OSAWA Mitsujiro 大澤光次郎

Researcher Number	70546770
Other IDs
Affiliation (based on the past Project Information) *help	2013 – 2015: 京都大学, iPS細胞研究所, 助教 2014: 京都大学, iPS細胞研究所, 特定助教 2012: 千葉大学, 医学(系)研究科(研究院), 講師 2010 – 2011: 千葉大学, 大学院・医学研究院, 特任講師
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Pediatrics
Keywords	Principal Investigator 造血幹細胞 / SOX17 / hESCs / 造血発生 / ヒト多能性幹細胞 / human ES / Sox17 / HoxB4 / Activin A / 一酸化窒素供与体 … More / Sox17遺伝子 / TGFβ阻害剤 / ヒトiPS細胞 / ヒトES細胞 / 再生医学 / 血液内科学 … More Except Principal Investigator ES／iPS細胞 / ニッチ / ストロマ細胞 / 細胞内代謝 / 臨床応用 / 移植・再生医療 / ES/iPS細胞 / 造血幹細胞 Less

Induction and expansion of PSC-derived HSCs by manipulating culture microenvironment
- Principal Investigator
  
  Nakahata Tatsutoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
The humatopoietic stem cell induction from human embryonic stem cellsPrincipal Investigator
- Principal Investigator
  
  OSAWA Mitsujiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
  Chiba University
Development of efficient hematopoietic stem cell differentiation method from human iPS cellPrincipal Investigator
- Principal Investigator
  
  OSAWA Mitsujiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Patent

[Book] ES/iPS細胞　実験スタンダード2014
- Author(s)
  鈴木直也、大澤光次郎
- Total Pages
  10
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24591381
[Book] 造血幹細胞と再生医療2011
- Author(s)
  大澤光次郎, 大津真, 岩間厚志
- Publisher
  実験医学増刊号
- URL
  http://www.yodosha.co.jp/jikkenigaku/book/9784758103046/
- Data Source
  KAKENHI-PROJECT-22790898
[Book] 造血幹細胞と再生医療2010
- Author(s)
  大澤光次郎
- Total Pages
  8
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22790898
[Journal Article] Sox17 as a candidate regulator of myeloid restricted differentiation potential.2014
- Author(s)
  Anani M, Nobuhisa I, Osawa M, Iwama A, Harada K, Saito K, Taga T
- Journal Title
  
  Dev. Growth Differ.
  
  Volume: 56 Issue: 6 Pages: 469-479
- DOI
  10.1111/dgd.12147
- NAID
  40020174678
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22130008, KAKENHI-PROJECT-24300119, KAKENHI-PROJECT-24591381, KAKENHI-PROJECT-26440118
[Journal Article] Manipulation of hematopoietic stem cells for regenerative medicine2014
- Author(s)
  Nakajima-Takagi Y, Osawa M, Iwama A
- Journal Title
  
  The Anatomical Record
  
  Volume: 297 Issue: 1 Pages: 111-120
- DOI
  10.1002/ar.22804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591381
[Journal Article] Sox17-ediated Maintenance of Fetal Intra-ortic Hematopoietic Cell Clusters2014
- Author(s)
  Nobuhisa. Ikuo., Ozawa. M., Uemura. M., Kishikawa. Y., Azumi. M. Harada K. Takagi M Saito. K., Kanai-Azuma M. Kanai. Y Iwama. A. Tetsuya.
- Journal Title
  
  MCB
  
  Volume: (印刷中) Issue: 11 Pages: 1976-90
- DOI
  10.1128/mcb.01485-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J07573, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130008, KAKENHI-PROJECT-24228005, KAKENHI-PROJECT-24300119, KAKENHI-PROJECT-24500485, KAKENHI-PROJECT-24591381, KAKENHI-PROJECT-26440118
[Journal Article] Role of SOX17 in hematopoietic development from human embryonic stem cells.2013
- Author(s)
  Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.
- Journal Title
  
  Blood.
  
  Volume: 121 Issue: 3 Pages: 447-58
- DOI
  10.1182/blood-2012-05-431403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24591381, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23130502, KAKENHI-PUBLICLY-24116711
[Journal Article] Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice.2013
- Author(s)
  Wang C, Nakamura S, Oshima M, Mochizuki-Kashio M, Nakajima-Takagi Y, Osawa M, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, Iwama A
- Journal Title
  
  Int J Radiat Biol
  
  Volume: 89 Issue: 2 Pages: 132-137
- DOI
  10.3109/09553002.2013.734947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591381
[Journal Article] New approaches to expand hematopoietic stem and progenitor cells2012
- Author(s)
  Nishino T, Osawa M, Iwama A
- Journal Title
  
  Expert Opinion on Biological Therapy
  
  Volume: (in press) Issue: 6 Pages: 743-756
- DOI
  10.1517/14712598.2012.681372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790898
[Journal Article] Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells2011
- Author(s)
  Oshima
- Journal Title
  
  Blood
  
  Volume: 117 Issue: 15 Pages: e142-e150
- DOI
  10.1182/blood-2010-12-323212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289, KAKENHI-PROJECT-21602006, KAKENHI-PUBLICLY-22116513, KAKENHI-PROJECT-22790898, KAKENHI-PUBLICLY-23130502
[Journal Article] リプログラミングによる多能性造血前駆細胞創出の現状と展望2011
- Author(s)
  大澤光次郎
- Journal Title
  
  血液内科
  
  Volume: 63巻 Pages: 344-347
- URL
  http://www.kahyo.com/brand/b-KS201109-633
- Data Source
  KAKENHI-PROJECT-22790898
[Journal Article] Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase2011
- Author(s)
  Nishino T, Wang C, Mochizuki-Kashio M, Osawa M, Nakauchi H, Iwama A
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 9 Pages: e24298-e24298
- DOI
  10.1371/journal.pone.0024298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249059, KAKENHI-PROJECT-21390289, KAKENHI-PROJECT-22790898, KAKENHI-PUBLICLY-23130502
[Patent] 血幹細胞の効率的な誘導および増幅方法2011
- Inventor(s)
  岩間厚志, 大澤光次郎, 大島基彦, 小沼貴晶
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Number
  2010-193828
- Filing Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-22790898
[Patent] ヒト多能性幹細胞からの造血幹細胞の効率的な誘導方法2011
- Inventor(s)
  岩間厚志, 大澤光次郎, 中島やえ子
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Number
  2010-193827
- Filing Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-22790898
[Patent] ヒト多能性幹細胞からの造血幹細胞の効率的な誘導方法2010
- Inventor(s)
  大澤光次郎
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Number
  2010-193827
- Filing Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-22790898
[Patent] 造血幹細胞の効率的な誘導および増幅方法2010
- Inventor(s)
  大澤光次郎
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Number
  2010-193828
- Filing Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-22790898
[Presentation] Exploring the pathogenesis of transient my-exploliferative disorder using iPSCs.2015
- Author(s)
  Nishinaka Yoko, Niwa Akira, Osawa Mitsujiro, Nakahata Tatsutoshi, Saito Megumu K.
- Organizer
  ISSCR 2015 Annual Meeting
- Place of Presentation
  Stockholmsmässan Exhibition and Convention Center(Sweden)
- Year and Date
  2015-06-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670498
[Presentation] Sox17 protein-mediated maintenance of cells with stem cell phenotype in the hematopoietic cell clusters in the fetal AGM region2013
- Author(s)
  1) Ikuo Nobuhisa, Mitsujiro Osawa, Mami Uemura, Yoko Kishikawa, Maha Anani, Kaho Harada, Haruna Takagi, Masami Kanai-Azuma, Yoshiakira Kanai, Atsushi Iwama, Tetsuya Taga.
- Organizer
  The 11th Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] Introduction of Sox17 in the aorta-gonad-mesonephros-derived hematopoietic cells leads to increased common myeloid progenitors in transplanted mice2013
- Author(s)
  2) Ikuo Nobuhisa, Mitsujiro Osawa, Mami Uemura, Yoko Kishikawa, Maha Anani, Kaho Harada, Haruna Takagi, Masami Kanai-Azuma, Yoshiakira Kanai, Atsushi Iwama, Tetsuya Taga
- Organizer
  The 36th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] The Critical role of SOX17 in hematopoietic development from human embryonic stem cells2013
- Author(s)
  Osawa M, Nakajima Y, Oshima M, Takagi H and Iwama A
- Organizer
  Keystone Symposium: Hematopoiesis
- Place of Presentation
  Steamboat Springs, USA
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] Analysis of recipients transplantated with the bone marrow cells of Sox17-transduced cells-transplanted mice2013
- Author(s)
  3) Ikuo Nobuhisa, Mitsujiro Osawa, Kaho Harada, Maha Anani, Kiyoka Sito Haruna Takagi, Atsushi Iwama, Tetsuya Taga
- Organizer
  Annual Meeting of the Japan Society for Immunology
- Place of Presentation
  Chiba
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] Inhibition of TGF-beta signaling in the early mesoderm stage promotes the development of hematopoietic progenitors from human embryonic stem cells2012
- Author(s)
  Osawa M, Takagi H, Nakajima Y, Endoh M, Endo A.T and Iwama A
- Organizer
  The 10th International Society of Stem Cell Research, ISSCR
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] The Critical role of SOX17 in hematopoietic development from human embryonic stem cells2012
- Author(s)
  Osawa M, Nakajima Y, Oshima M, Takagi H, Endoh M, Endo T and Iwama A
- Organizer
  The 10th Stem Cell Research Symposium
- Place of Presentation
  Awaji, Japan
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] The Critical role of SOX17 in hematopoietic development from human embryonic stem cells2012
- Author(s)
  Nakajima Y, Osawa M, Oshima M, Takagi H and Iwama A
- Organizer
  The 10th International Society of Stem Cell Research, ISSCR
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] The Critical role of SOX17 in hematopoietic development from human embryonic stem cells2012
- Author(s)
  Nakajima Y, Osawa M, Oshima M, Takagi H, Endoh M, Endo A.T, Toyoda T, Koseki H and Iwama A
- Organizer
  The 72th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] Hematopoietic differentiation of human iPS cells induced by forced expression of hematopoietic key regulators2011
- Author(s)
  Mitsujiro Osawa
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22790898
[Presentation] Hematopoietic differentiation of human induced pluripotent stem cells induced by forced expression of hematopoietic key regulators2011
- Author(s)
  Mitsujiro Osawa
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22790898
[Presentation] Challenging of hematopoietic stem cell differentiation from human induced pluripotent stem cells.2011
- Author(s)
  Mitsujiro Osawa
- Organizer
  CREST/さきがけ「iPS細胞」研究領域合同シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-01-14
- Data Source
  KAKENHI-PROJECT-22790898
[Presentation] Hematopoietic differentiation of human iPS cells induced by forced expression of hematopoietic key regulators2011
- Author(s)
  Mitsujiro Osawa
- Organizer
  The 9th Stem Cell Research Symposium
- Place of Presentation
  Tokyo (Japan)
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22790898
[Presentation] Challenging of hematopoietic stem cell differentiation from human induced pluripotent stem cells2011
- Author(s)
  Mitsujiro Osawa
- Organizer
  CREST/さきがけ「iPS細胞」研究領域合同シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-01-14
- Data Source
  KAKENHI-PROJECT-22790898
[Presentation] Molecular mechanism of HoxB4 mediated self-renewal2010
- Author(s)
  Mitsujiro Osawa
- Organizer
  The 8th Stem Cell Research Symposium
- Place of Presentation
  Awaji (Japan)
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22790898
[Presentation] Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stemand progenitor cells developing from embryonic stem cells2010
- Author(s)
  Mitsujiro Osawa
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22790898
[Presentation] Sox17-transduction imparts fetal hematopoietic cells with the myeloid-restricted differentiation potential
- Author(s)
  Maha Anani, Ikuo Nobuhisa, Mitsujiro Osawa, Atsushi Iwama, Kaho Harada, Kiyoka Saito, Tetsuya Taga
- Organizer
  幹細胞シンポジウム（第12回）
- Place of Presentation
  九州大学医学部・百年講堂（福岡）
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] ヒト胚性幹細胞からの造血発生におけるSOX17の役割
- Author(s)
  大澤光次郎
- Organizer
  東京医科歯科大学駿河台国際シンポジウム（12th Surugadai International Symposium）
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] Exploring the Pathogenesis of Down Syndrome-Related Myeloproliferative Disorders Using iPSCs.
- Author(s)
  Nishinaka Yoko, Akira Niwa, Mitsujiro Osawa,, Akira Watanabe, Tatsutoshi Nakahata,, Megumu K Saito
- Organizer
  56th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
- Place of Presentation
  Mascone Convention Center(San Francisco,USA)
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-26670498
[Presentation] Sustained expression of Sox17 in the aorta-gonad-mesonephros-derived hematopoietic cells maintain the self-renewal capacity and the hematopoietic ability to produce myeloid progenitors
- Author(s)
  Maha Anani, Ikuo Nobuhisa, Mitsujiro Osawa, Atsushi Iwama, Kaho Harada, Kiyoka Saito, Tetsuya Taga
- Organizer
  分子生物学会（第37回）
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24591381
[Presentation] Sustained expression of Sox17 in AGM-derived hematopoietic stem/progenitor cells maintain the self-renewal capacity and the hematopoietic ability to produce myeloid progenitors
- Author(s)
  Maha Anani, Ikuo Nobuhisa, Mitsujiro Osawa, Atsushi Iwama, Kaho Harada, Kiyoka Saito, Tetsuya Taga
- Organizer
  免疫学会（第43回）
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24591381

1. Nakahata Tatsutoshi (20110744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. NIWA Akira (20546999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 古関明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 信久幾夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 田賀哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 中内啓光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OSAWA Mitsujiro 大澤 光次郎

Research Projects

Research Products

Co-Researchers

Induction and expansion of PSC-derived HSCs by manipulating culture microenvironment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The humatopoietic stem cell induction from human embryonic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of efficient hematopoietic stem cell differentiation method from human iPS cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ES/iPS細胞 実験スタンダード2014

Author(s)

Total Pages

Publisher

Data Source

[Book] 造血幹細胞と再生医療2011

Author(s)

Publisher

URL

Data Source

[Book] 造血幹細胞と再生医療2010

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Sox17 as a candidate regulator of myeloid restricted differentiation potential.2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Manipulation of hematopoietic stem cells for regenerative medicine2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sox17-ediated Maintenance of Fetal Intra-ortic Hematopoietic Cell Clusters2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of SOX17 in hematopoietic development from human embryonic stem cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New approaches to expand hematopoietic stem and progenitor cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] リプログラミングによる多能性造血前駆細胞創出の現状と展望2011

Author(s)

Journal Title

URL

Data Source

[Journal Article] Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase2011

Author(s)

OSAWA Mitsujiro 大澤光次郎

[Book] ES/iPS細胞　実験スタンダード2014