PROJECT-17J01122, KAKENHI-PROJECT-16K14587, KAKENHI-PROJECT-15H04579
[Journal Article] Estrous cycle stage-dependent manner of type I interferon-stimulated genes induction in the bovine endometrium2017
- Author(s)
  Shirozu T, Iwano H, Ogiso T, Suzuki T, Balboula AZ, Bai H, Kawahara M, Kimura K, Takahashi H, Rulan B, Kim SW, Yanagawa Y, Nagano M, Imakawa K, Takahashi M.
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 2017 Issue: 3 Pages: 211-220
- DOI
  10.1262/jrd.2016-176
- NAID
  130007314602
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14587, KAKENHI-PROJECT-15H04579
[Journal Article] Pyridoxine supplementation during oocyte maturation improves the developmental rate and quality of bovine preimplantation embryos.2017
- Author(s)
  Aboelenain M, Balboula AZ, Kawahara M, El-Monem Montaser A, Zaabel SM, Kim SW, Nagano M, Takahashi M.
- Journal Title
  
  Theriogenology
  
  Volume: 91 Pages: 127-133
- DOI
  10.1016/j.theriogenology.2016.12.022
- NAID
  120006370595
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14587, KAKENHI-PROJECT-15H04579
[Journal Article] Enhancement of sperm motility and viability by turmeric by-product dietary supplementation in roosters.2017
- Author(s)
  Yan W, Kanno C, Oshima E, Kuzuma Y, Kim SW, Bai H, Takahashi M, Yanagawa Y, Nagano M, Wakamatsu JI, Kawahara M.
- Journal Title
  
  Animal Reproduction Science
  
  Volume: 185 Pages: 195-204
- DOI
  10.1016/j.anireprosci.2017.08.021
- NAID
  120006523735
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15357, KAKENHI-PROJECT-16K14587
[Journal Article] Expression dynamics of bovine <i>MX</i> genes in the endometrium and placenta during early to mid pregnancy2016
- Author(s)
  Shirozu T., Sasaki K., Kawahara M., Yanagawa Y., Nagano M., Yamauchi N., and Takahashi M.
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 62 Issue: 1 Pages: 29-35
- DOI
  10.1262/jrd.2015-086
- NAID
  130005126316
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04579
[Journal Article] Requirement for nuclear autoantigenic sperm protein mRNA expression in bovine preimplantation development.2016
- Author(s)
  Nagatomo H., Kohri N., Akizawa H., Hoshino Y., Yamauchi N., Kono T., Takahashi M., and Kawahara M.
- Journal Title
  
  Animal Science Journal
  
  Volume: 87 Pages: 457-461
- DOI
  10.1111/asj.12538
- NAID
  120005981356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14587
[Journal Article] Conserved roles of fibroblast growth factor receptor 2 signaling in the regulation of inner cell mass development in bovine blastocysts.2016
- Author(s)
  Akizawa H., Nagatomo H., Odagiri H., Kohri N., Yamauchi N., Yanagawa Y., Nagano M., Takahashi M., and Kawahara M.
- Journal Title
  
  Molecular Reproduction and Development
  
  Volume: 83 Pages: 516-525
- DOI
  10.1002/mrd.22646
- NAID
  120006219875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14587
[Journal Article] Conserved roles of fibroblast growth factor receptor 2 signaling in the regulation of inner cell mass development in bovine blastocysts.2016
- Author(s)
  Akizawa H, Nagatomo H, Odagiri H, Kohri N, Yamauchi N, Yanagawa Y, Nagano M, Takahashi M, Kawahara M.
- Journal Title
  
  Mol Reprod Dev.
  
  Volume: 83 Pages: 516-25
- NAID
  120006219875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292141
[Journal Article] The Influence of Polyploidy and Genome Composition on Genomic Imprinting in Mice.2016
- Author(s)
  Yamazaki W., Amano T., Bai H., Takahashi M., and Kawahara M.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 291 Pages: 20924-20931
- NAID
  120006666502
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K14587
[Journal Article] Status of autophagy, lysosome activity and apoptosis during corpus luteum regression in cattle.2015
- Author(s)
  Aboelenain M, Kawahara M, Balboula AZ, Montasser AE, Zaabel SM, Okuda K, Takahashi M.
- Journal Title
  
  Journal of reproduction and development
  
  Volume: Epub ahead of print Pages: 1-8
- NAID
  130005077734
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24780265
[Journal Article] A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus.2014
- Author(s)
  Sasaki K, Tungtrakoolsub P, Morozumi T, Uenishi H, Kawahara M, Watanabe T.
- Journal Title
  
  Immunogenetics
  
  Volume: 66 Pages: 25-32
- NAID
  120005553686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780265
[Journal Article] Restricted development of mouse triploid fetuses with disorganized expression of imprinted genes.2014
- Author(s)
  Yamazaki W, Takahashi M, Kawahara M.
- Journal Title
  
  Zygote
  
  Volume: Epub ahead of print Pages: 1-11
- NAID
  120005768767
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24780265
[Journal Article] Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631.2013
- Author(s)
  Sasaki K, Yoneda A, Ninomiya A, Kawahara M, Watanabe T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 430 Pages: 161-166
- DOI
  10.1016/j.bbrc.2012.11.053
- NAID
  120005228264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780265
[Journal Article] Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation.2013
- Author(s)
  Balboula AZ, Yamanaka K, Sakatani M, Kawahara M, Hegab AO, Zaabel SM, Takahashi M.
- Journal Title
  
  Reproduction
  
  Volume: 146 Pages: 407-417
- DOI
  10.1530/rep-13-0179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780265
[Journal Article] Successful vitrification of bovine immature oocytes retrieved by ovum pick-u2013
- Author(s)
  Aono, A., Nagatomo, H., Takuma, T., Nonaka, R., Ono, Y., Wada, Y., Abe, Y., Watanabe, T., Kawahara, M.
- Journal Title
  
  Theriogenology
  
  Volume: 79 Pages: 1146-1152
- DOI
  10.1016/j.theriogenology.2013.02.009
- NAID
  120005572429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23780278, KAKENHI-PROJECT-24780265
[Journal Article] Transcriptional wiring for establishing cell lineage specification at the blastocyst stage in cattle.2013
- Author(s)
  Nagatomo, H., Kagawa, S., Kishi, Y., Takuma, T., Sada, A., Yamanaka, K., Abe, Y., Wada, Y., Takahashi, M., Kono, T., Kawahara, M.
- Journal Title
  
  Biology of Reproduction
  
  Volume: Jun 27;88(6) Pages: 1-10
- DOI
  10.1095/biolreprod.113.108993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23780278, KAKENHI-PROJECT-24580439, KAKENHI-PROJECT-24780265
[Journal Article] Longevity in mice without a father2010
- Author(s)
  川原学, 河野友宏
- Journal Title
  
  Human Reproduction 25巻
  
  Pages: 457-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Longevity in mice without a father2010
- Author(s)
  Manabu Kawahara, Tomohiro Kono.
- Journal Title
  
  Human Reproduction 25
  
  Pages: 457-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Early metaphase II oocytes treated with dibutyryl cyclic adenosine monophosphate provide suitable recipient cytoplasm for the production of miniature pig somatic cell nuclear transfer embryos2010
- Author(s)
  杉村智志, 山中謙一, 川原学, 若井拓哉, 横尾正樹, 佐藤英明
- Journal Title
  
  Animal Science Journal 81巻
  
  Pages: 48-57
- NAID
  10027888500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Involvement of insulin-like growth Factor 2 in angiogenic factor transcription in bi-maternal mouse conceptuses.2010
- Author(s)
  Manabu Kawahara, Qiong Wu, Tomohiro Kono.
- Journal Title
  
  Journal of Reproduction and Development 56
  
  Pages: 79-85
- NAID
  10026323565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Involvement of insulin-like growth Factor 2 in angiogenic factor transcription in bi-maternal mouse conceptuses2010
- Author(s)
  川原学, Qiong Wu, 河野友宏
- Journal Title
  
  Journal of Reproduction and Development 56巻
  
  Pages: 79-85
- NAID
  10026323565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Early metaphase II oocytes treated with dibutyryl cyclic adenosine monophosphate provide suitable recipient cytoplasm for the production of miniature pig somatic cell nuclear transfer embryos.2010
- Author(s)
  Satoshi Sugimura, Ken-ichi Yamanaka, Manabu Kawahara, Takuya Wakai, Masaki Yokoo, Eimei Sato.
- Journal Title
  
  Animal Science Journal 81
  
  Pages: 48-57
- NAID
  10027888500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Anomalous oxygen consumption in porcine somatic cell nuclear transfer embryos2010
- Author(s)
  杉村智志, 横尾正樹, 山中謙一, 川原学, 森安悟, 若井拓哉, 永井卓, 阿部宏之, 佐藤英明
- Journal Title
  
  Cellular Reprogramming (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Anomalous oxygen consumption in porcine somatic cell nuclear transferembryos.2010
- Author(s)
  Satoshi Sugimura, Masaki Yokoo, Ken-ichi Yamanaka, Manabu Kawahara, Satoru Moriyasu, Takuya Wakai, Takashi Nagai, Hiroyuki Abe, Eimei Sato.
- Journal Title
  
  Cellular Reprogramming (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos.2009
- Author(s)
  Ken-ichi Yamanaka, Satoshi Sugimura, Takuya Wakai, Manabu Kawahara, Eimei Sato.
- Journal Title
  
  Journal of Reproduction and Development 55
  
  Pages: 638-644
- NAID
  10026322712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Defining contributions of paternally methylated imprinted genes at the Igf2-H19 and Dlk1-Gtl2 domains to mouse placentation by transcriptomic analysis2009
- Author(s)
  川原学, 森田慎之介, 高橋望, 河野友宏
- Journal Title
  
  Journal of Biological Chemistry 284巻
  
  Pages: 17751-17765
- NAID
  120006377532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Defining contributions of paternally methylated imprinted genes at the IGF2-H19 and DLK1-GT12 domains to mouse placentation by transcriptomic analysis2009
- Author(s)
  Manabu Kawahara, Shinnosuke Morita, Nozomi Takahashi, Tomohiro Kono
- Journal Title
  
  The Journal of Biological Chemistry (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Journal Article] Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos2009
- Author(s)
  山中謙一, 杉村智志, 若井拓哉, 川原学, 佐藤英明
- Journal Title
  
  Journal of Reproduction and Development 55巻
  
  Pages: 638-644
- NAID
  10026322712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780201
[Patent] 内部細胞塊から腔再形成胚を作製する方法および腔再形成胚を用いたウシ個体の作出方法2019
- Inventor(s)
  川原学、郡七海、高橋昌志、唄花子
- Industrial Property Rights Holder
  川原学、郡七海、高橋昌志、唄花子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-172732
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02321
[Patent] 反芻動物の妊娠判定方法2017
- Inventor(s)
  高橋昌志、國井宏樹、伊藤月乃、川原　学、唄　花子、鈴木惇文
- Industrial Property Rights Holder
  高橋昌志、國井宏樹、伊藤月乃、川原　学、唄　花子、鈴木惇文
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-163839
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] Effect of EAS on HSP70 related progesterone synthesis in bovine cumulusgranulosa cells.2021
- Author(s)
  Khoi Thieu HO, Kohei HOMMA, Jun TAKANARI, Tomohiro MITANI, Hanako BAI, Manabu KAWAHARA, Kim Khang Thi NGUYEN, Masashi TAKAHASHI.
- Organizer
  日本畜産学会、九州大学(福岡県)
- Data Source
  KAKENHI-PROJECT-18H02321
[Presentation] Effect of zona pellucida on early development and gene expression in mouse embryos.2021
- Author(s)
  Weihong FAN, Hanako BAI, Manabu KAWAHARA, Masashi TAKAHASHI.
- Organizer
  日本畜産学会、九州大学(福岡県)
- Data Source
  KAKENHI-PROJECT-18H02321
[Presentation] Species-specific dynamics of mitochondrial content within an embryo during preimplantation development in mice and cattle.2020
- Author(s)
  Komatsu M., Yokoi F., Imai S., Yamane M., Bai H., Takahashi M., and Kawahara M.
- Organizer
  Fertility Conference and Exhibition 2020, Edinburgh (UK).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02321
[Presentation] 性選別精液による乳牛人工授精の受胎率に及ぼす環境要因の影響.2018
- Author(s)
  及川康平, 山崎武志, 山口諭, 阿部隼人, 唄花子, 高橋昌志, 川原学.
- Organizer
  日本繁殖生物学会 (長野県上田市)
- Data Source
  KAKENHI-PROJECT-18H02321
[Presentation] 乳牛の分娩前後における末梢血単核球のストレスおよび免疫関連因子の解析.2018
- Author(s)
  唄花子, Shabur Md Abdus TALUKDER, 国井宏樹, 伊藤月乃, 川原学, 高橋昌志.
- Organizer
  日本繁殖生物学会 (長野県上田市)
- Data Source
  KAKENHI-PROJECT-18H02321
[Presentation] ウシ子宮内膜上皮細胞を用いた暑熱負荷培養およびインターフェロン・タウ応答性の検証.2018
- Author(s)
  小松正明, 鈴木惇文, 国井宏樹, 川原学, 木村康二, 高橋昌志, 唄花子.
- Organizer
  日本繁殖生物学会 (長野県上田市)
- Data Source
  KAKENHI-PROJECT-18H02321
[Presentation] ウシ-マウス間ミトコンドリアヘテロプラスミー胚の栄養膜細胞形成能.2018
- Author(s)
  詫間光, 小松雅也, 唄花子, 高橋昌志, 小川英彦, 川原学.
- Organizer
  日本生殖発生医学会 (東京)
- Data Source
  KAKENHI-PROJECT-16K14587
[Presentation] Elucidation of lysosomal cathepsins in bovine blood leukocytes during early pregnancy2018
- Author(s)
  M.A.S. Talukder, A.Z. Balboula, H. Iwano, T. Suzuki, T. Ito, H. Bai, M. Kawahara, M. Takahashi
- Organizer
  1st International Conference on Challenges for Future Agriculture
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] Hippo経路標的分子TAZ 遺伝子の発現抑制がウシ初期胚に及ぼす影響.2018
- Author(s)
  山村頌太, 郡七海, 秋沢宏紀, 唄花子, 高橋昌志, 川原学.
- Organizer
  日本繁殖生物学会 (長野県上田市)
- Data Source
  KAKENHI-PROJECT-18H02321
[Presentation] Intracellur localizations of CDX2, TEAD4, and YAP proteins during preimplantation development in cattle.2017
- Author(s)
  Kohri N., Kagawa S., Bai H, Takahashi M. and Kawahara M.
- Organizer
  50th Annual Meeting of the Society for the Study of Reproduction, Washington D.C. (USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14587
[Presentation] Effects of downregulating connective tissue growth factor transcripts on preimplantation development of bovine embryos.2017
- Author(s)
  Akizawa H., Sada A., Nagatomo H., Bai H., Takahashi M. and KawaharaM.
- Organizer
  50th Annual Meeting of the Society for the Study of Reproduction, Washington D.C. (USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14587
[Presentation] Effect of IFNT on lysosomal function in bovine leukocytes during early pregnancy2017
- Author(s)
  M. A. S. Talukder, A. Z. Balboula, T. Shirozu, T. Suzuki, T. Ito, H. Bai, M. Kawahara, M. Takahashi
- Organizer
  第１２３回日本畜産学会大会
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] 胚由来IFNTによるウシ子宮外組織での新規応答性検出2017
- Author(s)
  国井宏樹、伊藤月乃、小木曽貴季、鈴木惇文、Balboula Ahmed Zaky、唄　花子、永野昌志、川原　学、高橋昌志
- Organizer
  第１２３回日本畜産学会大会
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] Cathepsin B regulation rescues the perturbation of spindle assembly checkpoint function in vitrified mouse oocytes.2016
- Author(s)
  Ahmed Z. Balboula, 唄花子, 川原学, 小谷友也, 高橋昌志.
- Organizer
  日本繁殖生物学会
- Place of Presentation
  相模原(麻布大学)
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-16K14587
[Presentation] 発情期及び妊娠認識時のウシ子宮組織におけるオートファジー-カテプシン関連因子の発現動態.2016
- Author(s)
  鈴木惇文, 白水貴大, 岩野弘暉, 小木曽貴季, 山内伸彦, 柳川洋二郎, 永野昌志, 唄花子, 川原学, 高橋昌志.
- Organizer
  日本繁殖生物学会
- Place of Presentation
  相模原(麻布大学)
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-16K14587
[Presentation] 発情期及び妊娠認識時のウシ子宮組織におけるオートファジー-カテプシン関連因子の発現動態2016
- Author(s)
  鈴木惇文、白水貴大、岩野弘暉、小木曽貴李、山内伸彦、栁川洋二郎、永野昌志、唄花子、川原学、高橋昌志
- Organizer
  第109回日本繁殖生物学会大会
- Place of Presentation
  麻布大学(神奈川県・相模原市)
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] MII期核置換による再構築卵母細胞由来マウスの出生後の生存性.2016
- Author(s)
  椎名浩己, 唄花子, 高橋昌志, 川原学.
- Organizer
  日本卵子学会
- Place of Presentation
  新潟(朱鷺メッセ)
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-16K14587
[Presentation] The effect of knock down of IFNAR by RNAi on expression of interferon-τ induced genes in bovine endometrial epithelial cells2016
- Author(s)
  Shirozu Takahiro, Suzuki Toshiyuki, Iwano Hiroki, Ogiso Takatoshi, Bai Hanako, Kawahara Manabu, Kimura Koji, Takahashi Masashi
- Organizer
  The 17th Asian-Australian Association of Animal Production Societies
- Place of Presentation
  九州産業大学(福岡県・福岡市)
- Year and Date
  2016-08-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] サブユニット特異的なI型インターフェロン（IFN）受容体発現抑制によるIFN-τシグナル関連遺伝子発現への影響2016
- Author(s)
  白水　貴大, 鈴木　惇文, 岩野　弘暉, 小木曽　貴季,　金　星佑, 唄　花子, 川原　学, 木村　康二, 高橋　昌志
- Organizer
  第109回日本繁殖生物学会大会
- Place of Presentation
  麻布大学(神奈川県・相模原市)
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] Dynamics of lysosomal cathepsin in bovine oocyte and preimplantation embryos2016
- Author(s)
  Li Jianye, 前地真奈, 郡七海, Aboelenain Mansour, Balboula Ahmed-Zaky, 金星佑, 成煥厚, 唄花子, 川原学, 高橋昌志
- Organizer
  日本畜産学会第１２１回大会
- Place of Presentation
  日本獣医生命科学大学(東京都・武蔵野市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] サブユニット特異的なI型インターフェロン(IFN)受容体発現抑制によるIFN-τシグナル関連遺伝子発現への影響.2016
- Author(s)
  白水貴大, 鈴木惇文, 岩野弘暉, 小木曽貴季, 金星佑, 唄花子, 川原学, 木村康二, 高橋昌志.
- Organizer
  日本繁殖生物学会
- Place of Presentation
  相模原(麻布大学)
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-16K14587
[Presentation] マウス胎子の倍数性変化がインプリント遺伝子発現とDMRメチル化状態に及ぼす影響.2016
- Author(s)
  山﨑渉, 天野朋子, 唄花子, 高橋昌志, 川原学.
- Organizer
  日本繁殖生物学会
- Place of Presentation
  相模原(麻布大学)
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-16K14587
[Presentation] 発情周期におけるウシ生殖器のアクポリン遺伝子群現動態2015
- Author(s)
  小木曽貴季，岩野弘暉，白水貴大，川原学，高橋昌志
- Organizer
  日本畜産学会第１２０回大会
- Place of Presentation
  酪農学園大学(北海道・江別市)
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15H04579
[Presentation] ウシ初期胚発生の進行に伴うCTGF およびTEAD4 遺伝子の発現動態．2013
- Author(s)
  定郁里，長友啓明，高橋昌志，川原学．
- Organizer
  日本繁殖生物学会
- Place of Presentation
  東京農工大学(東京)
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] マウス初期胚におけるRNAウイルスレセプターRIG-Iを介した抗ウイルス応答．2013
- Author(s)
  佐々木恵亮，高橋昌志，川原学．
- Organizer
  日本繁殖生物学会
- Place of Presentation
  東京農工大学(東京)
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] ウシ胚盤胞期胚における部位特異的発現を示す遺伝子の探索．2013
- Author(s)
  長友啓明，加川真二郎，定郁里，岸靖典，高橋昌志，河野友宏，川原学．
- Organizer
  日本卵子学会
- Place of Presentation
  学術総合センター(東京)
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] 異種間ミトコンドリアヘテロプラスミーが初期胚発生に及ぼす影響．2013
- Author(s)
  小山詩織，飯村さとみ，高橋昌志，川原学．
- Organizer
  北海道畜産草地学会
- Place of Presentation
  紋別市文化会館(紋別)
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] 二母性マウス胚を用いた新規父性メチル化インプリント遺伝子の検証．2013
- Author(s)
  山崎渉，馬狩柚子，河野友宏，高橋昌志，川原学．
- Organizer
  日本繁殖生物学会
- Place of Presentation
  東京農工大学(東京)
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] ウシ胚盤胞期胚におけるTEAD4およびYAPの発現動態に関する研究2012
- Author(s)
  加川真二朗，長友啓明，高橋昌志，川原学
- Organizer
  日本繁殖生物学会
- Place of Presentation
  筑波大学（つくば市）
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] 二母性マウス胚由来胎盤における網羅的遺伝子発現解析2009
- Author(s)
  川原学, 森田慎之助, 高橋望, 河野友宏
- Organizer
  第102回日本繁殖生物学会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-20780201
[Presentation] 二母性マウス胚由来胎盤における網羅的遺伝子発現解析2009
- Author(s)
  川原学, 森田慎之助, 高橋望, 河野友宏
- Organizer
  日本繁殖生物学会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-20780201
[Presentation] 二母性マウスの長命性について2009
- Author(s)
  河野友宏, 塚平俊貴, 川原学
- Organizer
  第102回日本繁殖生物学会
- Place of Presentation
  奈良
- Year and Date
  2009-09-12
- Data Source
  KAKENHI-PROJECT-20780201
[Presentation] 二母性マウスの長命性について2009
- Author(s)
  河野友宏, 塚平俊貴, 川原学
- Organizer
  日本繁殖生物学会
- Place of Presentation
  奈良
- Year and Date
  2009-09-12
- Data Source
  KAKENHI-PROJECT-20780201
[Presentation] マウス二母性胚の発生に対する父性メチル化制御インプリント遺伝子の発現アレルの影響2009
- Author(s)
  塚平俊貴, 川原学, 河野友宏
- Organizer
  第50回日本哺乳動物卵子学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20780201
[Presentation] 精子無し"マウスの作り方. 日本動物学会九州支部2008
- Author(s)
  川原学
- Organizer
  日本植物学会九州支部および日本生態学会九州地区三部合同例会
- Place of Presentation
  佐賀
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-20780201
[Presentation] マウス初期胚発生過程におけるパターン認識受容体TLR9の発現動態．
- Author(s)
  田中愛子，佐々木恵亮，高橋昌志，川原学．
- Organizer
  日本繁殖生物学会
- Place of Presentation
  帯広畜産大学(帯広)
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] The role of autophagy in regression of bovine corpus luteum in relation to lysosomal function．
- Author(s)
  Mansour ABOELENAIN, Manabu KAWAHARA, Abdel-Monem MONTASSER, Samy Moawad ZAABEL, Kiyoshi OKUDA, Masashi TAKAHASHI．
- Organizer
  日本繁殖生物学会
- Place of Presentation
  帯広畜産大学(帯広)
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] ウシ子宮内膜組織におけるMX1とMX1B発現に及ぼすI型インターフェロンの応答性およびその受容体の発情周期別比較．
- Author(s)
  白水貴大, 川原学, 木村康二, 高橋ひとみ, 柳川洋二郎, 永野昌志, 白汝嵐, 今川和彦, 高橋昌志．
- Organizer
  日本繁殖生物学会
- Place of Presentation
  帯広畜産大学(帯広)
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-24780265
[Presentation] マウス胎子成長に及ぼす倍数性およびインプリント遺伝子発現の影響．
- Author(s)
  山﨑渉，河野友宏，高橋昌志，川原学．
- Organizer
  日本繁殖生物学会
- Place of Presentation
  帯広畜産大学(帯広)
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-24780265

1. Yamauchi Nobuhiko (00363325)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 小林謙 (30449003)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 磯部直樹 (80284230)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 唄花子 (60775443)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
5. Takahashi Masashi (10343964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
6. 木村康二 (50355070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 小川英彦 (20339089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 永野昌志 (70312402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 柳川洋二郎 (20609656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Md. Rashedul Islam

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Mohamed El-Sharawy

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 奥田潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 長友啓明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 阿部靖之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kawahara Manabu 川原 学

KAWAHARA manabu 川原 学

KAWAHARA Manabu 川原 学

Research Projects

Research Products

Co-Researchers

初期胚分化制御機構の解明に基づくウシガラス化保存胚の発生能改善Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

物理化学的刺激を感知するTRPチャネルが乳腺組織の形態形成と乳分泌を制御する機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

乳腺上皮細胞の温度応答性分子群が乳腺組織の形態形成と機能発現を制御する機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Trophectoderm regeneration to support full-term development in the inner cell mass isolated from bovine blastocystPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of nuclear-mitochondrial interaction in mouse embryo implantationPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Role of autophagy-lysosomal related responses on uterine modulation at the time of maternal-fetal recogntion

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Elucidation of embryonic secretory factors using bovine endometrial spheroids

Principal Investigator

Project Period (FY)

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Research Institution

Exploring novel paternally methylated imprinted genes using bi-maternal mouse fetusesPrincipal Investigator

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Determination of paternally methylated imprinted regions in mouse genomePrincipal Investigator

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[Journal Article] Lipopolysaccharide and lipoteichoic acid influence milk production ability via different early responses in bovine mammary epithelial cells2021

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[Journal Article] Requirement for expression of WW domain containing transcription regulator 1 in bovine trophectoderm development2021

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[Journal Article] Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells2021

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[Journal Article] Establishment of an in vitro culture model to study milk production and the blood?milk barrier with bovine mammary epithelial cells2020

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Kawahara Manabu 川原学

KAWAHARA manabu 川原学

KAWAHARA Manabu 川原学