Yamashita Kazunari 山下和成

Researcher Number	70589481
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2024 – 2025: 順天堂大学, 医学部, 助教 2020 – 2022: 順天堂大学, 医学部, 助教 2017 – 2019: 東北大学, 生命科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 44010:Cell biology-related / General anatomy (including histology/embryology) Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator EGFRシグナル / 細胞可塑性 / 浸潤 / 食道扁平上皮癌 / がん関連線維芽細胞 / ストレス応答 / 炎症 / 炎症性サイトカイン / 転写因子 / 癌微小環境 … More / 乳癌 / 癌関連線維芽細胞 / 細胞生物学 / アクチン骨格制御 / メカノバイオロジー / メカノセンシング / RhoA-GEF / Solo / 解剖学 / 細胞・組織 / シグナル伝達 / クラスタリング / ASPP2 / PAR-3 / 上皮細胞 / 細胞極性 … More Except Principal Investigator 線維芽細胞 / 乳癌 Less

癌内線維芽細胞が誘導する食道癌細胞の集団浸潤と未分化転換を司る分子機序の解明Principal Investigator
- Principal Investigator
  
  山下和成
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Juntendo University
Development of a novel breast cancer treatment method by specifically suppressing the proliferation of intracancerous fibroblasts
- Principal Investigator
  
  折茂彰
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
炎症性がん関連線維芽細胞に必須な新規転写因子の同定とその機能解析Principal Investigator
- Principal Investigator
  
  山下和成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Juntendo University
The actin-regulatory manner of Solo, a Rho-GEF involved in mechanosensing.Principal Investigator
- Principal Investigator
  
  Yamashita Kazunari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Juntendo University
  Tohoku University
Identification of the novel cell polarity-regulating signal cascadePrincipal Investigator
- Principal Investigator
  
  Yamashita Kazunari
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Tohoku University

All 2022 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell?cell junction formation2020
- Author(s)
  Ninomiya Komaki、Ohta Kai、Yamashita Kazunari、Mizuno Kensaku、Ohashi Kazumasa
- Journal Title
  
  Journal of Cell Science
  
  Volume: 134 Issue: 2
- DOI
  10.1242/jcs.249078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03248, KAKENHI-PROJECT-20J12425, KAKENHI-PROJECT-19K06652
[Journal Article] The Rho-guanine nucleotide exchange factor Solo decelerates collective cell migration by modulating the Rho-ROCK pathway and keratin networks.2020
- Author(s)
  Isozaki, Y., Sakai, K., Kohiro, K., Kagoshima, K., Iwamura, Y., Sato, H., Rindner, D., Fujiwara, S., Yamashita, K., Mizuno, K., and Ohashi, K.
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 31 Issue: 8 Pages: 741-752
- DOI
  10.1091/mbc.e19-07-0357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19280, KAKENHI-PROJECT-20H03248, KAKENHI-PROJECT-19K06652
[Journal Article] 細胞の力覚応答におけるRho-GEFの機能2019
- Author(s)
  山下和成, 磯崎友亮, 鹿子嶋克彦, 國富葵, 大橋一正
- Journal Title
  
  細胞
  
  Volume: 51(13) Pages: 687-690
- Data Source
  KAKENHI-PROJECT-19K06652
[Journal Article] The epithelial circumferential actin belt regulates YAP/TAZ through nucleocytoplasmic shuttling of Merlin.2017
- Author(s)
  Furukawa T K, Yamashita K, Sakurai N, Ohno S
- Journal Title
  
  Cell Reports
  
  Volume: 20 Pages: 1435-1447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17991
[Presentation] CAFsは食道癌における術前化学療法抵抗性の獲得に関与する2022
- Author(s)
  野村美咲、山下和成、那須元美、阿部雅明、佐々木和教、橋本貴史、峯真司
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-22K07215
[Presentation] 上皮細胞のアクチン骨格制御と細胞間接着形成におけるRho-GEF, PLEKHG4Bの機能2020
- Author(s)
  二宮小牧, 太田海, 山下和成, 水野健作, 大橋一正
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06652
[Presentation] 上皮細胞の空間パターンを作る細胞極性制御因子PAR3のクラスタリング制御機構2018
- Author(s)
  山下和成, 水野恵子, 大野茂男
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K17991
[Presentation] FETAL AND MATERNAL ASYMMETRY IN PLASMA MEMBRANE DOMAINS OF SYNCYTIOTROPHOBLAST LAYER-I CELLS ARE MAINTAINED BY A POLARITY-REGULATING FACTOR, KIBRA-LIKE/WWC2.2018
- Author(s)
  Tamura-Furukawa Kana, Yamashita Kazunari, Ohno Shigeo
- Organizer
  International Federation of Placenta Associations
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17991

1. 折茂彰 (70275866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 大橋一正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 水野健作

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Kazunari 山下 和成

Research Projects

Research Products

Co-Researchers

癌内線維芽細胞が誘導する食道癌細胞の集団浸潤と未分化転換を司る分子機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel breast cancer treatment method by specifically suppressing the proliferation of intracancerous fibroblasts

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症性がん関連線維芽細胞に必須な新規転写因子の同定とその機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The actin-regulatory manner of Solo, a Rho-GEF involved in mechanosensing.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the novel cell polarity-regulating signal cascadePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell?cell junction formation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Rho-guanine nucleotide exchange factor Solo decelerates collective cell migration by modulating the Rho-ROCK pathway and keratin networks.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 細胞の力覚応答におけるRho-GEFの機能2019

Author(s)

Journal Title

Data Source

[Journal Article] The epithelial circumferential actin belt regulates YAP/TAZ through nucleocytoplasmic shuttling of Merlin.2017

Author(s)

Journal Title

Data Source

[Presentation] CAFsは食道癌における術前化学療法抵抗性の獲得に関与する2022

Author(s)

Organizer

Data Source

[Presentation] 上皮細胞のアクチン骨格制御と細胞間接着形成におけるRho-GEF, PLEKHG4Bの機能2020

Author(s)

Organizer

Data Source

[Presentation] 上皮細胞の空間パターンを作る細胞極性制御因子PAR3のクラスタリング制御機構2018

Author(s)

Organizer

Data Source

[Presentation] FETAL AND MATERNAL ASYMMETRY IN PLASMA MEMBRANE DOMAINS OF SYNCYTIOTROPHOBLAST LAYER-I CELLS ARE MAINTAINED BY A POLARITY-REGULATING FACTOR, KIBRA-LIKE/WWC2.2018

Author(s)

Organizer

Data Source

Yamashita Kazunari 山下和成