Oshima Motohiko 大島基彦

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OHSHIMA Motohiko 大島基彦

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Researcher Number	70506287
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京大学, 医科学研究所, 講師 2018 – 2022: 東京大学, 医科学研究所, 助教 2016 – 2017: 千葉大学, 大学院医学研究院, 助教 2015: 千葉大学, 大学院医学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Medical genome science Except Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Broad Section I
Keywords	Principal Investigator ATAC-seq / 造血幹細胞 / 骨髄異形成症候群 / MDS / 造血器腫瘍 / 転写因子 / Nrf2 / Ezh2リン酸化 / RNA-seq / 加齢変化 … More / 造血 / 加齢 / 血液内科学 / ポリコーム / H3K27me3 / 老化 / PRC2 / 老化造血幹細胞 … More Except Principal Investigator 造血幹細胞 / エピジェネティクス / プロテアソーム阻害剤 / 多発性骨髄腫 / オープンクロマチン解析 / HiC / クロマチンループ / 静止期 / CTCF / ヒト造血幹細胞 / 静止期制御 / クロマチン / エピゲノム / クロマチンアクセスビリティー / 骨髄異形成症候群 / エイジング / 加齢 / 血液内科学 / EZH2/1共阻害剤 / BRAF / UTX / EZH2/EZH1阻害剤 / 骨髄腫モデルマウス / EZH2/EZH1共阻害剤 / ヒストンメチル化異常 / EZH2阻害剤 / EZH2 / EZH2阻害薬 / ヒストンメチル化 / エピジェネティック異常 Less

クロマチン特性解析によるMDS分子病態の解明Principal Investigator
- Principal Investigator
  
  大島基彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Molecular basis of MDS pathogenesis and construction of novel MDS prognostic modelPrincipal Investigator
- Principal Investigator
  
  Oshima Motohiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Study for the regulation of exit from quiescent self-renewing programs in human hematopoietic stem cells by chromatin looping factor, CTCF
- Principal Investigator
  
  Takayama Naoya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Deciphering of the epigenetic machinery that determines the hallmarks of hematopoietic stem cell aging
- Principal Investigator
  
  Iwama Atsishi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  The University of Tokyo
Epigenetic changes in hematopoietic system during aging and molecular basis of hematopoietic tumorPrincipal Investigator
- Principal Investigator
  
  Oshima Motohiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Epigenetic bases for HSCs aging and development of hematopoietic disorderPrincipal Investigator
- Principal Investigator
  
  Oshima Motohiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  Chiba University
Epigenetic pathogenesis of multiple myeloma related to drug resistance
- Principal Investigator
  
  Naoya Mimura
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Abberant histone methylation as a therapeutic target in multiple myeloma
- Principal Investigator
  
  MIMURA Naoya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023
- Author(s)
  Rizq Ola、Mimura Naoya、Oshima Motohiko、Momose Shuji、Takayama Naoya、Itokawa Naoki、Koide Shuhei、Shibamiya Asuka、Miyamoto-Nagai Yurie、Rizk Mohamed、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Wang Changshan、Saraya Atsunori、Ito Ryoji、Seimiya Masanori、et al
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 9 Pages: 1895-1907
- DOI
  10.1038/s41375-023-01928-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07858, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K05608, KAKENHI-PROJECT-23K06449, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-20K07396, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16318, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
[Journal Article] The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms2023
- Author(s)
  1.Shibamiya A, Miyamoto-Nagai Y, Koide S, Oshima M, Rizq O, Aoyama K, Nakajima-Takagi Y, Kato R, Kayamori K, Isshiki Y, Oshima-Hasegawa N, Muto T, Tsukamoto S, Takeda Y, Koyama-Nasu R, Chiba T, Honda H, Yokote K, Iwama A, Sakaida E, Mimura N.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: － Issue: 8 Pages: 2635-2648
- DOI
  10.1007/s00262-023-03447-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19497, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
[Journal Article] Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis2023
- Author(s)
  Nakajima-Takagi Yaeko、Oshima Motohiko、Takano Junichiro、Koide Shuhei、Itokawa Naoki、Uemura Shun、Yamashita Masayuki、Andoh Shohei、Aoyama Kazumasa、Isshiki Yusuke、Shinoda Daisuke、Saraya Atsunori、Arai Fumio、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Ikawa Tomokatsu、Iwama Atsushi
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.83004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07806, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653
[Journal Article] YAP1/TAZ activity maintains vascular integrity and organismal survival2022
- Author(s)
  Uemura Shun、Yamashita Masayuki、Aoyama Kazumasa、Yokomizo-Nakano Takako、Oshima Motohiko、Nishio Miki、Masuko Masayoshi、Takizawa Jun、Sone Hirohito、Yamada Yasuhiro、Suzuki Akira、Iwama Atsushi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 619 Pages: 117-123
- DOI
  10.1016/j.bbrc.2022.06.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K08457, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21H04806, KAKENHI-PLANNED-19H05746
[Journal Article] Unraveling unique features of plasma cell clones in POEMS syndrome with single-cell analysis.2022
- Author(s)
  Isshiki Y, Oshima M, Mimura N, Kayamori K, Miyamoto-Nagai Y, Seki M, Nakajima-Takagi Y, Kanamori T, Iwamoto E, Muto T, Tsukamoto S, Takeda Y, Ohwada C, Misawa S, Ikeda JI, Sanada M, Kuwabara S, Suzuki Y, Sakaida E, Nakaseko C, Iwama A.
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 20 Pages: 1-13
- DOI
  10.1172/jci.insight.151482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07955, KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K08447, KAKENHI-PROJECT-22K08471, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20K08723, KAKENHI-PLANNED-19H05746
[Journal Article] Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells2022
- Author(s)
  Itokawa Naoki、Oshima Motohiko、Koide Shuhei、Takayama Naoya、Kuribayashi Wakako、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Yamazaki Satoshi、Yamaguchi Kiyoshi、Furukawa Yoichi、Eto Koji、Iwama Atsushi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 2691-2691
- DOI
  10.1038/s41467-022-30440-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-21F21108, KAKENHI-PROJECT-20K07563, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-21H05047
[Journal Article] Epigenetic Memories in Hematopoietic Stem and Progenitor Cells2022
- Author(s)
  Aoyama Kazumasa、Itokawa Naoki、Oshima Motohiko、Iwama Atsushi
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 14 Pages: 2187-2187
- DOI
  10.3390/cells11142187
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08366
[Journal Article] DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes2021
- Author(s)
  Kayamori Kensuke、Nagai Yurie、Zhong Cheng、Kuribayashi Wakako、Oshima Motohiko、Nakajima-Takagi Yaeko、Yamashita Masayuki、Mimura Naoya、Becker Hans Jiro、Izawa Kiyoko、Yamazaki Satoshi、Iwano Satoshi、Ito Ryoji、Lennox William、Sheedy Josephine、Yokote Koutaro、Iwama Atsushi
- Journal Title
  
  Blood Advances
  
  Volume: 5 Issue: 2 Pages: 438-450
- DOI
  10.1182/bloodadvances.2020001461
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-20K21612, KAKENHI-PLANNED-19H05746, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-20J21190, KAKENHI-PROJECT-20H03178, KAKENHI-PROJECT-21K08366
[Journal Article] Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche2021
- Author(s)
  Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A.
- Journal Title
  
  J Exp Med
  
  Volume: 218 Issue: 3
- DOI
  10.1084/jem.20192283
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21612, KAKENHI-PROJECT-19KK0216, KAKENHI-PLANNED-19H05746, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-20K17370, KAKENHI-PROJECT-21K08366
[Journal Article] Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis2021
- Author(s)
  Shinoda Daisuke、Nakajima-Takagi Yaeko、Oshima Motohiko、Koide Shuhei、Aoyama Kazumasa、Saraya Atsunori、Harada Hironori、Rahmutulla Bahityar、Kaneda Atsushi、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Shimoda Kazuya、Tanaka Tomoaki、Sashida Goro、Iwama Atsushi
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 2 Pages: 452-463
- DOI
  10.1038/s41375-021-01402-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-20K17370, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-19H03708, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-21K19398, KAKENHI-PROJECT-19H04355, KAKENHI-PROJECT-20K07563
[Journal Article] Efficacy of the novel tubulin polymerization inhibitor PTC‐028 for myelodysplastic syndrome2020
- Author(s)
  Zhong Cheng、Kayamori Kensuke、Koide Shuhei、Shinoda Daisuke、Oshima Motohiko、Nakajima‐Takagi Yaeko、Nagai Yurie、Mimura Naoya、Sakaida Emiko、Yamazaki Satoshi、Iwano Satoshi、Miyawaki Atsushi、Ito Ryoji、Tohyama Kaoru、Yamaguchi Kiyoshi、Furukawa Yoichi、Lennox William、Sheedy Josephine、Weetall Marla、Iwama Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4336-4347
- DOI
  10.1111/cas.14684
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-20K07563, KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707
[Journal Article] PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome2020
- Author(s)
  Aoyama K, Shinoda D, Suzuki E, Nakajima-Takagi Y, Oshima M, Koide S, Rizq O, Si S, Tara S, Sashida G, Iwama A.
- Journal Title
  
  Leukemia
  
  Volume: 4 Issue: 4 Pages: 1156-1165
- DOI
  10.1038/s41375-020-01023-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17370, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21K08366
[Journal Article] Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature.2020
- Author(s)
  Nitta E, Itokawa N, Yabata S, Koide S, Hou LB, Oshima M, Aoyama K, Saraya A, Iwama A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 521 Issue: 3 Pages: 612-619
- DOI
  10.1016/j.bbrc.2019.10.153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-17K09900, KAKENHI-PROJECT-18K19555
[Journal Article] Deregulated Polycomb functions in myeloproliferative neoplasms.2019
- Author(s)
  Sashida G, Oshima M, Iwama A.
- Journal Title
  
  Int J Hematol
  
  Volume: 110 Issue: 2 Pages: 170-178
- DOI
  10.1007/s12185-019-02600-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18H02842
[Journal Article] KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.2019
- Author(s)
  Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Rizk M, Kurosawa S, Saraya A, Kondo T, Sakaida E, Nakaseko C, Yokote K, Koseki H, Iwama A.
- Journal Title
  
  Blood Adv
  
  Volume: 3 Issue: 17 Pages: 2537-2549
- DOI
  10.1182/bloodadvances.2018028522
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-WRAPUP-19H05442, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-18K19555
[Journal Article] Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.2019
- Author(s)
  Rizk M, Rizq O, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, Mimura N.
- Journal Title
  
  Cancer Sci
  
  Volume: 110 Issue: 12 Pages: 3695-3707
- DOI
  10.1111/cas.14207
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-19K08807, KAKENHI-PUBLICLY-18H05095, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-18K19555
[Journal Article] The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.2019
- Author(s)
  Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, and Iwama A.
- Journal Title
  
  Blood
  
  Volume: - Issue: 23 Pages: 2495-2506
- DOI
  10.1182/blood.2019000468
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-19K08865, KAKENHI-WRAPUP-19H05442, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18K19555
[Journal Article] Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.2018
- Author(s)
  Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
- Journal Title
  
  iScience
  
  Volume: 9 Pages: 161-174
- DOI
  10.1016/j.isci.2018.10.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-16H06276
[Journal Article] Ezh2 loss propagates hypermethylation at T cell differentiation?regulating genes to promote leukemic transformation2018
- Author(s)
  Wang Changshan、Oshima Motohiko、Sato Daisuke、Matsui Hirotaka、Kubota Sho、Aoyama Kazumasa、Nakajima-Takagi Yaeko、Koide Shuhei、Matsubayashi Jun、Mochizuki-Kashio Makiko、Nakano-Yokomizo Takako、Bai Jie、Nagao Toshitaka、Kanai Akinori、Iwama Atsushi、Sashida Goro
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Issue: 9 Pages: 3872-3886
- DOI
  10.1172/jci94645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08705, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-18K18196, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-18K16078, KAKENHI-PROJECT-16H06276
[Journal Article] Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.2018
- Author(s)
  Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A.
- Journal Title
  
  Exp Hematol
  
  Volume: 63 Pages: 41-51
- DOI
  10.1016/j.exphem.2018.04.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-18K19553, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05095, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-16K09421
[Journal Article] Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.2018
- Author(s)
  Tara S, Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Tanaka T, Shinoda D, Koide S, Saraya A, Miyagi S, Manabe I, Matsui H, Koseki H, Bardwell VJ, Iwama A.
- Journal Title
  
  Blood
  
  Volume: 132(23) Issue: 23 Pages: 2470-2483
- DOI
  10.1182/blood-2018-01-827964
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K09840, KAKENHI-INTERNATIONAL-15K21751
[Journal Article] Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition.2017
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 23(16) Issue: 16 Pages: 4817-4830
- DOI
  10.1158/1078-0432.ccr-16-2735
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839, KAKENHI-INTERNATIONAL-15K21751, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies2017
- Author(s)
  Tanaka Tomoyuki、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Tara Shiro、Oshima Motohiko、Saraya Atsunori、Koide Shuhei、Si Sha、Manabe Ichiro、Sanada Masashi、Nakayama Manabu、Masuko Masayoshi、Sone Hirohito、Koseki Haruhiko、Iwama Atsushi
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 214 Issue: 10 Pages: 2901-2913
- DOI
  10.1084/jem.20170167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K10136, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K15498, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes.2016
- Author(s)
  Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y,Iwama A.
- Journal Title
  
  Blood
  
  Volume: 128(5) Issue: 5 Pages: 638-649
- DOI
  10.1182/blood-2016-01-694810
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15J04258, KAKENHI-PROJECT-26293228, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.2016
- Author(s)
  Sashida G, Wang S, Tomioka T, Oshima M, Kazumasa Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
- Journal Title
  
  J Experimenta l Medicine
  
  Volume: 213 Issue: 8 Pages: 1459-1477
- DOI
  10.1084/jem.20151121
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-15H03137, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-15K09460, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells2016
- Author(s)
  Si S, Nakajima-Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, Nakayama M, Ishikura T, Koseki H, Iwama A
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 5 Pages: e0154561-e0154561
- DOI
  10.1371/journal.pone.0154561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-14J40042, KAKENHI-PROJECT-15K19544, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.2016
- Author(s)
  Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.
- Journal Title
  
  Leukemia
  
  Volume: in press Issue: 4 Pages: 861-871
- DOI
  10.1038/leu.2016.268
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H05412, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-16K20959, KAKENHI-PROJECT-17K16530, KAKENHI-PUBLICLY-17H05649, KAKENHI-PROJECT-15K09478
[Journal Article] Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.2016
- Author(s)
  Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, George Wendt GR, Saraya A, Wang C, Shimoda K, Suzuki Y, Iwama A. Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.
- Journal Title
  
  Exp Hemato
  
  Volume: 44(4) Issue: 13 Pages: 282-296
- DOI
  10.1182/blood-2015-08-661421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20959
[Presentation] クロマチン特性解析による骨髄異形成症候群の病態解明2023
- Author(s)
  大島基彦, 高山直也, 中島やえ子, 小出周平, 原田浩徳, 原田結花, 岩間厚志
- Organizer
  第27回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-21K08366
[Presentation] Chromatin accessibility in stem cells unveils progressive transcriptional reprogramming in MDS2023
- Author(s)
  Oshima M, Takayama N, Nakajima-Takagi Y, Koide S, Harada H, Harada Y, Ding Y, Myojo T, Iwama A.
- Organizer
  第85回日本血液学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08366
[Presentation] Molecular pathogenesis in MDS stem and progenitor cells2022
- Author(s)
  Oshima M, Takayama N, Nakajima-Takagi Y, Koide S, Harada H, Harada Y, Ding Y, Myojo T, Iwama A.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08366
[Presentation] MDS病態の分子基盤の解明と新規予後予測システムの構築2021
- Author(s)
  大島基彦，高山直也，中島やえ子，小出周平，岩間厚志.
- Organizer
  第２５回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-21K08366
[Presentation] Profiling of chromatin accessibility of aged hematopoietic stem cells2020
- Author(s)
  Oshima M, Takayama N, Nakajima-Takagi Y, Koide S, Aoyama K, Iwama A.
- Organizer
  第15回生命医科学研究所ネットワーク国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348
[Presentation] Epigenetic changes in hematopoietic stem and progenitor cells during aging2020
- Author(s)
  Oshima M, Nakajima-Takagi Y, Koide S, Aoyama K, Takayama N, Iwama A.
- Organizer
  第82回日本血液学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348
[Presentation] Activation of Keap1-Nrf2 pathway in HSCs during aging.2019
- Author(s)
  Oshima M, Aoyama K, Nakajima-Takagi Y, Koide S, Iwama A.
- Organizer
  第17回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-18K08348
[Presentation] Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice2018
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
- Organizer
  The 60th ASH annual meeting (SanDiego, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Loss of Utx with Braf V600E induces mature B-cell tumorigenesis in a conditional mouse model2018
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
- Organizer
  第80回日本血液学会総会（大阪市）
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Activation of Keap1-Nrf2 pathway in HSCs during aging.2018
- Author(s)
  Oshima M, Aoyama K, Nakajima-Takagi Y, Koide S, Iwama A.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08348
[Presentation] Epigenetic hallmarks of aging hematopoietic stem cells.2018
- Author(s)
  Oshima M, Itokawa N, Kuribayashi W, Aoyama K, Nakajima-Takagi Y, Koide S, Iwama A.
- Organizer
  第16回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-18K08348
[Presentation] Loss of Utx Cooperates with Braf V600E Mutation to Induce Post-Germinal Center B-cell Disorders in Mice2018
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Syuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
- Organizer
  The 9th JSH international symposium (Kyoto, Japan)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Functional defect of Polycomb group complex during hematopoietic cell aging and myelid malignancies2017
- Author(s)
  Motohiko Oshima, Kazumasa Aoyama, Changshan Wang, Shuhei Koide, Atsushi Iwama
- Organizer
  NGS現場の会第五回研究会
- Data Source
  KAKENHI-PROJECT-16K20959
[Presentation] Functional defect of Polycomb group complex during hematopoietic stem cell aging and myelid malignancies2017
- Author(s)
  Motohiko Oshima, Kazumasa Aoyama, Changshan Wang, Shuhei Koide, Atsushi Iwama
- Organizer
  第15回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-16K20959
[Presentation] Combined inhibition of PRC2 and proteasome as a potential therapy for multiple myeloma2016
- Author(s)
  Ola Rizq, 三村尚也, 大島基彦, 更屋敦則, 小出周平, 加藤裕子, 青山和正, 井関徹, 中世古知昭, 岩間厚志
- Organizer
  第78回日本血液学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] PRC2 Inhibition Sensitizes Myeloma Cells to Proteasome Inhibitor.2016
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Changshan Wang, Tetsuhiro Chiba, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama.
- Organizer
  The 5th Japanese Cancer Association (JCA) - American Association for Cancer Research (AACR) Special Joint Conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club Resort（千葉県浦安市）
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Molecular mechanism behind the synergistic activity of proteasome inhibition and PRC2 inhibition in the treatment of multiple myeloma.2016
- Author(s)
  14.Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama.
- Organizer
  The 58th Annual Meeting of the American Society of Hematology
- Place of Presentation
  San Diego Convention Center, California, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] 造血幹細胞老化に関わるポリコーム群複合体機能異常の解明2016
- Author(s)
  大島基彦, 小出周平, 岩間厚志
- Organizer
  第８９回日本生化学会
- Place of Presentation
  仙台国際センター(宮城県、仙台市）
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20959
[Presentation] Profiling of transcriptional properties of aged hematopoietic stem and progenitor cells2016
- Author(s)
  Motohiko Oshima, Changshan Wang, Shuhei Koide, Atsushi Iwama
- Organizer
  第78回日本血液学会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-10-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20959
[Presentation] Synergistic activity of a novel EZH2 inhibitor UNC1999 and bortezomib in multiple myeloma2015
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuhei Koide, Tohru Iseki, Chiaki Nakaseko and Atsushi Iwama
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  ホテル日航金沢（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26860719

1. IWAMA Atsushi (70244126)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. MIMURA Naoya (00422220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. NAKAJIMA Yaeko (50749497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Nakaseko Chiaki (30323398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. Iseki Tohru (10232365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. Takayama Naoya (10584229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山崎聡 (50625580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. ITO Ryoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. Hara Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. OSHIMA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. SEIMIYA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 三澤園子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 小出周平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 増子正義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 古関明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 長尾俊孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oshima Motohiko 大島 基彦

OHSHIMA Motohiko 大島 基彦

Research Projects

Research Products

Co-Researchers

クロマチン特性解析によるMDS分子病態の解明Principal Investigator

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Molecular basis of MDS pathogenesis and construction of novel MDS prognostic modelPrincipal Investigator

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Study for the regulation of exit from quiescent self-renewing programs in human hematopoietic stem cells by chromatin looping factor, CTCF

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Deciphering of the epigenetic machinery that determines the hallmarks of hematopoietic stem cell aging

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Epigenetic changes in hematopoietic system during aging and molecular basis of hematopoietic tumorPrincipal Investigator

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Review Section

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Epigenetic bases for HSCs aging and development of hematopoietic disorderPrincipal Investigator

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Epigenetic pathogenesis of multiple myeloma related to drug resistance

Principal Investigator

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Abberant histone methylation as a therapeutic target in multiple myeloma

Principal Investigator

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[Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023

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[Journal Article] The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms2023

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[Journal Article] Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis2023

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[Journal Article] YAP1/TAZ activity maintains vascular integrity and organismal survival2022

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[Journal Article] Unraveling unique features of plasma cell clones in POEMS syndrome with single-cell analysis.2022

Author(s)

Journal Title

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[Journal Article] Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells2022

Author(s)

Oshima Motohiko 大島基彦

OHSHIMA Motohiko 大島基彦