Nishina Soji 仁科惣治

… Alternative Names

NISHINA Sohji 仁科惣治

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Researcher Number	70550961
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 川崎医科大学, 医学部, 教授 2022 – 2023: 川崎医科大学, 医学部, 教授 2020 – 2021: 川崎医科大学, 医学部, 准教授 2013 – 2019: 川崎医科大学, 医学部, 講師 2011 – 2012: 川崎医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝細胞癌 / 腫瘍免疫 / PLGA / 解糖系阻害剤 / ナノ粒子 / 解糖系 / がん / DPP4 / Ferroptosis / 近赤外線 … More / ナノDDS / グルコース誘導体 / 血管内皮細胞 / 2DG / drug delivery system / 2-Deoxy-D-Glucose / ２DG / 抗腫瘍免疫 / 2DG-PLGA-NP / 2-Deoxy-D-Glucose（2DG） / ドラッグデリバリー / 走化性 / NK細胞 / CXCL10 / DPP4阻害剤 / CD26 / CD26/DPP4 … More Except Principal Investigator ミトコンドリア / マイトファジー / C型肝炎ウイルス / 酸化ストレス / 鉄 / 活性酸素種 / Parkin / mitophagy / オートファジー / autophagy / 肝細胞癌 / Ｃ型肝炎ウイルス / 免疫チェックポイント阻害剤 / 解糖系抑制 / 脂肪酸合成 / メタボローム解析 / 免疫担当細胞 / Warburug効果 / 糖代謝 / 2DG-PLGA / 2-depxy-D-glucose / ナノ粒子 / Warburg効果 / がん微小環境 / 腫瘍免疫 / 鉄キレート / NASH / Mitophagy / リン酸化シグナル / リン酸化 / 肝癌 / ミトコンドリアフェリチン / 細胞内シグナル / 肝発癌 / HCV / エストロゲン / 性差 / 肝発がん Less

Development of a novel cancer treatment using a near-infrared responsive drug delivery system aimed at enhancing antitumor immunityPrincipal Investigator
- Principal Investigator
  
  仁科惣治
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kawasaki Medical School
The study for liver cancer specific glycolysis inhibition and efficiency of cancer immunity using novel drug delivery systemPrincipal Investigator
- Principal Investigator
  
  Sohji Nishina
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kawasaki Medical School
Activation of tumor immunity by metabolic reprogramming in liver cancer microenvironment
- Principal Investigator
  
  Hino Keisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kawasaki Medical School
Development of an anticancer therapy against liver cancer using 2-deoxy-D-glucose encapsulated in polymer poly (lactic-co-glycolic acid) nanoparticlesPrincipal Investigator
- Principal Investigator
  
  Nishina Sohji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kawasaki Medical School
Iron loss-induced mitophagy via mitochondria ferritin suppresses NASH-related hepatocellular carcinoma
- Principal Investigator
  
  HARA YUICHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
The therapeutic role of DPP-4 inhibitor for the progression of Hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Nishina Sohji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Investigation of hepatocarcinogenic mechanisms by comprehensive ahalysis of cellular signaling responding to oxidative stress
- Principal Investigator
  
  Hino Keisuke
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
The crosstalk between Liver fibrosis and Hepatocellular carcinoma in the point of FAP and DPP4Principal Investigator
- Principal Investigator
  
  Nishina Sohji
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Restoration of mitophagy as a strategy for inhibiting hepatocarcinogenesis
- Principal Investigator
  
  HINO Keisuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.
- Principal Investigator
  
  HARA Yuichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Analysis of hepatocarcinogenesis based on gender and mitochondrial biogenesis
- Principal Investigator
  
  HINO Keisuke
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2011 Other

All Journal Article Presentation Book Patent

[Book] HEPATOLOGY PRACTICE（第４巻）2014
- Author(s)
  仁科惣治, 日野啓輔
- Total Pages
  340
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-26293179
[Journal Article] CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma2022
- Author(s)
  Nishina S, Hino K.
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 2 Pages: 454-454
- DOI
  10.3390/cancers14020454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03644
[Journal Article] Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: A case report.2021
- Author(s)
  Nishina S, Tomiyama Y, Ikuta K, Tatsumi Y, Toki Y, Kato A, Kato K, Yoshioka N, Sasaki K, Hara Y, Hino K.
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21(1) Issue: 1 Pages: 111-111
- DOI
  10.1186/s12876-021-01674-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08347, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07995
[Journal Article] Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines2021
- Author(s)
  Nao Nishida, Masaya Sugiyama, Aiko Sakai, Katsushi Tokunaga, Masashi Mizokami et al.
- Journal Title
  
  Sci Rep
  
  Volume: 11(1) Issue: 1 Pages: 3703-3703
- DOI
  10.1038/s41598-021-82986-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16874, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07997
[Journal Article] Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice2021
- Author(s)
  Sasaki Kyo、Nishina Sohji、Yamauchi Akira、Fukuda Kotaro、Hara Yuichi、Yamamura Masahiro、Egashira Kensuke、Hino Keisuke
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 11 Issue: 3 Pages: 739-762
- DOI
  10.1016/j.jcmgh.2020.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07676, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-18K07923, KAKENHI-PROJECT-21K07995
[Journal Article] Iron and liver cancer: an inseparable connection2021
- Author(s)
  Hino Keisuke、Yanatori Izumi、Hara Yuichi、Nishina Sohji
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 24 Pages: 7810-7829
- DOI
  10.1111/febs.16208
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07309, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07995
[Journal Article] Mitochondrial damage and iron metabolic dysregulation in hepatitis C virus infection2019
- Author(s)
  Hino K, Nishina S, Sasaki K, Hara Y
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 133 Pages: 193-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice2019
- Author(s)
  Nishina S, Yamauchi A, Kawaguchi T, Kaku K, Goto M, Sasaki K, Hara Y, Tomiyama Y, Kuribayashi F, Torimura T, Hino K.
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 5 Pages: 115-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice2019
- Author(s)
  Nishina, S. Yamauchi, A. Kawaguchi, T. Kaku, K. Goto, M. Sasaki, K. Hara, Y. Tomiyama, Y. Kuribayashi, F. Torimura, T. Hino, K.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol
  
  Volume: 7 Issue: 1 Pages: 115-134
- DOI
  10.1016/j.jcmgh.2018.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03644
[Journal Article] Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine.2018
- Author(s)
  Nishida N, Sugiyama M, Sawai H, Nishina S, Sakai A, Ohashi J, Khor SS, Kakisaka K, Tsuchiura T, Hino K, Sumazaki R, Takikawa Y, Murata K, Kanda T, Yokosuka O, Tokunaga K, Mizokami M
- Journal Title
  
  Hepatology
  
  Volume: 印刷中 Issue: 3 Pages: 848-858
- DOI
  10.1002/hep.29876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09387, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-17H04168, KAKENHI-PROJECT-17K09448, KAKENHI-PROJECT-15K08986, KAKENHI-PROJECT-16K19629
[Journal Article] Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease.2018
- Author(s)
  Miwa Kawanaka, Yasuyuki Tomiyama, Hideyuki Hyogo, Masahiko Koda, Toshihide Shima, Hiroshi Tobita, Akira Hiramatsu, Ken Nishino, Toshiaki Okamoto, Shuichi Sato, Yuichi Hara, Sohji Nishina, Hirofumi Kawamoto, Kazuaki Chayama, Takeshi Okanoue, Keisuke Hino
- Journal Title
  
  Hepatology Research
  
  Volume: 48 Pages: 521-528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] 1.Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.2018
- Author(s)
  Miwa Kawanaka, Yasuyuki Tomiyama, Hideyuki Hyogo, Masahiko Koda, Toshihide Shima, Hiroshi Tobita, Akira Hiramatsu, Ken Nishino, Toshiaki Okamoto, Shuichi Sato, Yuichi Hara, Sohji Nishina, Hirofumi Kawamoto, Kazuaki Chayama, Takeshi Okanoue, Keisuke Hino.
- Journal Title
  
  Hepatol Res.
  
  Volume: 1 Issue: 7 Pages: 13054-13054
- DOI
  10.1111/hepr.13054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384, KAKENHI-PROJECT-26293179
[Journal Article] Assessment of clinical and MRI features of de novo hypervascular HCC using gadoxetic acid-enhanced MRI2017
- Author(s)
  Tamada, T. Korenaga, M. Yamamoto, A. Higaki, A. Kanki, A. Nishina, S. Hino, K. Ito, K
- Journal Title
  
  Hepatol Res
  
  Volume: 47 Issue: 3 Pages: 152-160
- DOI
  10.1111/hepr.12742
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-16K09384
[Journal Article] Branched-chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein-expressing mice.2015
- Author(s)
  Korenaga M, Nishina S, Korenaga K, Tomiyama Y, Yoshioka N, Hara Y, Sasaki Y, Shimonaka Y, Hino K.
- Journal Title
  
  Liver Int.
  
  Volume: 35 Issue: 4 Pages: 1303-14
- DOI
  10.1111/liv.12675
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-25461019, KAKENHI-PROJECT-26293179
[Journal Article] Fibroblast activation protein-alpha-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma2015
- Author(s)
  Kawase T, Yasui Y, Nishina S, Hara Y, Yanatori I, Tomiyama Y, Nakashima Y, Yoshida K, Kishi F, Nakamura M, Hino K
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 15 Issue: 1 Pages: 109-109
- DOI
  10.1186/s12876-015-0340-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Journal Article] Mitochondrial reactive oxygen species as a mystery voice in hepatitis C2014
- Author(s)
  Hino K, Hara Y, Nishina S
- Journal Title
  
  Hepatol Res
  
  Volume: 44 Issue: 2 Pages: 123-32
- DOI
  10.1111/hepr.12247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-26293179
[Journal Article] Hepatic oxidative stress in ovariectomized transgenic mice expressing the hepatitis C virus polyprotein is augmented through suppression of AMPK/PGC-1alpha signaling2014
- Author(s)
  Tomiyama Y, Nishina S, Hara Y, Kawase T, Hino K
- Journal Title
  
  Hepatol Res
  
  Volume: (in press) Issue: 10 Pages: 229-39
- DOI
  10.1111/hepr.12254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-26293179
[Journal Article] Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.2014
- Author(s)
  Hara Y, Yanatori I, Ikeda M, Kiyokage E, Nishina S, Tomiyama Y, Toida K, Kishi F, Kato N, Imamura M, Chayama K, Hino K.
- Journal Title
  
  Am J Pathol. 2014
  
  Volume: 184 Issue: 11 Pages: 3026-39
- DOI
  10.1016/j.ajpath.2014.07.024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-25293110
[Journal Article] Mitochondrial reactive oxygen species as a mystery voice in hepatits C2014
- Author(s)
  Hino K, Hara Y, Nishina S
- Journal Title
  
  Heparol Res
  
  Volume: 44 Pages: 123-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease.2013
- Author(s)
  Keiko Korenaga , Masaaki Korenaga, Fusako Teramoto, Toshiko Suzuki,Sohoji Nishina, Kyo Sasaki, Yoshihiro Nakashima,Yasuyuki Tomiyama, Naoko Yoshioka, Yuichi Hara, Takuya Moriya, Keisuke Hino
- Journal Title
  
  Hepatol Res
  
  Volume: 43 Pages: 1284-1294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Hepatic oxidative stress in ovariectomized transgenic mice expression the hepatitis C virus polyprotein is augmented through suppression of adenosine monophosphate-activated protein kinase/proliferator-activated receptor gamma co-activator 1 alpha signaling.2013
- Author(s)
  Yasuyuki Tomiyama Sohoji Nishina Yuichi hara Keisuke Hino
- Journal Title
  
  Hepatol Res
  
  Volume: １４ Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease2013
- Author(s)
  Korenaga K1, Korenaga M, Teramoto F, Suzuki T, Nishina S, Sasaki K, Nakashima Y, Tomiyama Y, Yoshioka N, Hara Y, Moriya T, Hino K.
- Journal Title
  
  Hepatol Res.
  
  Volume: 43 Issue: 12 Pages: 1284-1294
- DOI
  10.1111/hepr.12095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461019, KAKENHI-PROJECT-25670374
[Journal Article] Iron metabolic disorder in chronic hepatitis C: Mechanisms and relevance to hepatocarcinogenesis2013
- Author(s)
  Hino K, Nishina S, Hara Y
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 28 Suppl 4 Issue: S4 Pages: 93-8
- DOI
  10.1111/jgh.12243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374
[Journal Article] Iron metabolic disorder in chronic hepatitis C:Mechanisms and relevance to hepatocarcinogenesis.2013
- Author(s)
  Keisuke Hino, Sohoji Nishina, Yuichi hara
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 28 Pages: 93-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Iron metabolic disorder in chronic hepatitis C. Mechanisms and relevance to hepatocarcinogenesis2013
- Author(s)
  Hino K, Nishina S, Hara Y
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 28 Suppl 4 Pages: 93-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis.2013
- Author(s)
  Tomiyama Yasuyuki,Kazuyuki Takenaka ,Takahiro Kodama,Miwa Kawanaka , Kyo Sasaki,Sohoji Nishina , Naoko Yoshioka, Yuichi Hara Y, Keisuke Hino
- Journal Title
  
  Hepatol Res
  
  Volume: 52 Pages: 1553-1559
- NAID
  130003365701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis2013
- Author(s)
  Tomiyama Y, Takenaka K, Kodama T, Kawanaka M, sasaki K, Nishina S, Yoshioka N, Hara Y, Hino K
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 1553-9
- NAID
  130003365701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis2013
- Author(s)
  Tomiyama Y, Takenaka K, Kodama T, Kawanaka M, sasaki K, Nishina S, Yoshioka N, Hara Y, Hino K
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 1553-9
- NAID
  130003365701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670374
[Journal Article] A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice2011
- Author(s)
  Korenaga M, Hidaka I, Nishina S, Sakai A, Shinozaki A, Gondo T, Furutani T, Kawano H< sakaida I, Hino K
- Journal Title
  
  Liver Int
  
  Volume: 31 Pages: 552-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Patent] ケモカイン産生促進剤、免疫チェックポイント阻害剤抵抗性癌治療薬及び抗腫瘍免疫賦活剤2020
- Inventor(s)
  日野啓輔、仁科惣治、佐々木　恭、福田宏太郞
- Industrial Property Rights Holder
  日野啓輔、仁科惣治、佐々木　恭、福田宏太郞
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H03644
[Patent] 医薬組成物及び腫瘍免疫促進剤2020
- Inventor(s)
  日野啓輔、仁科惣治、佐々木　恭、福田宏太郞
- Industrial Property Rights Holder
  日野啓輔、仁科惣治、佐々木　恭、福田宏太郞
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03644
[Patent] ケモカイン産生促進剤、免疫チェックポイント阻害剤抵抗性癌治療薬及び抗腫瘍免疫賦活剤2019
- Inventor(s)
  佐々木　恭、仁科惣治、日野啓輔
- Industrial Property Rights Holder
  佐々木　恭、仁科惣治、日野啓輔
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-048743
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03644
[Patent] ケモカイン産生促進剤、免疫チェックポイント阻害剤抵抗性癌治療薬及び抗腫瘍免疫賦活剤」2019
- Inventor(s)
  日野啓輔、仁科惣治、佐々木恭、山内明
- Industrial Property Rights Holder
  日野啓輔、仁科惣治、佐々木恭、山内明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-048743
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K07923
[Patent] 医薬組成物及び腫瘍免疫活性促進剤2019
- Inventor(s)
  仁科　惣治日野　啓輔佐々木　恭福田　宏太郎
- Industrial Property Rights Holder
  仁科　惣治日野　啓輔佐々木　恭福田　宏太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19H03644
[Patent] 肝細胞癌の予防又は治療のための医薬2015
- Inventor(s)
  仁科惣治、日野啓輔、後藤守兄、秦　克美
- Industrial Property Rights Holder
  仁科惣治、日野啓輔、後藤守兄、秦　克美
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-27
- Data Source
  KAKENHI-PROJECT-26293179
[Patent] 肝細胞癌の予防又は治療のための医薬2015
- Inventor(s)
  仁科惣治、日野啓輔、後藤守兄
- Industrial Property Rights Holder
  仁科惣治、日野啓輔、後藤守兄
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-009736
- Filing Date
  2015-04-27
- Data Source
  KAKENHI-PROJECT-26860535
[Presentation] 高齢者に対する低侵襲的肝細胞癌薬物療法としての近赤外線応答型薬物送達システム開発2023
- Author(s)
  佐々木恭、仁科惣治、日野啓輔
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 肝がん局所環境に高効率で薬剤放出を可能とする近赤外線応答型薬物送達システム開発2023
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] A near-infrared-modulated system enabling efficient delivery of glucose derivative as a new therapeutic strategy for liver cancer2023
- Author(s)
  佐々木恭、新井敏、仁科惣治、日野啓輔
- Organizer
  AASLD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 抗腫瘍免疫活性化作用を有するがん選択的解糖系謝阻害剤による肝がん治療開発2022
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] HEPATIC MITOPHAGY RESTORES MITOCHONDRIAL FUNCTION IN SKELETAL MUSCLE VIA REDUCTION OF SELENOPROTEIN P SECRETION IN NASH-RELATED HEPATOCARCINOGENIC MICE2022
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  American Association for the Study of Liver Diseases(AASLD) Annual Meeting（国際学会）
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 解糖系を標的とした肝がん特異的薬剤送達システムの開発2022
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  JDDW 2022（第30回日本消化器関連学会週間）
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] がん特異的解糖系阻害剤による腫瘍免疫活性化を標的とした肝がん治療戦2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  JDDW 2021（第29回日本消化器関連学会週間）
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] Study of antitumor immunity activation based on cancer cell-specific glycolytic inhibition2021
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  American Association for the Study of Liver Diseases(AASLD) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] がん特異的解糖系阻害剤による肝細胞癌治療応用と免疫賦活化機構の解明2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] 肝細胞癌に対するナノ粒子を用いたがん細胞特異的解糖系阻害剤と腫瘍免疫応答効率化に関する検討2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第44回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] 新規抗腫瘍免疫活性化作用を標的としたがん特異的解糖系阻害剤による肝がん治療応用2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] 肝細胞癌に対するナノ粒子を用いたがん細胞特異的解糖系阻害と腫瘍免疫応答効率化に関する検討2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第44回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 新規抗腫瘍免疫活性化作用を標的としたがん特異的解糖系阻害剤による肝がん治療応用2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 肝細胞癌の糖代謝抑制による腫瘍免疫賦活化と治療展開2020
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] 2-deoxy-D-glucose encapsulated PLGA nanoparticles suppress hepatocellular carcinoma through cytotoxic effect and activation of antitumor immunity2020
- Author(s)
  Sohji Nishina, Kyo Sasaki, Akira Yamauchi, Kotaro Fukuda, Keisuke Hino
- Organizer
  American Association for the Study of Liver Diseases (AASLD)-The Liver Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] がん特異的解糖系阻害剤による肝細胞癌治療応用と免疫賦活化機構の解明2020
- Author(s)
  仁科惣治、佐々木　恭、日野啓輔
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] がん特異的解糖系阻害剤による肝細胞癌治療応用と腫瘍免疫活性化機構の解明2020
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] 肝癌細胞の糖代謝抑制によるがん微小環境での腫瘍免疫賦活作用とその臨床応用2019
- Author(s)
  佐々木恭、仁科惣治、日野啓輔
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] Specific inhibition of cancer cell glycolysis enhances antitumor immunity in hepatocellular carcinoma2019
- Author(s)
  佐々木恭、仁科惣治、山内明、原裕一、福田宏太郎、日野啓輔
- Organizer
  APASL Single Topic Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] NAFLD進展・発癌抑制のためのミトコンドリア品質管理とその分子機構2019
- Author(s)
  原裕一, 田中敦, 佐々木恭, 仁科惣治, 日野啓輔
- Organizer
  第15回酸化ストレスと肝研究会
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Immuno oncologyからみた肝細胞癌に対する2-deoxyD-glucose封入PLGAナノ粒子の抗腫傷効果2019
- Author(s)
  佐々木恭、仁科惣治、日野啓輔
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] Anti tumor effects of 20deoxy-D-glucose encapsulated PLGA nanoparticles against hepatocellular carcinoma in term of tumor immunity2019
- Author(s)
  Sasaki K, Nishina S, Yamauchi A, Hara Y, Fukuda K, Hino K
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] Treatment of hepatocellular carcinoma using 2-Antitumor effects of 2-deoxy-D-glucose encapsulated PLGA nanoparticles against hepatocellular carcinoma in terms of tumor immunity2019
- Author(s)
  佐々木恭、仁科惣治、山内明、原裕一、福田宏太郎、日野啓輔
- Organizer
  American Association for the Study of Liver Diseases(AASLD) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] Mitophagy誘導機構の解明2018
- Author(s)
  原裕一, 佐々木恭, 仁科惣治, 日野啓輔
- Organizer
  第14回酸化ストレスと肝研究会
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 肝糖代謝阻害薬2-deoxy-D-glucose封入PLGAナノ粒子を用いた肝細胞癌治療開発2018
- Author(s)
  佐々木恭、仁科惣治、日野啓輔ら
- Organizer
  Japan Digestive Disease Week 2018 (JDDW 2018)
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] Treatment of hepatocellular carcinoma using 2-deoxy-D-glucose encapsulated in PLGA nanoparticles in mice2018
- Author(s)
  佐々木恭、仁科惣治、日野啓輔ら
- Organizer
  American Association for the Study of Liver Diseases(AASLD) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] NAFLD 進展・発癌抑制のためのミトコンドリア品質管理とその分子機構2018
- Author(s)
  原裕一, 田中敦, 佐々木恭,仁科惣治, 日野啓輔
- Organizer
  肝類同壁細胞研究会構
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 細胞内鉄欠乏によるミトコンドリア選択的オートファジーの分子機構2018
- Author(s)
  原裕一, 佐々木恭, 仁科惣治, 日野啓輔
- Organizer
  第42回日本鉄バイオサイエンス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 肝発癌抑制機構としてのmitophagy誘導2018
- Author(s)
  原　裕一、仁科惣治、日野啓輔
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Treatment of hepatocellular carcinoma using 2-deoxy-D-glucose encapsulated in PLGA nanoparticles in mice2018
- Author(s)
  佐々木恭、仁科惣治、日野啓輔ら
- Organizer
  APASL Single Topic Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] ミトコンドリア内鉄欠乏によるmitophagy 誘導機構2018
- Author(s)
  原　裕一, 仁科惣治, 日野啓輔
- Organizer
  第42回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] ミトコンドリア内鉄欠乏によるmitophagy誘導機構2017
- Author(s)
  原裕一, 佐々木恭, 仁科惣治, 日野啓輔a, Keisuke Hino
- Organizer
  AASLD2015(American Association for the Study of Liver Diseases2015)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] DPP-4 inhibitor suppresses the progression of hepatocellular carcinoma through activation of chemotaxis of NK cells in mice2017
- Author(s)
  Sohji Nishina, Akira Yamauchi, Kyo Sasaki, Yasuyuki Tomiyamai, Yuichi Hara, Keisuke Hino
- Organizer
  The Asian Pacific Association for Study of the Liver (APASL) Single Topic Conference 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19374
[Presentation] 肝細胞癌に対する DPP4 阻害剤の抗腫瘍効果についての基礎的検討2017
- Author(s)
  仁科惣治、佐々木恭、富山恭行、吉岡奈穂子、原裕一、日野啓輔
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K19374
[Presentation] DPP4阻害剤のNK細胞走化性促進作用を介した肝細胞癌進展抑制効果の基礎的検討2017
- Author(s)
  仁科惣治、佐々木恭、富山恭行、吉岡奈穂子、原裕一、日野啓輔
- Organizer
  第21回日本肝臓学会大会(JDDW 2017)
- Data Source
  KAKENHI-PROJECT-16K19374
[Presentation] ミトコンドリア内鉄欠乏によるmitophagy誘導機構2017
- Author(s)
  原　裕一、仁科惣治、日野啓輔
- Organizer
  第42回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Dipeptidyl peptidase 4 inhibitors reduce hepatocellular carcinoma by activating natural killer cell chemotaxis in mice2017
- Author(s)
  Sohji Nishina, Akira Yamauchi, Kyo Sasaki, Yasuyuki Tomiyamai, Yuichi Hara, Keisuke Hino
- Organizer
  AASLD The Liver Meeting 201７
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19374
[Presentation] Loss of iron triggers mitophagy by inducing mitochondrial ferritin2017
- Author(s)
  Yuichi Hara, Kyo Sasaki, Soji Nishina, Keisuke Hino
- Organizer
  AASLD2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] NASH肝発癌抑制機構としてのmitophagy誘導2017
- Author(s)
  原裕一,仁科惣治, 日野啓輔
- Organizer
  第53回日本肝臓学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] LOSS OF IRON UPREGULATES MITOCHONDRIA FERRITIN AND TRIGGERS MITOPHAGY THROUGH THE BINDING OF MITOCHONDRIA FERRITIN TO NUCLEAR RECEPTOR COACTIVATOR 42017
- Author(s)
  Yuichi Hara, Izumi Yanatori, Kyo Sasaki, Sohji Nishina, Fumio Kishi, Keisuke Hino
- Organizer
  Seventh Congress of the International BioIron Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Los of iron up regulates mitochondria ferritin and triggers mitophagy2017
- Author(s)
  Hara Y, Sasaki K, Nishina S, Hino K
- Organizer
  The Annual Meeting of American Association for the Study of Liver Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] NASH肝発癌抑制機構としてのmitophagy誘導2017
- Author(s)
  原　裕一、仁科惣治、日野啓輔
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 糖尿病合併高齢肝細胞癌に対する抗腫瘍治療選択としての DPP4阻害剤の基礎的検討2017
- Author(s)
  仁科惣治、佐々木恭、富山恭行、吉岡奈穂子、原裕一、日野啓輔
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K19374
[Presentation] 鉄キレートはC型肝炎ウイルスによるmitophagyの抑制を回復させる2016
- Author(s)
  原裕―, 仁科惣治, 日野啓輔
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 鉄キレートはC型肝炎ウイルスによるmitophagyの抑制を回復させる2016
- Author(s)
  原裕―, 仁科惣治, 日野啓輔
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  幕張メッセ　千葉
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 肝細胞癌進展抑制におけるDPP4阻害薬の分子学的機序2016
- Author(s)
  仁科惣治, 山内明, 富山恭行, 吉岡奈穂子, 原裕一, 日野啓輔
- Organizer
  JDDW2016
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Comparison of therapeutic effect of sorafenib and drug eluting beads transcatheter arterial chemoembolization on hepatocellular carcinoma refractory to conventional transcatheter arterial chemoembolization2016
- Author(s)
  Yasuyuki Tomiyama, Naoko Yoshioka, Nobuko Koyama, Kyo Sasaki, Sohji Nishina, Yuichi Hara, Keisuke Hino
- Organizer
  the 12th JSH Single Topic Conference in Kanazawa
- Place of Presentation
  HOTEl nikko Kanazawa　Ｊａｐａｎ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] NASH肝発癌抑制機構としてのmitophagy誘導2016
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 肝細胞癌治療標的としてのCD26(DPP4) の意義2016
- Author(s)
  仁科惣治, 山内明, 小山展子, 富山恭行, 吉岡奈穂子, 原裕一, 日野啓輔
- Organizer
  第113回日本内科学会総会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 鉄キレートはC型肝炎ウイルスによるmitophagyの抑制を回復させる2016
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル　東京
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 肝細胞癌に対する DPP4阻害剤の抗腫瘍効果とその分子機構2016
- Author(s)
  仁科惣治
- Organizer
  第59回　日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ幕張(東京)
- Data Source
  KAKENHI-PROJECT-16K19374
[Presentation] Iron chelator suppresses hepatocarcinogenesis through mitophagy induction in STAM mice2016
- Author(s)
  Yuichi Hara, Kyo Sasaki, Soji Nishina, Keisuke Hino
- Organizer
  AASLD LiverLearning 2016
- Place of Presentation
  Boston,USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Dipeptidyl peptidase 4 (DPP4) inhibitor enhances natural killer cell chemotaxis, improving tumor immunity against hepatocellular carcinoma2016
- Author(s)
  Sohji Nishina, Akira Yamauchi, Yuichi Hara, Kyo Sasaki, Keisuke Hino
- Organizer
  Annual Meeting of AASLD
- Place of Presentation
  Boston（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Dipeptidyl peptidase 4 (DPP4) inhibitor enhances natural killer cell chemotaxis, improving tumor immunity against hepatocellular carcinoma2016
- Author(s)
  Sohji Nishina, Akira Yamauchi, Yuichi Hara, Kyo Sasaki, Keisuke Hino
- Organizer
  AASLD LiverLearning 2016
- Place of Presentation
  Boston,USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Iron chelator suppresses hepatocarcinogenesis through mitophagy induction in STAM mice2016
- Author(s)
  Yuichi Hara, Kyo Sasaki, Soji Nishina, Keisuke Hino
- Organizer
  Annual Meeting of AASLD
- Place of Presentation
  Boston（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 肝細胞癌進展抑制におけるDPP4阻害薬の分子学的機序2016
- Author(s)
  仁科惣治
- Organizer
  JDDW2016
- Place of Presentation
  神戸コンベンションセンター(神戸)
- Data Source
  KAKENHI-PROJECT-16K19374
[Presentation] The therapeutic role of DPP-4 inhibitor for the progression of Hepatocellular carcinoma2016
- Author(s)
  Sohji Nishina
- Organizer
  AASLD The Liver Meeting 2016
- Place of Presentation
  John B. Hynes Veterans Memorial Convention Center(ボストン、アメリカ）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19374
[Presentation] 肝細胞癌治療標的としての CD26 (DPP-4) の分子生物学的解析2015
- Author(s)
  仁科惣治
- Organizer
  第41回日本肝臓学会西部会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26860535
[Presentation] Iron chelation restores mitophagy suppressed by hepatitis C virus2015
- Author(s)
  Hara Y, Nishina S, Hirayama T, Nagasawa H, Hino K
- Organizer
  Annual Meeting of American Association for the Study of Liver Diseases 2015
- Place of Presentation
  San Francisco
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] DPP-4 inhibitor, anagliptin suppresses the progression of Hepatocellular carcinoma2015
- Author(s)
  Nishina S, Yamauchi A, Tomiyama Y, Hara Y, Hino K
- Organizer
  Annual Meeting of American Association for the Study of Liver Diseases 2015
- Place of Presentation
  San Francisco
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] CD26 (DPP-4) as a molecular target for HCC treatment2015
- Author(s)
  Sohji Nishina
- Organizer
  第19回日本肝臓学会大会　(International Session)
- Place of Presentation
  グランドプリンスホテル新高輪(東京)
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26860535
[Presentation] DPP-4 inhibitor, anagliptin suppresses the progression of Hepatocellular carcinoma2015
- Author(s)
  Sohji Nishina
- Organizer
  AAASLD The Liver Meeting 2015
- Place of Presentation
  サンフランシスコ（アメリカ）
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860535
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin in the context of mitochondrial depolarization2014
- Author(s)
  Hara Y, Yanatori I, Ikeda M, Kiyokage E, Nishina S, Tomiyama Y, Toida K, Kishi F, Kato N, Imamura M, Chayama K, Hino K
- Organizer
  5th World Congress on Targeting Mitochondria
- Place of Presentation
  Ritz Carlton Hotel, Berlin, Germany
- Year and Date
  2014-10-30
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Oral glucose tolerance test predicts hepatic fibrosis in nonalcoholic fatty liver disease patients without overt diabetes mellitus.2014
- Author(s)
  Nishina S, Hyogo H, Kawanaka M, Miyake T, Abe M, Yamashita S, Tobita H, Sato S, Hiasa Y, Chayama K, Hino K
- Organizer
  The 65th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes Convention Center, Boston, USA
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] HCVとミトコンドリアのバイオジェネーシスとの関連性2014
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] HCVとミトコンドリアのバイオジェネーシスとの関連性2014
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ、東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] HCV とミトコンドリアバイオジェネシスとの関連性2014
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin in the context of mitochondrial depolarization2014
- Author(s)
  Hara Y, Yanatori I, Ikeda M, Kiyokage E, Nishina S, Tomiyama Y, Toida K, Kishi F, Kato N, Imamura M, Chayama K, Hino K
- Organizer
  5th World Congress on Targeting Mitochondria
- Place of Presentation
  Ritz Carlton Hotel, Berlin, Germany
- Year and Date
  2014-10-30
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] HCVとミトコンドリアのバイオジェネーシスとの関連性2014
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ、東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin2013
- Author(s)
  Hara Y, Nishina S, Hino K, et al
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Washington DC
- Year and Date
  2013-11-02
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Suppressed mitophagy in transgenic mice expressing hepatitis C virus polyprotein2013
- Author(s)
  Yuichi Hara, Izumi Yanatori , Emi Kiyokage , Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida , Masanori Ikeda , Fumio Kishi , Nobuyuki Kato , Michio Imamura , Kazuaki Chayama , Keisuke Hino
- Organizer
  The 2nd JSGE International Topic Conference
- Place of Presentation
  Kagosima castle park hotel,Kagoshima, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] Hepatitis C virus core protein suppresses mitophagy2013
- Author(s)
  Yuichi Hara, Izumi Yanatori , Emi Kiyokage , Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida , Masanori Ikeda , Fumio Kishi , Nobuyuki Kato , Michio Imamura , Kazuaki Chayama , Keisuke Hino
- Organizer
  AASLD
- Place of Presentation
  Walter E. Washington Convention Center, Washington, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] Ovariectomized transgenic mice expressing hepatitis C virus poltprotein develop hepatic steatosis through suppression of AMPK/PGCα signaling2013
- Author(s)
  Tomiyama Y, Nishina S, Hara Y, Hino K
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Washington DC
- Year and Date
  2013-11-02
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Supressed Mitophagy in Transgenic mice Expressing Hepatitis C Virus Polyprotein2013
- Author(s)
  Yuichi Hara, Izumi Yanatori , Emi Kiyokage , Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida , Masanori Ikeda , Fumio Kishi , Nobuyuki Kato , Michio Imamura , Kazuaki Chayama , Keisuke Hino
- Organizer
  Cell Symposia : Mitochondria
- Place of Presentation
  Rua Latino Coelho, 1Lisbon,Portugal
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] HCVコア蛋白とParkinとの相互作用によるマイトファジーの抑制2013
- Author(s)
  原　裕一仁科惣治
- Organizer
  DDW
- Place of Presentation
  グランドプリンスホテル、東京、日本
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] The hepatitis C virus core protein suppresses mitophagy by interacting with Parkin2013
- Author(s)
  Hara Y, Nishina S, Hino K, et al
- Organizer
  Cell symposium Mitochondria : from signaling to disease
- Place of Presentation
  Lisbon
- Year and Date
  2013-05-05
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] HCVコア蛋白とParkinとの相互作用よるmitophagyの抑制及びHCV増殖に対する影響2013
- Author(s)
  原　裕一　仁科惣治　日野啓輔
- Organizer
  日本肝臓学会西部会
- Place of Presentation
  長良川国際会議場・岐阜都ホテル,岐阜、日本
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice
- Author(s)
  Sohji Nishina, Yuichi Hara, Yasuyuki Tomiyama, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  WALTER E. Washington Convention Center Washington,DC.USA
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Ovariectomized transgenic mice expressing hepatitis C virus polyprotein develop hepatic steatosis through suppression of AMPK/PGC1a signaling
- Author(s)
  Yasuyuki Tomiyama, Sohji Nishina , Yuichi Hara, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Waltere Washington Convention Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] HCVコア蛋白とParkinとの相互作用によるマイトファジーの抑制
- Author(s)
  原裕一，仁科惣治，日野啓輔
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice
- Author(s)
  Sohji Nishina, Yuichi Hara, Yasuyuki Tomiyama, Keisuke Hino
- Organizer
  17th International Symposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  Osaka International Convention Center, Osaka, Japan
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] The hepatitis C virus core protein suppresses mitophagy by affecting Parkin
- Author(s)
  Yuichi Hara, Izumi Yanatori , Masanori Ikeda, Sohji Nishina, Yasuyuki Tomiyama, Fumio Kishi, Kazunori Toida, Nobuyuki Kato, Kazuaki Chayama , Keisuke Hino
- Organizer
  Cell Sumposium Mitochondria:from Signaling to Disease
- Place of Presentation
  Sheraton Lisbosa, Lisbon, Portugal
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] HCVタンパクはエストロゲン欠乏起因性酸化ストレスに対する抗酸化機構を抑制する
- Author(s)
  富山恭行，小山展子，佐々木恭，仁科惣治，吉岡奈穂子，原　裕一，日野啓輔
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Ovariectomized transgenic mice expressing hepatitis C virus polyprotein develop hepatic steatosis through suppression of AMPK/PGC1a signaling
- Author(s)
  Yasuyuki Tomiyama, Sohji Nishina , Yuichi Hara, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  WALTER E. Washington Convention Center Washington,DC.US
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] The hepatitis C virus core protein suppresses mitophagy by affecting Parkin
- Author(s)
  Yuichi Hara, Izumi Yanatori , Masanori Ikeda, Sohji Nishina, Yasuyuki Tomiyama, Fumio Kishi, Kazunori Toida, Nobuyuki Kato, Kazuaki Chayama , Keisuke Hino
- Organizer
  Cell Symposium Mitochondria:from Signaling to Disease
- Place of Presentation
  Sheraton Lisboa, Lisbon, Portugal
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] HCVコア蛋白とParkinとの相互作用によるマイトファジーの抑制
- Author(s)
  原裕一，仁科惣治，日野啓輔
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice
- Author(s)
  Sohji Nishina, Yuichi Hara, Yasuyuki Tomiyama, Keisuke Hino
- Organizer
  17th International Symposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  Osaka International Convention Center, osaka, Japan
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin
- Author(s)
  Yuhichi Hara, Izumi Yanatori, EmiKiyokage, Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida, Masanori Ikeda, Fumio Kishi, Nobuyuki Kato, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Waltere Washington Convention Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin
- Author(s)
  Yuhichi Hara, Izumi Yanatori, EmiKiyokage, Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida, Masanori Ikeda, Fumio Kishi, Nobuyuki Kato, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  WALTER E. Washington Convention Center Washington,DC.US
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice
- Author(s)
  Sohji Nishina, Yuichi Hara, Yasuyuki Tomiyama, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Waltere Washington Convention Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] HCVタンパクはエストロゲン欠乏起因性酸化ストレスに対する抗酸化機構を抑制する
- Author(s)
  富山恭行，小山展子，佐々木恭，仁科惣治，吉岡奈穂子，原　裕一，日野啓輔
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-25670374

1. HINO Keisuke (80228741)

# of Collaborated Projects: 8 results

# of Collaborated Products: 102 results
2. HARA Yuichi (60550952)

# of Collaborated Projects: 6 results

# of Collaborated Products: 74 results
3. IKEDA Masanori (30315767)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. KISHI Fumio (40153077)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. KORENAGA Masaaki (70420536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 山内明 (80372431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 佐々木恭 (00584971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NISHIDA Nao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. Sugiyama Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. IKUTA Katsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. YAMAMURA Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. YANATORI Izumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 土岐康通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 酒井愛子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishina Soji 仁科 惣治

NISHINA Sohji 仁科 惣治

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Development of a novel cancer treatment using a near-infrared responsive drug delivery system aimed at enhancing antitumor immunityPrincipal Investigator

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The study for liver cancer specific glycolysis inhibition and efficiency of cancer immunity using novel drug delivery systemPrincipal Investigator

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Activation of tumor immunity by metabolic reprogramming in liver cancer microenvironment

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Development of an anticancer therapy against liver cancer using 2-deoxy-D-glucose encapsulated in polymer poly (lactic-co-glycolic acid) nanoparticlesPrincipal Investigator

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Iron loss-induced mitophagy via mitochondria ferritin suppresses NASH-related hepatocellular carcinoma

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The therapeutic role of DPP-4 inhibitor for the progression of Hepatocellular carcinomaPrincipal Investigator

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Investigation of hepatocarcinogenic mechanisms by comprehensive ahalysis of cellular signaling responding to oxidative stress

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The crosstalk between Liver fibrosis and Hepatocellular carcinoma in the point of FAP and DPP4Principal Investigator

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Restoration of mitophagy as a strategy for inhibiting hepatocarcinogenesis

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Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.

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Analysis of hepatocarcinogenesis based on gender and mitochondrial biogenesis

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[Book] HEPATOLOGY PRACTICE（第４巻）2014

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[Journal Article] CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma2022

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Nishina Soji 仁科惣治

NISHINA Sohji 仁科惣治