YOSHIKADO Takashi 吉門崇

Researcher Number	70535096
Affiliation (Current)	2025: 横浜薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 横浜薬科大学, 薬学部, 准教授 2017 – 2020: 横浜薬科大学, 薬学部, 講師 2015 – 2016: 国立研究開発法人理化学研究所, イノベーション推進センター, 研究員 2013 – 2014: 独立行政法人理化学研究所, イノベーション推進センター, 研究員 2012: 独立行政法人理化学研究所, 杉山特別研究室, 研究員 2011: 東京大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Keywords	Principal Investigator トランスポーター / バイオマーカー / 内在性基質 / 薬物相互作用 / 生理学的薬物速度論モデル / 生理学的速度論モデル / 内因性化合物 / 薬物動態学 / PBPKモデル / OATP1Bs … More / 薬物間相互作用 / コプロポルフィリン / 基質薬・阻害薬 / 発現量の変動 / 阻害剤 / 胆汁形成 / 胆汁ミセル / 胆汁酸非依存性胆汁 / 胆汁酸依存性胆汁 / 薬剤性肝障害 / 薬物誘発性胆汁うっ滞 … More Except Principal Investigator 薬物間相互作用 / 内在性バイオマーカー / 生理学的薬物速度論モデル（PBPK） / 個人間変動 / モデリング＆シミュレーション / 薬物相互作用の予測 / 内因性バイオマーカー / 生理学的薬物速度論（PBPK）モデル / 薬物相互作用 / アルブミン介在性輸送 / トランスポータ / 仮想臨床試験 / 薬物動態 / In vitroからin vivoへの予測 / 薬物間相互作用　（DDI） / 生理学的薬物速度論（PBPKモデル） / フェノタイピング / バーチャルクリニカルスタディ / 生理学的薬物速度論モデル / トランスポーター / 創薬支援システム / PET/SPECTプローブ / 遺伝子多型 / 薬物代謝酵素 / 薬物トランスポーター Less

Development of a physiologically-based kinetic analysis method for drugs and endogenous compounds using a cluster Gauss-Newton methodPrincipal Investigator
- Principal Investigator
  
  吉門崇
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Yokohama College of Pharmacy
Integrated development of quantitative prediction methods for complex drug-drug interactions involving transporters
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Josai International University
Establishment of a physiologically-based pharmacokinetic model through the analyses of pharmacokinetic mechanisms of endogenous hepatic OATP substratesPrincipal Investigator
- Principal Investigator
  
  Yoshikado Takashi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Yokohama College of Pharmacy
Establishment of a virtual clinical trial system considering variations in factors governing drug tissue distribution, efficacy, and side effects.
- Principal Investigator
  
  Sugiyama Yuichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Josai International University
  Institute of Physical and Chemical Research
Development of the prediction method for pharmacokinetics using biomarkers for drug transports and metabolismsPrincipal Investigator
- Principal Investigator
  
  Yoshikado Takashi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Yokohama College of Pharmacy
Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interaction
- Principal Investigator
  
  Sugiyama Yuichi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Medical pharmacy
- Research Institution
  Institute of Physical and Chemical Research
Analyses of transporter-mediated mechanisms of drug-induced cholestasisPrincipal Investigator
- Principal Investigator
  
  YOSHIKADO Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Physiologically-based pharmacokinetic model-based translation of OATP1B-mediated drug-drug interactions from coproporphyrin I to probe drugs2022
- Author(s)
  Mochizuki T, Aoki Y, Yoshikado T, Yoshida K, Lai Y, Hirabayashi H, Yamaura Y, Rockich K, Taskar K, Takashima T, Chu X, Zamek-Gliszczynski MJ, Mao J, Maeda K, Furihata K, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Clin Transl Sci.
  
  Volume: Online ahead of print Issue: 6 Pages: 1519-1531
- DOI
  10.1111/cts.13272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07209
[Journal Article] Cluster Gauss-Newton method analyses of PBPK model parameter combinations of coproporphyrin-I based on OATP1B-mediated rifampicin interaction studies.2022
- Author(s)
  Yoshikado T, Aoki Y, Mochizuki T, Rodrigues AD, Chiba K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  CPT Pharmacometrics Syst Pharmacol.
  
  Volume: 11 Issue: 10 Pages: 1341-1357
- DOI
  10.1002/psp4.12849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07209, KAKENHI-PROJECT-19H03392
[Journal Article] Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes2021
- Author(s)
  Yoshikado Takashi、Lee Wooin、Toshimoto Kota、Morita Kiyoe、Kiriake Aya、Chu Xiaoyan、Lee Nora、Kimoto Emi、Varma Manthena V.S.、Kikuchi Ryota、Scialis Renato J.、Shen Hong、Ishiguro Naoki、Lotz Ralf、Li Albert P.、Maeda Kazuya、Kusuhara Hiroyuki、Sugiyama Yuichi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 110 Issue: 1 Pages: 376-387
- DOI
  10.1016/j.xphs.2020.10.041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.2019
- Author(s)
  Mori D, Kashihara Y, Yoshikado T, Kimura M, Hirota T, Matsuki S, Maeda K, Irie S, Ieiri I, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 34 Issue: 1 Pages: 78-86
- DOI
  10.1016/j.dmpk.2018.09.003
- NAID
  50014558502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04100, KAKENHI-PROJECT-17K15536
[Journal Article] Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.2018
- Author(s)
  Takehara I, Yoshikado T, Ishigame K, Mori D, Furihata KI, Watanabe N, Ando O, Maeda K, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 35 Issue: 7 Pages: 138-138
- DOI
  10.1007/s11095-018-2416-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15536
[Journal Article] PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3.2018
- Author(s)
  Yoshikado T., Toshimoto K., Maeda K., Kusuhara H., Kimoto E., Rodrigues AD., Chiba K., Sugiyama Y.
- Journal Title
  
  CPT Pharmacometrics Syst Pharmacol.
  
  Volume: 7 Issue: 11 Pages: 739-747
- DOI
  10.1002/psp4.12348
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-17K15536, KAKENHI-PROJECT-17H04100
[Journal Article] Quantitative Analysis of Complex Drug&-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.2017
- Author(s)
  Kim SJ, Toshimoto K, Yao Y, Yoshikado T, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中 Issue: 9 Pages: 2715-2726
- DOI
  10.1016/j.xphs.2017.04.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Small-dosing clinical study: Pharmacokine- tic, pharmacogeno- mics (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit juice) profiles of 5 probes for OATP2B1 and BCRP.2017
- Author(s)
  Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Comparison of methods for estimating unbound intracellular-to-medium concentration ratios in rat and human hepatocytes using statins.2017
- Author(s)
  Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Kusuhara H, Maeda K, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 印刷中 Issue: 7 Pages: 779-789
- DOI
  10.1124/dmd.116.074823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.2016
- Author(s)
  Yoshikado T, Yoshida K, Kotani N, Nakada T, Asaumi R, Toshimoto K. Maeda K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 100 Issue: 5 Pages: 513-523
- DOI
  10.1002/cpt.391
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Clarification of the Mechanism of Clopidogrel- Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.2016
- Author(s)
  Kim SJ, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 44 Issue: 10 Pages: 1622-1632
- DOI
  10.1124/dmd.116.070276
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Ticlopidine, a Cholestatic Liver Injury-Inducible Drug, Causes Dysfunction of Bile Formation via Diminished Biliary Secretion of Phospholipids: Involvement of Biliary-Excreted Glutathione-Conjugated Ticlopidine Metabolites2013
- Author(s)
  Takashi Yoshikado, Tappei Takada, Hideaki Yamamoto, Jeng Kae Tan, Kousei Ito, Tomofumi Santa, Hiroshi Suzuki
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 83(2) Issue: 2 Pages: 552-562
- DOI
  10.1124/mol.112.081752
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PROJECT-23790174, KAKENHI-PLANNED-22136015
[Journal Article] Ticlopidine, a cholestatic liver injury-inducible drug, causes dysfunction of bile formation via diminished biliary secretion of phospholipids: involvement of biliary- excreted glutathione-conjugated ticlopidine metabolites.2013
- Author(s)
  Yoshikado T, Takada T, Yamamoto H, Tan JK, Ito K, Santa T, Suzuki H.
- Journal Title
  
  Mol Pharmacol.
  
  Volume: 83(2) Pages: 552-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790174
[Journal Article] Ursodeoxycholic acid stimulates the formation of the bile canalicular network.2012
- Author(s)
  Ikebuchi Y, Shimizu H, Ito K, Yoshikado T, Yamanashi Y, Takada T, Suzuki H.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 84 Issue: 7 Pages: 925-35
- DOI
  10.1016/j.bcp.2012.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790174
[Journal Article] Ursodeoxycholic acid stimulates the formation of the bile canalicular network.2012
- Author(s)
  Ikebuchi Y, Shimizu H, Ito K, Yoshikado T, Yamanashi Y, Takada T, Suzuki H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 84(7) Pages: 925-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790174
[Presentation] DPP-4体内分布とDPP-4介在性再吸収メカニズムに着目したシタグリプチン非線形体内動態のPBPKモデル解析2024
- Author(s)
  鈴木優樹, 吉門崇, 中村亮, 岡田賢二, 岡美佳子, 千葉康司
- Organizer
  日本薬学会第144年会，3月，横浜
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] OATP1B内在性基質コプロポルフィリンI体内動態の生理学的速度論モデル解析：ヒトとカニクザルの比較2024
- Author(s)
  葛西航貴, 吉門崇, 友田有加菜, 岡田賢二, 岡美佳子, 千葉康司
- Organizer
  日本薬学会第144年会，3月，横浜
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] DPP-4阻害薬ビルダグリプチン非線形体内動態の生理学的薬物速度論モデリング2024
- Author(s)
  榎本和輝, 吉門崇, 中村亮, 岡田賢二, 岡美佳子, 千葉康司
- Organizer
  日本薬学会第144年会，3月，横浜
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] Mrp2欠損ラットを用いたOATP1Bs内在性基質のPBPKモデル解析2024
- Author(s)
  友田有加菜, 吉門崇, 永田莞奈, 岡田賢二, 岡美佳子, 千葉康司
- Organizer
  日本薬学会第144年会，3月，横浜
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] 内因性化合物の生理学的速度論モデル解析に基づいた薬物相互作用予測法の開発2023
- Author(s)
  吉門崇
- Organizer
  日本薬剤学会第38年会，5月, 名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] Comprehensive PBPK analyses of coproporphyrin I, an endogenous substrate of hepatic OATP1B, by using a cluster Gauss-Newton method2023
- Author(s)
  Takashi Yoshikado
- Organizer
  23rd ICCP450/38th JSSX International Joint Meeting, September, Shizuoka
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] リナグリプチンの複雑なヒト非線形体内動態を説明可能な生理学的薬物速度論モデルパラメータの網羅的探索-クラスターガウスニュートン法の活用2023
- Author(s)
  中村　亮，吉門崇，原野華帆，榎本和輝，鳥越　寛，千葉康司
- Organizer
  日本薬剤学会第38年会，5月，名古屋
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] PBPKモデル解析におけるクラスターガウスニュートン法の活用は複雑な体内動態を示す薬物・内因性化合物の研究に役立つか2023
- Author(s)
  吉門崇
- Organizer
  薬物動態談話会第46年会，11月，浜松
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] Comprehensive analyses of DPP-4-mediated linagliptin nonlinear pharmacokinetics in human and rodents by PBPK modeling combined with a cluster Gauss-Newton method2023
- Author(s)
  Ryo Nakamura, Takashi Yoshikado, Kazuki Enomoto, Kan Torigoe, Koji Chiba
- Organizer
  23rd ICCP450/38th JSSX International Joint Meeting, September, Shizuoka
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] ラット臓器内リナグリプチン濃度に基づいたDPP-4のPBPKモデル解析2023
- Author(s)
  榎本和輝，吉門崇，中村　亮，原野華帆，岡田賢二，岡美佳子，千葉康司
- Organizer
  日本薬剤学会第38年会，5月，名古屋
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] 肝OATP1B内在性基質であるコプロポルフィリンIの体内動態解析―PBPKモデルを用いた包括的解析2022
- Author(s)
  葛西航貴，吉門崇，千葉康司
- Organizer
  第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] Proposals for predicting drug efficacy/safety based on the estimation of intracellular concentrations; from the perspective of in vitro experiments- and modeling-based pharmacokinetic analyses2022
- Author(s)
  Takashi Yoshikado
- Organizer
  37th JSSX Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] 薬物相互作用のPBPKモデリングに基づいた解析；トランスポーター内在性基質は予測精度を改善するために役立つか？2022
- Author(s)
  吉門崇
- Organizer
  日本薬学会第142年会、オンライン
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] 肝トランスポーターを介した薬物相互作用のバイオマーカーを用いた予測―新しい計算科学に基づいた生理学的薬物速度論モデル構築による予測法の提案2022
- Author(s)
  吉門崇
- Organizer
  日本薬剤学会第37年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] 生理学的薬物速度論解析の現在地; 新しい計算機科学との融合2021
- Author(s)
  吉門崇
- Organizer
  第65回日本薬学会関東支部大会、オンライン
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] ヒトC型肝炎治療薬グラゾプレビルの非線形薬物動態解析; Middle-out解析の重要性2021
- Author(s)
  吉門崇
- Organizer
  CBI学会第425研究講演会、オンライン
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] ATP1B内在性基質コプロポルフィリンIと阻害薬リファンピシンとの相互作用解析　～生理学的薬物速度論モデルとクラスターガウスニュートン法の活用～2021
- Author(s)
  吉門崇、青木康憲、望月達貴、千葉康司、楠原洋之、杉山雄一
- Organizer
  日本薬剤学会第36年会、オンライン
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] Global parameter estimation for the physiologically-based pharmacokinetic (PBPK) model of coproporphyrin I, an endogenous substrate for hepatic OATP1B, by Cluster Gauss-Newton method2021
- Author(s)
  Takashi Yoshikado, Yasunori Aoki, Tatsuki Mochizuki, Koji Chiba, Hiroyuki Kusuhara, and Yuichi Sugiyama
- Organizer
  36th JSSX Annual Meeting, online
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] トランスポーター内在性基質のPBPKモデリングに基づいた薬物相互作用リスクの定量的予測2021
- Author(s)
  吉門崇
- Organizer
  第25回薬物動態談話会セミナー、オンライン
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] 肝OATP内在性基質コプロポルフィリンIをバイオマーカーとして用いた薬物相互作用の予測： PBPKモデルを用いた定量的アプローチの例2021
- Author(s)
  吉門崇
- Organizer
  第42回日本臨床薬理学会学術総会、仙台
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] 薬物相互作用のメカニズムに基づいた定量的解析：OATP基質薬（プローブ）および内在性基質の活用2020
- Author(s)
  吉門崇
- Organizer
  第30回日本医療薬学会年会, 11月, オンライン
- Invited
- Data Source
  KAKENHI-PROJECT-20K07209
[Presentation] OATP1B内在性基質のコプロポルフィリンIをバイオマーカーとして用いた薬物間相互作用の予測2019
- Author(s)
  吉門崇、年本広太、前田和哉、楠原洋之、千葉康司、杉山雄一
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム　千葉
- Data Source
  KAKENHI-PROJECT-17K15536
[Presentation] OATP1B内在性基質コプロポルフィリンIの生理学的薬物速度論モデルを用いた薬物間相互作用予測法の提唱2019
- Author(s)
  吉門崇、年本広太、前田和哉、楠原洋之、千葉康司、杉山雄一
- Organizer
  日本薬剤学会第34年会　富山
- Data Source
  KAKENHI-PROJECT-17K15536
[Presentation] 肝トランスポーターを介したDDIの内在性バイオマーカーに基づく予測2019
- Author(s)
  吉門崇
- Organizer
  第29回日本医療薬学会年会　福岡
- Invited
- Data Source
  KAKENHI-PROJECT-17K15536
[Presentation] 生理学的薬物速度論モデルを用いたOATP1BsおよびMRP2内在性基質コプロポルフィリンIの体内動態解析2018
- Author(s)
  吉門崇、年本広太、前田和哉、楠原洋之、千葉康司、杉山雄一
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-17K15536
[Presentation] Construction of a physiologically-based pharmacokinetic model of coproporphyrin I, a putative endogenous probe for hepatic OATP1Bs and MRP22018
- Author(s)
  Yoshikado T, Toshimoto K, Maeda K, Kusuhara H, Chiba K, Sugiyama Y
- Organizer
  第39回日本臨床薬理学会学術総会/第18回国際薬理学・臨床薬理学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15536
[Presentation] Proposal for predicting drug-drug interactions using a PBPK model of coproporphyrin I as an endogenous OATP1B biomarker2018
- Author(s)
  吉門崇
- Organizer
  日本薬物動態学会第33回年会/MDO国際合同学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15536
[Presentation] 臨床ステージで行う内在性バイオマーカーに基づくDDIリスク評価　-肝トランスポーターを中心に-2018
- Author(s)
  吉門崇
- Organizer
  CBI学会第400研究講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15536
[Presentation] Small-dosing clinical study: pharmacoki- netic, pharmacogeno-mic (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit Juice) profiles of five probes for OATP2B1 and BCRP.2017
- Author(s)
  Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.
- Organizer
  15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Place of Presentation
  国立京都国際会館 (京都府京都市)
- Year and Date
  2017-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Construction of a physiologically-based pharmacokinetic model for coproporphyrin I, an endogenous probe for hepatic organic anion transporting polypeptides (OATPs)2017
- Author(s)
  Takashi Yoshikado, Kazuya Maeda, Hiroyuki Kusuhara, Koji Chiba, and Yuichi Sugiyama
- Organizer
  32nd JSSX Annual Meeting (Tokyo, Japan)
- Data Source
  KAKENHI-PROJECT-17K15536
[Presentation] 肝OATPおよびCYP3Aが関与する薬物間相互作用のPBPKモデル解析.2017
- Author(s)
  吉門崇, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第32年会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2017-05-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Analysis of drug-drug interactions caused by the inhibition of hepatic organic anion transporting polypeptides using a rational physiologically based pharmacokinetic model and parameters obtained from human hepatocytes.2016
- Author(s)
  Yoshikado T, Toshimoto K, Sugiyama Y.
- Organizer
  Experimental Biology 2016
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-04-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Evaluation of the alteration in BCRP function by c.421C>A polymorphism based on PBPK analysis of rosuvastatin.2016
- Author(s)
  Futatsugi A, Toshimoto K, Yoshikado T, Kato Y, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターと薬物代謝酵素が関与する肝消失律速過程の解析.2016
- Author(s)
  吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本動物実験代替法学会第29回大会
- Place of Presentation
  九州大学百年講堂（福岡県博多区）
- Year and Date
  2016-11-17
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターを介した薬物間相互作用の生理学的薬物速度論モデルを用いた予測.2016
- Author(s)
  吉門崇
- Organizer
  医療薬学フォーラム 2016
- Place of Presentation
  びわ湖ホール（滋賀県大津市）
- Year and Date
  2016-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 内在性基質の変動を利用したOATPを介した薬物間相互作用の定量的評価法の開発.2016
- Author(s)
  楠原洋之, 吉門崇, 前田和哉, 寺島花野, 中山丈史, 吉田美和, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Analysis of complex drug-drug interactions of cerivastatin using physiol- ogically based pharmacokinetic (PBPK) modeling.2016
- Author(s)
  Yao Y, Toshimoto K, Kim S.J, Yoshikado T, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] クロピドグレルの関与する薬物間相互作用のカセットドーズ臨床試験に基づいたメカニズム解析とin vitro試験に基づいた予測.2016
- Author(s)
  Soo-Jin Kim, 吉門崇, 家入一郎, 前田和哉, 木村美由紀, 入江伸, 楠原洋之, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] OATPs/CYP3A dual基質の薬物相互作用試験に基づいた肝消失律速過程の解析.2016
- Author(s)
  吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一, 杉山雄一.
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] In vitro estimation of unbound hepatocyte-to- medium concentration ratios (Kp,uu) of statins considering the membrane potential- dependent passive diffusion.2016
- Author(s)
  Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Ogawa K, Hisanaga N, Kusuhara H, Maeda K, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Identification of GCDCA-S as endogenous biomarkers for OATP1B1 and OATP1B3 in healthy subject.2016
- Author(s)
  Takehara I, Terashima H, Nakayama T, Yoshikado T, Yoshida M, Furihata K, Watanabe N, Maeda K, Ando O, Sugiyama Y, Kusuhara H.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Clopidogrel-mediated drug-drug interaction on CYP2C8 and OATP1B1: in vitro inhibitory effect and in vivo clinical study.2016
- Author(s)
  Kim S.J, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝臓におけるトランスポーターを介した薬物間相互作用の生理学的薬物速度論モデルに基づいた解析法の構築.2015
- Author(s)
  吉門崇, 杉山雄一.
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] PBPK モデルを用いたrepaglinide の複雑な薬物間相互作用の解析.2015
- Author(s)
  Soo-Jin Kim, 八尾祉顕, 年本広太, 吉門崇, 杉山雄一.
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] A clinical drug interaction study using hepatic OATPs/CYP3A dual substrates: analysis of the rate-determining process based on the extended clearance concept.2015
- Author(s)
  Yoshikado T, Furihata S, Terashima H, Nakayama T, Ishigame K, Tsunemoto K, Maeda K, Kusuhara H, Furihata K, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 薬物動態・相互作用予測を目的としたin vitro試験の現状における課題と研究の進展.2015
- Author(s)
  吉門崇
- Organizer
  CBI学会第367研究講演会
- Place of Presentation
  東京大学山上会館（東京都文京区）
- Year and Date
  2015-12-15
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝取り込みトランスポーターOATPs および代謝酵素CYP3A4 のdual 基質薬の関与する薬物間相互作用の臨床解析.2015
- Author(s)
  杉山雄一, 吉門崇, 降旗聖子, 寺島花野, 中山丈史, 石亀啓子, 常本和伸, 前田和哉, 楠原洋之, 降旗謙一.
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターが関与する肝取り込みおよび排出過程のサンドイッチ培養ヒト肝細胞を用いた定量的評価-肝消失律速過程の解析-2015
- Author(s)
  吉門崇, 杉山雄一.
- Organizer
  第10回トランスポーター研究会年会
- Place of Presentation
  慶應義塾大学薬学部（東京都港区）
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Predicting complex drug-drug interactions of repaglinide using physiologically based pharmacokinetic (PBPK) models with in vitro Ki data.2015
- Author(s)
  Soo-Jin Kim, 八尾祉顕, 年本広太, 吉門崇, 杉山雄一.
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 胆汁形成を担うトランスポーターのin vitro機能評価系に基づいた薬物誘発性胆汁うっ滞型肝障害のリスク評価.2015
- Author(s)
  吉門崇, 杉山雄一.
- Organizer
  日本動物実験代替法学会第28回大会,
- Place of Presentation
  ワークピア横浜（神奈川県横浜市）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Clarification of the mechanism of clopidogrel-mediated drug-drug interaction on the pharmacokinetics of repaglinide in a clinical cassette small-dose study.2015
- Author(s)
  Kim S.J, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y.
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] サンドイッチ培養ヒト肝細胞を用いたスタチンの肝消失律速過程の予測.2015
- Author(s)
  吉門崇, Rafal P. Witek, 杉山雄一.
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 肝OATPを介した薬物間相互作用のPBPKモデルを用いた解析－腸肝循環を考慮した合理的なモデルへの発展－2013
- Author(s)
  吉門崇，吉田健太，中田智久，小谷直生，前田和哉，杉山雄一
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターを介した薬物間相互作用予測のための腸肝循環およびIn vitro膜透過性を考慮した生理学的薬物速度論モデルの提案2013
- Author(s)
  吉門崇，吉田健太，前田和哉，杉山雄一
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] チクロヒ〓シ〓ン代謝物の胆汁排泄による胆汁形成の変化ーMRP2/ABCC2の関与ー2012
- Author(s)
  吉門崇、高田龍平、伊藤晃成、三田智文、鈴木洋史
- Organizer
  第20回肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-23790174
[Presentation] Construction of physiologically-based pharmacokinetic models explaining drug-drug interactions via the inhibition of organic anion transporting polypeptides (OATPs)2012
- Author(s)
  Yoshikado T, Maeda K, Nakada T, Kotani N, Yoshida K, Sugiyama Y.
- Organizer
  19th Microsomes and Drug Oxidations (MDO) and 12th European ISSX Meeting
- Place of Presentation
  Grand Hotel Huis ter Duin, Noordwijk aan Zee, the Netherlands
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Quantitative analyses of drug-drug interactions between statins and cyclosporine A using physiologically-based pharmacokinetic models2012
- Author(s)
  Takashi Yoshikado, Kazuya Maeda, Tomohisa Nakada, Yoshihisa Shitara, Kenta Yoshida, Yuichi Sugiyama
- Organizer
  27th JSSX Annual Meeting
- Place of Presentation
  Chiba, Japan
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] チクロピジン代謝物の胆汁排泄による胆汁形成の変化ーMRP2/ABCC2の関与ー2012
- Author(s)
  吉門崇、高田龍平、伊藤晃成、三田智文、鈴木洋史
- Organizer
  第２０回肝病態生理研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23790174
[Presentation] Involvement of MRP2/ABCC2-mediated bile flow in the ticlopidine-induced alteration of bile composition2011
- Author(s)
  吉門崇、高田龍平、伊藤晃成、三田智文、鈴木洋史
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23790174
[Presentation] Involvement of MRP2/ABCC2 -mediated bile flow in the ticlopidine-induced alteration of bile composition2011
- Author(s)
  吉門崇、高田龍平、伊藤晃成、三田智文、鈴木洋史
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23790174
[Presentation] Prediction of transporter- and enzyme-mediated complicated drug-drug interaction: taking Cerivastatin, withdrawn from the market due to its induced rhabdomyolysis as an example of victim drug
- Author(s)
  Kim S.J, Yao Y, Toshimoto K, Yoshikado T, Sugiyama Y.
- Organizer
  日本動物実験代替法学会第27回大会
- Place of Presentation
  神奈川県横浜市、横浜国立大学
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Analysis of drug-drug interactions between cerivastatin and interacting drugs, cyclosporine A and gemfibrozil, using physiologically based pharmacokinetic (PBPK) model.
- Author(s)
  Kim S.J, Yao Y, Yoshikado T, Toshimoto K, Sugiyama Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Establishing a versatile analysis method of drug-drug interactions with the physiologically-based pharmacokinetic model using the Cluster Newton Method.
- Author(s)
  Toshimoto K, Yoshida K, Yoshikado T, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] トランスポーターを介した薬物間相互作用のモデリング事例
- Author(s)
  吉門崇、杉山雄一
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  埼玉県さいたま市、大宮ソニックシティビル
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-24229002

1. Sugiyama Yuichi (80090471)

# of Collaborated Projects: 5 results

# of Collaborated Products: 40 results
2. 前田和哉 (00345258)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
3. 渡邊恭良 (40144399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 家入一郎 (60253473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 新垣友隆 (60643187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 伊藤澄人 (20728969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 速水謙 (20251358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小山智志 (60805761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 年本広太 (70740504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 加藤将夫 (30251440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 出口芳春 (40254255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 千葉康司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 鈴木洋史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 渡辺恭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 楠原洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIKADO Takashi 吉門 崇

Research Projects

Research Products

Co-Researchers

Development of a physiologically-based kinetic analysis method for drugs and endogenous compounds using a cluster Gauss-Newton methodPrincipal Investigator

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Integrated development of quantitative prediction methods for complex drug-drug interactions involving transporters

Principal Investigator

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Establishment of a physiologically-based pharmacokinetic model through the analyses of pharmacokinetic mechanisms of endogenous hepatic OATP substratesPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Establishment of a virtual clinical trial system considering variations in factors governing drug tissue distribution, efficacy, and side effects.

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Research Institution

Development of the prediction method for pharmacokinetics using biomarkers for drug transports and metabolismsPrincipal Investigator

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Research Institution

Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interaction

Principal Investigator

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Analyses of transporter-mediated mechanisms of drug-induced cholestasisPrincipal Investigator

Principal Investigator

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[Journal Article] Physiologically-based pharmacokinetic model-based translation of OATP1B-mediated drug-drug interactions from coproporphyrin I to probe drugs2022

Author(s)

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Data Source

[Journal Article] Cluster Gauss-Newton method analyses of PBPK model parameter combinations of coproporphyrin-I based on OATP1B-mediated rifampicin interaction studies.2022

Author(s)

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DOI

Data Source

[Journal Article] Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes2021

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[Journal Article] Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.2019

Author(s)

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DOI

NAID

Data Source

[Journal Article] Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative Analysis of Complex Drug&-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.2017

Author(s)

Journal Title

YOSHIKADO Takashi 吉門崇