Ishihara Tomohiko 石原智彦

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ISHIHARA Tomohiko 石原智彦

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Researcher Number	70612232
Other IDs
Affiliation (Current)	2026: 新潟大学, 脳研究所, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 新潟大学, 脳研究所, 特任准教授 2021 – 2022: 新潟大学, 医歯学総合病院, 講師 2019: 新潟大学, 医歯学総合病院, 講師 2011 – 2018: 新潟大学, 脳研究所, 助教 2012: 新潟大学, 脳研究所神経内科, 助教
Review Section/Research Field	Principal Investigator Neurology / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Neurology
Keywords	Principal Investigator ALS / 筋萎縮性側索硬化症 / TDP-43 / スプライシング / 人工知能 / エクソーム解析 / 病理多型 / テキストマイニング / biomarker / alternative splicing … More / バイオマーカー / 選択的スプライシング / iPS細胞 / stasimon / 介在ニューロン / GEM body / snRNAs / SMN / GEM / GEM小体 / U snRNAs / 内在性コントロール / U12 / ｓｎRNA / 逆転写定量PCR / U12 snRNA / snRNA … More Except Principal Investigator 筋萎縮性側索硬化症 / ALS / アンチセンスオリゴ / TDP-43 / 神経病態 Less

AIと剖検組織を用いたALSの新規原因遺伝子同定Principal Investigator
- Principal Investigator
  
  石原智彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
Exploring genetic factors that define TDP-43 pathological polymorphisms in ALS.Principal Investigator
- Principal Investigator
  
  Ishihara Tomohiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
The disease mechanism and biomarker of ALS, the view from TDP-43 alternative splicingPrincipal Investigator
- Principal Investigator
  
  Ishihara Tomohiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Therapeutic strategy for ALS with nucleic acid technology focusing on the vulnerability of TDP-43 autoregulation
- Principal Investigator
  
  Sugai Akihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Elucidation of a mechanism of ALS system selectivity focusing on TDP-43 function in interneurons.Principal Investigator
- Principal Investigator
  
  Ishihara Tomohiko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Autoreguation of TDP-43 in ALS
- Principal Investigator
  
  Nishizawa Masatoyo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
The pathogenesis of GEM bodies reduction in ALS affected tissues.Principal Investigator
- Principal Investigator
  
  ISHIHARA Tomohiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Alteration of snRNAs in amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Tomohiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Niigata University

All 2024 2023 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] Neurodegenerative Disorders as Systemic Diseases2015
- Author(s)
  Ishihara, Tomohiko，Nishizawa Masatoyo，Onodera, Osamu
- Total Pages
  20
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K19479
[Book] 新領域別症候群27 神経症候群II2014
- Author(s)
  酒井直子，石原智彦，小野寺理，西澤正豊
- Total Pages
  5
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-25860703
[Journal Article] Slow disease progression and characteristic TDP-43 inclusions in a patient with familial amyotrophic lateral sclerosis carrying a TARDBP G357S variant2024
- Author(s)
  Sainouchi, M. Oginezawa, S. Tada, M. Ishihara, T. Onodera, O. Kakita, A.
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: 50 Issue: 1
- DOI
  10.1111/nan.12966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07272, KAKENHI-PROJECT-23H00434, KAKENHI-PROJECT-23K24256
[Journal Article] Share SMN2 gene copy number affects the incidence and prognosis of motor neuron diseases in Japan.2024
- Author(s)
  Ishihara T, Koyama A, Atsuta N, Tada M, Toyoda S, Kashiwagi K, Hirokawa S, Hatano Y, Yokoseki A, Nakamura R, Tohnai G, Izumi Y, Kaji R, Morita M, Tamura A, Kano O, Aoki M, Kuwabara S, Kakita A, Sobue G, Onodera O.
- Journal Title
  
  BMC Med Genomics.
  
  Volume: 17(1) Issue: 1 Pages: 263-263
- DOI
  10.1186/s12920-024-02026-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-24K10506
[Journal Article] Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS2023
- Author(s)
  Hatano Yuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  BMC Bioinformatics
  
  Volume: 24 Issue: 1
- DOI
  10.1186/s12859-023-05338-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14771, KAKENHI-PROJECT-21K07272
[Journal Article] Endogenous human retrovirus-K is not increased in the affected tissues of Japanese ALS patients2022
- Author(s)
  Ishihara Tomohiko、Koyama Akihide、Hatano Yuya、Takeuchi Ryoko、Koike Yuka、Kato Taisuke、Tada Mari、Kakita Akiyoshi、Onodera Osamu
- Journal Title
  
  Neuroscience Research
  
  Volume: 178 Pages: 78-82
- DOI
  10.1016/j.neures.2022.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-21K07272
[Journal Article] Molecular mechanism of amyotrophic lateral sclerosis (ALS) from the viewpoint of the formation and degeneration of transactive response DNA-binding protein 43 kDa (TDP-43) inclusions2020
- Author(s)
  Kasahara Sou、Ishihara Tomohiko、Koike Yuka、Sugai Akihiro、Onodera Osamu
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 60 Issue: 2 Pages: 109-116
- DOI
  10.5692/clinicalneurol.cn-001362
- NAID
  130007802650
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09751, KAKENHI-PROJECT-19H01043
[Journal Article] Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation2019
- Author(s)
  Sugai Akihiro、Kato Taisuke、Koyama Akihide、Koike Yuka、Konno Takuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 130 Pages: 104534-104534
- DOI
  10.1016/j.nbd.2019.104534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751, KAKENHI-PROJECT-19H01043
[Journal Article] 増大特集 ALS2019 TDP-43封入体から解くALSの分子病態2019
- Author(s)
  坪口晋太朗、石原智彦、須貝章弘、横関明男、小野寺理
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 11 Pages: 1183-1189
- DOI
  10.11477/mf.1416201428
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-11-01
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751
[Journal Article] Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions.2019
- Author(s)
  Mori F, Tada M, Kon T, Miki Y, Tanji K, Kurotaki H, Tomiyama M, Ishihara T, Onodera O, Kakita A, Wakabayashi K.
- Journal Title
  
  Acta Neuropatholgica Communications
  
  Volume: 7 Issue: 1 Pages: 165-165
- DOI
  10.1186/s40478-019-0824-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-18H02533, KAKENHI-PROJECT-17K07088, KAKENHI-PROJECT-17K09751
[Journal Article] Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based on in Silico Data2018
- Author(s)
  Sugai Akihiro、Kato Taisuke、Koyama Akihide、Koike Yuka、Kasahara Sou、Konno Takuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 12 Pages: 0-0
- DOI
  10.3389/fnins.2018.00028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751, KAKENHI-PLANNED-26117006
[Journal Article] The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial2018
- Author(s)
  Oki Ryosuke、Izumi Yuishin、Nodera Hiroyuki、Ishihara Tomohiko，Kaji Ryuji、JETALS et al.
- Journal Title
  
  JMIR Research Protocols
  
  Volume: 7 Issue: 12 Pages: e12046-e12046
- DOI
  10.2196/12046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-17K09811, KAKENHI-PROJECT-17K16110, KAKENHI-PROJECT-16H05279
[Journal Article] Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43.2016
- Author(s)
  Koyama A, Sugai A, Kato T, Ishihara T, Shiga A, Toyoshima Y, Koyama M, Konno T, Hirokawa S, Yokoseki A, Nishizawa M, Kakita A, Takahashi H, Onodera O.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 44 Issue: 12 Pages: 5820-5836
- DOI
  10.1093/nar/gkw499
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26250017, KAKENHI-PROJECT-15H06225, KAKENHI-PROJECT-15K19479, KAKENHI-PLANNED-26117006
[Journal Article] Clinical course and serial brain MRI findings in a patient with Lissauer form of general paresis2015
- Author(s)
  Ishihara, T，Nishizawa, M
- Journal Title
  
  Rinsho shinkeigaku = Clinical neurology
  
  Volume: 55 Issue: 4 Pages: 238-242
- DOI
  10.5692/clinicalneurol.55.238
- NAID
  130005066234
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19479
[Journal Article] ALSにおけるGEM小体と U snRNA異常～RNA代謝異常は運動神経変性の共通した病態機序となるか2015
- Author(s)
  小池佑佳，石原智彦，西澤正豊，小野寺理
- Journal Title
  
  神経内科
  
  Volume: 83 Pages: 175-184
- Data Source
  KAKENHI-PROJECT-15K19479
[Journal Article] Varicella-zoster virus encephalitis localized to the bilateral medial temporal lobes2015
- Author(s)
  Yajima, R， Ishihara, T，Nishizawa, M
- Journal Title
  
  Neurology-Neuroimmunology Neuroinflammation
  
  Volume: 2 Issue: 4
- DOI
  10.1212/nxi.0000000000000108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19479
[Journal Article] Minor splicing pathway is not minor any more: Implications for thepathogenesis of motor neuron diseases.2014
- Author(s)
  Onodera O，Ishihara T, Shiga A, Nishizawa M, et.al.
- Journal Title
  
  Neuropathology.
  
  Volume: 1 Pages: 99-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860703
[Journal Article] Aberration of the spliceosome in amyotrophic lateral sclerosis2014
- Author(s)
  Ishihara T, Onodera O.et al.
- Journal Title
  
  臨床神経学
  
  Volume: 54 Pages: 1155-7
- Open Access
- Data Source
  KAKENHI-PROJECT-25860703
[Journal Article] [Aberration of the spliceosome in amyotrophic lateral sclerosis].2014
- Author(s)
  Ishihara T, Kakita A, Takahashi H, Onodera O, Nishizawa M.
- Journal Title
  
  Rinsho Shinkeigaku.
  
  Volume: 54 Pages: 1155-1157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253065
[Journal Article] Minor splicing pathway is not minor any more: implications for the pathogenesis of motor neuron diseases.2014
- Author(s)
  Onodera O, Ishihara T, Shiga A, Ariizumi Y, Yokoseki A, Nishizawa M.
- Journal Title
  
  Neuropathology
  
  Volume: 34 Issue: 1 Pages: 99-107
- DOI
  10.1111/neup.12070
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25110714, KAKENHI-PROJECT-25253065
[Journal Article] Decreased number of Gemini of coiled bodies and U12 snRNA levelin amyotrophic lateral sclerosis．2013
- Author(s)
  Ishihara T, Ariizumi Y, Shiga A, Onodera O， et.al.
- Journal Title
  
  Hum Mol Genet．
  
  Volume: 20 Pages: 4136-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860703
[Journal Article] Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.2013
- Author(s)
  Ishihara T, Ariizumi Y, Shiga A, et al ;
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 22 Issue: 20 Pages: 4136-4147
- DOI
  10.1093/hmg/ddt262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07914, KAKENHI-PROJECT-22249036, KAKENHI-PROJECT-23240049, KAKENHI-PROJECT-24790875, KAKENHI-PUBLICLY-25110714, KAKENHI-PROJECT-25253065
[Journal Article] Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS2012
- Author(s)
  Shiga,A. Ishihara,T.Onodera,O. et al
- Journal Title
  
  PLoS One
  
  Volume: vol.2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] MOVA: A method of missense variant pathogenicity usingAlphaFold22023
- Author(s)
  石原智彦
- Organizer
  Human Genetics Asia 2023（HGA2023）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07272
[Presentation] Alteration of DNA methylation status of TARDBP 3 'UTR in sporadic ALS brain2019
- Author(s)
  Yuka Koike, Akihiro Sugai , Akio Yokoseki, Tomohiko Ishihara, Norikazu Hara, Junko Ito Ikeuchi, Takeshi, Akiyoshi Kakita, Osamu Onodera
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] Exome analysis in 54 autopsied Japanese sporadic ALS patients.2019
- Author(s)
  石原智彦
- Organizer
  29th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] Efficacy evaluation of nusinersen in an adult spinal muscular atrophy case using peripheral blood mRNA.2018
- Author(s)
  Tomohiko Ishihara
- Organizer
  29th international symposium on ALS/MND，
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] The SMN2 gene copy number states can affect the onset risk and survival time in Japanese ALS.2018
- Author(s)
  Tomohiko Ishihara
- Organizer
  PACTALS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] The SMN2 gene copy number states can affect the onset risk and survival time in Japanese ALS.2017
- Author(s)
  Ishihara T
- Organizer
  28th international symposium on ALS/MND，
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] The SMN2 gene copy number states can affect the onset risk and survival time in Japanese ALS.2017
- Author(s)
  Ishihara T
- Organizer
  XXⅢ World Congress of Neurology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09750
[Presentation] A non-genetically modified iPSC-derived neuron model with an increased expression of intrinsic TDP-432017
- Author(s)
  Akihiro Sugai, Genri Tohyama, Taisuke Kato, Tomohiko Ishihara, Osamu Onodera
- Organizer
  Gordon Research Conferences 2017 Amyotrophic Lateral Sclerosis (ALS) & Related Motor Neuron Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] A non-genetically modified human neuronal model of ALS with an increased expression of intrinsic TDP-432017
- Author(s)
  Akihiro Sugai, Taisuke Kato, Tomohiko Ishihara, Osamu Onodera
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] The expression of endogenous Human retrovirus-K in the affected tissues of ALS patients.2016
- Author(s)
  Tomohiko Ishihara
- Organizer
  Keystone Symposia for the 2016 conference
- Place of Presentation
  Colorado．USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19479
[Presentation] The SMN gene copy number states in Japanese ALS patients2016
- Author(s)
  石原智彦
- Organizer
  第57回　日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K19479
[Presentation] The SMN gene copy number states in Japanese ALS patients.2015
- Author(s)
  Ishihara, T
- Organizer
  3rd RNA Metabolism in Neurological Disease Meeting
- Place of Presentation
  Chicago (USA)
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19479
[Presentation] Droplet digital PCR 法を用いたSMN遺伝子コピー数の解析2015
- Author(s)
  石原智彦
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟・新潟市）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K19479
[Presentation] The SMN gene copy number states in Japanese ALS patients.2015
- Author(s)
  T.Ishihara, S.Toyoda, A.Koyama, R.Nakamura, G. Tohnai, N.Atsuta, G.Sobue, M.Nishizawa, O. Onodera
- Organizer
  10th Brain Research Conference: RNA Metabolism in Neurological Disease
- Place of Presentation
  Chicag (USA)
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] The reduction of minor spliceosome and aberrant splicing in ALS.2014
- Author(s)
  石原智彦
- Organizer
  Cell symposia Regulatory RNAｓ
- Place of Presentation
  バークリー（USA)・Claremont Hotel & Spa
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] ALSでのStasimonヒトホモログ mRNAのスプライシング異常の検討2014
- Author(s)
  石原智彦
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡，福岡国際会議場
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] ALSにおけるspliceosome異常（シンポジウム発表）2014
- Author(s)
  石原智彦
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡，福岡国際会議場
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] Reduction of U11/U12 small nuclear ribonucleoprotein in amyotrophic lateral sclerosis2013
- Author(s)
  石原智彦
- Organizer
  the 24th International Symposium on ALS/MND
- Place of Presentation
  ミラノ, イタリア
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] TDP-43 is autoregulated by multiple excisions of introns in exon6 and reservation of mRNA in nucleus by TDP-432013
- Author(s)
  Akihide Koyama, Akihiro Sugai, Taisuke Kato, Takuya Konno, Tomohiko Ishihara, Masatoyo Nishizawa, Osamu Onodera
- Organizer
  24th International Symposium on ALS/MND
- Place of Presentation
  Milan　イタリア
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] Alternative splicing or polyadenylation, which is the major mechanism for auto-regulation of TDP-43?2013
- Author(s)
  Akihiro Sugai, Akihide Koyama, Taisuke Kato, Takuya Konno, Tomohiko Ishihara, Masatoyo Nishizawa, Osamu Onodera
- Organizer
  RNA Metabolism in Neurological Disease:8th Brain Research Conference
- Place of Presentation
  SanDiego アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] Reduction of U12 snRNAs in nervous tissues with TDP-43 pathology in amyotrophic lateral sclerosis2012
- Author(s)
  石原智彦
- Organizer
  第42回米国神経科学会
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] ALS患者神経組織ではスプライシング関連機能性RNAが低下する2012
- Author(s)
  石原智彦
- Organizer
  第53回神経学会総会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] ALS患者神経組織ではスプライシング関連機能性RNAが低下する2012
- Author(s)
  石原智彦
- Organizer
  第53回神経学会総会
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] Reduction of U12 snRNAs in nervous tissues with TDP-43 pathology in amyotrophic lateral sclerosis2012
- Author(s)
  石原智彦
- Organizer
  第42回　米国神経科学会
- Place of Presentation
  米国　ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] ALSにおけるGEM小体の異常： SMNとの関連2012
- Author(s)
  石原智彦
- Organizer
  平成24年度　神経変性疾患に関する調査研究班　班会議
- Place of Presentation
  東京　都市センターホテル
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] Alteration of snRNAs in amyotrophic lateral sclerosis.2011
- Author(s)
  石原智彦
- Organizer
  第41回　米国神経科学会
- Place of Presentation
  ワシントン（USA）
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] AlterationofsnRNAsinamyotrophiclateralsclerosis2011
- Author(s)
  石原智彦
- Organizer
  第41回米国神経科学会
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-23890060
[Presentation] ALS患者神経組織におけるU12 snRNAの減少とスプライシング異常
- Author(s)
  石原　智彦
- Organizer
  第５４回日本神経学会学術大会
- Place of Presentation
  東京，日本
- Data Source
  KAKENHI-PROJECT-25860703
[Presentation] Coordinated autoregulation of TDP-43 and its implication for TDP-43 pathology
- Author(s)
  須貝章弘　小山哲秀　加藤泰介　志賀篤　今野卓哉　小山美咲　石原智彦　西澤正豊　小野寺理
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-21 – 2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] The reduction of minor spliceosome and aberrant splicing in ALS.
- Author(s)
  T. Ishihara., A. Koyama M., Nishizawa. O. Onodera.
- Organizer
  Cell Symposium
- Place of Presentation
  Berkeley, CA, USA
- Year and Date
  2014-10-19 – 2014-10-21
- Data Source
  KAKENHI-PROJECT-25253065
[Presentation] Aberration of the spliceosome in amyotrophic lateral sclerosis
- Author(s)
  石原智彦，柿田明美，高橋均，小野寺理，西澤正豊
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-21 – 2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25253065

1. 他田真理 (30646394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Nishizawa Masatoyo (80198457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. ONODERA Osamu (20303167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. KAKITA Akiyoshi (80281012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. SATO Toshiya (90359703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Sugai Akihiro (70758903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 畠野雄也 (10943540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KATO Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. TOYOSHIMA Yasuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 熱田直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 中村亮一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 藤内玄規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 高橋均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishihara Tomohiko 石原 智彦

ISHIHARA Tomohiko 石原 智彦

Research Projects

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Co-Researchers

AIと剖検組織を用いたALSの新規原因遺伝子同定Principal Investigator

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Exploring genetic factors that define TDP-43 pathological polymorphisms in ALS.Principal Investigator

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The disease mechanism and biomarker of ALS, the view from TDP-43 alternative splicingPrincipal Investigator

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Therapeutic strategy for ALS with nucleic acid technology focusing on the vulnerability of TDP-43 autoregulation

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Elucidation of a mechanism of ALS system selectivity focusing on TDP-43 function in interneurons.Principal Investigator

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Autoreguation of TDP-43 in ALS

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The pathogenesis of GEM bodies reduction in ALS affected tissues.Principal Investigator

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Alteration of snRNAs in amyotrophic lateral sclerosisPrincipal Investigator

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[Book] Neurodegenerative Disorders as Systemic Diseases2015

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[Book] 新領域別症候群27 神経症候群II2014

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[Journal Article] Slow disease progression and characteristic TDP-43 inclusions in a patient with familial amyotrophic lateral sclerosis carrying a TARDBP G357S variant2024

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[Journal Article] Share SMN2 gene copy number affects the incidence and prognosis of motor neuron diseases in Japan.2024

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[Journal Article] Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS2023

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[Journal Article] Endogenous human retrovirus-K is not increased in the affected tissues of Japanese ALS patients2022

Author(s)

Ishihara Tomohiko 石原智彦

ISHIHARA Tomohiko 石原智彦