Chayama Hiromi 茶山弘美

… Alternative Names

茶山弘美チャヤマヒロミ

ABE Hiromi 阿部弘美

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Researcher Number	70572329
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所ウイルス第一部, 主任研究員
Affiliation (based on the past Project Information) *help	2025: 広島大学, 医系科学研究科(医), 准教授 2021 – 2023: 広島大学, 医系科学研究科(医), 准教授 2019: 広島大学, 医系科学研究科(医), 准教授 2017 – 2018: 広島大学, 医歯薬保健学研究科(医), 准教授 2013 – 2016: 広島大学, 医歯薬保健学研究院(医), 准教授 2012: 広島大学, 医歯薬保健学研究院(医), 助教 2010 – 2011: 広島大学, 大学院・医歯薬学総合研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Biofunction/Bioprocess Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / General internal medicine and related fields
Keywords	Principal Investigator ヒト肝細胞キメラマウス / 肝炎ウイルス / Tscm細胞 / HBV / 遺伝性肝疾患モデル / 遺伝性肝疾患 / ゲノム編集 / 次世代シーケンサー / ゲノム / ウイルス / ヒトゲノム / 肝臓学 … More Except Principal Investigator … More 肥満 / モデル動物 / NASH / ヒト肝細胞キメラマウス / 脂肪肝 / 治療 / 線維化 / 成長ホルモン / ヒト肝細胞 / 脂肪化 / ゲノム編集 / cas9 / lentivirus / cancer therapy / dsDNA / exosome / genome editing Less

HBV持続感染完治を目指すTscm細胞の動的変化機構の解明Principal Investigator
- Principal Investigator
  
  茶山弘美
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
B型肝炎ウイルス持続感染の完治を目指すHBV特異的Tscmを用いた新規治療の探索Principal Investigator
- Principal Investigator
  
  茶山弘美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
Study of NASH using human hepatocyte chimeric mouse and biopsy specimen
- Principal Investigator
  
  Chayama Kazuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hiroshima University
Establishment of highly safe gene therapy without usage of double stranded DNA
- Principal Investigator
  
  Chayama Kazuaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Hiroshima University
Novel animal models for hereditary diseases using human hepatocytes transplanted chimeric mice and vaculovirusPrincipal Investigator
- Principal Investigator
  
  Chayama Hiromi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Hiroshima University
Analysis of hepatitis virus genomes using human hepatocytes transplanted chimeric mice and ultra-deep sequencing.Principal Investigator
- Principal Investigator
  
  ABE Hiromi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University
Analysis of the relationship between IL28B SNP and HCV genomePrincipal Investigator
- Principal Investigator
  
  ABE Hiromi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University

[Book] 肝原発平滑筋肉腫の一例2019
- Author(s)
  山岡賢治, 児玉健一郎, 河岡友和, 難波麻衣子, 内川慎介, 大屋一輝, 盛生　慶, 中原隆志, 村上英介, 山内理海, 平松　憲, 今村道雄, 相方　浩, 織田麻琴, 有廣光司, 小林　剛, 大段秀樹, 茶山一彰
- Publisher
  肝臓
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice.2024
- Author(s)
  Ichikawa A, Miki D, Hayes CN, Teraoka Y, Nakahara H, Tateno C, Ishida Y, Chayama K, Oka S.
- Journal Title
  
  Sci Rep.
  
  Volume: 14(1) Issue: 1 Pages: 3362-3362
- DOI
  10.1038/s41598-024-53890-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07416, KAKENHI-PROJECT-21H04817
[Journal Article] Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.2022
- Author(s)
  Fujiwara-N, Chayama-K et al.
- Journal Title
  
  science translational medicine
  
  Volume: 14 Issue: 650 Pages: 1-28
- DOI
  10.1126/scitranslmed.abo4474
- Data Source
  KAKENHI-PROJECT-21H04817
[Journal Article] A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan.2020
- Author(s)
  Kawaguchi I, Chayama K, Gonzalez YS, Virabhak S, Mitchell D, Yuen C, Kumada H.
- Journal Title
  
  Adv Ther.
  
  Volume: 37 Issue: 1 Pages: 457-476
- DOI
  10.1007/s12325-019-01166-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases.2020
- Author(s)
  Daijo K, Nakahara T, Inagaki Y, Nanba M, Nishida Y, Uchikawa S, Kodama K, Oya K, Morio K, Fujino H, Ono A, Murakami E, Yamauchi M, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Hayes CN, Imamura M, Aikata H, Ochi H, Chayama K.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: - Issue: 8 Pages: 1412-1419
- DOI
  10.1111/jgh.14968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446, KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-18K15814
[Journal Article] Preoperative PET-CT is useful for predicting recurrent extrahepatic metastasis of hepatocellular carcinoma after resection.2020
- Author(s)
  Morio K, Kawaoka T, Aikata H, Namba M, Uchikawa S, Kodama K, Ohya K, Fujino H, Nakahara T, Murakami E, Yamauchi M, Tsuge M, Hiramatsu A, Imamura M, Nakamura Y, Akagi M, Awai K, Kobayashi T, Ohdan H, Chayama K.
- Journal Title
  
  Eur J Radiol.
  
  Volume: 124 Pages: 108828-108828
- DOI
  10.1016/j.ejrad.2020.108828
- NAID
  120007097014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-18K08706
[Journal Article] Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials.2020
- Author(s)
  Suleiman AA, Lin CW, Liu W, Eckert D, Mensing S, Burroughs M, Kato K, Chayama K, Kumada H, Oberoi RK.
- Journal Title
  
  J Clin Pharmacol.
  
  Volume: 60 Issue: 3 Pages: 331-339
- DOI
  10.1002/jcph.1524
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] A case of advanced HCC treated with lenvatinib after hepatic arterial infusion chemotherapy combined with radiation therapy treatment for portal vein tumor thrombosis in the main trunk.2020
- Author(s)
  Kosaka Y, Kawaoka T, Aikata H, Suehiro Y, Yamaoka K, Ando Y, Namba M, Takeuchi Y, Fujii Y, Uchikawa S, Kodama K, Oya K, Morio K, Fujino H, Nakahara T, Murakami E, Yamauchi M, Tsuge M, Hiramatsu A, Imamura M, Baba Y, Awai K, Kimura T, Nagata Y, Chayama K.
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: - Issue: 5 Pages: 839-843
- DOI
  10.1007/s12328-020-01093-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Management of refractory ascites attenuates muscle mass reduction and improves survival in patients with decompensated cirrhosis.2020
- Author(s)
  Namba M, Hiramatsu A, Aikata H, Kodama K, Uchikawa S, Ohya K, Morio K, Fujino H, Nakahara T, Murakami E, Yamauchi M, Kawaoka T, Tsuge M, Imamura M, Chayama K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 55 Issue: 2 Pages: 217-226
- DOI
  10.1007/s00535-019-01623-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease2020
- Author(s)
  Okamoto, K. Koda, M. Okamoto, T. Onoyama, T. Miyoshi, K. Kishina, M. Matono, T. Kato, J. Tokunaga, S. Sugihara, T. Hiramatsu, A. Hyogo, H. Tobita, H. Sato, S. Kawanaka, M. Hara, Y. Hino, K. Chayama, K. Murawaki, Y. Isomoto, H.
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 2 Pages: e0219412-e0219412
- DOI
  10.1371/journal.pone.0219412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-17H06269
[Journal Article] Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection2020
- Author(s)
  Ohya K, Kawaoka T, Imamura M, Morio K, Nakahara T, Murakami E, Yamauchi M, Hiramatsu A, Tsuge M, Aikata H, Chayama K.
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 7 Pages: 941-944
- DOI
  10.2169/internalmedicine.3824-19
- NAID
  130007825289
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Publisher Correction: Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP.2020
- Author(s)
  Makokha GN, Abe-Chayama H, Chowdhury S, Hayes CN, Tsuge M, Yoshima T, Ishida Y, Zhang Y, Uchida T, Tateno C, Akiyama R, Chayama K.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 2233-2233
- DOI
  10.1038/s41598-020-58888-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Regression of Idiopathic Thrombocytopenic Purpura in a Patient With Eradication of Hepatitis C Virus by Direct-Acting Antivirals.2020
- Author(s)
  Johira Y, Hatooka H, Mori N, Fukuhara T, Takaki S, Shimomura Y, Imamura M, Hayes CN, Tsuji K, Chayama K.
- Journal Title
  
  Hepatology.
  
  Volume: 71 Issue: 1 Pages: 389-391
- DOI
  10.1002/hep.30900
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations.2020
- Author(s)
  Fujita M, Yamaguchi R, Hasegawa T, Shimada S, Arihiro K, Hayashi S, Maejima K, Nakano K, Fujimoto A, Ono A, Aikata H, Ueno M, Hayami S, Tanaka H, Miyano S, Yamaue H, Chayama K, Kakimi K, Tanaka S, Imoto S, Nakagawa H.
- Journal Title
  
  EBioMedicine
  
  Volume: 53 Pages: 102659-102659
- DOI
  10.1016/j.ebiom.2020.102659
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10675, KAKENHI-PROJECT-18K19426, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-18H02680, KAKENHI-PROJECT-18H02696, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426, KAKENHI-PROJECT-18K19575, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-19K09206
[Journal Article] Incidence of microsatellite instability-high hepatocellular carcinoma among Japanese patients and response to pembrolizumab.2020
- Author(s)
  Kawaoka T, Ando Y, Yamauchi M, Suehiro Y, Yamaoka K, Kosaka Y, Fuji Y, Uchikawa S, Morio K, Fujino H, Nakahara T, Ono A, Murakami E, Takahashi S, Tsuge M, Hiramatsu A, Imamura M, Chayama K, Aikata H.
- Journal Title
  
  Hepatol Res.
  
  Volume: - Issue: 7 Pages: 885-888
- DOI
  10.1111/hepr.13496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426
[Journal Article] Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.2020
- Author(s)
  Cheng X, Uchida T, Xia Y, Umarova R, Liu CJ, Chen PJ, Gaggar A, Suri V, Mucke MM, Vermehren J, Zeuzem S, Teraoka Y, Osawa M, Aikata H, Tsuji K, Mori N, Hige S, Karino Y, Imamura M, Chayama K, Liang TJ.
- Journal Title
  
  J Clin Invest.
  
  Volume: - Issue: 6 Pages: 3205-3220
- DOI
  10.1172/jci135616
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426, KAKENHI-PROJECT-17K09427
[Journal Article] Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma.2020
- Author(s)
  Juhling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A, Roca Suarez AA, Goto K, Masia R, Sojoodi M, Arora G, Aikata H, Ono A, Tabrizian P, Schwartz M, Polyak SJ, Davidson I, Schmidl C, Chayama K, et al.
- Journal Title
  
  Gut.
  
  Volume: - Issue: 1 Pages: 157-169
- DOI
  10.1136/gutjnl-2019-318918
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Successful retreatment with 12 weeks of glecaprevir and pibrentasvir for a genotype 2a HCV-infected hemodialysis patient who failed to respond to 8 weeks of prior glecaprevir and pibrentasvir therapy.2020
- Author(s)
  Ohya K, Imamura M, Osawa M, Teraoka Y, Morio K, Fujino H, Ono A, Nakahara T, Murakami E, Yamauchi M, Kawaoka T, Hiramatsu A, Tsuge M, Aikata H, Hayes CN, Chayama K.
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: 13 Issue: 2 Pages: 267-270
- DOI
  10.1007/s12328-019-01039-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: The Phase IIa OMEGA-3 study.2020
- Author(s)
  Takehara T, Chayama K, Kurosaki M, Yatsuhashi H, Tanaka Y, Hiramatsu N, Sakamoto N, Asahina Y, Nozaki A, Nakano T, Hagiwara Y, Shimizu H, Yoshida H, Huang Y, Biermer M, Vijgen L, Hayashi N.
- Journal Title
  
  J Gastroenterol
  
  Volume: － Issue: 6 Pages: 640-652
- DOI
  10.1007/s00535-020-01672-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K19647
[Journal Article] Complete response to pembrolizumab in advanced hepatocellular carcinoma with microsatellite instability.2020
- Author(s)
  Ando Y, Yamauchi M, Suehiro Y, Yamaoka K, Kosaka Y, Fuji Y, Uchikawa S, Kodama K, Morio K, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Takahashi S, Tsuge M, Hiramatsu A, Imamura M, Chayama K, Aikata H.
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: - Issue: 5 Pages: 867-872
- DOI
  10.1007/s12328-020-01099-3
- NAID
  120007167205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes2019
- Author(s)
  Xue Ruidong、Chen Lu、Zhang Chong、Fujita Masashi et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 35 Issue: 6 Pages: 932-947
- DOI
  10.1016/j.ccell.2019.04.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09206, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-17H06269
[Journal Article] Comparative study on the replication of HCV1b genome between wild-type and cell culture-adaptive mutant in regard to sensitivities against anti-HCV drugs.2019
- Author(s)
  Miyayama Y, Lee H, Song H, Abe-Chayama H, Miki D, Imamura M, Chayama K, Hijikata M.
- Journal Title
  
  Microbiol Immunol.
  
  Volume: - Issue: 4 Pages: 296-303
- DOI
  10.1111/1348-0421.12768
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis.2019
- Author(s)
  Fujino H, Tanaka M, Imamura M, Morio K, Ono A, Nakahara T, Murakami E, Kawaoka T, Takahashi S, Miki D, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Chayama K.
- Journal Title
  
  BMC Gastroenterol.
  
  Volume: 19 Issue: 1 Pages: 169-169
- DOI
  10.1186/s12876-019-1092-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] Efficacy of a self-management program in patients with chronic viral hepatitis in China.2019
- Author(s)
  Cui Y, Moriyama M, Chayama K, Liu Y, Ya C, Muzembo BA, Rahman MM.
- Journal Title
  
  BMC Nurs.
  
  Volume: 18 Issue: 1 Pages: 44-44
- DOI
  10.1186/s12912-019-0366-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K19816
[Journal Article] Early changes in ammonia levels and liver function in patients with advanced hepatocellular carcinoma treated by lenvatinib therapy.2019
- Author(s)
  Ohya K, Kawaoka T, Namba M, Uchikawa S, Kodama K, Morio K, Nakahara T, Murakami E, Hiramatsu A, Tsuge M, Yamauchi M, Imamura M, Chayama K, Aikata H.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 12101-12101
- DOI
  10.1038/s41598-019-48045-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Percutaneous transvenous shunt occlusion for portosystemic encephalopathy due to lenvatinib administration to a patient with hepatocellular carcinoma and portosystemic shunt.2019
- Author(s)
  Namba M, Kawaoka T, Aikata H, Kodama K, Uchikawa S, Ohya K, Morio K, Fujino H, Nakahara T, Murakami E, Yamauchi M, Tsuge M, Hiramatsu A, Imamura M, Baba Y, Awai K, Chayama K.
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: 12 Issue: 4 Pages: 341-346
- DOI
  10.1007/s12328-019-00938-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.2019
- Author(s)
  Hamdane N, Juhling F, Crouchet E, El Saghire H, Thumann C, Oudot MA, Bandiera S, Saviano A, Ponsolles C, Roca Suarez AA, Li S, Fujiwara N, Ono A, Davidson I, Bardeesy N, Schmidl C, Bock C, Schuster C, Lupberger J, Habersetzer F, Doffoel M, Piardi T, Sommacale D, Imamura M, Chayama K. et al.
- Journal Title
  
  Gastroenterology.
  
  Volume: 156 Issue: 8 Pages: 2313-2329.e7
- DOI
  10.1053/j.gastro.2019.02.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] HOMA-IR: An independent predictor of advanced liver fibrosis in nondiabetic non-alcoholic fatty liver disease.2019
- Author(s)
  Fujii H, Yoneda M, et al.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: in press Issue: 8 Pages: 1-6
- DOI
  10.1111/jgh.14595
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07637, KAKENHI-PROJECT-17K15866, KAKENHI-PROJECT-17K09437, KAKENHI-PROJECT-19H03641, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09434
[Journal Article] Sinusoidal obstruction syndrome post-treatment with trastuzumab emtansine (T-DM1) in advanced breast cancer.2019
- Author(s)
  Fujii Y, Doi M, Tsukiyama N, Hattori Y, Ohya K, Shiroma N, Morio K, Morioka T, Aikata H, Shinozaki K, Chayama K.
- Journal Title
  
  Int Cancer Conf J.
  
  Volume: 9 Issue: 1 Pages: 18-23
- DOI
  10.1007/s13691-019-00392-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Reply: Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity -matched analysis in a single institution.2019
- Author(s)
  Nakano R, Ohira M, Kobayashi T, Ide K, Tahara H, Kuroda S, Shimizu S, Kimura T, Nagata Y, Aikata H, Chayama K, Ohdan H.
- Journal Title
  
  Surgery.
  
  Volume: 165 Issue: 5 Pages: 1054-1057
- DOI
  10.1016/j.surg.2018.10.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K10669
[Journal Article] Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis.2019
- Author(s)
  Yen CJ, Yang ST, Chen RY, Huang W, Chayama K, Lee MH, Yang SJ, Lai HS, Yen HY, Hsiao YW, Wang JM, Lin YJ, Hung LY.
- Journal Title
  
  J Biomed Sci.
  
  Volume: 26 Issue: 1 Pages: 44-44
- DOI
  10.1186/s12929-019-0534-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA2019
- Author(s)
  Mizuno Kei、Akamatsu Shusuke、Sumiyoshi Takayuki、Wong Jing Hao、Fujita Masashi et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 15017-15017
- DOI
  10.1038/s41598-019-51459-4
- NAID
  120006734882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09206, KAKENHI-PROJECT-18K19426, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-18H02680, KAKENHI-PROJECT-17H06269
[Journal Article] Clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis2019
- Author(s)
  Kodama Kazuhisa、Kawaguchi Takumi、Hyogo Hideyuki、Nakajima Tomoaki、Ono Masafumi、Sumida Yoshio、Kamada Yoshihiro、Fujii Hideki、Seko Yuya、Takehara Tetsuo、Itoh Yoshito、Nakajima Atsushi、Masaki Naohiko、Torimura Takuji、Saibara Toshiji、Karino Yoshiyasu、Chayama Kazuaki、Tokushige Katsutoshi
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: in press Issue: 9 Pages: 1626-1632
- DOI
  10.1111/jgh.14608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04810, KAKENHI-PROJECT-17H06269
[Journal Article] Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice2019
- Author(s)
  Tsushima K, Tsuge M, Hiraga N, Uchida T, Murakami E, Makokha GN, Kurihara M, Nomura Motonobu, Hiyama Y, Fujino H, Ono A, Nakahara T, Yamauchi M, Abe-Chayama H, Kawaoka T, Miki D, Imamura M, Aikata H, Hayes CN, Chayama K
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 印刷中 Issue: 7 Pages: 650-659
- DOI
  10.1007/s00535-019-01558-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07973, KAKENHI-PROJECT-17KK0194, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] The impact of interferon-free direct-acting antivirals on clinical outcome after curative treatment for hepatitis C virus-associated hepatocellular carcinoma: Comparison with interferon-based therapy.2019
- Author(s)
  Nagaoki Y, Imamura M, Nishida Y, Daijo K, Teraoka Y, Honda F, Nakamura Y, Morio K, Fujino H, Nakahara T, Kawaoka T, Tsuge M, Hiramatsu A, Kawakami Y, Miki D, Hiyama Y, Ochi H, Chayama K, Aikata H.
- Journal Title
  
  J Med Virol.
  
  Volume: 91 Issue: 4 Pages: 650-658
- DOI
  10.1002/jmv.25352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09446, KAKENHI-PROJECT-17H06269
[Journal Article] Ribavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy.2019
- Author(s)
  Saito Y, Imamura M, Uchida T, Osawa M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Serikawa M, Aikata H, Abe-Chayama H, Hayes CN, Chayama K.
- Journal Title
  
  J Med Virol.
  
  Volume: 92 Issue: 2 Pages: 210-218
- DOI
  10.1002/jmv.25602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP2019
- Author(s)
  Makokha Grace Naswa、Abe-Chayama Hiromi、Chowdhury Sajeda、Hayes C. Nelson、Tsuge Masataka、Yoshima Tadahiko、Ishida Yuji、Zhang Yizhou、Uchida Takuro、Tateno Chise、Akiyama Rie、Chayama Kazuaki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 8462-8462
- DOI
  10.1038/s41598-019-44934-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07973, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17KK0194
[Journal Article] Integrated analysis of 8-week glecaprevir/pibrentasvir in Japanese and overseas patients without cirrhosis and with hepatitis C virus genotype 1 or 2 infection.2019
- Author(s)
  Naganuma A, Chayama K, Notsumata K, Gane E, Foster GR, Wyles D, Kwo P, Crown E, Bhagat A, Mensa FJ, Otani T, Larsen L, Burroughs M, Kumada H.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 54 Issue: 8 Pages: 752-761
- DOI
  10.1007/s00535-019-01569-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Isolated cardiac metastases of hepatocellular carcinoma after resection: a case report.2019
- Author(s)
  Tamura Y, Kawaoka T, Aikata H, Namba M, Fujii Y, Morio K, Murakami E, Yamauchi M, Hiramatsu A, Nakahara T, Imamura M, Maruhashi T, Kobayashi T, Ohdan H, Kimura T, Nagata Y, Arihiro K, Chayama K.
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: - Issue: 3 Pages: 421-427
- DOI
  10.1007/s12328-019-01075-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus-Infected Cells and Liver to Identify Pathways Associated With Disease Development.2019
- Author(s)
  Lupberger J, Croonenborghs T, Roca Suarez AA, Van Renne N, Juhling F, Oudot MA, Virzi A, Bandiera S, Jamey C, Meszaros G, Brumaru D, Mukherji A, Durand SC, Heydmann L, Verrier ER, El Saghire H, Hamdane N, Bartenschlager R, Fereshetian S, Ramberger E, Sinha R, Nabian M, Chayama K. et al.
- Journal Title
  
  Gastroenterology.
  
  Volume: 157 Issue: 2 Pages: 537-551.e9
- DOI
  10.1053/j.gastro.2019.04.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Correlation between Early Tumor Marker Response and Imaging Response in Patients with Advanced Hepatocellular Carcinoma Treated with Lenvatinib.2019
- Author(s)
  Kodama K, Kawaoka T, Namba M, Uchikawa S, Ohya K, Morio K, Nakahara T, Murakami E, Yamauchi M, Hiramatsu A, Imamura M, Chayama K, Aikata H.
- Journal Title
  
  Oncology.
  
  Volume: 97 Issue: 2 Pages: 75-81
- DOI
  10.1159/000499715
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice.2019
- Author(s)
  Osawa M, Uchida T, Imamura M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Ishida Y, Tateno C, Miyayama Y, Hijikata M, Chayama K.
- Journal Title
  
  J Gen Virol.
  
  Volume: 100 Issue: 7 Pages: 1123-1131
- DOI
  10.1099/jgv.0.001268
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] Management of HCV patients in cases of direct-acting antiviral failure.2019
- Author(s)
  Hayes CN, Imamura M, Chayama K.
- Journal Title
  
  Expert Rev Gastroenterol Hepatol.
  
  Volume: 13 Issue: 9 Pages: 839-848
- DOI
  10.1080/17474124.2019.1651642
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] The Role of Lipids in Hepatocellular Carcinoma.2019
- Author(s)
  Hayes CN, Zhang P, Chayama K.
- Journal Title
  
  Hepatocellular Carcinoma.
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Real-world virological efficacy and safety of daclatasvir/asunaprevir/beclabuvir in patients with chronic hepatitis C virus genotype 1 infection in Japan.2019
- Author(s)
  Takaguchi K, Toyoda H, Tsutsui A, Suzuki Y, Nakamuta M, Imamura M, Senoh T, Nagano T, Tada T, Tachi Y, Hiraoka A, Michitaka K, Shibata H, Joko K, Okubo H, Tsuji K, Takaki S, Watanabe T, Ogawa C, Chayama K, Kumada T, Kudo M, Kumada H.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 54 Issue: 8 Pages: 742-751
- DOI
  10.1007/s00535-019-01568-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update.2019
- Author(s)
  Tateishi R, Uchino K, Fujiwara N, Takehara T, Okanoue T, Seike M, Yoshiji H, Yatsuhashi H, Shimizu M, Torimura T, Moriyama M, Sakaida I, Okada H, Chiba T, Chuma M, Nakao K, Isomoto H, Sasaki Y, Kaneko S, Masaki T, Chayama K, Koike K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 54 Issue: 4 Pages: 367-376
- DOI
  10.1007/s00535-018-1532-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-18K07945, KAKENHI-PROJECT-19K08465, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-18H02798
[Journal Article] Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.2018
- Author(s)
  Furuta M, Tanaka H, Shiraishi Y, Unida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H.
- Journal Title
  
  Oncotarget.
  
  Volume: 9 Issue: 38 Pages: 25075-25088
- DOI
  10.18632/oncotarget.25308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-16K15623
[Journal Article] Serial profiling of circulating tumor DNA for optimization of anti-VEGF chemotherapy in metastatic colorectal cancer patients.2018
- Author(s)
  Yamauchi M, Urabe Y, Ono A, Miki D, Ochi H, Chayama K.
- Journal Title
  
  Int J Cancer.
  
  Volume: 142 Issue: 7 Pages: 1418-1426
- DOI
  10.1002/ijc.31154
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.2018
- Author(s)
  Van Renne N, Roca Suarez AA, Duong FHT, Gondeau C, Calabrese D, Fontaine N, Ababsa A, Bandiera S, Croonenborghs T, Pochet N, De Blasi V, Pessaux P, Piardi T, Sommacale D, Ono A, Chayama K, Fujita M, Nakagawa H, Hoshida Y, Zeisel MB, Heim MH, Baumert TF, Lupberger J.
- Journal Title
  
  Gut.
  
  Volume: 67 Issue: 5 Pages: 953-962
- DOI
  10.1136/gutjnl-2016-312270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Genomic Characterization of Biliary Tract Cancers Identifies Driver Genes and Predisposing Mutations2018
- Author(s)
  Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T et al
- Journal Title
  
  J Hepatol
  
  Volume: - Issue: 5 Pages: 959-969
- DOI
  10.1016/j.jhep.2018.01.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08684, KAKENHI-PROJECT-15H04814, KAKENHI-PROJECT-17K10675, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-17H06269
[Journal Article] Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology.2017
- Author(s)
  Uchida T, Imamura M, Kan H, Hiraga N, Hayes CN, Tsuge M, Abe-Chayama H, Aikata H, Makokha GN, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K.
- Journal Title
  
  J Gen Virol.
  
  Volume: 印刷中 Issue: 5 Pages: 1040-1047
- DOI
  10.1099/jgv.0.000726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-17K09427, KAKENHI-PROJECT-15K09002
[Journal Article] Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer2017
- Author(s)
  Yuge R, Kitadai Y, Takigawa H, Naito T, Oue N, Yasui W, Tanaka S, Chayama K
- Journal Title
  
  Transl Oncol
  
  Volume: 11 Issue: 3 Pages: 575-584
- DOI
  10.1016/j.tranon.2018.02.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04713, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-18K07016
[Journal Article] Development of a novel site-specific pegylated interferon beta for antiviral therapy for chronic hepatitis B.2017
- Author(s)
  Tsuge M, Uchida T, Hiraga N, Kan H, Makokha GN, Abe-Chayama H, Miki D, Imamura M, Ochi H, Hayes CN, Shimozono R, Iwamura T, Narumi H, Suzuki T, Kainoh M, Taniguchi T, Chayama K.
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 印刷中 Issue: 6 Pages: 61-61
- DOI
  10.1128/aac.00183-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15K09002
[Journal Article] Mesenchymal Stem Cells Induce Epithelial to Mesenchymal Transition in Colon Cancer Cells through Direct Cell-to-Cell Contact.2017
- Author(s)
  Takigawa H, Kitadai Y, Shinagawa K, Yuge R, Higashi Y, Tanaka S, Yasui W, Chayama K.
- Journal Title
  
  Neoplasia.
  
  Volume: 19 Issue: 5 Pages: 429-438
- DOI
  10.1016/j.neo.2017.02.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus.2017
- Author(s)
  Miyaki E, Hiraga N, Imamura M, Uchida T, Kan H, Tsuge M, Abe-Chayama H, Hayes CN, Makokha GN, Serikawa M, Aikata H, Ochi H, Ishida Y, Tateno C, Ohdan H, Chayama K.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 3 Pages: e0172412-e0172412
- DOI
  10.1371/journal.pone.0172412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796
[Journal Article] Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus.2016
- Author(s)
  Sakuma T, Masaki K, Abe-Chayama H, Mochida K, Yamamoto T, Chayama K.
- Journal Title
  
  Genes Cells.
  
  Volume: 21 Issue: 11 Pages: 1253-1262
- DOI
  10.1111/gtc.12437
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-16K18478
[Journal Article] Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice.2016
- Author(s)
  Uchida T, Hiraga N, Imamura M, Yoshimi S, Kan H, Miyaki E, Tsuge M, Abe H, Hayes CN, Aikata H, Ishida Y, Tateno C, Ellis JD, Chayama K.
- Journal Title
  
  Virus Res.
  
  Volume: 213 Issue: 1 Pages: 62-68
- DOI
  10.1016/j.jinf.2015.09.038
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-15K09002
[Journal Article] Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection.2016
- Author(s)
  Tsuge M, Hiraga N, Uchida T, Kan H, Miyaki E, Masaki K, Ono A, Nakahara T, Abe-Chayama H, Zhang Y, Naswa MG, Kawaoka T, Miki D, Imamura M, Kawakami Y, Aikata H, Ochi H, Hayes CN, Chayama K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 51 Pages: 1073-1080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796
[Journal Article] Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice.2015
- Author(s)
  Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C.
- Journal Title
  
  Am J Pathol.
  
  Volume: 185 Issue: 5 Pages: 1275-1285
- DOI
  10.1016/j.ajpath.2015.01.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747
[Journal Article] Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay2015
- Author(s)
  Satoshi Yoshimi, Hidenori Ochi, Eisuke Murakami, Takuro Uchida, Hiromi Kan, Sakura Akamatsu, C. Nelson Hayes, Hiromi Abe, Daiki Miki, Nobuhiko Hiraga, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama.
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 6 Pages: e0130022-e0130022
- DOI
  10.1371/journal.pone.0130022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09004, KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26860536
[Journal Article] Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.2015
- Author(s)
  Akamatsu S, Hayes CN, Ochi H, Uchida T, Kan H, Murakami E, Abe H, Tsuge M, Miki D, Akiyama R, Hiraga N, Imamura M, Aikata H, Kawaoka T, Kawakami Y, Chayama K.
- Journal Title
  
  J Hepatol.
  
  Volume: 63 Issue: 3 Pages: 554-563
- DOI
  10.1016/j.jhep.2015.03.033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26860536
[Journal Article] The effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway.2015
- Author(s)
  Honda Y, Takahashi S, Zhang Y, Ono A, Murakami E, Shi N, Kawaoka T, Miki D, Tsuge M, Hiraga N, Abe H, Ochi H, Imamura M, Aikata H, Chayama K.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 30 Issue: 3 Pages: 619-627
- DOI
  10.1111/jgh.12715
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-26860191
[Journal Article] Differences in serum microRNA profiles in hepatitis B and C virus infection.2015
- Author(s)
  Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K.
- Journal Title
  
  J Infect.
  
  Volume: 70 Issue: 3 Pages: 273-287
- DOI
  10.1016/j.jinf.2014.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-15K09002
[Journal Article] Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy.2015
- Author(s)
  Yoshimi S, Imamura M, Murakami E, Hiraga N, Tsuge M, Kawakami Y, Aikata H, Abe H, Hayes CN, Sasaki T, Ochi H, Chayama K.
- Journal Title
  
  J Med Virol.
  
  Volume: 87 Issue: 11 Pages: 1913-1920
- DOI
  10.1002/jmv.24255
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26461008
[Journal Article] Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice.2015
- Author(s)
  Uchida T., Hiraga N., Imamura M., Tsuge M., Abe H., Hayes C.N., Aikata H., Ishida Y., Tateno C., Yoshizato K., Ohdan H., Murakami K. and Chayama K.
- Journal Title
  
  Journal of Virology
  
  Volume: 89 Issue: 19 Pages: 10087-96
- DOI
  10.1128/jvi.01126-15
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09002, KAKENHI-PROJECT-15K09003, KAKENHI-PROJECT-26420796
[Journal Article] Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1.2014
- Author(s)
  Kosaka K, Imamura M, Hayes CN, Abe H, Hiraga N, Yoshimi S, Murakami E, Kawaoka T, Tsuge M, Aikata H, Miki D, Ochi H, Matsui H, Kanai A, Inaba T, Chayama K.
- Journal Title
  
  J Viral Hepat.
  
  Volume: 22 Issue: 2 Pages: 158-165
- DOI
  10.1111/jvh.12271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-26860536
[Journal Article] Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA.2014
- Author(s)
  Kohno T, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Hayes CN, Chayama K.
- Journal Title
  
  J Viral Hepat.
  
  Volume: 21 Issue: 4 Pages: 369-375
- DOI
  10.3851/imp2777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-15K09002
[Journal Article] New insight into the enhanced effect of pegylated interferon-α.2014
- Author(s)
  Abe H, Hayes CN, Chayama K.
- Journal Title
  
  Hepatology.
  
  Volume: 60 Issue: 4 Pages: 1435-1437
- DOI
  10.1002/hep.27269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26670383
[Journal Article] Ribavirin dose reduction during telaprevir/ribavirin/peg-interferon therapy overcomes the effect of the ITPA gene polymorphism.2014
- Author(s)
  Akamatsu S, Hayes CN, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Chayama K; Hiroshima Liver Study Group.
- Journal Title
  
  J Viral Hepat.
  
  Volume: 22 Issue: 2 Pages: 166-174
- DOI
  10.1111/jvh.12275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26860536
[Journal Article] Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin2014
- Author(s)
  Murakami, E. Imamura, M. Hayes, C. N. Abe, H. Hiraga, N. Honda, Y. Ono, A. Kosaka, K. Kawaoka, T. Tsuge, M. Aikata, H. Takahashi, S. Miki, D. Ochi, H. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Chayama, K.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 58 Issue: 4 Pages: 2105-2112
- DOI
  10.1128/aac.02068-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
[Journal Article] A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing2013
- Author(s)
  Abe H, Hayes CN, Hiraga N, Imamura M, Tsuge M, Miki D, Takahashi S, Ochi H, Chayama K
- Journal Title
  
  Am J Gastroenterol
  
  Volume: 108 Issue: 9 Pages: 1464-1472
- DOI
  10.1038/ajg.2013.205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702
[Journal Article] HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study.2013
- Author(s)
  Miki D, Ochi H, Takahashi A, Hayes CN, Urabe Y, Abe H, Kawaoka T, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Akuta N, Suzuki F, Ikeda K, Kumada H, Karino Y, Toyota J, Tsunoda T, Kubo M, Kamatani N, Nakamura Y, Chayama K.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 12 Pages: e84226-e84226
- DOI
  10.1371/journal.pone.0084226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-25670369
[Journal Article] A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing.2013
- Author(s)
  Abe H, Hayes CN, Hiraga N, Imamura M, Tsuge M, Miki D, Takahashi S, Ochi H, Chayama K.
- Journal Title
  
  Am J Gastroenterol.
  
  Volume: 108 Issue: 7 Pages: 1464-1472
- DOI
  10.1038/ajg.2013.20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790701
[Journal Article] Changes in mRNA expression of hypothalamic appetite-regulating peptides during different phases of lactation in rats2013
- Author(s)
  Suzuki Y,Nakahara K, Maruyama K, Okame R, Ensho T, Inoue Y,Murakami N.
- Journal Title
  
  J Mol Endocrinol
  
  Volume: 52 Issue: 1 Pages: 97-109
- DOI
  10.1016/j.bbrc.2013.10.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380173, KAKENHI-PROJECT-24658247, KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-24791023, KAKENHI-PROJECT-25670369
[Journal Article] Severe necroinflammatory reaction caused by natural killer by Fas/ FasL interaction and dendritic cells in human hepatocyte chimeric mouse2012
- Author(s)
  Okazaki A, Hiraga N, Imamura M, NelsonHayes C, Tsuge M, Takahashi S, AikataH, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K
- Journal Title
  
  Hepatology
  
  Volume: (in press) Issue: 2 Pages: 25651-25651
- DOI
  10.1002/hep.25651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-24659368, KAKENHI-PROJECT-24791023
[Journal Article] Severe Necroinflammatory Reaction Caused by Natural Killer By Fas/ FasLInteraction and Dendritic Cells in Human Hepatocyte Chimeric Mouse2012
- Author(s)
  Okazaki A, Hiraga N, Imamura M, Hayes CN, Tsuge M, Takahashi S, Aikata H, Abe H, Miki D, Ochi H, TatenoC, Yoshizato K, Ohdan H, Chayama K
- Journal Title
  
  Hepatology. In press
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] IL28B polymorphism is associated with fatty change in the liver of chronichepatitis 1 C patients2012
- Author(s)
  Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, Takahashi S, Ochi H, Hayes CN, Tanaka S, Arihiro K, Chayama K
- Journal Title
  
  J Gastroenterol. In press
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Toward the establishment of a prediction system for the personalized treatment of chronic hepatitis C2012
- Author(s)
  Ochi H, Hayes CN, Abe H, Hayashida Y, Uchiyama T, Kamatani N, Nakamura Y, Chayama K
- Journal Title
  
  J Infect Dis
  
  Volume: 205 Pages: 204-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-al pha-2b plus ribavirin therapy in chronic hepatitis C virus infection2012
- Author(s)
  Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, Kamatani N, Nakamura Y, Chayama K
- Journal Title
  
  J Viral Hepat
  
  Volume: 19 Issue: 2 Pages: 126-133
- DOI
  10.1111/j.1365-2893.2011.01516.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-23590840, KAKENHI-PROJECT-24659368
[Journal Article] Toward the establishment of aprediction system for the personalized treatment of chronic hepatitis C2012
- Author(s)
  Ochi H, Hayes CN, Abe H, Hayashida Y, Uchiyama T, Kamatani N, Nakamura Y, Chayama K
- Journal Title
  
  J Infect Dis
  
  Volume: 205 Pages: 204-210
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis 1 C patients2012
- Author(s)
  Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, Takahashi S, Ochi H, Hayes CN, Tanaka S, Arihiro K, Chayama K
- Journal Title
  
  J Gastroenterol
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-α-2bplus ribavirin therapy in chronichepatitis C virus infection2012
- Author(s)
  Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, KamataniN, Nakamura Y, Chayama K
- Journal Title
  
  J Viral Hepat
  
  Volume: 19 Pages: 126-133
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Rapidemergence of telaprevir resistanthepatitis C virus strain from wildtypeclone in vivo2011
- Author(s)
  Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, TakahashiS, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, KanaiA, Inaba T, Tanaka S, Chayama K
- Journal Title
  
  Hepatology
  
  Volume: 54 Issue: 3 Pages: 781-788
- DOI
  10.1002/hep.24460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22118005, KAKENHI-PROJECT-22590737, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22659181, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-22790912, KAKENHI-PROJECT-23390253
[Journal Article] HCV substitutions and IL28B polymor phisms on out come of peg-interferon plus ribavirin combination the rapy2011
- Author(s)
  Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K
- Journal Title
  
  Gut
  
  Volume: 60 Pages: 261-267
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers2011
- Author(s)
  Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N, Chayama K
- Journal Title
  
  Nat Genet
  
  Volume: 43 Issue: 8 Pages: 797-800
- DOI
  10.1038/ng.876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22116010, KAKENHI-PLANNED-22134008, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-221S0001
[Journal Article] Animal model for study of human hepatitis viruses2011
- Author(s)
  Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M, Imamura M
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 26 Pages: 13-18
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients2011
- Author(s)
  Fujimoto Y, Ochi H, Maekawa T, Abe H, Hayes CN, Kumada H, Nakamura Y, Chayama K
- Journal Title
  
  J Hepatol
  
  Volume: 54 Pages: 629-639
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Effects of hepatitis B virus in fection on the interferon response in immunodeficient human hepatocyte chimeric mice2011
- Author(s)
  Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, HayesCN, Chayama K
- Journal Title
  
  J Infect Dis
  
  Volume: 204 Pages: 224-228
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy2011
- Author(s)
  Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N, Chayama K
- Journal Title
  
  J Med Virol
  
  Volume: 83 Issue: 6 Pages: 1048-1057
- DOI
  10.1002/jmv.22069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646
[Journal Article] HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.2011
- Author(s)
  Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K.
- Journal Title
  
  Gut.
  
  Volume: 60(2) Pages: 261-267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Amino acid substitutions in core and NS5A regions of the HCV genome canpredict virological decrease withpegylated interferon plus ribavirin therapy2011
- Author(s)
  Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN, Chayama K
- Journal Title
  
  Antivir Ther
  
  Volume: 15 Pages: 1087-1097
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Risk Locus in a Japanese Population2011
- Author(s)
  Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y, Matsuda K
- Journal Title
  
  Hum Mol Genet
  
  Volume: 20 Pages: 3884-3892
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Rapid emergence of telaprevir resistant hepatitis C virus strain fromwild type clone in vivo2011
- Author(s)
  Hiraga N, Imamura M, Abe H, NelsonHayes C, Kono T, Onishi M, Tsuge M, Takahashi S, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, MatsuiH, Kanai A, Inaba T, Tanaka S, Chayama K
- Journal Title
  
  Hepatology
  
  Volume: 54 Pages: 781-788
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] ME3738 enhances the effect of interferon and inhibits hepatitis C virusreplication both in vitro and in vivo2011
- Author(s)
  Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, OchiH, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K
- Journal Title
  
  J Hepatol
  
  Volume: 55 Pages: 11-18
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] IL28B But Not ITPA Polymorphism Is Predictive of Response to Pegylated Interferon, Ribavirin, and Telaprevir Triple Therapy in Patients With Genotype 1 Hepatitis C2011
- Author(s)
  Chayama K, Hayes CN, Abe H, Miki D, Ochi H, Karino Y, Toyota J, Nakamura Y, Kamatani N, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H
- Journal Title
  
  J Infect Dis
  
  Volume: 204 Pages: 84-93
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state2011
- Author(s)
  Abe H, Hayes CN, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
- Journal Title
  
  J Med Virol
  
  Volume: 83 Issue: 9 Pages: 1597-1607
- DOI
  10.1002/jmv.22158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646
[Journal Article] Hepatitis C virus in fection suppresses the interferon response in the liver of thehuman hepatocyte chimeric mouse2011
- Author(s)
  Tsuge M, Fujimoto Y, Hiraga N, Zhang Y, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, HayesCN, Miya F, Tsunoda T, Chayama K
- Journal Title
  
  PLoS One
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] IL-28B predicts response to chronichepatitis C therapy-fine-mapping andreplication study in Asian populations2011
- Author(s)
  Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, KuboM, Tsunoda T, Kumada H, Nakamura Y, Hayes CN, Chayama K
- Journal Title
  
  J Gen Virol
  
  Volume: 92 Pages: 1091-1081
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Predictive value of the IL28 Bpolymorphism on the effect of interferontherapy in chronic hepatitis C patientswith genotypes 2a and 2b2011
- Author(s)
  Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K
- Journal Title
  
  J Hepatol
  
  Volume: 54 Pages: 408-414
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Common genetic polymorphism of ITPA gene affects ribavirin-inducedanemia and effect of peg-interferon plusribavirin therapy2011
- Author(s)
  Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N, Chayama K
- Journal Title
  
  J Med. Virol
  
  Volume: 83 Pages: 1048-1057
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice2011
- Author(s)
  Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K
- Journal Title
  
  J Infect Dis
  
  Volume: 204 Pages: 224-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Inverse association of IL28 Bgenotype and liver mRNA expression of genes promoting or suppressing antiviralstate2011
- Author(s)
  Abe H, Hayes C. N, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
- Journal Title
  
  J Med. Virol
  
  Volume: 83 Pages: 1597-1607
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers2011
- Author(s)
  Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N, Chayama KMiki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, M, Nakamura Y, Kamatani N, Chayama K
- Journal Title
  
  Nat Genet
  
  Volume: 43 Pages: 797-800
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Eisk Locus in a Japanese Population2011
- Author(s)
  Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y, Matsuda K
- Journal Title
  
  Hum Mol Genet
  
  Volume: 20 Pages: 3884-3892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b2011
- Author(s)
  Hashimoto Y, Ochi H, Abe H, Hayashida Y, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson Hayes C, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y, Chayama K
- Journal Title
  
  J Med Virol
  
  Volume: 83 Issue: 6 Pages: 981-988
- DOI
  10.1002/jmv.22028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646
[Journal Article] IL-28B predicts response to chronic hepatitis C therapy-fine-mapping and replication study in Asian populations2011
- Author(s)
  Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, Kubo M, Tsunoda T, Kumada H, Nakamura Y, Hayes CN, Chayama K
- Journal Title
  
  J Gen Virol
  
  Volume: 92 Pages: 1071-1081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infectedwith hepatitis C virus genotype 1b2011
- Author(s)
  Hashimoto Y, Ochi H, Abe H, HayashidaY, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson HayesC, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y, Chayama K
- Journal Title
  
  J Med. Virol
  
  Volume: 83 Pages: 981-988
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] IL28 variation affects expression of interferon stimulated genes andpeg-interferon and ribavirin therapy2011
- Author(s)
  Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Chayama K
- Journal Title
  
  J Hepatol
  
  Volume: 54 Pages: 1094-1101
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis Cvirus2011
- Author(s)
  Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, TatenoC, Yoshizato K, Nakamura Y, KamataniN, Chayama K
- Journal Title
  
  Hepatology
  
  Volume: 54 Pages: 764-771
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Impact of viral aminoacid substitutions and hostinterleukin-28b polymorphism on replication and susceptibility tointerferon of hepatitis C virus2011
- Author(s)
  Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, TatenoC, Yoshizato K, Nakamura Y, KamataniN, Chayama K
- Journal Title
  
  Hepatology
  
  Volume: 54 Issue: 3 Pages: 764-711
- DOI
  10.1002/hep.24453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646
[Journal Article] Elimination of hepatitis C virus byshort term NS3-4A and NS5B inhibitorcombination the rapy in human hepatocyte chimeric mice2011
- Author(s)
  Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, Tsuge M, Takahashi S, Abe H, Hayes CN, Ochi H, Tateno C, Yoshizato K, Tanaka S, Chayama K
- Journal Title
  
  J Hepatol
  
  Volume: 54 Pages: 872-878
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Animal model for study of human hepatitis viruses.2011
- Author(s)
  Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M, Imamura M.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 26(1) Pages: 13-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse2011
- Author(s)
  Tsuge M, Fujimoto Y, Hiraga N, Zhang Y, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, Hayes CN, Miya F, Tsunoda T, Chayama K
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study of Japanese HCV virus patients.2010
- Author(s)
  Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K.
- Journal Title
  
  Gastroenterology
  
  Volume: 139(4) Pages: 1190-1197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Differential effects of interferon and lamivudine on serum HBV RNAinhibition in patients with chronichepatitisB2010
- Author(s)
  Huang YW, Chayama K, Tsuge M, Takahashi S, Hatakeyama T, Abe H, HuJT, Liu CJ, Lai MY, Chen DS, Yang SS, Kao JH
- Journal Title
  
  Antivir Ther
  
  Volume: 15 Pages: 177-184
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] G to A hypermutation of TT virus2010
- Author(s)
  Tsuge M, Noguchi C, Akiyama R, Matsushita M, Kunihiro K, Tanaka S, Abe H, Mitsui F, Kitamura S, Hatakeyama T, Kimura T, Miki D, Hiraga N, Imamura M, Takahashi S, Hayses CN, Chayama K.
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy.2010
- Author(s)
  Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN, Chayama K.
- Journal Title
  
  Antivir Ther.
  
  Volume: 15(8) Pages: 1087-1097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitisC virus patients2010
- Author(s)
  Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K
- Journal Title
  
  J Hepatol
  
  Volume: 53 Pages: 439-443
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] HBx protein is in dispensable for development of viraemia in humanhepatocyte chimeric mice2010
- Author(s)
  Tsuge M, Hiraga N, Akiyama R, TanakaS, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, TakahashiS, Hayes CN, Chayama K
- Journal Title
  
  J Gen Virol
  
  Volume: 91 Pages: 1854-1864
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Importance of serum concentration of adefovir for Lamivudine-adefovircombination therapy in patients withlamivudine-resistant chronic hepatitis2010
- Author(s)
  B. Mitsui F, Tsuge M, Kimura T, KitamuraS, Abe H, Saneto H, Kawaoka T, Miki D, Hatakeyama T, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Hayes CN, Igarashi H, Morimoto K, Shimizu M, Chayama K
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 54 Pages: 3205-3211
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.2010
- Author(s)
  Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K.
- Journal Title
  
  J Hepatol.
  
  Volume: 54(3) Pages: 408-414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] ITPA polymorphism affectsribavirin-induced anemia and outcomes of the rapy-a genome-wide study ofJapanese HCV virus patients2010
- Author(s)
  Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, HayesCN, Kumada H, Nakamura Y, Chayama K
- Journal Title
  
  Gastroenterology
  
  Volume: 139 Pages: 1190-1197
- Data Source
  KAKENHI-PROJECT-22790646
[Journal Article] Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.2010
- Author(s)
  Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K
- Journal Title
  
  J Hepatol.
  
  Volume: 53(3) Pages: 439-443
- NAID
  120002577227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790646
[Patent] Ｂ型肝炎治療用核酸分子2019
- Inventor(s)
  茶山一彰/吉間忠彦/水谷隆之
- Industrial Property Rights Holder
  茶山一彰/吉間忠彦/水谷隆之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-514692
- Filing Date
  2019
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-17H06269
[Presentation] Detection and functional analysis of HBV-specific stem cell memory T cells (Tscm)2023
- Author(s)
  茶山弘美
- Organizer
  EASL Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07984
[Presentation] Detection and functional analysis of HBV specific stem cell memory T cells (Tscm)2022
- Author(s)
  茶山弘美
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07984
[Presentation] ウイルス性肝炎研究の進歩と今後の課題2019
- Author(s)
  茶山一彰
- Organizer
  第23回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-17H06269
[Presentation] HCV治療の今後の展望-ウイルス性肝炎撲滅を目指した最新治療2019
- Author(s)
  茶山一彰
- Organizer
  第20回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-17H06269
[Presentation] 最新のC型肝炎、肝硬変の治療2019
- Author(s)
  茶山一彰
- Organizer
  第33回日本臨床内科医学会
- Data Source
  KAKENHI-PROJECT-17H06269
[Presentation] 肝硬変診療の課題2019
- Author(s)
  茶山一彰
- Organizer
  日本消化器関連学会機構（JDDW）2019
- Data Source
  KAKENHI-PROJECT-17H06269
[Presentation] HCV治療の今後の展望-ウイルス性肝炎撲滅を目指した最新治療2019
- Author(s)
  茶山一彰
- Organizer
  第45回日本急性肝不全研究会
- Data Source
  KAKENHI-PROJECT-17H06269
[Presentation] Malignant potential of early-stage serrated adenocarcinoma based on genetic analysis2018
- Author(s)
  Urabe Y, Tanaka S, Hirano D, Nakamura K, Ninomiya Y, Yuge R, Hayashi R, Oka S, Kitadai Y, Shimamoto F, Arihiro K, Chayama K
- Organizer
  26th United European Gastroenterology Week (UEGW) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269
[Presentation] Analysis of the effect on HBV by genome editing using CRISPR/Cas9 system2016
- Author(s)
  Keiichi Masaki, Hiromi Abe, Tetsushi Sakuma, Masataka Tsuge, Michio Imamura, Nelson Hayes, Hiroshi Aikata, Takashi Yamamoto, Kazuaki Chayama
- Organizer
  AASLD2016
- Place of Presentation
  アメリカ・ボストン
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26420796
[Presentation] Analysis of the effect on HBV life cycle by HBV genome editing using two different CRISPR/Cas9 systems.2015
- Author(s)
  Abe H, Masaki K, Sakuma T, Tsuge M, Hiraga N, Imamura M, Hayes CN, Aikata H, Yamamoto T, Chayama K.
- Organizer
  The 66th AASLD Annual Meeting
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26420796
[Presentation] ヒト肝細胞キメラマウスと次世代シーケンサーを用いた新規抗ウイルス薬に対するHCVゲノムの解析2013
- Author(s)
  阿部弘美 , C. Nelson Hayes,平賀伸彦 ,今村道雄 ,柘植雅貴 ,三木大樹 3,山田一麿呂,高橋祥一 ,越智秀典 ,茶山一彰
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京(口頭発表)
- Data Source
  KAKENHI-PROJECT-24790701
[Presentation] Expression levels of IFNL4 and other IFN.s are determined by dinucleotide polymorphism of IFNL4 and correlate with basal expression levels of interferon stimulated genes and effect of interferon2013
- Author(s)
  Abe H. Hayes CN, Hiraga N, Imamura M, Miki D, Tsuge M, Ochi H, Chayama K
- Organizer
  The 64th AASLD Annual Meeting
- Place of Presentation
  Washington DC, USA(Oral)
- Data Source
  KAKENHI-PROJECT-24790701
[Presentation] Expression levels of IFNL4 and other IFN-λs are determined by dinucleotide polymorphism of IFNL4 and correlate with basal expression levels of interferon stimulated genes and effect of interferon2013
- Author(s)
  Abe H. Hayes CN, Hiraga N, Imamura M, Miki D, Tsuge M, Ochi H, Chayama K
- Organizer
  The 64th AASLD Annual Meeting
- Place of Presentation
  アメリカ（ボストン）
- Data Source
  KAKENHI-PROJECT-24790701
[Presentation] ヒト肝細胞キメラマウスと次世代シーケンサーを用いた新規抗ウイルス薬に対するHCVゲノムの解析2013
- Author(s)
  阿部弘美, C. Nelson Hayes,　平賀伸彦, 今村道雄, 柘植雅貴, 三木大樹, 山田一麿呂, 高橋祥一, 越智秀典, 茶山一彰
- Organizer
  日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790701
[Presentation] Analysis of HCV genomes against direct-acting antiviral agents using human hepatocyte chimeric mice and ultra-deep sequencing2012
- Author(s)
  阿部弘美、平賀伸彦、今村道雄、Hayes CN、三木大樹、柘植雅貴、高橋祥一、越智秀典、茶山一彰
- Organizer
  AASLD Annual Meeting 2012
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24790701
[Presentation] Pretreatment of hepatomacell lines with IL28B delaysinterferon-induced ISG expression, whereas pretreatment with neutralizingan tibodies against IL28B reduces ISG expression levels2011
- Author(s)
  Abe H. et al
- Organizer
  46th Annual Meeting ofEuropean Association for the Study of theLiver(EASL)
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] IL28Bの遺伝子多型とその他の調節機構による抗ウイルス遺伝子と抑制性遺伝子の間の反対方向の調節2011
- Author(s)
  阿部弘美, C.Nelson Hayes, 越智秀典, 三木大樹, 柘植雅貴, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] IL28Bの遺伝子多型とその他の調節機構による抗ウイルス遺伝子と抑制性遺伝子の間の反対方向の調節2011
- Author(s)
  阿部弘美
- Organizer
  日本肝臓学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] Analysis of expression levels of interferon stimulated genes by IL28B genotypes in human hepatocyte chimeric mice during interferon alpha treatment against hepatitis C virus infection2011
- Author(s)
  Hiromi Abe, Nobuhiko Hiraga, Michio Imamura, C.Nelson Hayes, Daiki Miki, Masataka Tsuge, Shoichi Takahashi, Hidenori Ochi, Kazuaki Chayama
- Organizer
  AASLD Annual Meeting
- Place of Presentation
  アメリカ(サンフランシスコ)
- Year and Date
  2011-11-02
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] Reciprocal control of interferon stimulated gene mRNAs between positive anti-viral effecter and negative regulator by IL28B gene polymorphism and by another regulatory mechanism.2010
- Author(s)
  阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, C.Nelson Hayes, 茶山一彰
- Organizer
  2010 AASLD Annual Meeting
- Place of Presentation
  アメリカ(ボストン)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] IL28の多型とC型慢性肝炎の炎症、線維化、γGTPとの関連2010
- Author(s)
  阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形市
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] Different regulation of expression levels of interferon stimulated genes (ISGs) in peripheral blood versus liver by IL28B polymorphisms and influence on biochemical data and inflammation of the liver.2010
- Author(s)
  阿部弘美, C.Nelson Hayes, 越智秀典, 三木大樹, 柘植雅貴, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
- Organizer
  2010 HCV 2010 17^<th> International Meeting on Hepatitis C Virus and Related Viruses
- Place of Presentation
  横浜市
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] Reciprocal control of interferon stimulated gene mRNAs betweenpositive anti-viral effecter and negativeregulator by IL28B gene polymorphism andby another regulatory mechanism2010
- Author(s)
  Abe H. et al
- Organizer
  AASLDAnnual Meeting
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] C型慢性肝炎患者に対するPegIFN/RBV療法の治療効果とIL28 locusのSNPおよび肝内IFN誘導遺伝子発現量の関連2010
- Author(s)
  阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形市
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22790646
[Presentation] HCV感染におけるIFNL4の多型の違いによるIFN-λsの発現量とインターフェロン投与前後のインターフェロン誘導遺伝子の発現量の関係
- Author(s)
  阿部弘美, 三木大樹, 平賀伸彦, 今村道雄, 柘植雅貴, 小林知樹, 河岡友和, 川上由育, 相方浩, 越智秀典, 茶山一彰
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26420796

1. Chayama Kazuaki (00211376)

# of Collaborated Projects: 2 results

# of Collaborated Products: 50 results
2. 三木大樹 (10584592)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 林亮平 (80772053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Hayes C.Nelson (50572327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YONEDA Masato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. Ono Masafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. Sumida Yoshio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. Hyogo Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. UENO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. ASAHINA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. HATANAKA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 藤田征志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 大上直秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 安井弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 越智秀典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 日野啓輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 山上裕機

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 鎌田佳宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 柘植雅貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. 速水晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 千葉哲博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 三橋智子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 中原桂子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chayama Hiromi 茶山 弘美

茶山 弘美 チャヤマ ヒロミ

ABE Hiromi 阿部 弘美

Research Projects

Research Products

Co-Researchers

HBV持続感染完治を目指すTscm細胞の動的変化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

B型肝炎ウイルス持続感染の完治を目指すHBV特異的Tscmを用いた新規治療の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of NASH using human hepatocyte chimeric mouse and biopsy specimen

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of highly safe gene therapy without usage of double stranded DNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel animal models for hereditary diseases using human hepatocytes transplanted chimeric mice and vaculovirusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of hepatitis virus genomes using human hepatocytes transplanted chimeric mice and ultra-deep sequencing.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the relationship between IL28B SNP and HCV genomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肝原発平滑筋肉腫の一例2019

Author(s)

Publisher

Data Source

[Journal Article] Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preoperative PET-CT is useful for predicting recurrent extrahepatic metastasis of hepatocellular carcinoma after resection.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials.2020

Author(s)

Chayama Hiromi 茶山弘美

茶山弘美チャヤマヒロミ

ABE Hiromi 阿部弘美