Shigeyasu Kunitoshi 重安邦俊

Researcher Number	70544071
Other IDs	https://orcid.org/0000-0002-1266-2875
Affiliation (Current)	2025: 岡山大学, 医療開発領域, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 岡山大学, 大学病院, 助教 2018: 岡山大学, 医学部, 客員研究員 2017: 岡山大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords	Principal Investigator RNA editing / 大腸癌 / ADAR1 / RNA編集 / 免疫療法 / オキサリプラチン / 化学放射線療法 / 直腸癌 / ネオアンチゲン / バイオマーカー … More / 腫瘍免疫 / 癌 / 線維芽細胞 / AZIN1 / 癌関連線維芽細胞 / 微小環境 … More Except Principal Investigator 腫瘍免疫 / 肝内胆管癌 / ADAR1 / スプライシング異常 / リンチ症候群 / RNA編集酵素 / ネオアンチゲン / 磁気温熱治療 / RNA editing / 胆管癌 / ctDNA / リキッドバイオプシー / 膵癌 / molecular subtype / liquid biopsy / バイオマーカー / 難治性消化器がん / LAT1 / BPA / アミノ酸輸送体 / 消化器がん / グルコースBSH / グルコース輸送体 / ホウ素薬剤 / 膵がん / ホウ素中性子捕捉療法 Less

RNA編集をターゲットとしたmRNAネオアンチゲンワクチンによる膵癌免疫療法の開発
- Principal Investigator
  
  安井和也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
消化器癌腹膜播種に対する磁気温熱治療を併用したネオアンチゲン癌免疫治療の開発
- Principal Investigator
  
  岸本浩行
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Cancer prevention for Lynch syndrome through splicing mechanisms of RNA editing enzyme gene ADAR1
- Principal Investigator
  
  山本英喜
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Okayama University
Development of a cancer immunoregenerative therapy that blocks function-suppressive RNA editing signals from cancer cells to immune cells.Principal Investigator
- Principal Investigator
  
  重安邦俊
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
胆管癌のmolecular subtype分類の構築
- Principal Investigator
  
  楳田祐三
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Development of an algorithm for pancreatic cancer treatment using a combined DNA and RNA biomarker panel
- Principal Investigator
  
  Yoshida Ryuichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Exploring Novel Cancer Immunotherapy to Turn Cold Tumors into Hot Tumors by RNA EditingPrincipal Investigator
- Principal Investigator
  
  Shigeyasu Kunitoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Development of boron neutron capture therapy targeting gastrointestinal cancer and search for biomarkers of its efficacy
- Principal Investigator
  
  Teraishi Fuminori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Practical classification of molecular subtype of intrahepatic cholangiocarcinoma including liquid biopsy
- Principal Investigator
  
  Umeda Yuzo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Activation of RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Shigeyasu Kunitoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] 制御性T細胞による肝内胆管癌の免疫微小環境の制御2024
- Author(s)
  吉田一博、楳田祐三、重安邦俊、藤智和、安井和也、高木弘誠、藤原俊義
- Journal Title
  
  肝胆膵
  
  Volume: 88 Pages: 619-624
- Data Source
  KAKENHI-PROJECT-22K08775
[Journal Article] Dual antiplatelet therapy inhibits neutrophil extracellular traps to reduce liver micrometastases of intrahepatic cholangiocarcinoma2023
- Author(s)
  Yoshimoto Masashi、Kagawa Shunsuke、Kajioka Hiroki、Taniguchi Atsuki、Kuroda Shinji、Kikuchi Satoru、Kakiuchi Yoshihiko、Yagi Tomohiko、Nogi Shohei、Teraishi Fuminori、Shigeyasu Kunitoshi、Yoshida Ryuichi、Umeda Yuzo、Noma Kazuhiro、Tazawa Hiroshi、Fujiwara Toshiyoshi
- Journal Title
  
  Cancer Letters
  
  Volume: 567 Pages: 216260-216260
- DOI
  10.1016/j.canlet.2023.216260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08775, KAKENHI-PROJECT-23K24407
[Journal Article] Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma2022
- Author(s)
  Konishi DaisukeKishimoto Hiroyuki、Michiue Hiroyuki、Teraishi Fuminori、Kato Hironari、Tazawa Hiroshi、Yanai Hiroyuki、Yagi Takahito、Goel Ajay、Fujiwara Toshiyoshi
- Journal Title
  
  British Journal of Cancer
  
  Volume: 127 Issue: 4 Pages: 757-765
- DOI
  10.1038/s41416-022-01838-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09176, KAKENHI-PROJECT-22K08775, KAKENHI-PROJECT-21K16474, KAKENHI-PROJECT-19K18121, KAKENHI-PROJECT-23K24407
[Journal Article] RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer2022
- Author(s)
  Komatsu Yasuhiro、Shigeyasu Kunitoshi、Kagawa Shunsuke、Michiue Hiroyuki、Tazawa Hiroshi、Goel Ajay、Fujiwara Toshiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 00-00
- DOI
  10.1038/s41598-022-17773-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09176, KAKENHI-PROJECT-22K08775, KAKENHI-PROJECT-20K17653, KAKENHI-PROJECT-21K16474, KAKENHI-PROJECT-20K09110, KAKENHI-PROJECT-23K24407, KAKENHI-PROJECT-22K08873
[Journal Article] Clinical and epigenetic features of colorectal cancer patients with somatic POLE proofreading mutations.2021
- Author(s)
  Kawai T, Nyuya A, Mori Y, Tanaka T, Tanioka H, Yasui K, Toshima T, Taniguchi F, Shigeyasu K, Umeda Y, Fujiwara T, Okawaki M, Yamaguchi Y, Goel A, Nagasaka T.
- Journal Title
  
  Clin Epigenetics.
  
  Volume: 13 (1) Issue: 1 Pages: 117-117
- DOI
  10.1186/s13148-021-01104-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09217, KAKENHI-PROJECT-19K07787, KAKENHI-PROJECT-20K09110, KAKENHI-PROJECT-21K07185, KAKENHI-PROJECT-21K19934
[Journal Article] リアルタイムイメージングによる予後不良間葉型大腸癌の治療抵抗性EMTマーカーの発現の時空間的意義2021
- Author(s)
  三村直毅, 矢野修也, 田澤大, 家田偉史, 岡林弘樹, 重安邦俊, 武田正, 吉田一博, 寺石文則, 楳田祐三, 香川俊輔, 藤原俊義
- Journal Title
  
  日本分子腫瘍マーカー研究会誌
  
  Volume: 36 Pages: 18-20
- NAID
  130007987462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09217
[Journal Article] Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer2019
- Author(s)
  Takeda S, Shigeyasu K, Okugawa Y, Yoshida K, Mori Y, Yano S, Noma K, Umeda Y, Kondo Y, Kishimoto H, Teraishi F, Nagasaka T, Tazawa H, Kagawa S, Fujiwara T, Goel A.
- Journal Title
  
  Cancer Lett
  
  Volume: 444 Pages: 127-135
- DOI
  10.1016/j.canlet.2018.12.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10634, KAKENHI-PROJECT-18K08566, KAKENHI-PROJECT-18K08591, KAKENHI-PROJECT-19K09143, KAKENHI-PROJECT-19K09217, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-17K16557
[Presentation] Short outcomes of adjuvant immunotherapy for esophageal cancer in our institution2023
- Author(s)
  Hashimoto M, Noma K, Kawasaki K, Kato T, Maeda N, Kikuchi S, Shigeyasu K, Kondo Y, Tanabe S, Kuroda S,Teraishi F, Umeda Y, Kagawa S, Shirakawa Y, Fuhiwara T
- Organizer
  the Asian Oncology Society (AOS2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08775
[Presentation] Surgical management of borderline resectable colorectal liver metastases: vessel-skeletonized parenchymasparing hepatectomy (VESPAH)2023
- Author(s)
  Umeda Y, Fuji T, Takagi K, Yasui K, Shigeyasu K, Kuroda S, Noma K, Teraishi F, Fujiwara T
- Organizer
  the Asian Oncology Society (AOS2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08775
[Presentation] Prognostic significance of GATA6 expression after surgery in patients with pancreatic cancer2022
- Author(s)
  Yoshida R,Miyamoto K,Shigeyasu K,Yasui K,Takagi K,Fuji T,Umeda Y,Yagi T,FujiwaraT
- Organizer
  第53回日本膵臓学会大会・第26回国際膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08775
[Presentation] Combination analysis of pre- and postoperative KRAS mutation in circulating tumor DNA in patients with pancreatic cancer2022
- Author(s)
  Miyamoto K,Yoshida R,Shigeyasu K,Yasui K,Takagi K,Fuji T,Umeda Y,Yagi T,Fujiwara T
- Organizer
  第53回日本膵臓学会大会・第26回国際膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08775
[Presentation] EMT-MET 可視化バイオセンサーを用いてhybridE/M 状態での化学療法抵抗性をリアルタイムイメージングにより解き明かす2020
- Author(s)
  三村直毅、矢野修也、田澤大、家田偉史、岡林大樹、重安邦俊、武田正、吉田一博、寺石文則、楳田祐三、香川俊輔、藤原俊義
- Organizer
  第79回日本癌学会学術総会、シンポジウム
- Data Source
  KAKENHI-PROJECT-19K09217
[Presentation] 肝内胆管癌における免疫微小環境と治療予後の関連性2020
- Author(s)
  小西大輔、吉田一博、楳田祐三、重安邦俊、矢野修也、武田正、吉田龍一、杭瀬崇、藤智和、安井和也、松田達雄、田澤大、白川靖博、八木孝仁、藤原俊義
- Organizer
  第120回日本外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09217
[Presentation] 大腸癌化学放射線療法で活性化されるRNA 編集によるネオアンチゲンの人工的生成2020
- Author(s)
  小松泰浩、重安邦俊、武田正、髙橋一剛、畑七々子、吉田一博、矢野修也、大原利章、野間和広、楳田祐三、黒田新士、近藤喜太、寺石文則、田澤大、田澤大、香川俊輔、藤原俊義
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09217
[Presentation] 大腸癌化学放射線療法で活性化される RNA 編集によるネオアンチゲンの人工的生成2020
- Author(s)
  小松泰浩、重安邦俊、武田正、高橋一剛、畑七々子、吉田一博、矢野修也、大原利章、野間和広、楳田祐三、黒田新士、近藤喜太、寺石文則、田澤大、香川俊輔、藤原俊義
- Organizer
  The 79th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-20K17653
[Presentation] AZIN1 RNA editing is a novel mechanism that enhances malignant potential of colorectal cancer microenvironment2019
- Author(s)
  Takeda S, Shigeyasu K, Okugawa Y, Yoshida K, Mori Y, Yano S, Noma K, Umeda Y, Kondo Y, Kishimoto H, Teraishi F, Takeshi N, Tazawa H, Kagawa S, Ajay G, Fujiwara T
- Organizer
  JCA2019
- Data Source
  KAKENHI-PROJECT-17K16557
[Presentation] AZIN1RNA編集は大腸癌微小環境の再構成を促進し癌の進展に寄与する新たなメカニズムである2019
- Author(s)
  重安邦俊,吉田一博,母里淑子,矢野修也,近藤喜太,野間和広,寺石文則,楳田祐三,岸本浩行,田澤大,香川俊輔,藤原俊義
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09217
[Presentation] Activation of AZIN1 RNA editing facilitates and promotes invasive potential of cancer associated fibroblasts in colorectal cancer2019
- Author(s)
  Sho Takeda, Kunitoshi Shigeyasu, Yoshinaga Okugawa, Kazuhiro Yoshida, Yoshiko Mori, Shuya Yano, Kazuhiro Noma, Yuzo Umeda, Yoshitaka Kondo, Hiroyuki Kishimoto, Fuminori Teraishi, Hiroshi Tazawa, Shunsuke Kagawa, Ajay Goel, Toshiyoshi Fujiwara
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16557
[Presentation] Activation of AZIN1 RNA editing facilitates and promotes invasive potential of cancer associated fibroblasts in colorectal cancer2019
- Author(s)
  Sho Takeda, Kunitoshi Shigeyasu, Yoshinaga Okugawa, Kazuhiro Yoshida, Yoshiko Mori, Shuya Yano, Kazuhiro Noma, Yuzo Umeda, Yoshitaka Kondo, Hiroyuki Kishimoto, Fuminori Teraishi, Hiroshi Tazawa, Shunsuke Kagawa, Ajay Goel, Toshiyoshi Fujiwara.
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09217
[Presentation] Activation of AZIN1 RNA editing facilitates and promotes invasive potential of cancer associated fibroblasts in colorectal cancer2019
- Author(s)
  Takeda S, Shigeyasu K, Okugawa Y, Yoshida K, Mori Y, Yano S, Noma K, Umeda Y, Kondo Y, Kishimoto H, Teraishi F, Takeshi N, Tazawa H, Kagawa S, Ajay G, Fujiwara T
- Organizer
  AACR2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16557
[Presentation] Novel evidence for AZIN1 RNA editing-mediated oncogenic role in colorectal cancer2018
- Author(s)
  Kunitoshi Shigeyasu, Ajay Goel, Toshiyoshi Fujiwara
- Organizer
  JDDW 2018
- Data Source
  KAKENHI-PROJECT-17K16557
[Presentation] 大腸癌における AZIN1 のRNA 編集に関する新しい知見2017
- Author(s)
  重安邦俊、武田正、奥川喜永、問山裕二、永坂岳司、田澤大、香川俊輔、Ajay Goel、藤原俊義
- Organizer
  The 76th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K16557
[Presentation] Novel evidence for AZIN1 RNA editing-mediated oncogenic role in colorectal cancer2017
- Author(s)
  Kunitoshi Shigeyasu, Shusuke Toden, Yoshinaga Okugawa, Jinsei Miyoshi, Takeshi Nagasaka, Toshiyoshi Fujiwara, Leilei Chen and Ajay Goel
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16557

1. Umeda Yuzo (10573735)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. 藤原俊義 (00304303)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. 八木孝仁 (00304353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 永坂岳司 (30452569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 吉田一博 (60824761)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. 山本英喜 (10581697)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Teraishi Fuminori (40432661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yoshida Ryuichi (80534768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 道上宏之 (20572499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 香川俊輔 (00362971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 安井和也 (90991795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岸本浩行 (50613155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 平沢晃 (90296658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 冨田秀太 (10372111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 遠西大輔 (20825096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 母里淑子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shigeyasu Kunitoshi 重安 邦俊

Research Projects

Research Products

Co-Researchers

RNA編集をターゲットとしたmRNAネオアンチゲンワクチンによる膵癌免疫療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

消化器癌腹膜播種に対する磁気温熱治療を併用したネオアンチゲン癌免疫治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cancer prevention for Lynch syndrome through splicing mechanisms of RNA editing enzyme gene ADAR1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a cancer immunoregenerative therapy that blocks function-suppressive RNA editing signals from cancer cells to immune cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胆管癌のmolecular subtype分類の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an algorithm for pancreatic cancer treatment using a combined DNA and RNA biomarker panel

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring Novel Cancer Immunotherapy to Turn Cold Tumors into Hot Tumors by RNA EditingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of boron neutron capture therapy targeting gastrointestinal cancer and search for biomarkers of its efficacy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Practical classification of molecular subtype of intrahepatic cholangiocarcinoma including liquid biopsy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Activation of RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 制御性T細胞による肝内胆管癌の免疫微小環境の制御2024

Author(s)

Journal Title

Data Source

[Journal Article] Dual antiplatelet therapy inhibits neutrophil extracellular traps to reduce liver micrometastases of intrahepatic cholangiocarcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer2022

Author(s)

Shigeyasu Kunitoshi 重安邦俊

[Presentation] 大腸癌化学放射線療法で活性化される RNA 編集によるネオアンチゲンの人工的生成2020