Kawaguchi Daichi 川口大地

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KAWAGUCHI Daichi 川口大地

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Researcher Number	70549518
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2016 – 2021: 東京大学, 大学院薬学系研究科(薬学部), 助教 2010: The University of Tokyo, 分子細胞生物学研究所, 助教 2009: The University of Tokyo, 分子細胞生物学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Transformative Research Areas, Section (III) / Neurochemistry/Neuropharmacology / Developmental biology
Keywords	Principal Investigator 脳・神経 / 発生・分化 / 大脳 / 自閉症 / 前頭前野 / 前頭前皮質 / 大脳領野 / 大脳新皮質 / 神経幹細胞 / クロマチン … More / エピジェネティクス / 臨界期 / ストレス / 神経発達症 / Notch / 幹細胞ニッチ Less

神経発達症の病態理解に向けた前頭前野形成メカニズムの解明Principal Investigator
- Principal Investigator
  
  川口大地
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  The University of Tokyo
生後のストレス脆弱「臨界期」を担うクロマチン制御と神経回路の解明Principal Investigator
- Principal Investigator
  
  川口大地
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
発達期の局所脳形成異常に伴う社会行動の変容とその基盤となる広域脳動態の解明Principal Investigator
- Principal Investigator
  
  川口大地
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
自閉症の病態理解に向けた神経幹細胞運命制御メカニズムの解明Principal Investigator
- Principal Investigator
  
  川口大地
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  The University of Tokyo
Mechanism of region-specific neocortical malformation relevant to autism spectrum disorderPrincipal Investigator
- Principal Investigator
  
  Kawaguchi Daichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  The University of Tokyo
Molecular mechanisms of neocortical malformation relevant to autism spectrum disorderPrincipal Investigator
- Principal Investigator
  
  Kawaguchi Daichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
Regulatory mechanism of neural stem cell maintenance in the embryonic and adult brainPrincipal Investigator
- Principal Investigator
  
  KAWAGUCHI Daichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Developmental biology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2010 2009

All Journal Article Presentation

[Journal Article] 神経幹細胞の増殖・分化過程の制御異常と自閉スペクトラム症の関連2023
- Author(s)
  龍海暢輝、川口大地
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 828-831
- Data Source
  KAKENHI-PUBLICLY-23H04215
[Journal Article] 神経幹細胞の増殖・分化過程の制御異常と自閉スペクトラム症の関連2023
- Author(s)
  龍海暢輝、川口大地
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 828-831
- Data Source
  KAKENHI-PUBLICLY-23H04667
[Journal Article] TIMP3 promotes the maintenance of neural stem-progenitor cells in the mouse subventricular zone2023
- Author(s)
  Fang Lingyan、Kuniya Takaaki、Harada Yujin、Yasuda Osamu、Maeda Nobuyo、Suzuki Yutaka、Kawaguchi Daichi、Gotoh Yukiko
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 17 Pages: 1149603-1149603
- DOI
  10.3389/fnins.2023.1149603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06387, KAKENHI-PROJECT-22H00431
[Journal Article] 神経幹細胞の増殖・分化過程の制御異常と自閉スペクトラム症の関連2023
- Author(s)
  龍海暢輝、川口大地
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 828-831
- Data Source
  KAKENHI-PROJECT-21K06387
[Journal Article] Maintenance of neural stem‐progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon2021
- Author(s)
  Naoya Yuizumi、Yujin Harada、Takaaki Kuniya、Takehiko Sunabori、Masato Koike、Masaki Wakabayashi、Yasushi Ishihama、Yutaka Suzuki、Daichi Kawaguchi、Yukiko Gotoh
- Journal Title
  
  Stem Cells
  
  Volume: － Issue: 7 Pages: 929-944
- DOI
  10.1002/stem.3359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07743, KAKENHI-PROJECT-20K08485, KAKENHI-PROJECT-19J22938, KAKENHI-PROJECT-18K06477, KAKENHI-PLANNED-16H06481, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H06280
[Journal Article] Ezh1 regulates expression of <i>Cpg15/Neuritin</i> in mouse cortical neurons2021
- Author(s)
  Shun Utsunomiya#, Yusuke Kishi#, Masafumi Tsuboi, Daichii Kawaguchi, Yukiko Gotoh, Manabu Abe, Kenji Sakimura, Kazuma Maeda, and Hiroshi Takemoto (#Equal contribution)
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 15 Issue: 2 Pages: 55-65
- DOI
  10.5582/ddt.2021.01017
- NAID
  130008037031
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2021-04-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05253, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18K06477, KAKENHI-PROJECT-18K14622, KAKENHI-PROJECT-16H06279, KAKENHI-PUBLICLY-20H05383, KAKENHI-PUBLICLY-21H00242, KAKENHI-PROJECT-20H03179
[Journal Article] BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors2021
- Author(s)
  Omiya Hanae、○Yamaguchi Shima、Watanabe Tomoyuki、Kuniya Takaaki、Harada Yujin、Kawaguchi Daichi、Gotoh Yukiko
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 613-613
- DOI
  10.1038/s41598-020-79610-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J22995, KAKENHI-PROJECT-20J22817, KAKENHI-PROJECT-18K06477, KAKENHI-PROJECT-16H06279, KAKENHI-PLANNED-16H06481
[Journal Article] Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development2020
- Author(s)
  Yui Imaizumi, Shohei Furutachi, Tomoyuki Watanabe, Hiroaki Miya, Daichi Kawaguchi, Yukiko Gotoh
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1884-1884
- DOI
  10.1038/s41598-020-58629-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06477, KAKENHI-PROJECT-17J08651, KAKENHI-PROJECT-16H06279, KAKENHI-PLANNED-16H06481, KAKENHI-PROJECT-15H05773
[Journal Article] 神経系前駆細胞（放射状グリア）とアストロサイトの多様性2019
- Author(s)
  後藤昂宏，表伯俊，川口大地
- Journal Title
  
  実験医学増刊
  
  Volume: Vol.37 No.17 Pages: 2822-2827
- Data Source
  KAKENHI-PROJECT-18K06477
[Journal Article] Neurexin nanoclusters: A novel structure at presynaptic terminals2019
- Author(s)
  Daichi Kawaguchi, Yukiko Gotoh
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 218 Issue: 8 Pages: 2442-2443
- DOI
  10.1083/jcb.201907074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06477, KAKENHI-PLANNED-16H06481, KAKENHI-PROJECT-15H05773
[Journal Article] Mechanisms that regulate the number of neurons during mouse neocortical development.2010
- Author(s)
  Takaki Miyata, 川口大地, Ayano Kawaguchi, 後藤由季子
- Journal Title
  
  Current Opinion in Neurobiology 20
  
  Pages: 22-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870010
[Journal Article] Mechanisms that regulate the number of neurons during mouse neocortical development2010
- Author(s)
  宮田卓樹、川口大地、川口綾乃,後藤由季子
- Journal Title
  
  Current Opinion in Neurobiology 20
  
  Pages: 22-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870010
[Journal Article] 神経幹細胞の運命制御に関わるシグナル伝達2009
- Author(s)
  川口大地、後藤由季子
- Journal Title
  
  最新医学 64巻6月増刊号
  
  Pages: 1417-1425
- Data Source
  KAKENHI-PROJECT-21870010
[Journal Article] 神経幹細胞の運命制御に関わるシグナル伝達2009
- Author(s)
  川口大地, 後藤由季子
- Journal Title
  
  最新医学 64巻6月増刊号
  
  Pages: 1417-1425
- Data Source
  KAKENHI-PROJECT-21870010
[Presentation] 自閉スペクトラム症早期にみられる領域特異的な大脳皮質肥大化に関わる分子機構2024
- Author(s)
  川口大地
- Organizer
  生理研研究会：胎児脳発達研究会2024
- Invited
- Data Source
  KAKENHI-PROJECT-21K06387
[Presentation] A mechanism of developmental cortical overgrowth associated with autism spectrum disorder2023
- Author(s)
  Daichi Kawaguchi, Nobuto Watanabe, Kenichiro Nagahama, Takaki Watanabe, Masanobu Kano, Yukiko Gotoh
- Organizer
  The 21st Takeda Science Foundation Symposium on Biosciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06387
[Presentation] Developmental Cortical Overgrowth Associated with Autism Spectrum Disorder2022
- Author(s)
  Daichi Kawaguchi
- Organizer
  Gordon Research Conference: Molecular and Cellular Neurobiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06387
[Presentation] A mechanism of region-specific neocortical overgrowth relevant to autism spectrum disorder.2019
- Author(s)
  Daichi Kawaguchi, Nobuto Watanabe, Yukiko Goto
- Organizer
  第19回蛋白質科学学会・第71回日本細胞生物学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06477
[Presentation] Brain overgrowth and Autism2018
- Author(s)
  Daichi Kawaguchi
- Organizer
  Cutting Edge in Life Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06477
[Presentation] A mechanism of region-specific neocortical overgrowth relevant to autism spectrum disorder2018
- Author(s)
  Daichi Kawaguchi, Dennis O'Leary and Yukiko Gotoh
- Organizer
  22nd Biennial Meeting of the International Society for Developmental Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06477
[Presentation] A mechanism of region-specific neocortical overgrowth relevant to autism spectrum disorder.2017
- Author(s)
  Daichi Kawaguchi, Dennis O'Leary, Yukiko Gotoh
- Organizer
  第40回　日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06729
[Presentation] A mechanism of region-specific neocortical overgrowth relevant to autism spectrum disorder.2017
- Author(s)
  Daichi Kawaguchi, Dennis O'Leary, Yukiko Gotoh
- Organizer
  EMBO Conference, Gene regulatory mechanisms in neural fate decisions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06729
[Presentation] A mechanism of autism-related cortical overgrowth at early postnatal stages2017
- Author(s)
  Daichi Kawaguchi, Dennis O'Leary, Yukiko Gotoh
- Organizer
  The 10th Annual Meeting for Japanese Developmental Neuroscientists
- Data Source
  KAKENHI-PROJECT-16H06729
[Presentation] A mechanism of autism-related cortical overgrowth at early postnatal stages2016
- Author(s)
  Daichi Kawaguchi, Dennis O'Leary, Yukiko Gotoh
- Organizer
  第39回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16H06729
[Presentation] Notch ligand regulation of adult neural stem cells2010
- Author(s)
  川口大地、後藤由季子
- Organizer
  CDB Symposium 2010
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-21870010
[Presentation] Notch ligand regulation of adult neural stem cells2010
- Author(s)
  川口大地、後藤由季子
- Organizer
  Global COE International Symposium 2010
- Place of Presentation
  東京
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-21870010
[Presentation] Notch ligand regulation of adult neural stem cells2009
- Author(s)
  川口大地、後藤由季子
- Organizer
  Construction and Reconstruction of the Brain
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-21870010

1. GOTOH Yukiko (70252525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawaguchi Daichi 川口 大地

KAWAGUCHI Daichi 川口 大地

Research Projects

Research Products

Co-Researchers

神経発達症の病態理解に向けた前頭前野形成メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生後のストレス脆弱「臨界期」を担うクロマチン制御と神経回路の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

発達期の局所脳形成異常に伴う社会行動の変容とその基盤となる広域脳動態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自閉症の病態理解に向けた神経幹細胞運命制御メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of region-specific neocortical malformation relevant to autism spectrum disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of neocortical malformation relevant to autism spectrum disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanism of neural stem cell maintenance in the embryonic and adult brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 神経幹細胞の増殖・分化過程の制御異常と自閉スペクトラム症の関連2023

Author(s)

Journal Title

Data Source

[Journal Article] 神経幹細胞の増殖・分化過程の制御異常と自閉スペクトラム症の関連2023

Author(s)

Journal Title

Data Source

[Journal Article] TIMP3 promotes the maintenance of neural stem-progenitor cells in the mouse subventricular zone2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 神経幹細胞の増殖・分化過程の制御異常と自閉スペクトラム症の関連2023

Author(s)

Journal Title

Data Source

[Journal Article] Maintenance of neural stem‐progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ezh1 regulates expression of <i>Cpg15/Neuritin</i> in mouse cortical neurons2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors2021

Author(s)

Kawaguchi Daichi 川口大地

KAWAGUCHI Daichi 川口大地