Kadoya Hiroyuki 角谷裕之

Researcher Number	70509265
Other IDs
Affiliation (Current)	2026: 川崎医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 川崎医科大学, 医学部, 准教授 2022: 川崎医科大学, 腎臓・高血圧内科学, 講師 2019 – 2022: 川崎医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related Except Principal Investigator Basic Section 53040:Nephrology-related
Keywords	Principal Investigator 内皮機能障害 / 糖尿病性腎臓病 / CD44 / 糖尿病関連腎臓病 / ヒアルロン酸 / glycocalyx / wnt/beta-catenin経路 / 一酸化窒素（NO） / Wnt/β-catenin / sGC活性化薬 … More / eNOS / wnt/β-catenin / 可溶性グアニル酸シクラーゼ（sGC） / 一酸化窒素(NO) / 腎間質線維化 … More Except Principal Investigator TRPC / PKG / ポドサイト / NO / 活性酸素種 / Calcium dynamics / Oxidative stress / GFR / Keap1/Nrf2 / 細胞内カルシウム / GFR制御 / Keap1-Nrf2機構 / 糸球体濾過量 / Keap1-Nrf2 / 内皮細胞 / 繊維化 / 線維化 / 酸化ストレス / 血行動態変化 / 内皮障害 / 慢性腎臓病 Less

Unraveling the pathophysiology of kidney disease and developing treatments based on the endothelial/epithelial pathomechanical linkage and ROS/NO imbalance.
- Principal Investigator
  
  柏原直樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Elucidation of the role of the Keap1-Nrf2 mechanism in the regulation of glomerular filtration rate (GFR)
- Principal Investigator
  
  Kidokoro Kengo
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Development of a comprehensive spatio-temporal understanding of the pathogenesis and progression of chronic kidney disease and the development of therapeutic strategies
- Principal Investigator
  
  Kashihara Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Elucidation of Molecular Mechanisms of Glomerular Endothelial Glycocalyx Homeostasis Disruption in Diabetic Kidney DiseasePrincipal Investigator
- Principal Investigator
  
  Kadoya Hiroyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Nitric oxide attenuates renal interstitial fibrosisPrincipal Investigator
- Principal Investigator
  
  Kadoya Hiroyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice.2024
- Author(s)
  Kajimoto E, Nagasu H, Takasu M, Kishi S, Wada M, Tatsugawa R, Hirano A, Iwakura T, Umeno R, Wada Y, Itano S, Kadoya H, Kidokoro K, Sasaki T, Kashihara N.
- Journal Title
  
  Sci Rep.
  
  Volume: 14 Issue: 1 Pages: 26438-26438
- DOI
  10.1038/s41598-024-77577-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K02468
[Journal Article] Effects of Beraprost on Intestinal Microcirculation and Barrier Function in a Mouse Model of Renal Failure.2024
- Author(s)
  Hirano A, Kadoya H, Takasu M, Iwakura T, Kajimoto E, Tatsugawa R, Matsuura T, Kurumatani H, Yamamoto T, Kidokoro K, Kishi S, Nagasu H, Sasaki T, Kashihara N.
- Journal Title
  
  Microcirculation.
  
  Volume: 31 Issue: 8
- DOI
  10.1111/micc.12889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K02468
[Journal Article] Evaluation of glomerular hemodynamic changes by sodium-glucose-transporter 2 inhibition in type 2 diabetic rats using in vivo imaging.2024
- Author(s)
  Wada Y, Kidokoro K, Kondo M, Tokuyama A, Kadoya H, Nagasu H, Kanda E, Sasaki T, Cherney DZI, Kashihara N.
- Journal Title
  
  Kidney Int.
  
  Volume: 106 Issue: 3 Pages: 408-418
- DOI
  10.1016/j.kint.2024.05.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02468
[Journal Article] Treatment of chronic kidney disease in older populations.2024
- Author(s)
  Kishi S, Kadoya H, Kashihara N.
- Journal Title
  
  Nat Rev Nephrol.
  
  Volume: 20 Issue: 9 Pages: 586-602
- DOI
  10.1038/s41581-024-00854-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K02468, KAKENHI-PROJECT-24K11443
[Journal Article] 生体イメージングを用いた腎疾患の病態解析2023
- Author(s)
  角谷裕之
- Journal Title
  
  医学のあゆみ
  
  Volume: 286巻5号
- Data Source
  KAKENHI-PROJECT-21K16199
[Journal Article] IL-1β may be an indicator of peritoneal deterioration after healing of peritoneal dialysis-associated peritonitis.2023
- Author(s)
  Hirano A, Kadoya H, Yamanouchi Y, Kishi S, Sasaki T, Kashihara N.
- Journal Title
  
  BMC Nephrol.
  
  Volume: 24 Issue: 1 Pages: 374-374
- DOI
  10.1186/s12882-023-03431-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02937
[Journal Article] Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis2023
- Author(s)
  Kadoya Hiroyuki、Hirano Akira、Umeno Reina、Kajimoto Eriko、Iwakura Tsukasa、Kondo Megumi、Wada Yoshihisa、Kidokoro Kengo、Kishi Seiji、Nagasu Hajime、Sasaki Tamaki、Taniguchi Shun’ichiro、Takahashi Masafumi、Kashihara Naoki
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 9
- DOI
  10.1096/fj.202201777rrr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06613, KAKENHI-PROJECT-21K08114, KAKENHI-PROJECT-21K16199, KAKENHI-PROJECT-21H02937
[Journal Article] Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway.2023
- Author(s)
  Kidokoro K, Kadoya H, Cherney DZI, Kondo M, Wada Y, Umeno R, Kishi S, Nagasu H, Nagai K, Suzuki T, Sasaki T, Yamamoto M, Kanwar YS, Kashihara N.
- Journal Title
  
  Kidney360.
  
  Volume: 4 Issue: 10 Pages: 1454-1466
- DOI
  10.34067/kid.0000000000000171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02937
[Journal Article] Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation2021
- Author(s)
  Wada Y、Umeno R、Nagasu H、Kondo M、Tokuyama A、Kadoya H、Kidokoro K、Taniguchi S、Takahashi M、Sasaki T、Kashihara N
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 17 Pages: 9269-9269
- DOI
  10.3390/ijms22179269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02937, KAKENHI-PROJECT-20K08602, KAKENHI-PROJECT-21K06613
[Journal Article] Dipeptidyl peptidase-4 inhibitor linagliptin reduces urinary albumin excretion through the protection of glomerular endothelial function2021
- Author(s)
  Kondo M, Kidokoro K, Uchida A, Kadoya H, Umeno R, Tokuyama A, Wada Y, Nagasu H, Kanda E, Sasaki T, Kashihara N
- Journal Title
  
  Kawasaki Medical Journal
  
  Volume: 47 Pages: 131-141
- DOI
  10.11482/KMJ-E202147131
- ISSN
  0385-0234, 2434-3404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] Klotho蛋白による脂肪炎症改善およびインスリン抵抗性改善効果の検討2024
- Author(s)
  角谷裕之, 杉本研, 秋山真樹, 山本稔也, 柏原直樹
- Organizer
  第66回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-24K02468
[Presentation] Impaired Glomerular Epithelial Cell sGC Activation Promotes Glomer- Significance of Glomerular Epithelial Cell sGC Activation via eNOS-NO Pathway in Diabetic Kidney Disease2024
- Author(s)
  Eriko Kajimoto, Masanobu Takasu, Rie Tatsugawa, Akira Hirano, Tsukasa Iwakura, Kengo Kidokoro, Seiji Kishi, Hajime Nagasu, Hiroyuki Kadoya, Naoki Kashihara
- Organizer
  日本腎臓学会欧州腎臓学会合同シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02468
[Presentation] SGLT2 Inhibition suppresses residual nephron glomerular hyperfiltration in Non-Diabetic Chronic Kidney Disease2024
- Author(s)
  Akira Hirano, Kengo Kidokoro, Masanobu Takasu, Rie Tatsugawa, Eriko Kajimoto, Tsukasa Iwakura, Hiroyuki Kadoya, Seiji Kishi, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara
- Organizer
  日本腎臓学会欧州腎臓学会合同シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02468
[Presentation] Elucidation of glomerular hemodynamic changes by mineralocorticoid receptor blocker esaxerenone in diabetic kidney disease2024
- Author(s)
  Rie Tatsugawa, Kengo Kidokoro, Masanobu Takasu, Akira Hirano, Tukasa Iwakura, Hiroyuki Kadoya, Seiji Kishi, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara
- Organizer
  日本腎臓学会欧州腎臓学会合同シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02468
[Presentation] Elucidation of the Molecular Mechanism of Albuminuria Improvement by Non-Steroidal Mineralocorticoid Receptor (MR) Antagonists Finerenone.2024
- Author(s)
  Tsukasa Iwakura, Kengo Kidokoro, Eriko Kajimoto, Masanobu Takasu, Akira Hirano, Rie Tatsugawa, Hiroyuki Kadoya, Seiji Kishi, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara
- Organizer
  日本腎臓学会欧州腎臓学会合同シンポジウム
- Data Source
  KAKENHI-PROJECT-24K02468
[Presentation] 糖尿病関連腎臓病におけるエサキセレノンによる腎糸球体血行動態変化の解析2024
- Author(s)
  立川理絵、城所研吾、高須将伸、平野憲、岩倉主、角谷裕之、岸誠司、長洲一、佐々木環、柏原直樹
- Organizer
  第46回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-24K02468
[Presentation] Endothelial Dysfunction Fuels Progression from Acute to Chronic Kidney Disease through Macrophage-Mediated β-Catenin Activation2024
- Author(s)
  Masanobu Takasu, Seiji Kishi, Hajime Nagasu, Rie Tatsugawa, Eriko Kajimoto, Akira Hirano, Tsukasa Iwakura, Hiroyuki Kadoya, Kengo Kidokoro, Tamaki Sasaki, Naoki Kashihara
- Organizer
  日本腎臓学会欧州腎臓学会合同シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02468
[Presentation] 可溶性グアニル酸シクラーゼ刺激薬による腎保護作用の可能性2023
- Author(s)
  角谷裕之, 長洲一
- Organizer
  第53回日本腎臓学会西部学術大会
- Data Source
  KAKENHI-PROJECT-21K16199
[Presentation] 腎不全モデルマウスにおけるプロスタサイクリン誘導体の腸管微小血流及びバリア機能に対する作用の検討.2023
- Author(s)
  平野憲、角谷裕之、松浦巧、車谷元、城所研吾、柏原直樹.
- Organizer
  第66回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 内皮機能障害はβカテニンの活性化によるM1/ M2マクロファージ分化誘導を介して、AKI to CKD transition を促進する.2023
- Author(s)
  高須将伸、岸誠司、長洲一、立川理絵、梶本恵莉子、平野憲、岩倉主、梅野怜奈、角谷裕之、城所研吾、佐々木環、柏原直樹.
- Organizer
  第13回腎不全研究会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] Endothelial dysfunction exacerbates kidney dysfunction in ageing kidney via activation of inflammasome2022
- Author(s)
  Yoshihisa Wada, Hajime Nagasu, Hiroyuki Kadoya, Naoki Kashihara
- Organizer
  the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] eNOS-NO pathway modulates AKI to CKD transition in IRI model mice via regulation of βCatenin translocation2022
- Author(s)
  Masanobu Takasu, Megumi Kondo, Hajime Nagasu, Hiroyuki Kadoya, Seiji Kishi, Kengo Kidokoro, Naoki Kashihara
- Organizer
  the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] eNOS/NO signaling regulates renal interstitial fibrosis by increasing cytoplasmic beta-catenin degradation2022
- Author(s)
  Masanobu Takasu, Hiroyuki Kadoya, Hajime Nagasu, Seiji Kishi, Tamaki Sasaki, Naoki Kashihara
- Organizer
  the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 腎疾患進展におけるインフラマソーム活性化の意義2022
- Author(s)
  角谷裕之、長洲一、岸誠司、佐々木環、柏原直樹
- Organizer
  第65回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 糖尿病性腎臓病の進展にはインフラマソームの活性化が関与する2022
- Author(s)
  梅野怜奈、長洲一、角谷裕之、城所研吾、岸　誠司、柏原直樹
- Organizer
  第３３回日本糖尿病性腎症研究会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] eNOS-NO pathway regulates inflammasome activation in diabetic mice via modulation of CEBP translocation2022
- Author(s)
  Hajime Nagasu, Reiko Umeno, Hiroyuki Kadoya, Naoki Kashihara
- Organizer
  the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] Regulatory mechanism of glomerular filtration rate by the Keap1/Nrf2 pathway2022
- Author(s)
  Kengo Kidokoro, Hiroyuki Kadoya, Naoki Kashihara
- Organizer
  the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] SGLT2阻害薬による内皮NOS機能異常改善を介した腎保護効果の検証2021
- Author(s)
  近藤恵、城所研吾、角谷裕之、和田佳久、長洲一、佐々木環、柏原直樹
- Organizer
  第21回日本NO学会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] eNOS/sGC/PKG経路活性化はWnt/beta-catenin経路抑制効果を介して腎間質線維化を抑制する2020
- Author(s)
  角谷裕之, 長洲一, 佐々木環, 柏原直樹
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17726
[Presentation] eNOS/sGC/PKG経路活性化はWnt/β-catenin経路抑制効果を介して腎間質線維化を抑制する2020
- Author(s)
  角谷裕之
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17726

1. Kashihara Naoki (10233701)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
2. Kidokoro Kengo (50435020)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
3. 長洲一 (40412176)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
4. 岸誠司 (10519507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. 谷口俊一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kadoya Hiroyuki 角谷 裕之

Research Projects

Research Products

Co-Researchers

Unraveling the pathophysiology of kidney disease and developing treatments based on the endothelial/epithelial pathomechanical linkage and ROS/NO imbalance.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of the Keap1-Nrf2 mechanism in the regulation of glomerular filtration rate (GFR)

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a comprehensive spatio-temporal understanding of the pathogenesis and progression of chronic kidney disease and the development of therapeutic strategies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Molecular Mechanisms of Glomerular Endothelial Glycocalyx Homeostasis Disruption in Diabetic Kidney DiseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nitric oxide attenuates renal interstitial fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Beraprost on Intestinal Microcirculation and Barrier Function in a Mouse Model of Renal Failure.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of glomerular hemodynamic changes by sodium-glucose-transporter 2 inhibition in type 2 diabetic rats using in vivo imaging.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment of chronic kidney disease in older populations.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 生体イメージングを用いた腎疾患の病態解析2023

Author(s)

Journal Title

Data Source

[Journal Article] IL-1β may be an indicator of peritoneal deterioration after healing of peritoneal dialysis-associated peritonitis.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dipeptidyl peptidase-4 inhibitor linagliptin reduces urinary albumin excretion through the protection of glomerular endothelial function2021

Author(s)

Kadoya Hiroyuki 角谷裕之