HAKODA AKIKO 箱田明子

… Alternative Names

SAITO AKIKO

HAKODA Akiko 箱田明子

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Researcher Number	70509398
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2017: 東北大学, 医学系研究科, 大学院非常勤講師 2015: 東北大学, 医学(系)研究科(研究院), 非常勤講師 2015: JR仙台病院, 小児科, 医長 2015: 東北大学, 大学院医学系研究科, 非常勤講師 2013 – 2014: 東北大学, 医学(系)研究科(研究院), 助教 2009 – 2011: Tohoku University, 病院, 医員
Review Section/Research Field	Principal Investigator Endocrinology / Pediatrics Except Principal Investigator Pediatrics / Endocrinology
Keywords	Principal Investigator CYP11B2 / RXR / レチノイド / 高血圧 / アルドステロン / FGF23 / レチノイン酸 / 骨芽細胞 / 小児内分泌学 Except Principal Investigator 創薬 … More / 糖尿病性腎症 / DNAマイクロアレイ / 遺伝子改変マウス / CYP11B2 / 高血圧 / 糖尿病 / アルドステロン / エクソーム解析 / ビスフォスフォネート治療 / 骨形成不全症症 / PPIB / COL1A2 / COL1A1 / 骨形成不全症 / アルカリフォスファターゼ / GPIアンカー / 全エクソンシークエンス / HPMR症候群 / Mabry症候群 / 発達遅滞 / GPI / 高アルカリフォスファターゼ血症 / リン調節機構 / 骨代謝 / DMP1 / FGF23 / 低リン血性くる病 Less

Innovation of novel therapeutics against hypertension targeting CYP11B2 by RXR activationPrincipal Investigator
- Principal Investigator
  
  Hakoda Akiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University
The elucidation of the molecular biologic pathology in the Osteogenesis imperfecta and new molecular target treatment by the Wnt signal pathway.
- Principal Investigator
  
  Kanno Junko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Genetic analysis of HPMR syndrome
- Principal Investigator
  
  Fujiwara Ikuma
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
An approach to identify novel therapeutics against diabetic nephropathy based on aldosterone synthase gene regulation
- Principal Investigator
  
  Sugawara Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University
Analysis of phosphate metabolism and treatment for hereditary hypophosphatemic rickets
- Principal Investigator
  
  FUJIWARA Ikuma
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
The effect of all-trans retinoic acid on FGF23 expression/secretion in human osteoblastsPrincipal Investigator
- Principal Investigator
  
  HAKODA Akiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University

All 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion2018
- Author(s)
  Satoshi Aoki, Akiko Saito-Hakoda, Takeo Yoshikawa, Kyoko Shimizu, Kiyomi Kisu, Susumu Suzuki, Kiyoshi Takagi, Shuji Mizumoto, Shuhei Yamada, Toin H. van Kuppevelt, Atsushi Yokoyama, Taiji Matsusaka, Hiroshi Sato, Sadayoshi Ito, and Akira Sugawara
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 33 Issue: 1 Pages: 26-33
- DOI
  10.1093/ndt/gfx218
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08251, KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16K08645, KAKENHI-PROJECT-15K07951, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492, KAKENHI-PROJECT-16H03252
[Journal Article] High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells2017
- Author(s)
  Shimada Hiroki、Kogure Naotaka、Noro Erika、Kudo Masataka、Sugawara Kaori、Sato Ikuko、Shimizu Kyoko、Kobayashi Makoto、Suzuki Dai、Parvin Rehana、Saito-Ito Takako、Uruno Akira、Saito-Hakoda Akiko、Rainey William E.、Ito Sadayoshi、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  FEBS Open Bio
  
  Volume: 7 Issue: 9 Pages: 1410-1421
- DOI
  10.1002/2211-5463.12277
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16K09600, KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492
[Journal Article] Responsiveness to Pamidronate Treatment Is Not Related to Genotype of Type I Collagen in Patients with Osteogenesis Imperfecta2017
- Author(s)
  Junko Kanno, Akiko Saito-Hakoda, Shigeo Kure, Ikuma Fujiwara
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461541
[Journal Article] Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure2017
- Author(s)
  Suzuki Dai、Saito-Hakoda Akiko、Ito Ryo、Shimizu Kyoko、Parvin Rehana、Shimada Hiroki、Noro Erika、Suzuki Susumu、Fujiwara Ikuma、Kagechika Hiroyuki、Rainey William E.、Kure Shigeo、Ito Sadayoshi、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 8 Pages: e0181055-e0181055
- DOI
  10.1371/journal.pone.0181055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492, KAKENHI-PROJECT-16K19550
[Journal Article] Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid.2017
- Author(s)
  Parvin R, Saito-Hakoda A, Shimada H, Shimizu K, Noro E, Iwasaki Y, Fujiwara K, Yokoyama A, Sugawara A.
- Journal Title
  
  PLoS One.
  
  Volume: 12(4) Issue: 4 Pages: e0175435-e0175435
- DOI
  10.1371/journal.pone.0175435
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492
[Journal Article] Effects of RXR agonists on cell proliferation/apoptosis and ACTH secretion/Pomc expression2015
- Author(s)
  Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, Saito-Ito T, Sato I, Kogure N, Suzuki D, Shimada H, Yoshikawa T, Fujiwara I, Kagechika H, Iwasaki Y, Kure S, Ito S, Sugawara A
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 12 Pages: e0141960-e0141960
- DOI
  10.1371/journal.pone.0141960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-25461381, KAKENHI-PROJECT-26830041
[Journal Article] Mutations in PIGL in a patient with Mabry syndrome.2015
- Author(s)
  Fujiwara I, Murakami Y, Niihori T, Kanno J, Hakoda A, Sakamoto O, Okamoto N, Funayama R, Nagashima T, Nakayama K, Kinoshita T, Kure S, Matsubara Y, Aoki Y.
- Journal Title
  
  Am J Med Genet A.
  
  Volume: in press Issue: 4 Pages: 777-785
- DOI
  10.1002/ajmg.a.36987
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25129705, KAKENHI-PROJECT-25461535, KAKENHI-PROJECT-26461520, KAKENHI-PROJECT-26830064, KAKENHI-PROJECT-15K15024, KAKENHI-PROJECT-26293059
[Journal Article] Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.2014
- Author(s)
  Matsuda K, Uruno A, Kogure N, Sugawara K, Shimada H, Nezu M, Saito-Ito T, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T, Satoh F, Ito R, Yokoyama A, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A.
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 383(1-2) Issue: 1-2 Pages: 60-68
- DOI
  10.1016/j.mce.2013.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091, KAKENHI-PROJECT-24790306, KAKENHI-PROJECT-25461381, KAKENHI-PROJECT-26460383
[Journal Article] Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells.2014
- Author(s)
  Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, Shimizu K, Sato I, Kudo M, Yoshikawa T, Kagechika H, Iwasaki Y, Ito S, Sugawara A.
- Journal Title
  
  Endocr J.
  
  Volume: 61 Pages: 1105-1114
- NAID
  130004677954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461381
[Journal Article] Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA).2014
- Author(s)
  Nakamura Y, Hattangady NG, Ye P, Satoh F, Morimoto R, Ito-Saito T, Sugawara A, Ohba K, Takahashi K, Rainey WE, Sasano H.
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 384 Issue: 1-2 Pages: 102-108
- DOI
  10.1016/j.mce.2014.01.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461381
[Presentation] MEKT1, a novel PPAR-gamma agonist, significantly suppressed Pomc expression/ACTH secretion in AtT20 cells2018
- Author(s)
  Rehana Parvin, Akiko Saito-Hakoda, Hiroki Shimada, Erika Noro, Susumu Suzuki, Hiroyuki Miyachi Atsushi Yokoyama, Akira Sugawara
- Organizer
  ENDO2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09420
[Presentation] Suppressive effects of retinoid X receptor (RXR) agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion, and blood pressure2016
- Author(s)
  Dai Suzuki, Akiko Saito-Hakoda, Ryo Ito, Kyoko Shimizu, Naotaka Kogure, Hiroyuki Kagechika, Shigeo Kure, Atsushi Yokoyama, Akira Sugawara
- Organizer
  41th Meeting of the International Aldosterone Conference
- Place of Presentation
  アメリカ合衆国ボストン市
- Year and Date
  2016-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09420
[Presentation] Suppressive effects of retinoid X receptor (RXR) agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion, and blood pressure2016
- Author(s)
  Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Kogure N, Kagechika H, Kure S, Yokoyama A, Sugawara A
- Organizer
  41st International Aldosterone Conference
- Place of Presentation
  アメリカ合衆国ボストン市
- Year and Date
  2016-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461381
[Presentation] Suppressive effects of retinoid X receptor (RXR) agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion, and blood pressure2016
- Author(s)
  Dai Suzuki, Akiko Saito-Hakoda, Ryo Ito, Kyoko Shimizu, Naotaka Kogure, Hiroyuki Kagechika, Shigeo Kure, Atsushi Yokoyama, Akira Sugawara
- Organizer
  The 9th International Aldosterone Forum in Japan
- Place of Presentation
  東京（品川グランドホール）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09420
[Presentation] Inhibitory effects of retinoid X receptor pan-agonist PA024 on adrenal CYP11B2 expression and aldosterone secretion2016
- Author(s)
  Dai Suzuki, Akiko Saito-Hakoda, Ryo Ito, Kyoko Shimizu, Naotaka Kogure, Hiroyuki Kagechika, Shigeo Kure, Atsushi Yokoyama, Akira Sugawara
- Organizer
  ENDO 2016
- Place of Presentation
  アメリカ合衆国ボストン市
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09420
[Presentation] レチノイドX受容体アゴニストPA024が副腎CYP11B2発現・アルドステロン分泌に及ぼす影響の検討2015
- Author(s)
  鈴木大、箱田明子、清水恭子、レハナ・パービン、宇留野晃、青木聡、佐藤郁子、島田洋樹、小暮直敬、藤原幾麿、伊藤貞嘉、影近弘之、横山敦、菅原明
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  東京、ホテルニューオータニ
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K09420
[Presentation] PIGL遺伝子変異はhyperphosphatasia mental retardation（HPMR）症候群（Mabry症候群）の原因となる2015
- Author(s)
  藤原幾磨、村上良子、新堀哲也、菅野潤子、箱田明子、木下タロウ、松原洋一、青木洋子
- Organizer
  第49回日本小児内分泌学会
- Place of Presentation
  東京（タワーホール船堀）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25461535
[Presentation] 種々のレチノイドX受容体アゴニストは、AtT20細胞の増殖・アポトーシス・Pomc発現・ACTH分泌に異なる影響を及ぼす2015
- Author(s)
  箱田明子、宇留野晃、清水恭子、レハナ・パービン、横山敦、吉川雄朗、工藤正孝、影近弘之、岩崎泰正、伊藤貞嘉、菅原明
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  東京、ホテルニューオータニ
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K09420
[Presentation] Generation of a stable H295R cell line expressing 11-hydroxylase gene promoter and the effect of high-glucose on its expression2014
- Author(s)
  Kaori Sugawara, Ken Matsuda, Naotaka Kogure, Akira Uruno, Ikuko Sato, Kyoko Shimizu, Rehana Parvin, Takeo Yoshikawa Masataka Kudo, Akiko Saito-Hakoda, Ryo Ito, Atsushi Yokoyama, Sadayoshi Ito, Akira Sugawara
- Organizer
  ICE/ENDO2014
- Place of Presentation
  アメリカ合衆国シカゴ
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25461381
[Presentation] High-glucose stimulates aldosterone synthase gene (CYP11B2) expression via the induction of T-type calcium channels in H295R cells2014
- Author(s)
  Naotaka Kogure, Ken Matsuda, Akira Uruno, Kaori Sugawara, Ikuko Sato, Kyoko Shimizu, Rehana Parvin, Takeo Yoshikawa Masataka Kudo, Akiko Saito-Hakoda, Ryo Ito, Atsushi Yokoyama, Sadayoshi Ito, Akira Sugawara
- Organizer
  ICE/ENDO2014
- Place of Presentation
  アメリカ合衆国シカゴ
- Year and Date
  2014-06-23
- Data Source
  KAKENHI-PROJECT-25461381

1. FUJIWARA Ikuma (10271909)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KANNO Junko (30509386)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. NIIHORI Tetsuya (40436134)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Sugawara Akira (90270834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
5. ITO TAKAKO (10375173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. KUDO MASATAKA (20509583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. MATSUDA KEN (60645935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. MURAKAMI Yoshiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. YOKOYAMA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. SHIMA hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. NORO erika

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. MIZUMOTO Shuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. ITO ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. SHIMADA hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 藤原幾麿

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 菅原一幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 山田修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAKODA AKIKO 箱田 明子

SAITO AKIKO

HAKODA Akiko 箱田 明子

Research Projects

Research Products

Co-Researchers

Innovation of novel therapeutics against hypertension targeting CYP11B2 by RXR activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of the molecular biologic pathology in the Osteogenesis imperfecta and new molecular target treatment by the Wnt signal pathway.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic analysis of HPMR syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An approach to identify novel therapeutics against diabetic nephropathy based on aldosterone synthase gene regulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of phosphate metabolism and treatment for hereditary hypophosphatemic rickets

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of all-trans retinoic acid on FGF23 expression/secretion in human osteoblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Responsiveness to Pamidronate Treatment Is Not Related to Genotype of Type I Collagen in Patients with Osteogenesis Imperfecta2017

Author(s)

Journal Title

Data Source

[Journal Article] Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of RXR agonists on cell proliferation/apoptosis and ACTH secretion/Pomc expression2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutations in PIGL in a patient with Mabry syndrome.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.2014

Author(s)

Journal Title

DOI

HAKODA AKIKO 箱田明子

HAKODA Akiko 箱田明子

[Presentation] Generation of a stable H295R cell line expressing 11-hydroxylase gene promoter and the effect of high-glucose on its expression2014