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ADACHI NAOKO  足立 直子

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Adachi Naoko  足立 直子

ADACHI Naoko  足立 直子

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Researcher Number 70604510
Other IDs
Affiliation (Current) 2025: 神戸大学, バイオシグナル総合研究センター, 助教
Affiliation (based on the past Project Information) *help 2021 – 2024: 神戸大学, バイオシグナル総合研究センター, 助教
2016 – 2019: 神戸大学, バイオシグナル総合研究センター, 助教
2016: 神戸大学, 学内共同利用施設等, 助教
2013 – 2015: 神戸大学, バイオシグナル研究センター, 助教
2012: 神戸大学, 学内共同利用施設等, 助教
2011: 神戸大学, バイオシグナル研究センター, 助教
Review Section/Research Field
Principal Investigator
General pharmacology / Basic Section 48030:Pharmacology-related
Except Principal Investigator
Basic Section 48030:Pharmacology-related / General pharmacology
Keywords
Principal Investigator
パルミトイル化 / パルミトイル化修飾 / 翻訳後修飾 / GPCR / ベータ3アドレナリン受容体 / ニトロシル化 / 遺伝子多型 / ADRB3 / ニトロシル化修飾 / zDHHC … More / 一酸化窒素 / ヒト化マウス / β3アドレナリン受容体 / シグナル伝達 / b3AR / アドレナリン受容体 / lipidation / S-palmitoylation / ヒト化マウスモデル / βアドレナリン受容体 / 薬理学 / b3-adrenergic receptor / palmitoylation / β3アドレナリン受容体 / β3 アドレナリン受容体 … More
Except Principal Investigator
難聴 / ROS / モデル動物 / リン酸化酵素 / NADPH oxidase / 後天性難聴 / 活性酸素 / 後天性感音難聴 / Hspファミリー / 創薬 / アミロイド / ドーパミン / 質量分析 / モデルマウス / プロテインキナーゼC / リン酸化プロテオーム / 治療薬 / パーキンソン病 Less
  • Research Projects

    (10 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (13 People)
  •  活性酸素産生酵素NOX3の発現制御機序解明による後天性及び片側性難聴の治療法開発

    • Principal Investigator
      上山 健彦
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Kobe University
  •  一酸化窒素によるS-パルミトイル化修飾酵素抑制機構の解明Principal Investigator

    • Principal Investigator
      足立 直子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Kobe University
  •  Elucidation of acquired SNHL mechanism caused from Nox3-derived ROS and beyond

    • Principal Investigator
      Ueyama Takehiko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Kobe University
  •  Exploration of the impact of beta3 adrenergic receptor gene polymorphism on overactive bladder(Fostering Joint International Research)Principal Investigator

    • Principal Investigator
      Adachi Naoko
    • Project Period (FY)
      2017 – 2022
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • Research Field
      General pharmacology
    • Research Institution
      Kobe University
  •  Analysis of differential S-palmitoylation of the human and rodent beta3 adrenergic receptorPrincipal Investigator

    • Principal Investigator
      Adachi Naoko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Kobe University
  •  Elucidation of amyloid formation mechanism in Spinocerebellar ataxia and its application to drug therapy

    • Principal Investigator
      SAITO NAOAKI
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Kobe University
  •  Functional roles of novel S-palmitoylation on beta 3-adrenergic receptorPrincipal Investigator

    • Principal Investigator
      Adachi Naoko
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      Kobe University
  •  Determination of PKC substrate involved in neurodegenerative diseases and its application for drug design

    • Principal Investigator
      SAITO NAOAKI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Kobe University
  •  Analysis of protein Cysteome modification in G protein-coupled receptorPrincipal Investigator

    • Principal Investigator
      ADACHI Naoko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      Kobe University
  •  タンパク質のニトロシル化とパルミトイル化修飾の相互制御システムの解析Principal Investigator

    • Principal Investigator
      足立 直子
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      General pharmacology
    • Research Institution
      Kobe University

All 2023 2022 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book

  • [Book] 脳科学辞典2016

    • Author(s)
      足立直子、齋藤尚亮
    • Publisher
      脳科学辞典編集委員会
    • Data Source
      KAKENHI-PROJECT-15K18988
  • [Journal Article] S-Palmitoylation of Tyrosinase at Cysteine500 Regulates Melanogenesis2023

    • Author(s)
      Niki Yoko、Adachi Naoko、Fukata Masaki、Fukata Yuko、Oku Shinichiro、Makino-Okamura Chieko、Takeuchi Seiji、Wakamatsu Kazumasa、Ito Shosuke、Declercq Lieve、Yarosh Daniel B.、Mammone Tomas、Nishigori Chikako、Saito Naoaki、Ueyama Takehiko
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 143 Issue: 2 Pages: 317-327.e6

    • DOI

      10.1016/j.jid.2022.08.040

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06858, KAKENHI-PROJECT-20H00459, KAKENHI-PROJECT-21H02672, KAKENHI-PROJECT-16KK0181, KAKENHI-PROJECT-23K23986
  • [Journal Article] Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant2022

    • Author(s)
      Hirakawa Haruki、Taguchi Kei、Murakawa Seiya、Asano Masaya、Noguchi Soma、Kikkawa Satoshi、Harada Kana、Adachi Naoko、Ueyama Takehiko、Hide Izumi、Tanaka Shigeru、Sakai Norio
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 148 Issue: 1 Pages: 187-195

    • DOI

      10.1016/j.jphs.2021.11.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22472, KAKENHI-PROJECT-19H03409, KAKENHI-PROJECT-21H02672, KAKENHI-PROJECT-21K06802, KAKENHI-PROJECT-21K07274
  • [Journal Article] S-nitrosylation is required for β2AR desensitization and experimental asthma2022

    • Author(s)
      Fonseca Fabio V.、Raffay Thomas M.、Xiao Kunhong、McLaughlin Precious J.、Qian Zhaoxia、Grimmett Zachary W.、Adachi Naoko、Wang Benlian、Hausladen Alfred、Cobb Brian A.、Zhang Rongli、Hess Douglas T.、Gaston Benjamin、Lambert Nevin A.、Reynolds James D.、Premont Richard T.、Stamler Jonathan S.
    • Journal Title

      Molecular Cell

      Volume: 82 Issue: 16 Pages: 3089-3102.e7

    • DOI

      10.1016/j.molcel.2022.06.033

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KK0181
  • [Journal Article] Differential S-palmitoylation of the human and rodent β3-adrenergic receptors.2019

    • Author(s)
      Adachi N, Hess DT, Kaku M, Ueda C, Numa C, Saito N.
    • Journal Title

      J Biol Chem.

      Volume: 15;294(7) Issue: 7 Pages: 2569-2578

    • DOI

      10.1074/jbc.ra118.004978

    • NAID

      120006604674

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08595, KAKENHI-PROJECT-17H04032
  • [Journal Article] Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene2019

    • Author(s)
      Shirafuji T, Shimazaki H, Miyagi T, Ueyama T, Adachi N, Tanaka T, Hide I, Saito S, Sakai S
    • Journal Title

      Mol. Cell. Neurosci.

      Volume: 98 Pages: 46-53

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04032
  • [Journal Article] Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 142018

    • Author(s)
      Nakazono, A., Adachi, N., Takahashi, H., Seki, T., Hamada, D., Ueyama, T., Sakai, N. and Saito, N.
    • Journal Title

      J. Biol. Chem.

      Volume: 293 Issue: 38 Pages: 14758-14774

    • DOI

      10.1074/jbc.ra118.002913

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05133, KAKENHI-PROJECT-17H04032, KAKENHI-PROJECT-17H04042, KAKENHI-PROJECT-16K08276, KAKENHI-PROJECT-16K15318
  • [Journal Article] The Role of Cysteine String Protein Alpha (CSPα) Phosphorylation at Serine 10, and 34, by Protein Kinase Cγ for Presynaptic Maintenance.2018

    • Author(s)
      Shirafuji T, Ueyama T, Adachi N, Yoshino KI, Sotomaru Y, Uwada J, Kaneoka A, Ueda T, Tanaka S, Hide I, Saito N, Sakai N
    • Journal Title

      J. Neurosci.

      Volume: 38 Issue: 2 Pages: 278-290

    • DOI

      10.1523/jneurosci.1649-17.2017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08234, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-17H04032, KAKENHI-PROJECT-17H04042, KAKENHI-PROJECT-15K09317, KAKENHI-PROJECT-18K06891, KAKENHI-PROJECT-16H05133, KAKENHI-PROJECT-16K15318
  • [Journal Article] Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3.2017

    • Author(s)
      Kakumu E
    • Journal Title

      Genes Cells.

      Volume: 3 Issue: 3 Pages: 310-327

    • DOI

      10.1111/gtc.12479

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01307, KAKENHI-PUBLICLY-16H01311, KAKENHI-WRAPUP-16H01688, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-16H07295, KAKENHI-PROJECT-26281020, KAKENHI-PROJECT-26281026, KAKENHI-PROJECT-15K12203, KAKENHI-PROJECT-15K18988, KAKENHI-PROJECT-16H06307, KAKENHI-PROJECT-16K18473
  • [Journal Article] Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities2017

    • Author(s)
      Yusuke Hanaki, Masayuki Kikumori, Harukini Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie
    • Journal Title

      Molecules

      Volume: 22 Issue: 4 Pages: 631-631

    • DOI

      10.3390/molecules22040631

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16J04817, KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-17H04032, KAKENHI-PROJECT-16H06276
  • [Journal Article] S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.2016

    • Author(s)
      Adachi N, Hess DT, McLaughlin P, Stamler JS.
    • Journal Title

      J Biol Chem.

      Volume: 291(38) Issue: 38 Pages: 20232-46

    • DOI

      10.1074/jbc.m116.725762

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18988
  • [Journal Article] Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.2015

    • Author(s)
      Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, *Saito N.
    • Journal Title

      Hum Mol Genet.

      Volume: 24 Issue: 2 Pages: 525-539

    • DOI

      10.1093/hmg/ddu472

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25113715, KAKENHI-PROJECT-25293060, KAKENHI-PROJECT-25430065, KAKENHI-PROJECT-26460340, KAKENHI-PROJECT-26670124, KAKENHI-PROJECT-26440076, KAKENHI-PROJECT-25293061
  • [Journal Article] Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14.2014

    • Author(s)
      Yamamoto K, Seki T, Yamamoto H, Adachi N, Tanaka S, Hide I, Saito N, Sakai N
    • Journal Title

      Front Physiol.

      Volume: 5 Pages: 126-126

    • DOI

      10.3389/fphys.2014.00126

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590321, KAKENHI-PROJECT-24591264, KAKENHI-PROJECT-24659117, KAKENHI-PROJECT-24790252, KAKENHI-PUBLICLY-25113715, KAKENHI-PROJECT-25293060, KAKENHI-PROJECT-25293061, KAKENHI-PROJECT-25430065
  • [Journal Article] The role of Pak-interacting exchange factor-β phosphorylation at serines 340 and 583 by PKCγ in dopamine release.2014

    • Author(s)
      Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T, Toda T, Sakai N, Saito N.
    • Journal Title

      J Neurosci

      Volume: 34 Issue: 28 Pages: 9268-9280

    • DOI

      10.1523/jneurosci.4278-13.2014

    • NAID

      120005619641

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22129006, KAKENHI-PUBLICLY-25113715, KAKENHI-PROJECT-25293060, KAKENHI-PROJECT-25293061, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-26460340, KAKENHI-PROJECT-26670124
  • [Journal Article] Mutant gammaPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's cytotoxicity.2013

    • Author(s)
      Ogawa, K., Seki, T., Onji, T., Adachi, N., Tanaka, S., Hide, I., Saito, N., Sakai, N.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 440 Issue: 1 Pages: 25-30

    • DOI

      10.1016/j.bbrc.2013.09.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590321, KAKENHI-PROJECT-24591264, KAKENHI-PROJECT-24659117, KAKENHI-PUBLICLY-25113715, KAKENHI-PROJECT-25293060, KAKENHI-PROJECT-25293061, KAKENHI-PROJECT-25430065
  • [Journal Article] Mutant γPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's cytotoxicity.2013

    • Author(s)
      Ogawa K, Seki T, Onji T, Adachi N, Tanaka S, Hide I, Saito N, Sakai N.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 11;440(1) Pages: 25-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790252
  • [Presentation] パルミトイル化修飾酵素DHHCタンパク質の新規活性測定法の開発と機能解析2023

    • Author(s)
      足立直子、Douglas T. Hess、上山健彦
    • Organizer
      第144回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-22K06858
  • [Presentation] チロシナーゼのパルミトイル化修飾によるメラニン合成制御機構2022

    • Author(s)
      仁木洋子、足立直子、深田正紀、深田優子、錦織千佳子、齋藤尚亮、上山健彦
    • Organizer
      第141回日本薬理学会 近畿部会
    • Data Source
      KAKENHI-PROJECT-16KK0181
  • [Presentation] チロシナーゼのパルミトイル化修飾によるメラニン合成制御機構2022

    • Author(s)
      仁木洋子、足立直子、深田正紀、深田優子、錦織千佳子、齋藤尚亮、上山健彦
    • Organizer
      第141回日本薬理学会 近畿部会
    • Data Source
      KAKENHI-PROJECT-22K06858
  • [Presentation] S-パルミトイル化修飾によるβ3アドレナリン受容体の機能調節2019

    • Author(s)
      足立直子, Douglas T. Hess , 上田知永、賀来美嘉 、齋藤尚亮
    • Organizer
      第133日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-17K08595
  • [Presentation] パルミトイル化修飾によるβ3アドレナリン受容体の機能制御-ヒトとマウスの違い-2017

    • Author(s)
      Naoko Adachi, Chisato Numa, Mika Kaku, Chie Ueda, Takehiko Ueyama, Naoaki Saito
    • Organizer
      第90日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K18988
  • [Presentation] 刺激依存的パルミトイル化修飾によるβ2アドレナリン受容体(β2AR)の脱感作メカニズム2016

    • Author(s)
      Naoko Adachi, Douglas T. Hess, Precious McLaughlin, Jonathan S. Stamler
    • Organizer
      第129回日本薬理学会近畿部会
    • Place of Presentation
      広島
    • Year and Date
      2016-06-24
    • Data Source
      KAKENHI-PROJECT-15K18988
  • [Presentation] Agonist-induced S-palmitoylation of a novel site within the b2-adrenergic receptor is associated with a novel intracellular itinerary and mechanism of receptor desensitization2016

    • Author(s)
      Naoko Adachi, Douglas T. Hess, Precious McLaughlin, Jonathan S. Stamler
    • Organizer
      Biochemical Society, Protein S-palmitoylation: From Mechanism to Application
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18988
  • [Presentation] 脊髄小脳変性症14型におけるPKCのアミロイド様構造体の形成と疾患への関与2015

    • Author(s)
      足立直子、高橋英之、白藤俊彦、上山健彦、Michele, Vendruscolo., 入江一浩、平井宏和、酒井規雄、齋藤尚亮
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-25293060
  • [Presentation] 黒質線条体系におけるPKCγの基質の解析:β2PIXリン酸化のドパミン遊離への 役割2013

    • Author(s)
      白藤 俊彦、上山 健彦、吉野 健一、足立 直子、高橋 英之、香田 健、 平松 直樹、吾郷 由希夫、松田 敏夫、酒井 規雄、齋藤 尚亮
    • Organizer
      第124回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-25293060
  • 1.  UEYAMA Takehiko (80346254)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  SAITO Naoaki (60178499)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  坂口 博史 (00515223)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  中村 高志 (80724179)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  SHIRAFUJI Toshihiko (30595765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  吉野 健一 (90280792)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KAKU Mika
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  UEDA Chie
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TANAKA SHIGERU
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  秀 和泉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 11.  酒井 規雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 12.  斎藤 尚亮
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 13.  戸田 達史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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