Hokuto Daisuke 北東大督

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HOKUTO Daisuke 北東大督

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Researcher Number	70526821
Other IDs	https://orcid.org/0000-0003-1661-6224
Affiliation (based on the past Project Information) *help	2016 – 2021: 奈良県立医科大学, 医学部, 助教 2012 – 2013: 奈良県立医科大学, 医学部附属病院, 研究員
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator T細胞不活化経路 / ＨＶＥＭ / Ｔ細胞不活化経路 / 免疫療法 / 大腸癌肝転移 / 肝細胞癌 / 腫瘍免疫 / HVEM / 抗癌剤 / 癌免疫療法 / 免疫治療 / 腫瘍内浸潤リンパ球 … More Except Principal Investigator … More 抗血栓療法 / 消化器癌 / ADAMTS13 / Von Willebrand factor / 静脈⾎栓塞栓症 Less

消化器癌における静脈血栓塞栓症機序の新概念と次世代型抗血栓療法の開発
- Principal Investigator
  
  野見武男
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nara Medical University
Development of a novel combination of tumor immunotherapy targeting the T-cell negative pathway and anti-tumor drugsPrincipal Investigator
- Principal Investigator
  
  Hokuto Daisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nara Medical University
Research of new immunotherapy for colorectal liver metastasis using T-cell negative pathwayPrincipal Investigator
- Principal Investigator
  
  Hokuto Daisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nara Medical University
Research for realization of cancer therapy targeted for T cell negative pathway of hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  HOKUTO Daisuke
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Nara Medical University

All 2022 2021 2020 2019 2018 2017 2016 2012 Other

All Journal Article Presentation

[Journal Article] The Impact of a Preoperative Staging System on Accurate Prediction of Prognosis in Intrahepatic Cholangiocarcinoma2022
- Author(s)
  Kosaka Hisashi、Ueno Masaki、Komeda Koji、Hokuto Daisuke、Iida Hiroya、Hirokawa Fumitoshi、Matsui Kosuke、Sekimoto Mitsugu、Kaibori Masaki
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 5 Pages: 1107-1107
- DOI
  10.3390/cancers14051107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Impact of laparoscopic parenchyma-sparing resection of lesions in the right posterosuperior liver segments on surgical outcomes: A?multicenter study based on propensity score analysis2022
- Author(s)
  Shinkawa Hiroji、Hirokawa Fumitoshi、Kaibori Masaki、Kabata Daijiro、Nomi Takeo、Ueno Masaki、Ikoma Hisashi、Nakai Takuya、Iida Hiroya、Tanaka Shogo、Komeda Koji、Kosaka Hisashi、Hokuto Daisuke、Hayami Shinya、Morimura Ryo、Matsumoto Masataka、Maehira Hiromitsu、Takemura Shigekazu、Kubo Shoji
- Journal Title
  
  Surgery
  
  Volume: 171 Issue: 5 Pages: 1311-1319
- DOI
  10.1016/j.surg.2021.09.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09203, KAKENHI-PROJECT-21K08690, KAKENHI-PROJECT-19K09152
[Journal Article] Integrative analysis identifies activated anti-tumor immune microenvironment in lung metastasis of pancreatic cancer2022
- Author(s)
  Sasaki Toshihide、Nishiwada Satoshi、Nakagawa Kenji、Nagai Minako、Terai Taichi、Hokuto Daisuke、Yasuda Satoshi、Matsuo Yasuko、Doi Shunsuke、Sho Masayuki
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 5 Pages: 948-957
- DOI
  10.1007/s10147-022-02131-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203, KAKENHI-PROJECT-20K17660, KAKENHI-PROJECT-19H03734, KAKENHI-PROJECT-22K16541
[Journal Article] Clinically Relevant Late-Onset Biliary Complications After Pancreatoduodenectomy2022
- Author(s)
  Nagai Minako、Nakagawa Kenji、Nishiwada Satoshi、Terai Taichi、Hokuto Daisuke、Yasuda Satoshi、Matsuo Yasuko、Doi Shunsuke、Akahori Takahiro、Sho Masayuki
- Journal Title
  
  World Journal of Surgery
  
  Volume: 46 Issue: 6 Pages: 1465-1473
- DOI
  10.1007/s00268-022-06511-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203, KAKENHI-PROJECT-20K17660, KAKENHI-PROJECT-22K16541
[Journal Article] Clinical Importance of CD200 Expression in Colorectal Liver Metastasis2021
- Author(s)
  Matsuo Yasuko、Sho Masayuki、Nomi Takeo、Hokuto Daisuke、Yoshikawa Takahiro、Kamitani Naoki、Nakamura Kota、Iwasa Yosuke
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: XX Issue: 9 Pages: 5362-5372
- DOI
  10.1245/s10434-020-09471-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22668, KAKENHI-PROJECT-19K18129, KAKENHI-PROJECT-19K09203, KAKENHI-PROJECT-19H03734
[Journal Article] Treatment strategy for resectable colorectal cancer liver metastases from the viewpoint of time to surgical failure2021
- Author(s)
  Hirokawa Fumitoshi、Ueno Masaki、Nakai Takuya、Kaibori Masaki、Nomi Takeo、Iida Hiroya、Tanaka Shogo、Komeda Koji、Hayami Shinya、Kosaka Hisashi、Hokuto Daisuke、Kubo Shoji、Uchiyama Kazuhisa
- Journal Title
  
  Langenbeck's Archives of Surgery
  
  Volume: 407 Issue: 2 Pages: 699-706
- DOI
  10.1007/s00423-021-02372-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Restrictive Pulmonary Dysfunction May Increase Blood Loss During Liver Resection2021
- Author(s)
  Yoshikawa Takahiro、Hokuto Daisuke、Yasuda Satoshi、Kamitani Naoki、Matsuo Yasuko、Sho Masayuki
- Journal Title
  
  The American Surgeon
  
  Volume: 87 Issue: 12 Pages: 1886-1892
- DOI
  10.1177/00031348211060425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Neoadjuvant Chemotherapy Versus Upfront Surgery for Resectable Liver Metastases from Colorectal Cancer: a Multicenter, Propensity Score?Matched Cohort Study2021
- Author(s)
  Hirokawa Fumitoshi、Ueno Masaki、Nakai Takuya、Kaibori Masaki、Nomi Takeo、Iida Hiroya、Tanaka Shogo、Komeda Koji、Hayami Shinya、Kosaka Hisashi、Hokuto Daisuke、Kubo Shoji、Uchiyama Kazuhisa
- Journal Title
  
  Journal of Gastrointestinal Surgery
  
  Volume: 26 Issue: 4 Pages: 772-781
- DOI
  10.1007/s11605-021-05175-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203, KAKENHI-PROJECT-19K09152
[Journal Article] Prognostic impact of neoadjuvant chemotherapy in patients with synchronous colorectal liver metastasis: A propensity score matching comparative study2021
- Author(s)
  Ueno Masaki、Komeda Koji、Kosaka Hisashi、Nakai Takuya、Nomi Takeo、Iida Hiroya、Tanaka Shogo、Ikoma Hisashi、Matsuda Kenji、Hirokawa Fumitoshi、Matsumoto Masataka、Hokuto Daisuke、Mori Haruki、Morimura Ryo、Kaibori Masaki、Yamaue Hiroki、Kubo Shoji
- Journal Title
  
  International Journal of Surgery
  
  Volume: 94 Pages: 106106-106106
- DOI
  10.1016/j.ijsu.2021.106106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Outcomes in Patients with Chronic Kidney Disease After Liver Resection for Hepatocellular Carcinoma2020
- Author(s)
  Yoshikawa Takahiro、Nomi Takeo、Hokuto Daisuke、Kamitani Naoki、Matsuo Yasuko、Sho Masayuki
- Journal Title
  
  World Journal of Surgery
  
  Volume: 45 Issue: 2 Pages: 598-606
- DOI
  10.1007/s00268-020-05829-z
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Preventative effects of ramelteon against postoperative delirium after elective liver resection2020
- Author(s)
  Hokuto Daisuke、Nomi Takeo、Yoshikawa Takahiro、Matsuo Yasfuko、Kamitani Naoki、Sho Masayuki
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 11 Pages: 0241673-0241673
- DOI
  10.1371/journal.pone.0241673
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Characteristics of Five-year Survivors After Liver Resection for Colorectal Liver Metastases in Modern Chemotherapy2020
- Author(s)
  NAKAMOTO TAKAYUKI、HOKUTO DAISUKE、NOMI TAKEO、YOSHIKAWA TAKAHIRO、KAMITANI NAOKI、MATSUO YASUKO、OBARA SHINSAKU、KUGE HIROYUKI、KOYAMA FUMIKAZU、SHO MASAYUKI
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 2 Pages: 1107-1116
- DOI
  10.21873/anticanres.14050
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Influence of the Glissonean Pedicle Transection Approach in Spiegel Lobe-Preserving Left Hepatectomy on Spiegel Lobe Volume and Remnant Liver Functions2020
- Author(s)
  Kamitani Naoki、Nomi Takeo、Hokuto Daisuke、Yoshikawa Takahiro、Matsuo Yasuko、Sho Masayuki
- Journal Title
  
  World Journal of Surgery
  
  Volume: 44 Issue: 9 Pages: 3079-3085
- DOI
  10.1007/s00268-020-05548-5
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Clamp?Crush Technique for Laparoscopic Liver Resection2020
- Author(s)
  Nomi Takeo、Hokuto Daisuke、Yoshikawa Takahiro、Kamitani Naoki、Matsuo Yasuko、Sho Masayuki
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 28 Issue: 2 Pages: 866-866
- DOI
  10.1245/s10434-020-08822-x
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] The prognosis and recurrence pattern of right- and left- sided colon cancer in Stages II, III, and liver metastasis after curative resection2020
- Author(s)
  Nakamura Yasuyuki、Hokuto Daisuke、Koyama Fumikazu、Matsuo Yasuko、Nomi Takeo、Yoshikawa Takahiro、Kamitani Naoki、Sadamitsu Tomomi、Takei Takeshi、Matsumoto Yayoi、Iwasa Yosuke、Fukuoka Kohei、Obara Shinsaku、Nakamoto Takayuki、Kuge Hiroyuki、Sho Masayuki
- Journal Title
  
  Annals of Coloproctology
  
  Volume: ahead of print Issue: 5 Pages: 326-336
- DOI
  10.3393/ac.2020.09.14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Pulmonary complications after laparoscopic liver resection2020
- Author(s)
  Matsuo Yasuko、Nomi Takeo、Hokuto Daisuke、Yoshikawa Takahiro、Kamitani Naoki、Sho Masayuki
- Journal Title
  
  Surgical Endoscopy
  
  Volume: - Issue: 4 Pages: 1659-1666
- DOI
  10.1007/s00464-020-07549-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18129, KAKENHI-PROJECT-19K09203
[Journal Article] Significance of Herpesvirus Entry Mediator Expression in Human Colorectal Liver Metastasis2019
- Author(s)
  Sasaki Y, Hokuto D, Inoue T, Nomi T, Yoshikawa T, Matsuo Y, Koyama F, Sho M
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 26 Issue: 12 Pages: 3982-3989
- DOI
  10.1245/s10434-019-07625-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09203
[Journal Article] Significance of bacterial culturing of prophylactic drainage fluid in the early postoperative period after liver resection for predicting the development of surgical site infections2018
- Author(s)
  Ishioka Kohei、Hokuto Daisuke、Nomi Takeo、Yasuda Satoshi、Yoshikawa Takahiro、Matsuo Yasuko、Akahori Takahiro、Nishiwada Satoshi、Nakagawa Kenji、Nagai Minako、Nakamura Kota、Ikeda Naoya、Sho Masayuki
- Journal Title
  
  Surgery Today
  
  Volume: 48 Issue: 6 Pages: 625-631
- DOI
  10.1007/s00595-018-1629-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10579
[Journal Article] Does anatomic resection improve the postoperative outcomes of solitary hepatocellular carcinomas located on the liver surface?2018
- Author(s)
  Hokuto Daisuke、Nomi Takeo、Yasuda Satoshi、Yoshikawa Takahiro、Ishioka Kohei、Yamada Takatsugu、Takahiro Akahori、Nakagawa Kenji、Nagai Minako、Nakamura Kota、Kanehiro Hiromichi、Sho Masayuki
- Journal Title
  
  Surgery
  
  Volume: 163 Issue: 2 Pages: 285-290
- DOI
  10.1016/j.surg.2017.08.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10579
[Journal Article] Long-term observation and treatment of a widespread intraductal papillary neoplasm of the bile duct extending from the intrapancreatic bile duct to the bilateral intrahepatic bile duct: A case report2017
- Author(s)
  Hokuto Daisuke、Nomi Takeo、Yasuda Satoshi、Yoshikawa Takahiro、Ishioka Kohei、Yamada Takatsugu、Akahori Takahiro、Nakagawa Kenji、Nagai Minako、Nakamura Kota、Obara Shinsaku、Kanehiro Hiromichi、Sho Masayuki
- Journal Title
  
  International Journal of Surgery Case Reports
  
  Volume: 38 Pages: 166-171
- DOI
  10.1016/j.ijscr.2017.07.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10579
[Journal Article] The safety of the early removal of prophylactic drainage after liver resection based solely on predetermined criteria: a propensity score analysis2017
- Author(s)
  Hokuto Daisuke、Nomi Takeo、Yasuda Satoshi、Kawaguchi Chihiro、Yoshikawa Takahiro、Ishioka Kohei、Obara Shinsaku、Yamada Takatsugu、Kanehiro Hiromichi
- Journal Title
  
  HPB
  
  Volume: 19 Issue: 4 Pages: 359-364
- DOI
  10.1016/j.hpb.2016.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10579
[Journal Article] Risk Factors for Unresectable Recurrence After Up-Front Surgery for Colorectal Liver Metastasis2017
- Author(s)
  Hokuto Daisuke、Nomi Takeo、Yasuda Satoshi、Yoshikawa Takahiro、Ishioka Kohei、Yamada Takatsugu、Akahori Takahiro、Nakagawa Kenji、Nagai Minako、Nakamura Kota、Obara Shinsaku、Kanehiro Hiromichi、Sho Masayuki
- Journal Title
  
  World Journal of Surgery
  
  Volume: 42 Issue: 3 Pages: 884-891
- DOI
  10.1007/s00268-017-4195-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10579
[Journal Article] The prognosis of liver resection for patients with four or more colorectal liver metastases has not improved in the era of modern chemotherapy.2016
- Author(s)
  Hokuto D, Nomi T, Yamato I, Yasuda S, Obara S, Yoshikawa T, Kawaguchi C, Yamada T, Kanehiro H, Nakajima Y.
- Journal Title
  
  Journal of surgical oncology
  
  Volume: 114 Issue: 8 Pages: 959-965
- DOI
  10.1002/jso.24461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10579
[Presentation] Clinical Impact of Herpesvirus Entry Mediator (HVEM) in Malignant Liver Tumors2020
- Author(s)
  Daisuke Hokuto
- Organizer
  IHPBA 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09203
[Presentation] 大腸癌肝転移におけるＨＶＥＭ発現の意義2019
- Author(s)
  佐々木義之，北東大督
- Organizer
  第１１９回　日本外科学会
- Data Source
  KAKENHI-PROJECT-16K10579
[Presentation] ヒト肝細胞癌におけるHVEM発現の臨床病理学的意義および獲得免疫機構との関連2012
- Author(s)
  北東大督
- Organizer
  日本癌治療学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24791445
[Presentation] ヒト肝細胞癌におけるHVEM 発現の臨床病理学的意義
- Author(s)
  北東大督, 庄雅之, 山田高嗣, 野見武男, 山戸一郎, 赤堀宇広, 安田里司, 尾原伸作, 川口千尋, 金廣裕道, 中島祥介
- Organizer
  第112 日本外科学会
- Data Source
  KAKENHI-PROJECT-24791445
[Presentation] ヒト肝細胞癌におけるHVEM 発現の臨床病理学的意義および獲得免疫機構との関連
- Author(s)
  北東大督, 庄雅之, 山田高嗣, 野見武男, 山戸一郎, 赤堀宇広, 安田里司, 尾原伸作, 川口千尋, 金廣裕道, 中島祥介
- Organizer
  第48回日本癌治療学会
- Data Source
  KAKENHI-PROJECT-24791445

1. 野見武男 (50570991)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. 松尾泰子 (10812315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 松本雅則 (60316081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 吉川高宏 (80773275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 症雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hokuto Daisuke 北東 大督

HOKUTO Daisuke 北東 大督

Research Projects

Research Products

Co-Researchers

消化器癌における静脈血栓塞栓症機序の新概念と次世代型抗血栓療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel combination of tumor immunotherapy targeting the T-cell negative pathway and anti-tumor drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research of new immunotherapy for colorectal liver metastasis using T-cell negative pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for realization of cancer therapy targeted for T cell negative pathway of hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Impact of a Preoperative Staging System on Accurate Prediction of Prognosis in Intrahepatic Cholangiocarcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of laparoscopic parenchyma-sparing resection of lesions in the right posterosuperior liver segments on surgical outcomes: A?multicenter study based on propensity score analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integrative analysis identifies activated anti-tumor immune microenvironment in lung metastasis of pancreatic cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinically Relevant Late-Onset Biliary Complications After Pancreatoduodenectomy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Importance of CD200 Expression in Colorectal Liver Metastasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment strategy for resectable colorectal cancer liver metastases from the viewpoint of time to surgical failure2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Restrictive Pulmonary Dysfunction May Increase Blood Loss During Liver Resection2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neoadjuvant Chemotherapy Versus Upfront Surgery for Resectable Liver Metastases from Colorectal Cancer: a Multicenter, Propensity Score?Matched Cohort Study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic impact of neoadjuvant chemotherapy in patients with synchronous colorectal liver metastasis: A propensity score matching comparative study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Outcomes in Patients with Chronic Kidney Disease After Liver Resection for Hepatocellular Carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preventative effects of ramelteon against postoperative delirium after elective liver resection2020

Hokuto Daisuke 北東大督

HOKUTO Daisuke 北東大督