Kubota Yuji 久保田裕二

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KUBOTA Yuji 久保田裕二

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Researcher Number	70614973
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京大学, 医科学研究所, 講師 2019 – 2020: 東京大学, 医科学研究所, 助教 2012 – 2017: 東京大学, 医科学研究所, 助教 2011: 名古屋大学, 環境医学研究所, 助教
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 49030:Experimental pathology-related / Basic Section 50010:Tumor biology-related / Molecular biology Except Principal Investigator General medical chemistry / Pathological medical chemistry
Keywords	Principal Investigator がん / シグナル伝達 / MAPK経路 / MAPK / 癌 / PanIN / 膵臓癌 / 抗癌剤抵抗性 / 再発癌 / ERK経路 … More / O-GlcNAc修飾 / O-GlcNAc / 遺伝子変異 / 先天性疾患 / 翻訳後修飾 / MEK / Ras-MAPK症候群 / SUMO / ERK … More Except Principal Investigator 生体分子 / プロテオーム / バイオテクノロジー / 細胞 / 核酸 / 機能性RNA / 蛋白質 / 非コードRNA / EMT / リン酸化 / 発現制御 / 癌 / 遺伝子 / シグナル伝達 / 転写制御 / CtBP / MAPキナーゼ / ERK / がん / エピゲノム制御 Less

膵前癌病変PanINモデル細胞株を用いた膵管癌発生の分子基盤解明Principal Investigator
- Principal Investigator
  
  久保田裕二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Elucidation of the molecular mechanism of cancer growth signaling by protein O-GlcNAcylationPrincipal Investigator
- Principal Investigator
  
  Kubota Yuji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Functional analysis of ERK-regulated genes responsible for onset/relapse of cancersPrincipal Investigator
- Principal Investigator
  
  Kubota Yuji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Development of a novel method for the identification of ncRNA-binding proteins
- Principal Investigator
  
  Takekawa Mutsuhiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Molecular analysis of carcinogenesis caused by mutation-dependent activation of the ERK pathwayPrincipal Investigator
- Principal Investigator
  
  Kubota Yuji
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Regulation of gene expression by novel ERK substrates and its failure in cancer
- Principal Investigator
  
  Takekawa Mutsuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Development of methods for quantitative and qualitatve analyses of protein O-GlcNAcylation.Principal Investigator
- Principal Investigator
  
  KUBOTA Yuji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Regulation of the ERK-MAPK cascade and cell-transformation by MEKsumoylationPrincipal Investigator
- Principal Investigator
  
  KUBOTA Yuji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
  Nagoya University

All 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] Protein Modifications in Pathogenic Dysregulation of Signaling2015
- Author(s)
  Mutsuhiro Takekawa, Yuji Kubota
- Total Pages
  324
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25650003
[Book] Protein Modifications in Pathogenic Dysregulation of Signaling,2015
- Author(s)
  Mutsuhiro Takekawa, Yuji Kubota
- Total Pages
  348
- Publisher
  Springer Press
- Data Source
  KAKENHI-PROJECT-15K19019
[Book] ユビキチンおよびユビキチン様タンパク質によるMAPキナーゼ経路の制御2012
- Author(s)
  久保田裕二、中亮介、武川睦寛
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23890077
[Journal Article] A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.2018
- Author(s)
  M. Iijima, Yuji Kubota, R. Sawa, Yumiko Kubota, M. Hatano, M. Igarashi, M. Kawada, I. Momose, M. Takekawa, M. Shibasaki.
- Journal Title
  
  J. Antibiot.
  
  Volume: 71 Issue: 1 Pages: 135-138
- DOI
  10.1038/ja.2017.100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01811, KAKENHI-INTERNATIONAL-16K21739, KAKENHI-ORGANIZER-16H06573, KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-15H04703, KAKENHI-PROJECT-16K15212, KAKENHI-PROJECT-17K08650
[Journal Article] WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins2017
- Author(s)
  Kubota Yuji、Fujioka Ko、Takekawa Mutsuhiro
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 7 Pages: e0180714-e0180714
- DOI
  10.1371/journal.pone.0180714
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-INTERNATIONAL-16K21739, KAKENHI-ORGANIZER-16H06573, KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-15H04703, KAKENHI-PROJECT-16K15212, KAKENHI-PROJECT-17K08650
[Journal Article] A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.2016
- Author(s)
  Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T.
- Journal Title
  
  Proteomics
  
  Volume: 16 Issue: 13 Pages: 1825-1836
- DOI
  10.1002/pmic.201500494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01205, KAKENHI-ORGANIZER-16H06573, KAKENHI-PROJECT-15H04703, KAKENHI-PROJECT-25293005, KAKENHI-PROJECT-26460036, KAKENHI-PROJECT-15K07887, KAKENHI-PROJECT-16K15212, KAKENHI-INTERNATIONAL-16K21739, KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-15K19019
[Journal Article] Detection and Functional Analysis of SUMO-modified MEK2016
- Author(s)
  Yuji Kubota and Mutsuhiro Takekawa
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 印刷中
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19019
[Journal Article] Detection and functional analysis of SUMO-modified MEK.2016
- Author(s)
  Kubota Y and Takekawa M.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1487 Pages: 99-111
- DOI
  10.1007/978-1-4939-6424-6_7
- ISBN
  9781493964222, 9781493964246
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-16H06573, KAKENHI-PROJECT-15H04703, KAKENHI-PROJECT-16K15212, KAKENHI-INTERNATIONAL-16K21739, KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-15K19019
[Journal Article] Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity2015
- Author(s)
  Sato, Y., Goto, E., Shibata, Y., Kubota, Y., Yamagata, A., Goto-Ito, S., Kubota, K., Inoue, J., Takekawa, M., Tokunaga, F. and Fukai, S.
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 22 Issue: 3 Pages: 222-229
- DOI
  10.1038/nsmb.2970
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22117001, KAKENHI-PLANNED-22117003, KAKENHI-PLANNED-22117006, KAKENHI-PLANNED-22121003, KAKENHI-PROJECT-24247014, KAKENHI-PROJECT-24390079, KAKENHI-PROJECT-24570126, KAKENHI-PROJECT-24687012, KAKENHI-PUBLICLY-25112505, KAKENHI-PUBLICLY-25117711, KAKENHI-PROJECT-25650003, KAKENHI-PROJECT-25670137, KAKENHI-PROJECT-26840062, KAKENHI-PROJECT-15K08259, KAKENHI-PLANNED-22117002
[Journal Article] Mitogen-activated protein kinase signaling and cancer.2015
- Author(s)
  Takekawa M and Kubota Y.
- Journal Title
  
  Protein Modifications in Pathogenic Dysregulation of Signaling
  
  Volume: 1 Pages: 211-231
- Data Source
  KAKENHI-PROJECT-15H04703
[Journal Article] ストレス顆粒の生理機能と疾患2015
- Author(s)
  久保田裕二、松崎(有本)京子、武川睦寛
- Journal Title
  
  医学のあゆみ
  
  Volume: 254 Pages: 409-415
- Data Source
  KAKENHI-PROJECT-15H04703
[Journal Article] MCRIP1, an ERK substrate, mediates ERK-induced epigenetic gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP2015
- Author(s)
  Kenji Ichikawa, Yuji Kubota, Takanori Nakamura, Jane S. Weng, Taichiro Tomida, Haruo Saito and Mutsuhiro Takekawa
- Journal Title
  
  Molecular Cell
  
  Volume: 58 Issue: 1 Pages: 35-46
- DOI
  10.1016/j.molcel.2015.01.023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22117001, KAKENHI-PLANNED-22117003, KAKENHI-PROJECT-24247034, KAKENHI-PROJECT-24390079, KAKENHI-PROJECT-25440043, KAKENHI-PROJECT-25650003, KAKENHI-PROJECT-15K19003, KAKENHI-PUBLICLY-15H01205, KAKENHI-PROJECT-15H04703, KAKENHI-PROJECT-15J07710
[Journal Article] ストレス顆粒の生理機能と疾患2015
- Author(s)
  久保田裕二, 松崎（有本）京子, 武川睦寛
- Journal Title
  
  医学のあゆみ
  
  Volume: 254 Pages: 409-415
- Data Source
  KAKENHI-PROJECT-15K19019
[Journal Article] p38とそのカスケード2013
- Author(s)
  久保田裕二、武川睦寛
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 31 Pages: 657-660
- Data Source
  KAKENHI-PROJECT-25650003
[Journal Article] ユビキチンおよびユビキチン様タンパク質によるMAPキナーゼ経路の制御2012
- Author(s)
  久保田裕二
- Journal Title
  
  実験医学(増刊)
  
  Volume: 30 Pages: 72-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890077
[Journal Article] Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation2011
- Author(s)
  Yuji Kubota, Pauline O'Grady, Haruo Saito, and Mutsuhiro Takekawa
- Journal Title
  
  Nature Cell Biology
  
  Volume: 13 Pages: 282-291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] フィードバック・リン酸化によるERKシグナル制御機構の数理シミュレーション解析2018
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  第1回MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] フィードバック・リン酸化によるERKシグナル制御機構の数理シミュレーション解析2018
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  第1回MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] フィードバック・リン酸化によるERKシグナル制御機構の数理シミュレーション解析2018
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  第１回 MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
- Data Source
  KAKENHI-PROJECT-17K08650
[Presentation] 癌に由来するMEK遺伝子変異体の異常リン酸化の機能解析および病理学的意義の解明2018
- Author(s)
  久保田裕二、木下栄司、武川睦寛
- Organizer
  東京大学医科学研究所共同研究拠点事業平成２９年度成果報告会
- Data Source
  KAKENHI-PROJECT-17K08650
[Presentation] Analysis of a novel O-GlcNAc protein involved in the MAPK pathway2017
- Author(s)
  Ko Fujioka, Yuji Kubota and Mutsuhiro Takekawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] Identification of novel ERK substrates by yeast three hybrid screening2017
- Author(s)
  Seina Ohe, Yuji Kubota and Mutsuhiro Takekawa
- Organizer
  東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 蛋白質O-GlcNAc化を定量的かつ簡便に検出する新たな解析方法の開発2017
- Author(s)
  久保田裕二、藤岡興、武川睦寛
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification of a novel protein that is induced by hyperactiveation of the ERK pathway2017
- Author(s)
  Yusuke Takagi, Yuji Kubota and Mutsuhiro Takekawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] WGA-based lectin affinity gel electrophoresis. A novel method for the detection of O-GlcNAc-modified proteins2017
- Author(s)
  Yuji Kubota, Ko Fujioka and Mutsuhiro Takekawa
- Organizer
  生命科学系学会合同年次大会（第40回日本分子生学会、第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08650
[Presentation] Negative regulation of the ERK pathway by caspase-mediated cleavage of MEK1 during apoptosis.2017
- Author(s)
  Yuji Kubota, Tomoyuki Tsuchiya and Mutsuhiro Takekawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification and phosphorylation analysis of a novel MAPK substrate2017
- Author(s)
  Sae Uchida, Yuji Kubota, Mutsuhiro Takekawa
- Organizer
  IMSUT G2リトリート
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 蛋白質O-GlcNAc化によるMAPK経路の新たな制御メカニズムの解明2017
- Author(s)
  藤岡興、久保田裕二、武川睦寛
- Organizer
  第５４回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] エクソソーム中に蓄積するがん特異的miRNAの同定およびその早期診断マーカーとしての応用2017
- Author(s)
  広瀬思帆、久保田裕二、武川睦寛
- Organizer
  GLAFS研究進捗状況報告会
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] エクソソーム中に蓄積するがん特異的miRNAの同定およびその早期診断マーカーとしての応用2017
- Author(s)
  広瀬思帆、久保田裕二、武川睦寛
- Organizer
  GLAFS研究進捗状況報告会
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定と機能解析2017
- Author(s)
  中野雄太、久保田裕二、武川睦寛
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 蛋白質O-GlcNAc化によるMAPK経路の新たな制御メカニズムの解明2017
- Author(s)
  藤岡興、久保田裕二、武川睦寛
- Organizer
  第５４回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定2017
- Author(s)
  中野雄太、久保田裕二、武川睦寛
- Organizer
  第５４回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] Identification of a novel protein that is induced by hyperactiveation of the ERK pathway2017
- Author(s)
  Yusuke Takagi, Yuji Kubota and Mutsuhiro Takekawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Negative regulation of the ERK pathway by caspase-mediated cleavage of MEK1 during apoptosis.2017
- Author(s)
  Yuji Kubota, Tomoyuki Tsuchiya and Mutsuhiro Takekawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] Identification of novel ERK substrates by yeast three hybrid screening2017
- Author(s)
  Seina Ohe, Yuji Kubota and Mutsuhiro Takekawa
- Organizer
  東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] ERK経路の異常活性化により発現が亢進する新規遺伝子の同定と機能解析2017
- Author(s)
  高木祐輔、久保田裕二、武川睦寛
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] A novel method for the detection of O-GlcNAc-modified proteins: WGA-based lectin affinity gel electrophoresis (WGA-SDS-PAGE)2017
- Author(s)
  Yuji Kubota, Ko Fujioka and Mutsuhiro Takekawa
- Organizer
  プロテイン・アイランド松山
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08650
[Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定と機能解析2017
- Author(s)
  中野雄太、久保田裕二、武川睦寛
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] 癌および先天性Ras/MAPK 症候群におけるMEK 変異体の異常活性化機構の解明と特異的阻害剤の同定2017
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  新学術領域研究　数理シグナル第１回若手ワークショップ
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] ERK経路の異常活性化により発現が亢進する新規遺伝子の同定と機能解析2017
- Author(s)
  高木祐輔、久保田裕二、武川睦寛
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] A novel method for the detection of O-GlcNAc-modified proteins: WGA-based lectin affinity gel electrophoresis (WGA-SDS-PAGE)2017
- Author(s)
  Yuji Kubota, Ko Fujioka and Mutsuhiro Takekawa
- Organizer
  プロテイン・アイランド松山
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 癌および先天性Ras/MAPK 症候群におけるMEK 変異体の異常活性化機構の解明と特異的阻害剤の同定2017
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  新学術領域「数理シグナル」　第1回若手ワークショップ
- Data Source
  KAKENHI-PROJECT-17K08650
[Presentation] A novel method for the detection of O-GlcNAc-modified proteins: WGA-based lectin affinity gel electrophoresis (WGA-SDS-PAGE)2017
- Author(s)
  Yuji Kubota, Ko Fujioka and Mutsuhiro Takekawa
- Organizer
  プロテイン・アイランド松山
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] 蛋白質O-GlcNAc化を定量的かつ簡便に検出する新たな解析方法の開発2017
- Author(s)
  久保田裕二、藤岡興、武川睦寛
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] Analysis of a novel O-GlcNAc protein involved in the MAPK pathway2017
- Author(s)
  Ko Fujioka, Yuji Kubota and Mutsuhiro Takekawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 癌および先天性Ras/MAPK 症候群におけるMEK 変異体の異常活性化機構の解明と特異的阻害剤の同定2017
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  新学術領域研究　数理シグナル第１回若手ワークショップ
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Negative regulation of the ERK pathway by caspase-mediated cleavage of MEK1 during apoptosis.2017
- Author(s)
  Yuji Kubota, Tomoyuki Tsuchiya and Mutsuhiro Takekawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08650
[Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定2017
- Author(s)
  中野雄太、久保田裕二、武川睦寛
- Organizer
  第５４回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification and phosphorylation analysis of a novel MAPK substrate2017
- Author(s)
  Sae Uchida, Yuji Kubota, Mutsuhiro Takekawa
- Organizer
  IMSUT G2リトリート
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] 酵母Three Hybrid法による新規ERK基質分子の同定と生理機能の解明2016
- Author(s)
  大江星菜, 久保田裕二、武川睦寛
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification of a novel gene that is induced by hyperactivation of the ERK pathway2016
- Author(s)
  Yusuke Takagi, Yuji Kubota, Masaaki Oyama, Hiroko Kozuka-Hata, Mutsuhiro Takekawa
- Organizer
  医科学研究所創立記念研究発表会
- Place of Presentation
  医科学研究所創立記念研究発表会
- Year and Date
  2016-06-04
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] Identification of a novel gene that is induced by hyperactivation of the ERK pathway2016
- Author(s)
  Yusuke Takagi, Yuji Kubota, Masaaki Oyama, Hiroko Kozuka-Hata, Mutsuhiro Takekawa
- Organizer
  医科学研究所創立記念研究発表会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2016-06-04
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 酵母Three Hybrid法による新規ERK基質分子の同定と生理機能の解明2016
- Author(s)
  大江星菜, 久保田裕二、武川睦寛
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] ERK経路の異常活性化により発現変化する新規遺伝子の機能解析2016
- Author(s)
  高木祐輔、久保田裕二、川邊庸介、武川睦寛
- Organizer
  第53回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification of novel ERK substrates by yeast three-hybrid screening2016
- Author(s)
  大江星菜、久保田裕二、武川睦寛
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] 新規ERK応答性non-coding RNAの同定およびその機能解析2016
- Author(s)
  川邊庸介、久保田裕二、武川睦寛
- Organizer
  第53回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] ERK経路の異常活性化により発現変化する新規遺伝子の機能解析2016
- Author(s)
  高木祐輔、久保田裕二、川邊庸介、武川睦寛
- Organizer
  第53回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] 新規ERK応答性long non-coding RNAの同定およびその機能解析2016
- Author(s)
  川邊庸介、久保田裕二、武川睦寛
- Organizer
  第53回　日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム(東京都千代田区)
- Year and Date
  2016-04-16
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] 新規ERK応答性non-coding RNAの同定およびその機能解析2016
- Author(s)
  川邊庸介、久保田裕二、武川睦寛
- Organizer
  第53回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] フォスタグ技術とプロテオミクス情報を活用した細胞内MEK1リン酸化ダイナミクスのプロファイリング2016
- Author(s)
  木下英司、木下恵美子、久保田裕二、武川睦寛、小池透
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification of a novel gene that is induced by hyperactivation of the ERK pathway2016
- Author(s)
  Yusuke Takagi, Yuji Kubota, Masaaki Oyama, Hiroko Kozuka-Hata, Mutsuhiro Takekawa
- Organizer
  平成28年度　東京大学医科学研究所研究成果発表会
- Place of Presentation
  東京大学医科学研究所(東京都港区)
- Year and Date
  2016-06-04
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] フォスタグ技術とプロテオミクス情報を活用した細胞内MEK1リン酸化ダイナミクスのプロファイリング2016
- Author(s)
  木下英司、木下恵美子、久保田裕二、武川睦寛、小池透
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K15212
[Presentation] ERK経路の異常活性化により発現変化する新規遺伝子の機能解析2016
- Author(s)
  高木祐輔、久保田裕二、川邊庸介、武川睦寛
- Organizer
  第53回　日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム(東京都千代田区)
- Year and Date
  2016-04-16
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] MEK mutants derived from sporadic cancers and congenital Ras/MAPK syndromes induce differential gene-expression profiles by modulating spatio-temporal properties of ERK signaling2015
- Author(s)
  Yuji Kubota and Mutsuhiro Takekawa
- Organizer
  第10回研究者ネットワーク国際シンポジウム
- Place of Presentation
  北海道大学医学部学友会館（北海道札幌市）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] 癌および先天性Ras/MAPK症候群で認められるMEKミスセンス変異体の異常活性化機構と疾患発症メカニズムの解明2015
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  第52回日本臨床分子医学会
- Place of Presentation
  みやこめっせ（京都）
- Year and Date
  2015-04-10
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] レクチンアフィニティーゲル電気泳動を利用したO-GlcNAc化蛋白質の解析2015
- Author(s)
  藤岡興、久保田祐二、武川睦寛
- Organizer
  第66回日本電気泳動学会総会
- Place of Presentation
  東京工科大学蒲田キャンパス（東京）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] EIG-1, a novel ERK-inducible gene, promotes cell motility2015
- Author(s)
  Takagi Y, Kubota Y, Kawabe Y, Takekawa M
- Organizer
  第15回東京大学生命科学シンポジウム
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification of a novel JNK substrate using yeast three-hybrid system2015
- Author(s)
  Naka R, Kubota Y, and Takekawa M
- Organizer
  42rd IMSUT Founding Commemorative Symposium
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-06-01
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification of a novel gene induced by ERK activation2015
- Author(s)
  Yusuke Takagi、Yuji Kubota、Yosuke Kawabe、Mutsuhiro Takekawa
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] EIG-1, a novel ERK-inducible gene, promotes cell motility2015
- Author(s)
  Yusuke Takagi、Yuji Kubota、Yosuke Kawabe、Mutsuhiro Takekawa
- Organizer
  第15回東京大学生命科学シンポジウム
- Place of Presentation
  東京大学武田先端知ビル（東京都文京区）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] Identification of a novel JNK substrate using yeast three-hybrid system2015
- Author(s)
  Ryosuke Naka、Yuji Kubota、Mutsuhiro Takekawa
- Organizer
  第42回医科学研究所創立記念シンポジウム
- Place of Presentation
  東京大学医科学研究所（東京都港区）
- Year and Date
  2015-06-01
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] Identification of a novel gene that is induced by hyperactivation of the ERK pathway2015
- Author(s)
  高木祐輔、久保田裕二、川邉庸介、武川睦寛
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 質量分析法を利用したERK応答性lncRNAに対する結合タンパク質の同定2015
- Author(s)
  川邉庸介、久保田祐二、武川睦寛
- Organizer
  第66回日本電気泳動学会総会
- Place of Presentation
  東京工科大学蒲田キャンパス（東京）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 癌および先天性Ras/MAPK症候群で認められるMEKミスセンス変異体の異常活性化機構と疾患発症メカニズムの解明2015
- Author(s)
  久保田　裕二、　武川　睦寛
- Organizer
  第５２回　日本臨床分子医学会学術集会
- Place of Presentation
  京都市勧業館（京都府京都市）
- Year and Date
  2015-04-10
- Data Source
  KAKENHI-PROJECT-15K19019
[Presentation] 酵母3-ハイブリッド法によるJNK新規基質分子の同定2015
- Author(s)
  中亮介、久保田裕二、武川睦寛
- Organizer
  BMB2015（日本分子生物学会・生化学会合同総会）
- Place of Presentation
  神戸ポートピアホテル（神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] Identification of novel O-GlcNAcylated proteins that regulate MAPK signaling.2015
- Author(s)
  Fujioka K, Kubota Y, and Takekawa M
- Organizer
  IMSUT G2 retreat
- Place of Presentation
  検見川セミナーハウス（千葉）
- Year and Date
  2015-10-28
- Data Source
  KAKENHI-PROJECT-15H04703
[Presentation] 癌および先天性Ras/MAPK症候群で認められるMEK ミスセンス変異体の異常活性化機構と疾患発症メカニズムの解明2014
- Author(s)
  久保田裕二, 武川睦寛
- Organizer
  日本臨床分子医学会
- Place of Presentation
  京都市勧業館「みやこめっせ」
- Year and Date
  2014-04-10
- Data Source
  KAKENHI-PROJECT-25650003
[Presentation] ERKシグナルの時空間制御異常による遺伝子発現プロファイルの変化2014
- Author(s)
  久保田裕二, 武川睦寛
- Organizer
  第３回修飾シグナル病若手ワークショップ
- Place of Presentation
  神奈川県
- Year and Date
  2014-10-01
- Data Source
  KAKENHI-PROJECT-25650003
[Presentation] 癌およびRas/MAPK症候群におけるMEK変異体の異常活性化機構と抗癌剤抵抗性2014
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25650003
[Presentation] Germ-line and somatic mutations of the MEK gene modulate its kinase activity in congenital Ras-MAPK syndromes and sporadic cancers2014
- Author(s)
  Yuji Kubota, Mutsuhiro Takekawa
- Organizer
  第９回研究所ネットワーク国際シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-25650003
[Presentation] 癌および先天性Ras/MAPK症候群における変異型MEKの異常活性化メカニズムの解明2013
- Author(s)
  久保田裕二,武川睦寛
- Organizer
  平成24年度文部科学省新学術領域研究「がん研究分野の特性等を踏まえた支援活動」冬期シンポジウム
- Place of Presentation
  学術総合センター(東京都)
- Year and Date
  2013-01-30
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] 癌遺伝子Rasの新たな発癌機構-蛋白質SUMO化による細胞増殖ERKシグナル制御と癌におけるその破綻2012
- Author(s)
  久保田裕二,武川睦寛
- Organizer
  第49回日本臨床分子医学会学術集会
- Place of Presentation
  みやこめっせ(京都府)
- Year and Date
  2012-04-13
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] 癌及び先天性Ras/MAPK症候群におけるMEK変異体の異常活性化機構の解明2012
- Author(s)
  久保田裕二,武川睦寛
- Organizer
  「新学術領域研究」修飾シグナル病若手ワークショップ
- Place of Presentation
  ホテルあかね(神奈川県)
- Year and Date
  2012-10-03
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] Molecular basis of constitutively active MEK mutants in the congenital Ras/MAPK syndromes and sporadic cancers2012
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡(福岡県)
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] A novel activation mechanism of MEK1/2 mutants in the congenital Ras/MAPK syndromes and sporadic cancers2011
- Author(s)
  久保田裕二,武川睦寛
- Organizer
  第34回日本分子生物学会年
- Place of Presentation
  横浜パシフィコ(神奈川県)
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] A novel activation mechanism of MEK1/2 mutants in the congenital Ras/MAPK syndromes and sporadic cancers2011
- Author(s)
  久保田裕二
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜パシフィコ(神奈川県)(一般演題)(ポスター発表)
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] Negative regulation of the ERK pathway and cell transformation by MEK SUMOylation2011
- Author(s)
  久保田裕二
- Organizer
  平成23年度がん若手研究者ワークショップ
- Place of Presentation
  アートランドホテル蓼科(長野県)(口演発表)
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] Negative regulation of the ERK pathway and cell transformation by MEK SUMOylation2011
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  平成23年度がん若手研究者ワークショプ
- Place of Presentation
  アートランドホテル蓼科(長野県)
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] 新規ERK基質分子MCRIP1によるERK依存的ジーンサイレンシングと上皮間葉転換の制御
- Author(s)
  市川研史、久保田裕二、Jane Weng、中村貴紀、武川睦寛
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインクあいち（愛知県産業労働センター）
- Data Source
  KAKENHI-PROJECT-25650003
[Presentation] 癌及び先天性Ras/MAPK症候群におけるMEK変異体の異常活性化機構の解明と特異的阻害剤の同定 (口演発表)
- Author(s)
  久保田　裕二
- Organizer
  「新学術領域研究」修飾シグナル病若手ワークショップ
- Place of Presentation
  ホテルあかね（神奈川県）
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] 癌および先天性Ras/MAPK症候群における変異型MEKの異常活性化メカニズムの解明と選択的阻害剤の開発
- Author(s)
  久保田　裕二
- Organizer
  平成24年度文部科学省新学術領域研究「がん研究分野の特性等を踏まえた支援活動」冬期シンポジウム
- Place of Presentation
  学術総合センター（東京都）
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] 癌および先天性Ras/MAPK 症候群におけるMEK 遺伝子変異体の異常活性化メカニズムと疾患発症機構の解明
- Author(s)
  久保田裕二、武川睦寛
- Organizer
  第2 回修飾シグナル病若手ワークショップ
- Place of Presentation
  群馬県伊香保温泉
- Data Source
  KAKENHI-PROJECT-25650003
[Presentation] Molecular basis of constitutively active MEK mutants in the congenital Ras/MAPK syndromes and sporadic cancers. (ポスター発表、演題番号：4ST5-023)
- Author(s)
  久保田　裕二
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡（福岡県）
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] 癌遺伝子Rasの新たな発癌機構 -蛋白質SUMO化による細胞増殖ERKシグナル制御と癌におけるその破綻-（口演発表）
- Author(s)
  久保田　裕二
- Organizer
  第49回日本臨床分子医学会学術集会
- Place of Presentation
  みやこめっせ（京都府）
- Data Source
  KAKENHI-PROJECT-23890077
[Presentation] 「Ras/MAPK症候群」および「孤発性癌」で認められる MEK遺伝子変異体の異常活性化機構と疾患発症メカニズムの解明
- Author(s)
  久保田裕二、木下英司、武川睦寛
- Organizer
  第64回日本電気泳動学会総会
- Place of Presentation
  東北福祉大学ステーションキャンパス
- Data Source
  KAKENHI-PROJECT-25650003

1. Takekawa Mutsuhiro (30322332)

# of Collaborated Projects: 2 results

# of Collaborated Products: 53 results
2. NAKAMURA TAKANORI (30707576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NISHIZUMI NORIKO (30396882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Takagi Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. Kawabe Yosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. ICHIKAWA Kazuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. IIJIMA Masatomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 井上純一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 百瀬功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubota Yuji 久保田 裕二

KUBOTA Yuji 久保田 裕二

Research Projects

Research Products

Co-Researchers

膵前癌病変PanINモデル細胞株を用いた膵管癌発生の分子基盤解明Principal Investigator

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Elucidation of the molecular mechanism of cancer growth signaling by protein O-GlcNAcylationPrincipal Investigator

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Functional analysis of ERK-regulated genes responsible for onset/relapse of cancersPrincipal Investigator

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Development of a novel method for the identification of ncRNA-binding proteins

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Molecular analysis of carcinogenesis caused by mutation-dependent activation of the ERK pathwayPrincipal Investigator

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Regulation of gene expression by novel ERK substrates and its failure in cancer

Principal Investigator

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Development of methods for quantitative and qualitatve analyses of protein O-GlcNAcylation.Principal Investigator

Principal Investigator

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Regulation of the ERK-MAPK cascade and cell-transformation by MEKsumoylationPrincipal Investigator

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[Book] Protein Modifications in Pathogenic Dysregulation of Signaling2015

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[Book] Protein Modifications in Pathogenic Dysregulation of Signaling,2015

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[Book] ユビキチンおよびユビキチン様タンパク質によるMAPキナーゼ経路の制御2012

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[Journal Article] A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.2018

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[Journal Article] WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins2017

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[Journal Article] A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.2016

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Kubota Yuji 久保田裕二

KUBOTA Yuji 久保田裕二

[Presentation] 癌に由来するMEK遺伝子変異体の異常リン酸化の機能解析および病理学的意義の解明2018