Isomura Akihiro 磯村彰宏

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ISOMURA Akihiro 磯村彰宏

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Researcher Number	70512466
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 副チームリーダー 2022 – 2023: 京都大学, 医生物学研究所, 特定准教授 2020 – 2022: 京都大学, 高等研究院, 連携助教 2021: 京都大学, ウイルス・再生医科学研究所, 特定助教 2018 – 2019: 京都大学, 高等研究院, 特定助教 … More 2017: 京都大学, ウイルス・再生医科学研究所, 共同研究者 2016: 京都大学, ウイルス・再生医科学研究所, その他 2015: 京都大学, ウイルス研究所, その他 2012 – 2014: 京都大学, ウイルス研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related / Complex systems / Transformative Research Areas, Section (III) / Life / Health / Medical informatics / Bioinformatics/Life informatics Except Principal Investigator Biological Sciences / Basic Section 62010:Life, health and medical informatics-related
Keywords	Principal Investigator 光遺伝学 / 合成生物学 / 分節時計 / 人工遺伝子回路 / システム生物学 / オルガノイド / Notchシグナル / シグナル伝達 / FGFシグナル / 体節形成 … More / 細胞間コミュニケーション / 蛍光イメージング / 生物物理 / 非線形動力学 / 遺伝子発現振動 / 生体生命情報学 / 細胞・組織 / 定量生物学 … More Except Principal Investigator 認知機能 / 成体脳ニューロン新生 / 若返り / anti-Dyrk1a / Plagl2 / Ascl1 / 生物時計 / 神経発生 / 振動遺伝子 / 短周期振動 / Dusp7 / Erk / p21 / サイクリン依存性キナーゼ阻害因子 / 中間前駆細胞 / Neurog2 / Tbr2 / 短周期発現振動 / 細胞周期 / 光遺伝学 / Hes1 / 発現振動 / 神経幹細胞 / フィードバック制御 / マイクロ流体技術 / タンパク質発現量の制御 / マイクロ流体デバイス / タンパク質発現ダイナミクス / 光遺伝学技術 / マイクロ流体 Less

分節時計タンパク質の光制御と機能解明Principal Investigator
- Principal Investigator
  
  磯村彰宏
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
合成生物学による分節時計の再構成と機能解明Principal Investigator
- Principal Investigator
  
  磯村彰宏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Institute of Physical and Chemical Research
Physiological significance of ultradian oscillatory gene expression
- Principal Investigator
  
  影山龍一郎
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
Programming somitogenesis with synthetic cell-cell signalingPrincipal Investigator
- Principal Investigator
  
  Isomura Akihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Kyoto University
Control of protein expression dynamics by using microfluidic and optogenetic technology
- Principal Investigator
  
  Kaneda Shohei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Kogakuin University
光制御と光計測によるシグナル伝達経路間の動的相互作用の解明Principal Investigator
- Principal Investigator
  
  磯村彰宏
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
タンパク質発現動態の光制御と多重蛍光計測のための基盤技術の構築Principal Investigator
- Principal Investigator
  
  磯村彰宏
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Kyoto University
Engineering synthetic cell-cell signaling that transmit dynamic informationPrincipal Investigator
- Principal Investigator
  
  Isomura Akihiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Kyoto University
Dissection and reconstitution of ultradian genetic oscillators responsive to dynamic signaling inputsPrincipal Investigator
- Principal Investigator
  
  Isomura Akihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Kyoto University
遺伝子発現の光応答性人工トグルスイッチ回路の構築Principal Investigator
- Principal Investigator
  
  磯村彰宏
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Biological functions of ultradian oscillation revealed by bioluminescence and fluorescence imagingPrincipal Investigator
- Principal Investigator
  
  ISOMURA Akihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  Kyoto University

All 2023 2020 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation Patent

[Journal Article] Biological Significance of the Coupling Delay in Synchronized Oscillations2023
- Author(s)
  Kageyama Ryoichiro、Isomura Akihiro、Shimojo Hiromi
- Journal Title
  
  Physiology
  
  Volume: 38 Issue: 2 Pages: 63-72
- DOI
  10.1152/physiol.00023.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04976, KAKENHI-PROJECT-18K06254, KAKENHI-PROJECT-21H03540
[Journal Article] Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p212023
- Author(s)
  Maeda Yuki、Isomura Akihiro、Masaki Taimu、Kageyama Ryoichiro
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 5 Pages: 112520-112520
- DOI
  10.1016/j.celrep.2023.112520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04976, KAKENHI-PROJECT-21H03540
[Journal Article] Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation2020
- Author(s)
  Takagi Akari、Isomura Akihiro、Yoshioka-Kobayashi Kumiko、Kageyama Ryoichiro
- Journal Title
  
  Gene Expression Patterns
  
  Volume: 35 Pages: 119094-119094
- DOI
  10.1016/j.gep.2019.119094
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PUBLICLY-18H04734, KAKENHI-PUBLICLY-19H04960, KAKENHI-PROJECT-18H03332
[Journal Article] Coupling delay controls synchronized oscillation in the segmentation clock2020
- Author(s)
  K. Yoshioka-Kobayashi, M. Matsumiya, Y. Niino, A. Isomura, H. Kori, A. Miyawaki, R. Kageyama
- Journal Title
  
  Nature
  
  Volume: 580 Issue: 7801 Pages: 119-123
- DOI
  10.1038/s41586-019-1882-z
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-16H06480, KAKENHI-PUBLICLY-18H04734, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PUBLICLY-19H04960, KAKENHI-PROJECT-18H03332
[Journal Article] Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells2019
- Author(s)
  Lahmann Ines、Brohl Dominique、Zyrianova Tatiana、Isomura Akihiro、Czajkowski Maciej T.、Kapoor Varun、Griger Joscha、Ruffault Pierre-Louis、Mademtzoglou Despoina、Zammit Peter S.、Wunderlich Thomas、Spuler Simone、Kuhn Ralf、Preibisch Stephan、Wolf Jana、Kageyama Ryoichiro、Birchmeier Carmen
- Journal Title
  
  Genes & Development
  
  Volume: 33 Issue: 9-10 Pages: 524-535
- DOI
  10.1101/gad.322818.118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PUBLICLY-18H04734, KAKENHI-PUBLICLY-19H04960, KAKENHI-PROJECT-18H03332
[Journal Article] ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock2018
- Author(s)
  Matsumiya Marina、Tomita Takehito、Yoshioka-Kobayashi Kumiko、Isomura Akihiro、Kageyama Ryoichiro
- Journal Title
  
  Development
  
  Volume: 145 Issue: 4
- DOI
  10.1242/dev.156836
- NAID
  120006540184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-15H05326
[Journal Article] Illuminating information transfer in signaling dynamics by optogenetics2017
- Author(s)
  Isomura Akihiro、Kageyama Ryoichiro
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 49 Pages: 9-15
- DOI
  10.1016/j.ceb.2017.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-15H02349, KAKENHI-PROJECT-15H05326
[Journal Article] Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information.2017
- Author(s)
  Isomura, A., Ogushi, F., Kori, H., and Kageyama, R.
- Journal Title
  
  Genes & Development
  
  Volume: 31 Issue: 5 Pages: 524-535
- DOI
  10.1101/gad.294546.116
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06480, KAKENHI-PROJECT-15H02349, KAKENHI-PROJECT-15H05326, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05876
[Journal Article] Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis.2016
- Author(s)
  Shimojo H, Isomura A, Ohtsuka T, Kori H, Miyachi H, Kageyama R
- Journal Title
  
  Genes Dev.
  
  Volume: 30 Issue: 1 Pages: 102-116
- DOI
  10.1101/gad.270785.115
- NAID
  120005980896
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06773, KAKENHI-PUBLICLY-26119708, KAKENHI-PROJECT-15H02349, KAKENHI-PROJECT-15H05326
[Journal Article] Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions.2014
- Author(s)
  Isomura A, Kageyama R.
- Journal Title
  
  Development
  
  Volume: 141 Issue: 19 Pages: 3627-3636
- DOI
  10.1242/dev.104497
- NAID
  120005512266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22123002, KAKENHI-PROJECT-24240049, KAKENHI-PROJECT-24700293, KAKENHI-PUBLICLY-26119708
[Journal Article] Oscillatory control of factors determining multipotency and fate in mouse neural progenitors2013
- Author(s)
  I. Imayoshi, A. Isomura, Y. Harima, K. Kawaguchi, H. Kori, H. Miyachi, T. Fujiwara, F. Ishidate, and R. Kageyama
- Journal Title
  
  Science
  
  Volume: 342 Issue: 6163 Pages: 1203-1208
- DOI
  10.1126/science.1242366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08031, KAKENHI-PLANNED-22123002, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24240049, KAKENHI-PROJECT-24680035, KAKENHI-PROJECT-24700293, KAKENHI-PROJECT-25890010
[Patent] 幹細胞の増殖と分化の光遺伝学的制御方法2014
- Inventor(s)
  影山龍一郎、磯村彰宏、今吉格
- Industrial Property Rights Holder
  影山龍一郎、磯村彰宏、今吉格
- Industrial Property Rights Type
  特許
- Filing Date
  2014-09-17
- Data Source
  KAKENHI-PROJECT-24700293
[Presentation] 人工遺伝子回路による分節時計の再構成と操作2023
- Author(s)
  磯村彰宏
- Organizer
  第46 回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-21H03540
[Presentation] 分節時計における遺伝子発現振動波の制御機構2023
- Author(s)
  磯村彰宏
- Organizer
  第75 回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03540
[Presentation] Notchシグナルによる動的情報伝達の光制御と光計測2018
- Author(s)
  磯村彰宏
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03332
[Presentation] Notchシグナルによる動的情報伝達の光制御と光計測2018
- Author(s)
  磯村彰宏
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04734
[Presentation] 遺伝子発現リズムの細胞間位相同期の再構成2017
- Author(s)
  磯村彰宏
- Organizer
  定量生物学の会第八回年会
- Place of Presentation
  自然科学研究機構岡崎コンファレンスセンター
- Year and Date
  2017-01-08
- Data Source
  KAKENHI-PROJECT-15H05326
[Presentation] 光遺伝学による遺伝子発現リズムの細胞間情報伝達機構の解明2016
- Author(s)
  磯村彰宏
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H05326
[Presentation] Interrogating oscillatory gene expression by optogenetics2015
- Author(s)
  Akihiro Isomura
- Organizer
  International Symposium on Synthetic Systems Biology Joint 14th Symposium of Biochemical Systems Theory (BST2015)
- Place of Presentation
  福岡
- Year and Date
  2015-09-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26119708
[Presentation] Controlling Natural Genetic Oscillators by Light2015
- Author(s)
  Akihiro Isomura, Fumiko Ogushi, Hiroshi Kori, Ryoichiro Kageyama
- Organizer
  The 2015 Winter q-bio meeting
- Place of Presentation
  The Westin Maui
- Year and Date
  2015-02-19
- Data Source
  KAKENHI-PUBLICLY-26119708
[Presentation] Interrogating oscillatory gene expression by optogenetics2015
- Author(s)
  Akihiro Isomura
- Organizer
  International Symposium on Synthetic Systems Biology Joint 14th Symposium of Biochemical Systems Theory (BST2015)
- Place of Presentation
  福岡
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15H05326
[Presentation] 光遺伝学による短周期遺伝子発現リズムの引き込み同調2014
- Author(s)
  磯村彰宏
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PUBLICLY-26119708
[Presentation] Notch受容体/リガンドの発現量による短周期遺伝子発現リズムの定量的制御2012
- Author(s)
  磯村彰宏
- Organizer
  定量生物学の会　第五回年会
- Place of Presentation
  東京大学駒場IIキャンパス生産技術研究所 An棟コンベンションホール
- Data Source
  KAKENHI-PROJECT-24700293

1. Kaneda Shohei (10542467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 影山龍一郎 (80224369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. 大塚俊之 (20324709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Isomura Akihiro 磯村 彰宏

ISOMURA Akihiro 磯村 彰宏

Research Projects

Research Products

Co-Researchers

分節時計タンパク質の光制御と機能解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

合成生物学による分節時計の再構成と機能解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological significance of ultradian oscillatory gene expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Programming somitogenesis with synthetic cell-cell signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of protein expression dynamics by using microfluidic and optogenetic technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

光制御と光計測によるシグナル伝達経路間の動的相互作用の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タンパク質発現動態の光制御と多重蛍光計測のための基盤技術の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Engineering synthetic cell-cell signaling that transmit dynamic informationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dissection and reconstitution of ultradian genetic oscillators responsive to dynamic signaling inputsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子発現の光応答性人工トグルスイッチ回路の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological functions of ultradian oscillation revealed by bioluminescence and fluorescence imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Biological Significance of the Coupling Delay in Synchronized Oscillations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p212023

Author(s)

Journal Title

DOI

Data Source

Isomura Akihiro 磯村彰宏

ISOMURA Akihiro 磯村彰宏

[Patent] 幹細胞の増殖と分化の光遺伝学的制御方法2014