Oshima Nobu 大嶋野歩

… Alternative Names

OSHIMA NOBU 大嶋野歩

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Researcher Number	70571454
Other IDs	https://orcid.org/0000-0003-2178-5241
Affiliation (Current)	2024: 京都大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2020 – 2023: 京都大学, 医学研究科, 客員研究員 2017: 京都大学, 医学(系)研究科(研究院), 客員研究員 2016 – 2017: 京都大学, 医学研究科, 客員研究員 2015: 京都大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery
Keywords	Principal Investigator 大腸癌 / セラノスティクス / 超偏極13CMRI / 癌代謝 / 3D培養 / LDH阻害剤 / 胃癌 / ワールバーグ効果 / 乳酸脱水素酵素 / がん代謝 … More / 代謝阻害療法 / 代謝 / 膵癌 / OxPhos / 解糖系 / LDH阻害 / ピルビン酸代謝 / 超偏極13C-MRI / LDH阻害薬 / LDH / 転写因子ネットワーク / 薬剤排泄能 / 多様性形成 / 大腸癌幹細胞 / 転写因子 / iPS細胞技術 / 幹細胞生物学 / 人工癌幹細胞 / 癌幹細胞 Less

Establishment of Non-clinical POC using hyperpolarized MRI and 3D cultured cancer tissue for personalized medicine of metabolic inhibitor therapy.Principal Investigator
- Principal Investigator
  
  大嶋野歩
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
Dynamic Imaging of LDH Inhibition in Tumors by 13C-MRI to Treat Colon CancerPrincipal Investigator
- Principal Investigator
  
  OSHIMA NOBU
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
Application of induced colon cancer stem cells to elucidation of the molecular basis of cancer stem cell property in colon cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  OSHIMA NOBU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2016 2015

All Journal Article Presentation

[Journal Article] Timing of real‐time indocyanine green fluorescence visualization for lymph node dissection during laparoscopic colon cancer surgery2023
- Author(s)
  Hiromitsu Kinoshita, Kenji Kawada, Yoshiro Itatani, Ryosuke Okamura, Nobu Oshima, Tomoaki Okada, Koya Hida, Kazutaka Obama
- Journal Title
  
  Langenbeck's Archives of Surgery
  
  Volume: 408 Issue: 1
- DOI
  10.1007/s00423-023-02808-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo2022
- Author(s)
  Yutaro Saito, Hiroyuki Yatabe, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Nobu Oshima, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna, Shinsuke Sando
- Journal Title
  
  Science advances
  
  Volume: 8 Issue: 13
- DOI
  10.1126/sciadv.abj2667
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15396, KAKENHI-PUBLICLY-20H05090, KAKENHI-PROJECT-19H00919, KAKENHI-PROJECT-19KK0369, KAKENHI-PROJECT-20H03217, KAKENHI-PROJECT-20K09054, KAKENHI-PROJECT-18H01186
[Journal Article] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-Time Monitoring of Pyruvate Metabolic Fluxes in Vivo and Targeting Intra-Tumor Metabolic Plasticity with Small Molecules2022
- Author(s)
  Nobu OSHIMA, et al.
- Journal Title
  
  Journal of the American College of Surgeons
  
  Volume: 235 Issue: 5 Pages: S5-S16
- DOI
  10.1097/01.xcs.0000893008.02117.d2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] Real-Time insight into in vivo redox status utilizing hyperpolarized [1- 13 C] N-acetyl cysteine2021
- Author(s)
  Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Jan H. Ardenkjr-Larsen, Mitchell JB, Linehan WM, Swenson RE & Krishna MC
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 12155-12155
- DOI
  10.1038/s41598-021-90921-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma2020
- Author(s)
  Yamamoto Kazutoshi、Brender Jeffrey R.、Seki Tomohiro、Kishimoto Shun、Oshima Nobu、Choudhuri Rajani、Adler Stephen S.、Jagoda Elaine M.、Saito Keita、Devasahayam Nallathamby、Choyke Peter L.、Mitchell James B.、Krishna Murali C.
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 11 Pages: 2087-2093
- DOI
  10.1158/0008-5472.can-19-0928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy2020
- Author(s)
  Oshima N, Ishida R, Kishimoto S, Beebe K, Brender J, Yamamoto K, Urban D, Squadrito GL, Crooks D, Jackson J, Joshi A,
- Journal Title
  
  Cell Reports
  
  Volume: 30 Issue: 6 Pages: 1798-1810.e4
- DOI
  10.1016/j.celrep.2020.01.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] 超偏極13CMRIを用いた膵癌に対するLDH阻害治療効果の動的な可視化2020
- Author(s)
  大嶋野歩, 岸本俊, 石田諒, 愛須佑樹, 岡田倫明, 錦織達人, 板谷喜朗, 久森重夫, 角田茂, 肥田侯矢, 河田健二, 兵藤文紀, 松尾政之, 中本裕士, 小濱和貴, Neckers LM, Krishna MC, 坂井義治
- Journal Title
  
  胆と膵
  
  Volume: 41 Pages: 751-6
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties2020
- Author(s)
  Rai Ganesha、Urban Daniel J.、Jana Somnath、Muttil Pavan、Anderson Tamara、Kunda Nitesh K.、Oshima Nobu、Cherukuri Murali、、Dang Chi V.、Stott Gordon M.、Neckers Leonard
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 63 Issue: 19 Pages: 10984-11011
- DOI
  10.1021/acs.jmedchem.0c00916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] Laparoscopic left hemicolectomy with regional lymph node navigation and intracorporeal anastomosis for splenic flexure colon cancer2020
- Author(s)
  Itatani Yoshiro、Kawada Kenji、Hida Koya、Deguchi Yasunori、Oshima Nobu、Mizuno Rei、Wada Toshiaki、Okada Tomoaki、Sakai Yoshiharu
- Journal Title
  
  International Cancer Conference Journal
  
  Volume: 9 Issue: 4 Pages: 170-174
- DOI
  10.1007/s13691-020-00424-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] iPS細胞と大腸がん-人工大腸がん幹細胞の作製2016
- Author(s)
  大嶋野歩、青井貴之
- Journal Title
  
  G.I.Research
  
  Volume: 24(2) Pages: 81-89
- Data Source
  KAKENHI-PROJECT-15K10139
[Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022
- Author(s)
  Nobu Oshima, Yuki Aisu, Ryo Ishida, Shun kishimoto, Shigeo Hisamori, Shigeru Tsunoda, Satoshi Kaihara, Kazutaka Obama, Murali C. Krishna, Len Neckers
- Organizer
  American College of Surgeons: Owen H Wangensteen Scientific Forum 2022, Excellence in reserach
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Comprehensive monitoring of pyruvate metabolism in cancer cells and tumors reveals vulnerability to metabolic inhibition therapy with small molecules2022
- Author(s)
  Nobu Oshima, Yuki Aisu, Shigeo Hisamori, Shigeru Tsunoda, Hiroki Hashida, Kenji Uryuhara, Hiroyuki Kobayashi, Masato Kondo, Koji Kitamura, Satoshi Kaihara, Kazutaka Obama, Krishna C. Murali, Len M. Neckers.
- Organizer
  The AACR Annual Meeting　2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 超偏極13C-MRIによる腫瘍組織内でのピルビン酸代謝の動的観察とセラノスティクスへの展開2022
- Author(s)
  大嶋野歩, 愛須佑樹, 久森重夫, 角田茂, 兵藤文紀, 松尾政之, 板谷喜朗, 橋田裕毅, 貝原聡, 小濱和貴
- Organizer
  第77回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] A newly designed hyperpolarized molecular probe enables the in vivo detection of aminopeptidase N activity from the tumor regions in animals2022
- Author(s)
  Hiroyuki Yatabe, Yutaro Saito, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Nobu Oshima, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna, Shinsuke Sando
- Organizer
  World Molecular Imaging Congress (WMIC) 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 外科医からみた超偏極・代謝 MRI イメージング:ユーザーの視点から2022
- Author(s)
  大嶋野歩
- Organizer
  日本磁気共鳴医学会:スタディグループミーティング「臨床応用を指向する超偏極・代謝 MRIイメージング」
- Invited
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022
- Author(s)
  Nobu Oshima, Yuki Aisu, Ryo Ishida, Shun kishimoto, Shigeo Hisamori, Shigeru Tsunoda, Satoshi Kaihara, Kazutaka Obama, Murali C. Krishna, Len Neckers
- Organizer
  American College of Surgeons, Clinical Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 消化器癌でのピルビン酸代謝モニタリングと治療応用2022
- Author(s)
  愛須佑樹, 大嶋野歩, 花田圭太, 岡田倫明, 板谷喜朗, 久森重夫, 角田茂, 河田健二, 兵藤文紀, 松尾政之, 小濱和貴
- Organizer
  第77回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 進行再発大腸癌に対する集学的アプローチの最先端超偏極13C-MRIによる、大腸癌腫瘍内における代謝反応の動的な可視化2021
- Author(s)
  大嶋野歩, 兵藤文紀, 松尾政之, 角田茂, 久森重夫, 板谷喜郎, 岡田倫明, 小林裕之, 橋田裕毅, 瓜生原健嗣, 近藤正人, 北村好史, 喜多亮介, 貝原聡, 小濱和貴
- Organizer
  第121回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 食道癌におけるこだわりの手術手技臓器鞘コンセプトに基づくロボット支援胸腔鏡下上縦隔リンパ節郭清2021
- Author(s)
  角田茂, 久森重夫, 錦織達人, 岡村亮輔, 前川久継, 大森敦仁, 板谷喜朗, 岡田倫明, 大嶋野歩, 肥田侯矢, 河田健二, 喜安佳之, 山本高正, 星野伸明, 村上克宏, 樽本浩司, 小濱和貴
- Organizer
  第121回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Monitoring of pyruvate metabolism in tumors: application of 13C-MRSI to a novel treatment of targeting cancer metabolism2021
- Author(s)
  Nobu Oshima, Hiroki Hashida, Shigeo Hisamori, Shigeru Tsunoda, Kazutaka Obama2, Krishna MC, Neckers LM
- Organizer
  The 80th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 超偏極13C-MRI用いた，薬剤による腫瘍組織内におけるピルビン酸代謝変容のモニタリング2021
- Author(s)
  大嶋野歩, 石田諒,　愛須佑樹, 久森重夫, 板谷喜郎, 兵藤文紀, 松尾政之, 角田茂, 貝原聡, 小濱和貴
- Organizer
  第76回　日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 胃癌におけるピルビン酸代謝のモニタリングと代謝阻害療法の開発2021
- Author(s)
  愛須佑樹, 大嶋野歩, 花田圭太, 岡田倫明, 板谷喜朗, 久森重夫, 角田茂, 兵藤文紀, 松尾政之, 小濱和貴
- Organizer
  第76回　日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized13C MRI2020
- Author(s)
  Nobu Oshima, Ryo Ishida, Shun Kishimoto, Jeffrey R. Brender, Tomoaki Okada, Kazuataka Obama, Yoshiharu Sakai, Murali C. Krishna and Leonard M. Neckers
- Organizer
  AACR Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes γ-Glutamyl Transferase Activities in vivo Tumor Xenografts2020
- Author(s)
  T. Seki, K. Yamamoto, N. Oshima, M. Itoda, Y. Kondo, Y. Saito, Y. Takakusagi, S. Kishimoto, JR Brender, RM Malinowski, JH A-Larsen, H. Nonaka, MC Krishna, S Sando
- Organizer
  ISMRM & SMRT Virtual Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 超偏極13C-MRIを用いた，LDH阻害剤およびメトホルミンの大腸癌組織内薬剤効果の可視化と癌治療への応用2020
- Author(s)
  大嶋野歩, 岡田倫明, 板谷喜朗, 出口靖記, 肥田侯矢, 河田健二, Murali Krishna, Leonard Neckers, 小濱和貴, 坂井義治
- Organizer
  第75回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] MRIを用いた大腸癌におけるセラノスティクスー超偏極13C-MRIを用いた腫瘍内における代謝阻害剤効果のDynamic Monitoring～2020
- Author(s)
  大嶋野歩, 小濱和貴, 河田健二, 肥田候矢, 久森重夫, 出口靖記, 板谷喜郎, 水野礼, 和田聡朗, 錦織達人, 奥知慶久, 岡田倫明, 我如古理規, Krishna Murali, Neckers Leonard, 坂井義治
- Organizer
  第120回日本外科学会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Real-time Monitoring of in vivo free radical scavengers through hyperpolarized [1-13C] N-acetyl cysteine2020
- Author(s)
  K. Yamamoto, A. Opina, K. Saito, RM Malinowski, T. Seki, N. Oshima, D. Sail, JR Brender, S Kishimoto, N Deva, JH A-Larsen, JB Mitchell, RE Swenson, MC Krishna
- Organizer
  ISMRM & SMRT Virtual Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] microRNA-137/DCLK1 axis: A novel mechanism regulating tumorigenicity of colon cancer stem cell2016
- Author(s)
  Masazumi Sakaguchi, Shigeo Hisamori, Nobu Oshima, Yoshiharu Sakai
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, LA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10139
[Presentation] 大腸癌幹細胞におけるmiR-137/DCLK1 axisの重要性2016
- Author(s)
  坂口正純、久森重夫、大嶋野歩、坂井義治
- Organizer
  第14回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-15K10139
[Presentation] Application of iPS Technology to Cancer Stem Cell Research: Generation of Induced Cancer Stem Cells from Colon Cancer Cells by Introducing OCT3/4, SOX2 and KLF42015
- Author(s)
  Oshima N, Yamada Y, Sakai Y, Aoi T
- Organizer
  ISSCR 2015 Annual Meeting
- Place of Presentation
  Stockholm
- Year and Date
  2015-06-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10139

1. 久森重夫 (50534351)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. 兵藤文紀 (10380693)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. AOI Takashi (00546997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 坂井義治 (60273455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 板谷喜朗 (80814029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. 高草木洋一 (60439916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 齋藤雄太朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oshima Nobu 大嶋 野歩

OSHIMA NOBU 大嶋 野歩

Research Projects

Research Products

Co-Researchers

Establishment of Non-clinical POC using hyperpolarized MRI and 3D cultured cancer tissue for personalized medicine of metabolic inhibitor therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dynamic Imaging of LDH Inhibition in Tumors by 13C-MRI to Treat Colon CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Application of induced colon cancer stem cells to elucidation of the molecular basis of cancer stem cell property in colon cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Timing of real‐time indocyanine green fluorescence visualization for lymph node dissection during laparoscopic colon cancer surgery2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-Time Monitoring of Pyruvate Metabolic Fluxes in Vivo and Targeting Intra-Tumor Metabolic Plasticity with Small Molecules2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Real-Time insight into in vivo redox status utilizing hyperpolarized [1- 13 C] N-acetyl cysteine2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 超偏極13CMRIを用いた膵癌に対するLDH阻害治療効果の動的な可視化2020

Author(s)

Journal Title

Data Source

[Journal Article] Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Laparoscopic left hemicolectomy with regional lymph node navigation and intracorporeal anastomosis for splenic flexure colon cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPS細胞と大腸がん-人工大腸がん幹細胞の作製2016

Author(s)

Journal Title

Data Source

[Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022

Author(s)

Organizer

Data Source

[Presentation] Comprehensive monitoring of pyruvate metabolism in cancer cells and tumors reveals vulnerability to metabolic inhibition therapy with small molecules2022

Author(s)

Organizer

Data Source

[Presentation] 超偏極13C-MRIによる腫瘍組織内でのピルビン酸代謝の動的観察とセラノスティクスへの展開2022

Oshima Nobu 大嶋野歩

OSHIMA NOBU 大嶋野歩

[Presentation] 進行再発大腸癌に対する集学的アプローチの最先端超偏極13C-MRIによる、大腸癌腫瘍内における代謝反応の動的な可視化2021

[Presentation] 食道癌におけるこだわりの手術手技臓器鞘コンセプトに基づくロボット支援胸腔鏡下上縦隔リンパ節郭清2021

[Presentation] 超偏極13C-MRI用いた，薬剤による腫瘍組織内におけるピルビン酸代謝変容のモニタリング2021