Sugawara Tohru 菅原亨

… Alternative Names

菅原亨スガワラトオル

SUGAWARA Toru 菅原亨

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Researcher Number	70553460
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 生命医科学研究科, 准教授 2025: 国立研究開発法人国立成育医療研究センター, 細胞医療研究部, リサーチアソシエイト
Affiliation (based on the past Project Information) *help	2022 – 2024: 横浜市立大学, 生命医科学研究科, 准教授 2020 – 2021: 国立研究開発法人国立成育医療研究センター, 細胞医療研究部, 上級研究員 2018 – 2019: 国立研究開発法人国立成育医療研究センター, 細胞医療研究部, (非)研究員 2014: 独立行政法人国立成育医療研究センター, その他部局等, その他 2011: 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 研究員 2010: 独立行政法人国立成育医療研究センター, 再生医療センター生殖・細胞医療研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Medical genome science / Evolutionary biology Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 49020:Human pathology-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator 病態モデル / ミニ腸 / 疾患モデル / ヒト胚性幹細胞 / ヒト人工多能性幹細胞 / CRISPR/Cas9 / hsa-miR-302 / ゲノム編集 / オルガノイド / RET遺伝子 … More / Hirschsprung病 / 小腸オルガノイド / microRNA / ヒト多能性幹細胞 / 神経堤症 / 神経堤細胞 / 感覚受容体 / 多型 / 幹細胞 / 苦味受容体 / 霊長類 / ニホンザル / チンパンジー / ゲノム / 進化 / 遺伝子 … More Except Principal Investigator 多能性幹細胞 / ゲノム編集技術 / 細胞移植治療 / ライソゾーム酵素 / ムコリピドーシス / genome editing / Mucolipidosis / メタボローム / ATP産生 / mtDNA / 代謝 / ES細胞 / ミトコンドリア / 初期化 / 核置換 / 胚性ゲノム活性化 / iPS細胞 / テロメア / ZGA / ゲノム安定性 / テラトーマ / 小児がん診断システム / バイオビッグデータ / 機械学習 / LC/MS/MS / プロテオミクス / 品質評価 / 細胞外小胞 / 幹細胞 Less

Development of a method for predicting cell quality in continuous production for the practical application of stem cell products - the use of extracellular vesicles
- Principal Investigator
  
  川崎ナナ
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Yokohama City University
ムコリピドーシスを始めとした小児代謝性疾患に対する幹細胞移植による治療戦略の創成
- Principal Investigator
  
  福原康之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Child Health and Development
小児がん及びヒト多能性幹細胞に対する畳込ニューラルネットワークによる分類器の創成
- Principal Investigator
  
  梅澤明弘
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  National Center for Child Health and Development
全能性獲得へのロードマップ：幹細胞のミトコンドリア・ゲノム安定性機構の解明
- Principal Investigator
  
  山田満稔
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Keio University
Application of human pluripotent stem cell-derived neural crest cells for cell therapy in mini-gutPrincipal Investigator
- Principal Investigator
  
  Sugawara Tohru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  National Center for Child Health and Development
ヒト胎盤発生の新規分子を標的とした胎盤機能不全メカニズムの解明Principal Investigator
- Principal Investigator
  
  菅原亨
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  National Research Institute for Child Health and Development
Molecular mechanisms of adaptive evolution in primate taste receptorsPrincipal Investigator
- Principal Investigator
  
  SUGAWARA Toru
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Evolutionary biology
- Research Institution
  National Research Institute for Child Health and Development

All 2023 2022 2021 2020 2019 2012 2011 2010

All Journal Article Presentation Book

[Book] Post genome biology of primates focusing on taste perception2012
- Author(s)
  Tohru Sugawara and Hiroo Imai
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-22770233
[Book] Post-Genome Biology of Primates (Primatology Monographs)2012
- Author(s)
  Tohru Sugawara, Hiroo Imai
- Total Pages
  286
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-22770233
[Journal Article] A single allele of the hsa-miR-302/367 cluster maintains human pluripotent stem cells2022
- Author(s)
  Sugawara Tohru、Kawamoto Yuki、Kawasaki Tomoyuki、Umezawa Akihiro、Akutsu Hidenori
- Journal Title
  
  Regenerative Therapy
  
  Volume: 21 Pages: 37-45
- DOI
  10.1016/j.reth.2022.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08906, KAKENHI-PROJECT-20H00550, KAKENHI-PROJECT-23K20315
[Journal Article] Using piggyBac transposon gene expression vectors to transfect Zscan5b gene into mouse pluripotent stem cells2021
- Author(s)
  Yamada Mitsutoshi、Sugawara Tohru、Usami Shinju、Nakanishi Rina、Akustu Hidenori
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 3 Pages: 100811-100811
- DOI
  10.1016/j.xpro.2021.100811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-23K20330
[Journal Article] The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP22020
- Author(s)
  Tohru Sugawara, Takumi Miura, Tomoyuki Kawasaki, Akihiro Umezawa, Hidenori Akutsu*
- Journal Title
  
  Regenerative Therapy
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08666
[Journal Article] The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP22020
- Author(s)
  Sugawara T, Miura T, Kawasaki T, Umezawa A, Akutsu H.
- Journal Title
  
  Regen Ther
  
  Volume: 15 Pages: 1-9
- DOI
  10.1016/j.reth.2020.03.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17K01443, KAKENHI-PROJECT-18K08666
[Journal Article] Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.2019
- Author(s)
  Ogawa S, Yamada M, Nakamura A, Sugawara T, Nakamura A, Miyajima S, Harada Y, Ooka R, Okawa R, Miyauchi J, Tsumura H, Yoshimura Y, Miyado K, Akutsu H, Tanaka M, Umezawa A, Hamatani T.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 12 Issue: 6 Pages: 1366-1379
- DOI
  10.1016/j.stemcr.2019.05.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08666, KAKENHI-PROJECT-19K22602, KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-16H05475, KAKENHI-PROJECT-17H04236, KAKENHI-PROJECT-17H05100
[Journal Article] Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.2019
- Author(s)
  Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK.
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 15
- DOI
  10.1172/jci.insight.127736
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08666
[Journal Article] Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells2012
- Author(s)
  Sugawara T, Nishino K, Umezawa A, Akutsu H
- Journal Title
  
  Stem Cell Res Ther
  
  Volume: 3(2) Issue: 2 Pages: 8-8
- DOI
  10.1186/scrt99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770233
[Journal Article] Correlation between nuptial colors and visual sensitivities tuned by opsins leads to species richness in sympatric Lake Victoria cichlid fishes2012
- Author(s)
  Miyagi R, Terai Y, Aibara M, Sugawara T, Imai H, Tachida H, Mzighani SI, Okitsu T, Wada A, Okada N
- Journal Title
  
  Mol Biol Evol
  
  Volume: 29 Issue: 11 Pages: 3281-96
- DOI
  10.1093/molbev/mss139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21227002, KAKENHI-PROJECT-22770233, KAKENHI-PROJECT-23590141, KAKENHI-PROJECT-24590038, KAKENHI-PUBLICLY-23128503
[Journal Article] Reverse evolution in RH1 for adaptation of cichlids to water depth in Lake Tanganyika.2011
- Author(s)
  Nagai H, Terai Y, Sugawara T, Imai H, Nishihara H, Hori M, Okada N.
- Journal Title
  
  Molecular Biology and Evolution
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770233
[Journal Article] Diversification of bitter taste receptor gene family in western chimpanzees.2011
- Author(s)
  Sugawara T, Go Y, Udono T, Morimura N, Tomonaga M, Hirai H, Imai H.
- Journal Title
  
  Molecular Biology and Evolution
  
  Volume: 28 Pages: 921-931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770233
[Journal Article] Reverse Evolution in RH1 for adaptation of cichlids to water depth in Lake Tanganyika2011
- Author(s)
  Nagai, H., Terai, Y., Sugawara, T., Imai, H., Nishihara, H., Hori, M.and Okada, N.
- Journal Title
  
  Molecular Biology and Evolution
  
  Volume: 28(6) Issue: 6 Pages: 1769-1776
- DOI
  10.1093/molbev/msq344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20405007, KAKENHI-PROJECT-21227002, KAKENHI-PROJECT-21370010, KAKENHI-PROJECT-21370109, KAKENHI-PROJECT-22650053, KAKENHI-PROJECT-22770080, KAKENHI-PROJECT-22770233, KAKENHI-PUBLICLY-23123504
[Journal Article] Diversification of bitter taste receptor gene family in western chimpanzees2011
- Author(s)
  Sugawara T, Go Y, Udono T, Morimura N, Tomonaga M, Hirai H, Imai H
- Journal Title
  
  Mol Biol Evol
  
  Volume: 28(2) Issue: 2 Pages: 921-931
- DOI
  10.1093/molbev/msq279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770233, KAKENHI-PROJECT-22770240
[Journal Article] Identification of non-taster Japanese macaques for a specific bitter taste2010
- Author(s)
  Suzuki N, Sugawara T, Matsui A, Go Y, Hirai H, Imai H
- Journal Title
  
  Primates
  
  Volume: 51(4) Issue: 4 Pages: 285-289
- DOI
  10.1007/s10329-010-0209-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770233, KAKENHI-PROJECT-22770240
[Journal Article] Identification of non-taster Japanese macaques for a specific bitter taste.2010
- Author(s)
  Suzuki N, Sugawara T, Matsui A, Go Y, Hirai H, Imai H.
- Journal Title
  
  Primates
  
  Volume: 51 Pages: 285-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770233
[Presentation] ムコリピドーシスを対象としたCRISPR/Cas3 によるEx vivo自家細胞移植療法の開発2023
- Author(s)
  1.福原康之, 菅原亨, 眞田龍ノ助, 関戸悠希, 蘇哲民, 小須賀基通, 梅澤明弘
- Organizer
  第64回日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-23K07304
[Presentation] 「ヒト多能性幹細胞におけるPTEN遺伝子変異」ポスター発表2023
- Author(s)
  菅原亨
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K07304
[Presentation] AGE-DEPENDENT CHARACTERISTICS OF TRANSCRIPTION AND METABOLISM IN PLURIPOTENT STEM CELLS2020
- Author(s)
  Reina Ooka, Mitsutoshi Yamada*, Akihiro Nakamura, Tohru Sugawara, Kohsuke Kanekura, Kenji Miyado, Hidenori Akutsu, Mamoru Tanaka, and Akihiro Umezawa (*correspondence to)
- Organizer
  ISSCR Annual meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20330
[Presentation] Hsa-miR-302s are essential for self-renew of human pluripotent stem cells2019
- Author(s)
  菅原亨、三浦巧、川崎友之、梅澤明弘、阿久津英憲
- Organizer
  第17回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-18K08666
[Presentation] The hsa-miR-302 cluster is essential for self-renewal in human pluripotent stem cell2019
- Author(s)
  Sugawara T, Miura T, Kawasaki T, Umezawa A, Akutsu H.
- Organizer
  17th Annual meeting of International Society for Stem Cell Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08666
[Presentation] 霊長類味覚受容体の進化2011
- Author(s)
  今井啓雄、鈴木南美、早川卓志、菅原亨、松井淳、郷康広、櫻井敬展、石丸喜朗、Lijie Yin, Wenshi Pan, 阿部啓子、三坂巧、平井啓久
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  長野県松本市
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-22770233
[Presentation] 霊長類味覚受容体の進化2011
- Author(s)
  今井啓雄、鈴木南美、早川卓志、菅原亨、松井淳、郷康広、櫻井敬展、石丸喜朗、Lijie Yin, Wenshi Pan,阿部啓子、三坂巧、平井啓久
- Organizer
  第89回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-22770233
[Presentation] Diversification of bitter taste receptor gene family in chimpanzees2010
- Author(s)
  Sugawara T, Go Y, Udono T, Morimura N, Tomonaga M, Hirai H, Imai H
- Organizer
  International Primatological Society XXIII Congress
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22770233
[Presentation] DIVERSIFICATION OF BITTER TASTE RECEPTOR GENE FAMILY IN CHIMPANZEES2010
- Author(s)
  T.Sugawara, Y.Go, T.Udono, N.Morimura, M.Tomonaga, H.Hirai, H.Imai
- Organizer
  International Primatological Society XXIII Congress
- Place of Presentation
  Kyoto
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-22770233

1. 梅澤明弘 (70213486)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 川崎ナナ (20186167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 高倉大輔 (90760231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 三上修治 (20338180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 青砥早希 (60775972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岡村浩司 (80456194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山田満稔 (40383864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 金蔵孝介 (10508568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 阿久津英憲 (50347225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 中村彰宏 (50750973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 福原康之 (20317184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. TERAI Yohey

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 岡田典弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 堀道雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sugawara Tohru 菅原 亨

菅原 亨 スガワラ トオル

SUGAWARA Toru 菅原 亨

Research Projects

Research Products

Co-Researchers

Development of a method for predicting cell quality in continuous production for the practical application of stem cell products - the use of extracellular vesicles

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ムコリピドーシスを始めとした小児代謝性疾患に対する幹細胞移植による治療戦略の創成

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小児がん及びヒト多能性幹細胞に対する畳込ニューラルネットワークによる分類器の創成

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

全能性獲得へのロードマップ：幹細胞のミトコンドリア・ゲノム安定性機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Application of human pluripotent stem cell-derived neural crest cells for cell therapy in mini-gutPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト胎盤発生の新規分子を標的とした胎盤機能不全メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of adaptive evolution in primate taste receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Post genome biology of primates focusing on taste perception2012

Author(s)

Publisher

Data Source

[Book] Post-Genome Biology of Primates (Primatology Monographs)2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] A single allele of the hsa-miR-302/367 cluster maintains human pluripotent stem cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Using piggyBac transposon gene expression vectors to transfect Zscan5b gene into mouse pluripotent stem cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP22020

Author(s)

Journal Title

Data Source

[Journal Article] The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP22020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.2019

Author(s)

Journal Title

DOI

Sugawara Tohru 菅原亨

菅原亨スガワラトオル

SUGAWARA Toru 菅原亨