Umeda Tomohiro 梅田知宙

… Alternative Names

梅田知宙ウメダトモヒロ

UMEDA Tomohiro 梅田知宙

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Researcher Number	70549790
Other IDs
Affiliation (Current)	2026: 大阪公立大学, 大学院医学研究科, 講師
Affiliation (based on the past Project Information) *help	2024: 大阪公立大学, 大学院医学研究科, 講師 2021: 大阪市立大学, 大学院医学研究科, 特任講師 2015 – 2020: 大阪市立大学, 大学院医学研究科, 助教 2013 – 2014: 大阪市立大学, 医学(系)研究科(研究院), 助教 2013: 大阪市立大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Pathological medical chemistry Except Principal Investigator Natural medicines / Nerve anatomy/Neuropathology / Neurology
Keywords	Principal Investigator アルツハイマー病 / 認知症 / 神経変性疾患 / リファンピシン / タウ / ドラッグリポジショニング / ミトコンドリア / トランスレーショナルリサーチ / Rifampicin / 認知症進行の抑制 … More / tauopathy / progression / propagation / tau oligomers / rifampicin / 神経病理伝播 / 予防薬・治療薬 / 老化 / 伝播 / tau / オートファジー … More Except Principal Investigator 生薬 / 生薬抽出物 / 腸内フローラ / 認知症 / Memory / Model mouse / Herb extract / Fecal transplantation / Antibiotic / Alzheimer's dsease / Dementia / Gut microbiota / オリゴマー / アミロイド / 老化 / 痴呆 / 脳神経疾患 / 病理伝播 / アミロイドβ / タウ / Aβ / トランスジェニックマウス / アルツハイマー病 / マイクロダイアリシス Less

C9orf72関連ALS/FTDにおける異常RNA転写・異常翻訳を引き起こすミトコンドリアの役割Principal Investigator
- Principal Investigator
  
  梅田知宙
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka Metropolitan University
Prevention of progressive dementia by drug-repositioning of rifampicinPrincipal Investigator
- Principal Investigator
  
  Umeda Tomohiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka City University
Autophagy-mediated tau pathology formation and propagationPrincipal Investigator
- Principal Investigator
  
  Umeda Tomohiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka City University
Dementia and gut microbiota
- Principal Investigator
  
  TOMIYAMA Takami
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  Osaka City University
The molecular action of Abeta oligomer on Alzheimer's disease.
- Principal Investigator
  
  MORI HIROSHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Osaka City University
Transmission study of Alzheimer pathology using brain microdialysis
- Principal Investigator
  
  TOMIYAMA Takami
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Osaka City University

All 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation Patent

[Journal Article] Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice2022
- Author(s)
  Umeda Tomohiro、Uekado Rumi、Shigemori Keiko、Eguchi Hiroshi、Tomiyama Takami
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 2 Pages: 297-297
- DOI
  10.3390/biomedicines10020297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07847
[Journal Article] Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination : A Preclinical Study in Model Mice2021
- Author(s)
  Umeda Tomohiro、Sakai Ayumi、Shigemori Keiko、Yokota Ayumi、Kumagai Toru、Tomiyama Takami
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 15 Pages: 763476
- DOI
  10.3389/fnins.2021.763476
- NAID
  120007181786
- URL
  https://ocu-omu.repo.nii.ac.jp/records/2019854
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07847
[Journal Article] Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers2021
- Author(s)
  Umeda Tomohiro、Hatanaka Yukari、Sakai Ayumi、Tomiyama Takami
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8453-8453
- DOI
  10.3390/ijms22168453
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07847
[Journal Article] Intranasal rifampicin for Alzheimer's disease prevention2018
- Author(s)
  Tomohiro Umeda, Akiko Tanaka, Ayumi Sakai, Akira Yamamoto, Toshiyasu Sakane, Takami Tomiyama
- Journal Title
  
  Alzheimer's & Dementia: Translational Research & Clinical Interventions
  
  Volume: 4 Issue: 1 Pages: 304-313
- DOI
  10.1016/j.trci.2018.06.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19057
[Journal Article] Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease : analysis of Osaka mutation-knockin mice2017
- Author(s)
  Umeda Tomohiro、Kimura Tetsuya、Yoshida Kayo、Takao Keizo、Fujita Yuki、Matsuyama Shogo、Sakai Ayumi、Yamashita Minato、Yamashita Yuki、Ohnishi Kiyouhisa、Suzuki Mamiko、Takuma Hiroshi、Miyakawa Tsuyoshi、Takashima Akihiko、Morita Takashi、Mori Hiroshi、Tomiyama Takami
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 5 Issue: 1 Pages: 59
- DOI
  10.1186/s40478-017-0461-5
- NAID
  120006371271
- URL
  https://ocu-omu.repo.nii.ac.jp/records/2019593
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01946, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-16K19057, KAKENHI-PUBLICLY-16H01270, KAKENHI-PUBLICLY-17H06051, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16H06276
[Journal Article] Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers2016
- Author(s)
  Umeda T., Ono K., Sakai A., Yamashita M., Mizuguchi M, Klein W.L., Yamada M., Mori H., Tomiyama T
- Journal Title
  
  Brain
  
  Volume: 139 Issue: 5 Pages: 1568-1586
- DOI
  10.1093/brain/aww042
- NAID
  120006371274
- URL
  https://ocu-omu.repo.nii.ac.jp/records/2019690
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-26461266, KAKENHI-PROJECT-16K19057
[Journal Article] Passive immunotherapy of tauopathy targeting pSer413-tau : a pilot study in mice2015
- Author(s)
  Umeda T, Eguchi H, Kunori Y, Matsumoto Y, Taniguchi T, Mori H, Tomiyama T
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 2 Issue: 3 Pages: 241-255
- DOI
  10.1002/acn3.171
- NAID
  120006371273
- URL
  https://ocu-omu.repo.nii.ac.jp/records/2019613
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25290018
[Journal Article] Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.2015
- Author(s)
  Umeda T., Ramser E.M., Yamashita M., Nakajima K., Mori H., Silverman M.A., Tomiyama T
- Journal Title
  
  Acta Neuropathol. Commun
  
  Volume: 3 Issue: 1 Pages: 51-51
- DOI
  10.1186/s40478-016-0273-z
- NAID
  120006371272
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290018
[Journal Article] Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice2014
- Author(s)
  Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Acta Neuropathol
  
  Volume: 127 Pages: 684-698
- Data Source
  KAKENHI-PROJECT-24659434
[Journal Article] Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.2014
- Author(s)
  Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 127(5) Issue: 5 Pages: 685-98
- DOI
  10.1007/s00401-014-1259-1
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-24659434, KAKENHI-PROJECT-25290018, KAKENHI-PLANNED-26117004
[Journal Article] Neurodegenerative disorder FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Am J Pathol
  
  Volume: 183 Pages: 211-225
- Data Source
  KAKENHI-PROJECT-24659434
[Journal Article] Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.2013
- Author(s)
  Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Am J Pathol.
  
  Volume: 183(1) Issue: 1 Pages: 211-25
- DOI
  10.1016/j.ajpath.2013.03.015
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-24659434, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25461266
[Journal Article] Neurodegenerative disorder FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H
- Journal Title
  
  Am J Pathol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659434
[Journal Article] The E693D (Osaka) Mutation in Amyloid Precursor Protein Potentiates Cholesterol-Mediated Intracellular Amyloid b Toxicity Via Its Impaired Cholesterol Efflux2013
- Author(s)
  Nomura S , Umeda T, Tomiyama T, Mori H.
- Journal Title
  
  J Neurosci Res
  
  Volume: 91 Issue: 12 Pages: 1541-1550
- DOI
  10.1002/jnr.23278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290018
[Patent] ノックインマウス2014
- Inventor(s)
  森啓、富山貴美、梅田知宙、森田隆、吉田佳世
- Industrial Property Rights Holder
  公立大学法人大阪市立大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-14
- Overseas
- Data Source
  KAKENHI-PROJECT-25290018
[Presentation] 認知症モデルマウスの作製と抗認知症薬の開発2019
- Author(s)
  梅田知宙
- Organizer
  第38回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07847
[Presentation] 末梢におけるAβの産生と生理作用2019
- Author(s)
  重森慶子，梅田知宙，野村幸子，富山貴美
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07847
[Presentation] 経鼻リファンピシン-リファンピシンの新しい投与経路による認知症予防2018
- Author(s)
  梅田知宙、田中晶子、酒井亜由美、山本昌、坂根稔康、富山貴美
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19057
[Presentation] 既存医薬品リファンピシンはオリゴマーを標的とする認知症予防薬の有望な候補である2016
- Author(s)
  梅田知宙, 小野賢二郎, 酒井亜由美, 山下港, 水口峰之, 山田正仁, 森啓, 富山貴美
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K19057
[Presentation] Ser413リン酸化タウを標的としたタウオパチーの受動免疫療法の開発2015
- Author(s)
  梅田　知宙
- Organizer
  第88回生化学会大会
- Place of Presentation
  神戸ポートピアホテル（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-25290018
[Presentation] Intracellular Aβ Oligomers Cause Tau-Independent Spine Alteration and Defect of2015
- Author(s)
  梅田　知宙
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-25290018
[Presentation] Osaka mutation　の発見とAβオリゴマーの毒性2015
- Author(s)
  梅田　知宙
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-04
- Data Source
  KAKENHI-PROJECT-25290018
[Presentation] INTRANEURONAL AMYLOID BETA OLIGOMERS CAUSE ABERRANT SPINE MORPHOLOGY AND DISRUPT AXONAL AND DENDRITIC TRAFFICKING INDEPENDENTLY OF TAU2015
- Author(s)
  Tomohiro Umeda
- Organizer
  The 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders
- Place of Presentation
  Nice（France）
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PROJECT-25290018
[Presentation] FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Tomiyama T, Umeda T, Yamashita T, Ohnishi K, Takuma H, Mori H.
- Organizer
  International Conference on Alzheimer's & Parkinson's Diseases (AD/PD2013)
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-24659434
[Presentation] FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Tomiyama T, Umeda T, Yamashita T, Ohnishi K, Takuma H, Mori H
- Organizer
  The 11th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD2013)
- Place of Presentation
  Firenze Fiera, Florence, Italy
- Data Source
  KAKENHI-PROJECT-24659434
[Presentation] Intron変異を有する新規FTDP-17モデルマウスの作製と解析2012
- Author(s)
  梅田知宙、山下雄也、富山貴美、詫間浩、大西紀陽久、森啓
- Organizer
  第31回日本認知症学会学
- Place of Presentation
  つくば国際会議場、茨城県つくば市
- Data Source
  KAKENHI-PROJECT-24659434

1. TOMIYAMA Takami (10305633)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. MORI HIROSHI (10159189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 高島明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Umeda Tomohiro 梅田 知宙

梅田 知宙 ウメダ トモヒロ

UMEDA Tomohiro 梅田 知宙

Research Projects

Research Products

Co-Researchers

C9orf72関連ALS/FTDにおける異常RNA転写・異常翻訳を引き起こすミトコンドリアの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prevention of progressive dementia by drug-repositioning of rifampicinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Autophagy-mediated tau pathology formation and propagationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dementia and gut microbiota

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular action of Abeta oligomer on Alzheimer's disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transmission study of Alzheimer pathology using brain microdialysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination : A Preclinical Study in Model Mice2021

Author(s)

Journal Title

DOI

NAID

URL

Language

Data Source

[Journal Article] Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intranasal rifampicin for Alzheimer's disease prevention2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease : analysis of Osaka mutation-knockin mice2017

Author(s)

Journal Title

DOI

NAID

URL

Language

Data Source

[Journal Article] Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers2016

Author(s)

Journal Title

DOI

NAID

URL

Language

Umeda Tomohiro 梅田知宙

梅田知宙ウメダトモヒロ

UMEDA Tomohiro 梅田知宙