Shuto Keiko 首藤恵子

… Alternative Names

SHUTO Keiko 首藤恵子

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Researcher Number	70510692
Other IDs
Affiliation (Current)	2026: 崇城大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 崇城大学, 薬学部, 講師 2014 – 2017: 崇城大学, 薬学部, 助教 2010 – 2012: 崇城大学, 薬学部, 助教 2008 – 2009: Sojo University, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy / Biological pharmacy
Keywords	Principal Investigator SIGIRR / 嚢胞性線維症（CF） / 嚢胞性線維症 / IL-37 / 炎症制御 / HDAC3 / スプライスバリアント / スプライススイッチ / CF / LPS … More / 抗炎症作用 / SIGIRR/IL-18Rα複合体 / Split NanoLuc / 分子間相互作用 / スクリーニング系構築 / ヘテロ二量体形成 / IL-18受容体α / 抗炎症 / ZIP2 / ヒストン脱アセチル化酵素（HDAC）阻害 / 化合物探索 / Toll-like receptor / 細胞膜上発現 / Δ8-SIGIRR / IL-37b / Sp1 / p38MAPキナーゼ / TLRシグナル制御 / SIGIRR/TIR8 / 自然免疫 / 発現調節 Less

Establishment of the molecular basis of a novel anti-inflammatory therapy based on SIGIRR/IL-18R alpha complex formationPrincipal Investigator
- Principal Investigator
  
  Shuto Keiko
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sojo University
Elucidation of the regulation mechanism of cystic fibrosis-specific splice variant expression and development of novel therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  Shuto Keiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sojo University
Therapeutic application to cystic fibrosis based on IL-37 and stabilized cell surface expression of SIGIRRPrincipal Investigator
- Principal Investigator
  
  SHUTO Keiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Sojo University
Molecular basis of SIGIRR expression and regulatory function in Cystic Fibrosis and its therapeutic approachPrincipal Investigator
- Principal Investigator
  
  SHUTO Keiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Sojo University
Regulatory mechanism of SIGIRR/TIR8 expressionn LPS-mediated signaling.Principal Investigator
- Principal Investigator
  
  SHUTO Keiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Sojo University
Expression regulation and synthetic pathway of SIGIRR/TIR8, a negative regulator of Toll like receptor signalingPrincipal Investigator
- Principal Investigator
  
  SHUTO Keiko
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Biological pharmacy
- Research Institution
  Sojo University

All 2024 2022 2021 2020 2019 2018 2017 2016 2014 2012 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells2022
- Author(s)
  Keiko Ueno-Shuto, Shunsuke Kamei, Megumi Hayashi, Ayami Fukuyama, Yuji Uchida, Naofumi Tokutomi, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 14 Pages: 7748-7748
- DOI
  10.3390/ijms23147748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06642, KAKENHI-PROJECT-22K20716
[Journal Article] Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases.2020
- Author(s)
  Hirofumi Nohara, Ryunosuke Nakashima, Shunsuke Kamei, Haruka Fujikawa, KeikoUeno-Shuto, Taisei Kawakami, Yuka Eto, Mary Ann Suico, Jian-DongLi, Hirofumi Kai, Tsuyoshi Shuto.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 332-339
- DOI
  10.1016/j.bbrc.2020.01.081
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07114
[Journal Article] Azithromycin Inhibits Constitutive Airway Epithelial Sodium Channel Activation in Vitro and Modulates Downstream Pathogenesis in Vivo2020
- Author(s)
 Haruka Fujikawa, Taise Kawakami, Ryunosuke Nakashima, Aoi Nasu, Shunsuke Kamei, Hirofumi Nohara, Yuka Eto, Keiko Ueno-Shuto, Toru Takeo, Naomi Nakagata, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto.
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 43 Issue: 4 Pages: 725-730
- DOI
 10.1248/bpb.b19-01091
- NAID
 130007825345
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2020-04-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07114, KAKENHI-PROJECT-17H03570, KAKENHI-PROJECT-19H03379, KAKENHI-PROJECT-17K08309
[Journal Article] Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor Against Pathophysiological Decline of Lung Function2020
- Author(s)
  Fujikawa H, Sakamoto Y, Masuda N, Oniki K, Kamei S, Nohara H, Nakashima R, Maruta K, Kawakami T, Eto Y, Takahashi N, Takeo T, Nakagata N, Watanabe H, Otake K, Ogata Y, Tomioka NH, Hosoyamada M, Takada T, Ueno-Shuto K , Suico MA, Kai H, Saruwatari J, Shuto T.
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 5 Pages: 387-387
- DOI
  10.3390/antiox9050387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07114, KAKENHI-PROJECT-19K07166, KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-18KK0247, KAKENHI-PROJECT-20H00568
[Journal Article] The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties.2020
- Author(s)
 Kentaro Oniki, Hirofumi Nohara, Ryunosuke Nakashima, Yui Obata, Narumi Muto, Yuki Sakamoto, Keiko Ueno-Shuto, Tadashi Imafuku, Yu Ishima, Hiroshi Watanabe, Toru Maruyama, Koji Otake, Yasuhiro Ogata, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto, and Junji Saruwatari.
- Journal Title
 
 Scientific Reports
 
 Volume: 10 Issue: 1 Pages: 5973-5973
- DOI
 10.1038/s41598-020-62872-5
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07114, KAKENHI-PROJECT-19K07166, KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-20K21485
[Journal Article] Lipopolysaccharide Decreases Single Immunoglobulin Interleukin-1 Receptor-Related Molecule (SIGIRR) Expression by Suppressing Sp1 via TLR4-p38 pathway in monocytes and neutrophils2014
- Author(s)
  Keiko Ueno-Shuto, Kosuke Kato, Miki Sato, Keizo Sato, Hiromichi Sakai, Tomomi Ono, Mary Ann Suico, Yuji Uchida, Naofumi Tokutomi, Hirofumi Kai, and Tsuyoshi Shuto
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Issue: 26 Pages: 18097-18109
- DOI
  10.1074/jbc.m113.532093
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860062
[Journal Article] MUCl mucin is a negative regulator of Toll-like receptor signaling2008
- Author(s)
  Ueno-Shuto, K, et al.
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology 38
  
  Pages: 263-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890276
[Presentation] HDAC3阻害がSIGIRRおよびIL-18Rαの発現を促進しIL-37依存性抗炎症経路を増強する2024
- Author(s)
  首藤恵子, 福山絢美, 林恵, スイコメリーアン , 甲斐広文, 徳冨直史, 首藤剛
- Organizer
  第18回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06642
[Presentation] HDAC3阻害によるSIGIRR/IL-18Rα発現誘導を介したIL-37依存的抗炎症経路の増強2024
- Author(s)
  首藤恵子, 福山絢美, 林恵, スイコメリーアン , 甲斐広文, 徳冨直史, 首藤剛
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06642
[Presentation] TLR抑制分子MUC1およびSIGIRRの発現・機能解析とその抗炎症増強に関する研究2024
- Author(s)
  首藤恵子
- Organizer
  第41回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-22K06642
[Presentation] 嚢胞性線維症における抗炎症タンパク質SIGIRRのスプライスバリアントの発現・機能解析2022
- Author(s)
  福山絢美, 首藤恵子, 林恵, Mary Ann Suico, 甲斐広文, 徳冨直史, 首藤剛
- Organizer
  第39回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-22K06642
[Presentation] 正常および慢性閉塞性肺疾患モデルにおける抗ウイルス免疫抑制分子 PD-L1 の発現変動2021
- Author(s)
  林恵、中嶋竜之介、高橋宜暉、那須葵、岸本朋樹、首藤恵子、Mary Ann Suico、甲斐広文、首藤剛
- Organizer
  第38回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-19K07114
[Presentation] A splice switch in SIGIRR causes a defect of Poly(I:C)-dependent anti-inflammatory IL-37b-SIGIRR negative feedback loop in cystic fibrosis airway epithelial cells2019
- Author(s)
  Keiko Ueno-Shuto, Shunsuke Kamei, Mary Ann Suico, Hirofumi Kai, Yuji Uchida, Naofumi Tokutomi, Tsuyoshi Shuto
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08291
[Presentation] 嚢胞性線維症気道上皮細胞におけるSIGIRRスプライスアイソフォームの発現上昇とその炎症調節における役割2018
- Author(s)
  首藤恵子、亀井竣輔、内田友二、甲斐広文、徳冨直史、首藤剛
- Organizer
  第71回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-16K08291
[Presentation] Poly(I:C)-dependent anti-inflammatory IL-37b-SIGIRR negative feedback loop is defective in cystic fibrosis airway epithelial cells2017
- Author(s)
  Keiko Ueno-Shuto
- Organizer
  15th Cytokines & Inflammation Conference
- Place of Presentation
  Hard Rock Hotel in San Diego（USA, California）
- Year and Date
  2017-02-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08291
[Presentation] 嚢胞性線維症気道上皮細胞における炎症抑制性IL-37b-SIGIRR axisの破綻2017
- Author(s)
  首藤恵子，亀井峻輔，内田友二，甲斐広文，徳富直史，首藤剛
- Organizer
  第34回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-16K08291
[Presentation] POLY(I:C)-DEPENDENT ANTI-INFLAMMATORY IL-37B-SIGIRR NEGATIVE FEEDBACK LOOP IS DEFECTIVE IN CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS2017
- Author(s)
  Keiko Ueno-Shuto, Shunsuke Kamei, Mary Ann Suico, Hirofumi Kai, Yuji Uchida, Naofumi Tokutomi, Tsuyoshi Shuto
- Organizer
  Northern American Cystic Fibrosis Conference 2017 (NACFC2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08291
[Presentation] 嚢胞性線維症気道上皮細胞における炎症抑制性IL-37b-SIGIRR axisの破綻2016
- Author(s)
  首藤　恵子
- Organizer
  第69回日本薬理学会西南部会
- Place of Presentation
  松山大学（愛媛県, 松山市）
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-16K08291
[Presentation] LPS刺激下の単球・好中球におけるIgおよびTIRドメイン含有受容体SIGIRRの発現および機能解析2012
- Author(s)
  首藤恵子,首藤剛,佐藤美希,佐藤圭創,MaryAnnSuico,内田友二,徳冨直史,甲斐広文
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  マリンメッセ福岡(福岡)
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-22790100
[Presentation] SIGIRR expression by suppressing Sp1 via -pT3L8R4MAP kinase pathway in monocytes and neutrophils2012
- Author(s)
  Keiko Uen-oShuto, Tsuyoshi Shuto, Miki Sato, Keizo Sato, Mary Ann Suico, Yuji Uchida, Naofumi Tokutomi, and Hirofumi Kai Lipopolysaccharide decreases
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡(福岡)
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-22790100
[Presentation] 変異CFTR発現気道上皮細胞におけるTLR2/4依存的IL-8発現誘導作用に対するIL-17Aの作用2010
- Author(s)
  首藤恵子
- Organizer
  第4回トランスポーター研究会九州部会
- Place of Presentation
  ハウステンボスユトレヒト会議室
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22790100
[Presentation] LIPOPOLYSACCHARIDE DECREASES SIGIRR/TIR8 GENE EXPRESSI-ON POSSIBLY BY SUPPRESSING SP1 VIA TLR4-P38 MAP KINASE PATHWAY2009
- Author(s)
  首藤恵子
- Organizer
  Tri-Society Meeting of International Cytokine Society (ICS), International Society for Interferon and Cytokine Research (ISICR), and Society for Leukocyte Biology (SLB)
- Place of Presentation
  Lisbon Congress Centre
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20890276
[Presentation] LPSによるTollシグナル抑制分子SIGIRRの発現低下とその分子機構の解明2009
- Author(s)
  首藤恵子
- Organizer
  第26回日本薬学会九州支部大
- Place of Presentation
  九州大学
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20890276
[Presentation] Lipopolysaccharide decreases SIGIRR/TIR8 gene expression possibly by suppressing Sp1 via TLR4-p38 MAP kinase pathway2009
- Author(s)
  首藤恵子
- Organizer
  Tri-society Annual Conference 2009 of the Society for Leukocyte Biology, International Cytokine Society, and International Society for Interferon and Cytokine Research.
- Place of Presentation
  Lisbon, Portugal, Lisboa Congress Center
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20890276
[Presentation] Tollシグナル抑制分子SIGIRRのLPS誘導性発現抑制機構の解明2009
- Author(s)
  首藤恵子
- Organizer
  日本薬学会九州支部大会
- Place of Presentation
  九州大学
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20890276
[Presentation] Lipopolysaccharide decreases SIGIRR expression by suppressing Sp1 via TLR4-p38 MAP kinase pathway in monocytes and neutrophils
- Author(s)
  首藤恵子
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡 (福岡県)
- Data Source
  KAKENHI-PROJECT-22790100
[Presentation] LPS刺激下の単球・好中球におけるIgおよびTIRドメイン含有受容体SIGIRRの発現および機能解析
- Author(s)
  首藤恵子
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  マリンメッセ福岡 (福岡県)
- Data Source
  KAKENHI-PROJECT-22790100

1. KAI Hirofumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Shuto Keiko 首藤 恵子

SHUTO Keiko 首藤 恵子

Research Projects

Research Products

Co-Researchers

Establishment of the molecular basis of a novel anti-inflammatory therapy based on SIGIRR/IL-18R alpha complex formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the regulation mechanism of cystic fibrosis-specific splice variant expression and development of novel therapeutic strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic application to cystic fibrosis based on IL-37 and stabilized cell surface expression of SIGIRRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of SIGIRR expression and regulatory function in Cystic Fibrosis and its therapeutic approachPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanism of SIGIRR/TIR8 expressionn LPS-mediated signaling.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression regulation and synthetic pathway of SIGIRR/TIR8, a negative regulator of Toll like receptor signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Azithromycin Inhibits Constitutive Airway Epithelial Sodium Channel Activation <i>in Vitro</i> and Modulates Downstream Pathogenesis <i>in Vivo</i>2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor Against Pathophysiological Decline of Lung Function2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The<I> DsbA-L</I> gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipopolysaccharide Decreases Single Immunoglobulin Interleukin-1 Receptor-Related Molecule (SIGIRR) Expression by Suppressing Sp1 via TLR4-p38 pathway in monocytes and neutrophils2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MUCl mucin is a negative regulator of Toll-like receptor signaling2008

Author(s)

Journal Title

Data Source

[Presentation] HDAC3阻害がSIGIRRおよびIL-18Rαの発現を促進しIL-37依存性抗炎症経路を増強する2024

Shuto Keiko 首藤恵子

SHUTO Keiko 首藤恵子