TAKEUCHI YOSHINORI 武内謙憲

… Alternative Names

Takeuchi Yoshinori 武内謙憲

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Researcher Number	70508093
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 自治医科大学, 医学部, 講師 2017 – 2024: 筑波大学, 医学医療系, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 48020:Physiology-related / Environmental physiology(including physical medicine and nutritional physiology) Except Principal Investigator Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator 栄養代謝 / プロモーター解析 / KLF15 / ニュートリゲノミクス / アミノ酸 / 分子修飾 / 翻訳後修飾 / 転写因子 / 転写 / 脂質代謝 … More Except Principal Investigator … More 転写複合体 / 生体イメージング / エネルギー代謝 / ニュートリゲノミクス / エピジェネティクス / グリコーゲン / 脂肪酸 / O-GlcNAc修飾 / NASH Less

栄養センサーPtx4のO-GlcNAc糖鎖修飾を起点とする脂肪性肝炎治療戦略
- Principal Investigator
  
  泉田欣彦
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Saitama Medical University
生体イメージングによるKLF15発現調節解析を基盤とするアミノ酸シグナルの実体解明Principal Investigator
- Principal Investigator
  
  武内謙憲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Jichi Medical University
生体イメージングと転写複合体解析技術によるエネルギー代謝スイッチング機構の解明
- Principal Investigator
  
  矢作直也
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Jichi Medical University
  University of Tsukuba
核内受容体型転写因子LXRの分子修飾による生体での栄養代謝制御機構の解明Principal Investigator
- Principal Investigator
  
  武内謙憲
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  University of Tsukuba
Analysis of gene expression mechanism regulated by nutrition signal using in vivo imagingPrincipal Investigator
- Principal Investigator
  
  Takeuchi Yoshinori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  University of Tsukuba

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] New balance capability index as a screening tool for mild cognitive impairment2023
- Author(s)
  Suzuki Yasuhiro、Tsubaki Takumi、Nakaya Kensuke、Kondo Genta、Takeuchi Yoshinori、Aita Yuichi、Murayama Yuki、Shikama Akito、Masuda Yukari、Suzuki Hiroaki、Kawakami Yasushi、Shimano Hitoshi、Arai Tetsuaki、Hada Yasushi、Yahagi Naoya
- Journal Title
  
  BMC Geriatrics
  
  Volume: 23 Issue: 1 Pages: 74-74
- DOI
  10.1186/s12877-023-03777-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11851, KAKENHI-PROJECT-20K15479, KAKENHI-PROJECT-20H04063, KAKENHI-PROJECT-23K24760
[Journal Article] FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin2021
- Author(s)
  Takeuchi Yoshinori、Yahagi Naoya、Aita Yuichi、Mehrazad-Saber Zahra、Ho Man Hei、Huyan Yiren、Murayama Yuki、Shikama Akito、Masuda Yukari、Izumida Yoshihiko、Miyamoto Takafumi、Matsuzaka Takashi、Kawakami Yasushi、Shimano Hitoshi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 12 Pages: 103446-103446
- DOI
  10.1016/j.isci.2021.103446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-19K20175, KAKENHI-PROJECT-20K17505, KAKENHI-PROJECT-21K19064
[Journal Article] CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF22021
- Author(s)
  Kainoh Kenta、Takano Ryo、Sekiya Motohiro、Saito Kenji、Sugasawa Takehito、Ma Yang、Murayama Yuki、Sugano Yoko、Osaki Yoshinori、Iwasaki Hitoshi、Takeuchi Yoshinori、Yahagi Naoya、Suzuki Hiroaki、Miyamoto Takafumi、Nakagawa Yoshimi、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 562 Pages: 146-153
- DOI
  10.1016/j.bbrc.2021.05.069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-20K17505, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-21K19064
[Journal Article] High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways2021
- Author(s)
  Mehrazad Saber Zahra、Takeuchi Yoshinori、Sawada Yoshikazu、Aita Yuichi、Ho Man Hei、Karkoutly Samia、Tao Duhan、Katabami Kyoka、Ye Chen、Murayama Yuki、Shikama Akito、Masuda Yukari、Izumida Yoshihiko、Miyamoto Takafumi、Matsuzaka Takashi、Sugasawa Takehito、Takekoshi Kazuhiro、Kawakami Yasushi、Shimano Hitoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 582 Pages: 35-42
- DOI
  10.1016/j.bbrc.2021.10.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-19K20175, KAKENHI-PROJECT-20K17505, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-21K19064
[Journal Article] Genome-wide screening of upstream transcription factors using an expression library2021
- Author(s)
  Yahagi Naoya、Takeuchi Yoshinori
- Journal Title
  
  F1000Research
  
  Volume: 10:51 Pages: 1-14
- DOI
  10.12688/f1000research.27532.2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07272
[Journal Article] The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis2021
- Author(s)
  Sekiya Motohiro、Kainoh Kenta、Sugasawa Takehito、Yoshino Ryunosuke、Hirokawa Takatsugu、Tokiwa Hiroaki、Nakano Shogo、Nagatoishi Satoru、Tsumoto Kouhei、Takeuchi Yoshinori、Miyamoto Takafumi、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-19
- DOI
  10.1038/s41467-021-26638-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07272, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-21K19064, KAKENHI-PROJECT-20H02531
[Journal Article] The detection of trans gene fragments of hEPO in gene doping model mice by Taqman qPCR assay2020
- Author(s)
  Aoki Kai、Sugasawa Takehito、Yanazawa Kouki、Watanabe Koichi、Takemasa Tohru、Takeuchi Yoshinori、Aita Yuichi、Yahagi Naoya、Yoshida Yasuko、Kuji Tomoaki、Sekine Nanami、Takeuchi Kaoru、Ueda Haruna、Kawakami Yasushi、Takekoshi Kazuhiro
- Journal Title
  
  PeerJ
  
  Volume: 8 Pages: e8595-e8595
- DOI
  10.7717/peerj.8595
- NAID
  120007132949
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20175, KAKENHI-PROJECT-17H05060
[Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice2020
- Author(s)
  Matsuzaka T、Kuba M、Koyasu S、Yamamoto Y、Motomura K、Arulmozhiraja S、Ohno H、Sharma R、Shimura T、Okajima Y、Han SI、Aita Y、Mizunoe Y、Osaki Y、Iwasaki H、Yatoh S、Suzuki H、Sone H、Takeuchi Y、Yahagi N、Miyamoto T、Sekiya M、Nakagawa Y、Ema M、Takahashi S、Tokiwa H、Shimano H
- Journal Title
  
  Hepatology
  
  Volume: 71 Issue: 5 Pages: 1609-1625
- DOI
  10.1002/hep.30953
- NAID
  120007132717
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20175, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-20K21611, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18K06206
[Journal Article] Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT12020
- Author(s)
  Ma Yang、Sekiya Motohiro、Kainoh Kenta、Matsuda Takaaki、Iwasaki Hitoshi、Osaki Yoshinori、Sugano Yoko、Suzuki Hiroaki、Takeuchi Yoshinori、Miyamoto Takafumi、Yahagi Naoya、Nakagawa Yoshimi、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Issue: 2 Pages: 354-360
- DOI
  10.1016/j.bbrc.2019.12.070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11713, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-18K06206
[Journal Article] Characterization of Osteoarthritis in a Medial Meniscectomy-Induced Animal Model Using Contrast-Enhanced X-ray Microtomography2020
- Author(s)
  Sugasawa Takehito、Kuji Tomoaki、Aoki Kai、Yanazawa Koki、Takenouchi Akiko、Watanabe Makoto、Tome Yoshiya、Takeuchi Yoshinori、Aita Yuichi、Yahagi Naoya、Shishikura Yasuhiro、Ono Seiko、Yoshida Yasuko、Kawakami Yasushi、Takekoshi Kazuhiro
- Journal Title
  
  Biomedicines
  
  Volume: 8 Issue: 3 Pages: 56-56
- DOI
  10.3390/biomedicines8030056
- NAID
  120007132651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20175, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-20K07272
[Journal Article] Detection of Transgenes in Gene Delivery Model Mice by Adenoviral Vector Using ddPCR2019
- Author(s)
  Sugasawa Takehito、Aoki Kai、Watanabe Koichi、Yanazawa Koki、Natsume Tohru、Takemasa Tohru、Yamaguchi Kaori、Takeuchi Yoshinori、Aita Yuichi、Yahagi Naoya、Yoshida Yasuko、Tokinoya Katsuyuki、Sekine Nanami、Takeuchi Kaoru、Ueda Haruna、Kawakami Yasushi、Shimizu Satoshi、Takekoshi Kazuhiro
- Journal Title
  
  Genes
  
  Volume: 10 Issue: 6 Pages: 436-436
- DOI
  10.3390/genes10060436
- NAID
  120007133346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20175, KAKENHI-PROJECT-17H05060
[Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex2019
- Author(s)
  Murayama Yuki, Takafumi Miyamoto, et al.
- Journal Title
  
  FEBS Letters
  
  Volume: 593 Issue: 4 Pages: 423-432
- DOI
  10.1002/1873-3468.13328
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17K12895, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-17K00846
[Journal Article] Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism2019
- Author(s)
  Sharma Rahu, Takafumi Miyamoto, et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 5169-5169
- DOI
  10.1038/s41598-019-41631-1
- NAID
  120007133465
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PROJECT-18K19724, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17H05060
[Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance.2018
- Author(s)
  Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
- Journal Title
  
  Endocrinology.
  
  Volume: 159(6) Issue: 6 Pages: 2308-2323
- DOI
  10.1210/en.2017-03179
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19724, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17H05060
[Journal Article] A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.2018
- Author(s)
  Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
- Journal Title
  
  FEBS Lett.
  
  Volume: 592(3) Issue: 3 Pages: 422-433
- DOI
  10.1002/1873-3468.12975
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00846, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03092, KAKENHI-PROJECT-16K13040, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H05060
[Journal Article] Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry2017
- Author(s)
  Sawada Yoshikazu、Izumida Yoshihiko、Takeuchi Yoshinori、Aita Yuichi、Wada Nobuhiro、Li EnXu、Murayama Yuki、Piao Xianying、Shikama Akito、Masuda Yukari、Nishi-Tatsumi Makiko、Kubota Midori、Sekiya Motohiro、Matsuzaka Takashi、Nakagawa Yoshimi、Shimano Hitoshi、Yahagi Naoya
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 493 Issue: 1 Pages: 40-45
- DOI
  10.1016/j.bbrc.2017.09.081
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03092, KAKENHI-PROJECT-16K13040, KAKENHI-PROJECT-17H05060
[Journal Article] Elovl6 Deficiency Improves Glycemic Control in Diabetic db / db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity2017
- Author(s)
  Zhao Hui、Matsuzaka Takashi、Nakano Yuta、Motomura Kaori、Tang Nie、Yokoo Tomotaka、Okajima Yuka、Han Song-iee、Takeuchi Yoshinori、Aita Yuichi、Iwasaki Hitoshi、Yatoh Shigeru、Suzuki Hiroaki、Sekiya Motohiro、Yahagi Naoya、Nakagawa Yoshimi、Sone Hirohito、Yamada Nobuhiro、Shimano Hitoshi
- Journal Title
  
  Diabetes
  
  Volume: 66 Issue: 7 Pages: 1833-1846
- DOI
  10.2337/db16-1277
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-16K09738, KAKENHI-PROJECT-17K13217, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03092, KAKENHI-PROJECT-15H03093, KAKENHI-PROJECT-16K13040, KAKENHI-PROJECT-17H05060
[Journal Article] A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes.2017
- Author(s)
  Nishi-Tatsumi M, Yahagi N, Takeuchi Y, Toya N, Takarada A, Murayama Y, Aita Y, Sawada Y, Piao X, Oya Y, Shikama A, Masuda Y, Kubota M, Izumida Y, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Kawakami Y, Kadowaki T, Yamada N, Shimano H.
- Journal Title
  
  FEBS Lett
  
  Volume: 591 Issue: 7 Pages: 965-978
- DOI
  10.1002/1873-3468.12620
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H03092, KAKENHI-PROJECT-16K13040, KAKENHI-PROJECT-17K00846, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03093, KAKENHI-PROJECT-17H05060
[Presentation] FoxO-KLF15経路を介したインスリンによる三大栄養素制御メカニズムの解明2022
- Author(s)
  武内謙憲, 矢作直也, 會田雄, Mehrazad Saber Zahra, 何敏煕, Samia Karkoutly,陶都罕, 方波見京香, Ye Chen, 村山友樹, 志鎌明人, 升田紫, 泉田欣彦, 川上康, 島野仁
- Organizer
  第54回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K24760
[Presentation] causal SNV探索を通じたApoAI遺伝子の新たな発現調節機構の解明2022
- Author(s)
  會田雄一, 矢作直也, 武内謙憲, 方波見京香, 平井花音, Ye Chen, 陶都罕, Samia Karkoutly, Mehrazad Saber Zahra, 村山友樹, 志鎌明人, 升田紫, 泉田欣彦, 松坂賢, 川上康, 島野仁
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24760
[Presentation] 脂質合成転写因子SREBP-1が多価不飽和脂肪酸を感受する機構の解明2022
- Author(s)
  升田紫, 矢作直也, 武内謙憲, 和田亘弘, 呼延宜人, Zahra Mehrazad Saber, 沢田義一, 村山友樹, 會田雄一, 西（辰巳）真貴子, 泉田欣彦, 位高啓史, 片岡一則, 島野仁, 門脇孝, 山内敏正
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K24760
[Presentation] High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.2022
- Author(s)
  Mehrazad-Saber Z, Takeuchi Y, Aita Y, Masuda Y, Hirai K, Katabami K, Ye C, Tao D, Karkoutly S, Murayama Y, Shikama A, Izumida Y, Matsuzaka T, Kawakami Y, Shimano H, Yahagi N
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24760
[Presentation] TFEL SNP scanによるTCF7L2遺伝子内のSNP関連エンハンサーの同定2022
- Author(s)
  方波見京香, 朴賢英, 武内謙憲, 會田雄一, 平井花音, Ye Chen, 陶都罕, Samia Karkoutly, Mehrazad Saber Zahra, 村山友樹, 志鎌明人, 升田紫, 泉田欣彦, 松坂賢, 川上康, 島野仁, 矢作直也
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24760
[Presentation] FoxO-KLF15経路を介したインスリンによる三大栄養素制御メカニズムの解明2022
- Author(s)
  武内謙憲, 矢作直也, 會田雄一, Mehrazad Saber Zahra, Karkoutly Samia, 陶都罕, 方波見京香, Ye Chen, 平井花音, 村山友樹, 志鎌明人, 升田紫, 泉田欣彦, 川上康, 島野仁
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24760
[Presentation] 生体イメージングを用いたニュートリゲノミクスへのアプローチ2021
- Author(s)
  武内謙憲、矢作直也、會田雄一、村山友樹、Mehrazad Saber Zahra、何敏煕、Samia Karkoutly、陶都罕、方波見京香、志鎌明人、升田紫、泉田欣彦、川上康、島野仁
- Organizer
  第7回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07272
[Presentation] Elucidation Of Apoa1 Gene Regulatory Mechanism Through Searching Causal Single-Nucleotide Variants.2020
- Author(s)
  Aita Yuichi, Yahagi Naoya, Takeuchi Yoshinori, Ho Man Hei, Saber Zahra Mehrazad, Huyan Yiren, Murayama Yuki, Shikama Akito, Masuda Yukari, Izumida Yoshihiko, Sekiya Motohiro, Nakagawa Yoshimi, Matsuzaka Takashi, Kawakami Yasushi, Shimano Hitoshi
- Organizer
  American Heart Association Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07272
[Presentation] グルココルチコイドによるGR-Bmal/Clock複合体を介した時計遺伝子Nr1d1の抑制性転写制御機構2020
- Author(s)
  村山友樹、矢作直也、武内謙憲、曾田雄一、何敏熙、Zahra Meharazad Saber、志鎌明人、升田紫、泉田欣彦、宮本崇史、関谷元博、中川嘉、松坂賢、菅野洋子、岩崎仁、鈴木浩明、川上康、島野仁
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07272
[Presentation] 生体イメージングで迫る糖・脂質代謝に重要な KLF15遺伝子発現制御機構の解明2020
- Author(s)
  武内謙憲
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K07272
[Presentation] 肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する2020
- Author(s)
  松坂賢、久芳素子、小安さおり、本村香織、大野博、Sharma R、武内謙憲、矢作直也、宮本崇史、関谷元博、中川嘉、島野仁
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07272
[Presentation] causal SNV探索を通じたApoA1遺伝子の新たな発現調節機構の解明2020
- Author(s)
  會田雄一、矢作直也、武内謙憲、何敏熙、Zahra Mehrazad Saber、呼延宜人、村山友樹、志鎌明人、升田紫、泉田欣彦、関谷元博、中川嘉、松坂賢、川上康、島野仁
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K07272
[Presentation] Hepatic KLF15 is involved in lipogenesis via inhibitory effect on SREBP-1c promoter during fasting.2019
- Author(s)
  Yoshinori Takeuchi, Naoya Yahagi, Yuichi Aita, Yuki Murayama, Mehrazad Saber Zahra, Ho Man Hei, Nobuhiro Wada, EnXu Li, Yiren Huyan, Yukari Masuda, Yoshihiko Izumida, Hitoshi Shimano
- Organizer
  IDF Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明2019
- Author(s)
  升田紫、矢作直也、武内謙憲、和田亘弘、呼延宜人、李恩旭、Mehrazad Saber Zahra、沢田義一、村山友樹、曾田雄一、西真貴子（辰巳）、泉田欣彦、飯塚陽子、位高啓史、片岡一則、島野仁、門脇孝
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] Octacosanol prevents HFD-induced obesity by activating energy expenditure and thermogenesis in brown and beige fats.2019
- Author(s)
  松坂賢、Sharma Rahul、本村香織、武内謙憲、矢作直也、宮本崇史、関谷元博、中川嘉、島野仁
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 糖と脂肪酸のエネルギー基質動員を制御する分子基盤の探求2019
- Author(s)
  泉田欣彦、和田亘弘、矢作直也、武内謙憲、李恩旭、呼延宜人、升田紫、沢田義一、戸谷直樹、朴賢英、曾田雄一、志謙明人、飯塚陽子、島野仁、山内敏正、門脇孝
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] SNP rs7074440は肝細胞において転写因子C-FOSとの結合を介してTCF7L2遺伝子発現を調節している機能性SNPである2019
- Author(s)
  武内謙憲、矢作直也、朴賢英、會田雄一、村山友樹、Mehrazad Saber Zahra、何敏煕、升田紫、泉田欣彦、宮本崇史、関谷元博、松坂賢、中川嘉、川上康、島野仁
- Organizer
  第51回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 新しい糖尿病治療薬開発に向けた代謝産物センサー分子CtBP2の構造機能連関の理解2019
- Author(s)
  関谷元博、戒能賢太、馬洋、武内謙憲、中川嘉、松坂賢、宮本崇史、中野祥吾、常盤広明、Hotamisligil Gokhan、島野仁
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] メタボリックシンドロームの病態形成に重要と考えられる代謝産物センサー分子CtBP2の活性化化合物の探索2019
- Author(s)
  戒能賢太、関谷元博、馬洋、武内謙憲、松坂賢、中川嘉、島野仁
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] TFEL scan法を用いたapoAI遺伝子プロモーターのSNP解析2018
- Author(s)
  會田雄一、矢作直也、武内謙憲、朴賢英、呼延宜人、和田亘弘、李恩旭、村山友樹、沢田義一、志鎌明人、升田紫、泉田欣彦、関谷元博、中川嘉、松坂賢、川上康、島野仁
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 糖質・脂肪酸エネルギー基質動員に関する協調制御機構の解明2018
- Author(s)
  和田亘弘、泉田欣彦、矢作直也、武内謙憲、升田紫、李恩旭、沢田義一、呼延宜人、島野仁、門脇孝
- Organizer
  第72回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 糖質・脂質酸エネルギー基質動員に関する協調制御機構の解明2018
- Author(s)
  泉田欣彦、和田亘弘、矢作直也、升田紫、李恩旭、呼延宜人、武内謙憲、島野仁、門脇孝
- Organizer
  第55回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] Hepatic KLF15 modulates lipogenesis via inhibition of LXR activity by recruiting corepressor RIP140 on SREBP-1c promoter during fasting.2018
- Author(s)
  武内謙憲、矢作直也、曾田雄一、升田紫、泉田欣彦、島野仁
- Organizer
  The 6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors (KLF-2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明2018
- Author(s)
  升田紫、矢作直也、武内謙憲、和田亘弘、呼延宜人、李恩旭、沢田義一、村山友樹、會田雄一、西真貴子、泉田欣彦、位高啓史、片岡一則、島野仁、門脇孝
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] Hepatic KLF15 modulates lipogenesis via inhibition of LXR activity by recruiting corepressor RIP140 on SREBP-1c promoter during fasting.2018
- Author(s)
  武内謙憲、矢作直也、曾田雄一、村山友樹、Mehrazad Saber Zahra、和田亘弘、李恩旭、呼延宜人、升田紫、泉田欣彦、島野仁
- Organizer
  Asia Pacific Nutrigenomics & Nutrigenetics Organization（APNNO）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 代謝産物センサーを軸とした新しい代謝制御システムの解明と医療応用2018
- Author(s)
  関谷元博、菅澤威仁、馬洋、戒能賢太、関根七海、松坂賢、中川嘉、矢作直也、武内謙憲、島野仁
- Organizer
  第55回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] SGLT2阻害薬による肝臓-脳-脂肪神経回路を介した体重低下作用のメカニズムの解明2018
- Author(s)
  沢田義一、泉田欣彦、武内謙憲、曾田雄一、升田紫、村山友樹、関谷元博、松坂賢、中川嘉、島野仁、矢作直也
- Organizer
  第55回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] A candidate functional SNP re7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.2018
- Author(s)
  朴賢英、矢作直也、武内謙憲、曾田雄一、村山友樹、沢田義一、関谷元博、松坂賢、中川嘉、川上康、島野仁
- Organizer
  第55回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 肝臓-脳-脂肪神経回路を介したSGLT2阻害薬による体重低下作用のメカニズム解明2018
- Author(s)
  沢田義一、泉田欣彦、武内謙憲、曾田雄一、升田紫、村山友樹、朴賢英、志鎌明人、和田亘弘、関谷元博、松坂賢、中川嘉、島野仁、矢作直也
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 多価不飽和脂肪酸（PUFA）によるSREBP-1特異的な抑制機序の解明2018
- Author(s)
  升田紫、矢作直也、武内謙憲、和田亘弘、呼延宜人、李恩旭、沢田義一、村山友樹、朴賢英、會田雄一、志鎌明人、西真貴子、泉田欣彦、飯塚陽子、位高啓史、片岡一則、島野仁、門脇孝
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 糖質・脂肪酸エネルギー基質動員に関する協調制御機構の解明2018
- Author(s)
  泉田欣彦、和田亘弘、矢作直也、武内謙憲、李恩旭、升田紫、沢田義一、戸谷直樹、呼延宜人、朴賢英、會田雄一、志鎌明人、飯塚陽子、島野仁、門脇孝
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] KLF15は絶食時に中性脂肪合成から糖新生への速やかな切り替えを可能にする（若手奨励賞）2017
- Author(s)
  武内謙憲、矢作直也、會田雄一、村山友樹、沢田義一、朴賢英、志鎌明人、升田紫、泉田欣彦、関谷元博、松坂賢、中川嘉、川上康、島野仁
- Organizer
  第39回日本臨床栄養学総会・第38回日本臨床栄養協会総会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 新規代謝制御分子CtBP2による脂質合成系遺伝子群の転写制御機構2017
- Author(s)
  菅澤威仁、関谷元博、馬洋、武内謙憲、佐藤葵、松坂賢、中川嘉、矢作直也、Gurol Tuncman、Gokhan Hotamisligil、島野仁
- Organizer
  第54回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.2017
- Author(s)
  沢田義一、泉田欣彦、武内謙憲、會田雄一、和田亘弘、李恩旭、村山友樹、朴賢英、志鎌明人、升田紫、西真貴子、久保田みどり、関谷元博、松坂賢、中川嘉、島野仁、矢作直也
- Organizer
  第40回日本分子生物学会年会・第90回日本生化学会大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 糖質・脂質酸エネルギー基質動員に関する協調制御機構の解明2017
- Author(s)
  和田亘弘、泉田欣彦、矢作直也、升田紫、李恩旭、沢田義一、武内謙憲、島野仁、門脇孝
- Organizer
  第71回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] KLF15は絶食時において脂質代謝と糖代謝を制御する重要な因子である2017
- Author(s)
  武内謙憲、矢作直也、會田雄一、村山友樹、沢田義一、朴賢英、志鎌明人、関谷元博、松坂賢、中川嘉、川上康、島野仁
- Organizer
  第54回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] Functional analysis of TCF7L2 SNPs associated with type 2 diabetes.2017
- Author(s)
  朴賢英、矢作直也、武内謙憲、會田雄一、村山友樹、沢田義一、志鎌明人、升田紫、泉田欣彦、関谷元博、松坂賢、中川嘉、川上康、島野仁
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] KLF15絶食時において脂質代謝と糖代謝を制御する重要な因子である2017
- Author(s)
  武内謙憲、矢作直也、會田雄一、村山友樹、沢田義一、朴賢英、志鎌明人、升田紫、泉田欣彦、関谷元博、松坂賢、中川嘉、川上康、山田信博、島野仁
- Organizer
  第49回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] KLF15は絶食時において脂質代謝と糖代謝を制御する重要な因子である2017
- Author(s)
  武内謙憲、矢作直也、會田雄一、村山友樹、沢田義一、朴賢英、志鎌明人、升田紫、泉田欣彦、関谷元博、松坂賢、中川嘉、川上康、山田信博、島野仁
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H05060
[Presentation] 脳における脂肪酸伸長酵素Elovl6の役割2017
- Author(s)
  志村拓哉、松坂賢、大野博、吉田恵里子、所司慶太、伏見友希、武内謙憲、関谷元博、中川嘉、矢作直也、山田信博、島野仁
- Organizer
  第54回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05060

1. 矢作直也 (60420246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 泉田欣彦 (80384410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 島野仁 (20251241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 升田紫 (50768554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 會田雄一 (60752152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. 松坂賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 宮本崇史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 中川嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 韓松伊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKEUCHI YOSHINORI 武内 謙憲

Takeuchi Yoshinori 武内 謙憲

Research Projects

Research Products

Co-Researchers

栄養センサーPtx4のO-GlcNAc糖鎖修飾を起点とする脂肪性肝炎治療戦略

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

生体イメージングによるKLF15発現調節解析を基盤とするアミノ酸シグナルの実体解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生体イメージングと転写複合体解析技術によるエネルギー代謝スイッチング機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核内受容体型転写因子LXRの分子修飾による生体での栄養代謝制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of gene expression mechanism regulated by nutrition signal using in vivo imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] New balance capability index as a screening tool for mild cognitive impairment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF22021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide screening of upstream transcription factors using an expression library2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The detection of trans gene fragments of hEPO in gene doping model mice by Taqman qPCR assay2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice2020

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Journal Title

DOI

NAID

Data Source

[Journal Article] Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT12020

Author(s)

Journal Title

TAKEUCHI YOSHINORI 武内謙憲

Takeuchi Yoshinori 武内謙憲