Shirakawa Jun 白川純

… Alternative Names

SHIRAKAWA Jun 白川純

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Researcher Number	70625532
Other IDs
Affiliation (Current)	2025: 群馬大学, 生体調節研究所, 教授 2025: 横浜市立大学, 医学研究科, 客員教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 群馬大学, 生体調節研究所, 教授 2020 – 2024: 横浜市立大学, 医学研究科, 客員教授 2019: 横浜市立大学, 医学部, 講師 2017 – 2018: 横浜市立大学, 医学部, 助教 2014: 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 2012 – 2013: 横浜市立大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Basic Section 59040:Nutrition science and health science-related / Metabolomics Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Keywords	Principal Investigator 糖尿病 / 膵β細胞 / 膵島 / 分化転換 / 不均一性 / 炎症 / マクロファージ / 臓器連関 / 栄養素 / インスリン抵抗性 … More / 肥満 / 交感神経 / 内分泌学 / 代謝学 / インスリン / 脱分化 / 膵β細胞量 / グルコキナーゼ / 2型糖尿病 / 小胞体ストレス / アポトーシス … More Except Principal Investigator 糖尿病 / 膵β細胞 / 膵島 / グルコキナーゼ / AldB / UCP2 / インスリン / ミトコンドリア / S100A8 / アルドラーゼB / 糖脂肪毒性 / 膵島炎症 / TLR4 / Aldolase B / インスリン抵抗性 / 骨格筋 / 2型糖尿病 / サルコペニア / 糖 / 分化 / アポトーシス / 増殖 / グルコース / グルコースシグナル Less

機能的な膵β細胞量を増加させる「膵β細胞のhealthy expansion」の分子機構の解明
- Principal Investigator
  
  寺内康夫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
Exploring inter-organ crosstalk to uncover mechanisms that regulate islet function under insulin resistance or obesityPrincipal Investigator
- Principal Investigator
  
  白川純
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gunma University
Regulation of beta cell fate during dedifferentiationPrincipal Investigator
- Principal Investigator
  
  Shirakawa Jun
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Gunma University
Elucidation of pathogenesis and treatment of islet mitochondrial dysfunction and inflammation under glucolipotoxicity
- Principal Investigator
  
  TERAUCHI Yasuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
A novel sarcopenia model by insulin / IGF-1 receptor inhibition
- Principal Investigator
  
  TOGASHI Yu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
Heterogeneity of pancreatic isletsPrincipal Investigator
- Principal Investigator
  
  Shirakawa Jun
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
Fate determination of pancreatic beta cells by glucokinase activation
- Principal Investigator
  
  Terauchi Yasuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
Glucokinase Activation Ameliorates ER Stress-Induced Apoptosis in Pancreatic Beta-CellsPrincipal Investigator
- Principal Investigator
  
  SHIRAKAWA JUN
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
Establishing a base for tailor-made therapy on diabetes from the view point of the pancreatic beta cell mass
- Principal Investigator
  
  TERAUCHI Yasuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Encapsulated human islets in alginate fiber maintain long-term functionality2024
- Author(s)
  Nishida Junko、Tsuno Takahiro、G. Yabe Shigeharu、Kin Tatsuya、Fukuda Satsuki、Takeda Fujie、Shirakawa Jun、Okochi Hitoshi
- Journal Title
  
  Endocr J
  
  Volume: 71 Issue: 3 Pages: 253-264
- DOI
  10.1507/endocrj.EJ23-0474
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K28014
[Journal Article] Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion2023
- Author(s)
  Moon Sohyun、Alsarkhi Lamyaa、Lin Tai‐Tu、Inoue Ryota、Tahiri Azeddine、Colson Cecilia、Cai Weikang、Shirakawa Jun、Qian Wei‐Jun、Zhao Jerry Yingtao、El?Ouaamari Abdelfattah
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 10
- DOI
  10.1096/fj.202300941r
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K28014
[Journal Article] Signaling pathways that regulate adaptive β‐cell proliferation for the treatment of diabetes2023
- Author(s)
  Shirakawa Jun
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 14 Issue: 6 Pages: 735-740
- DOI
  10.1111/jdi.14002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K28014
[Journal Article] Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice2023
- Author(s)
  Nishiyama Kuniyuki、Ono Masato、Tsuno Takahiro、Inoue Ryota、Fukunaka Ayako、Okuyama Tomoko、Kyohara Mayu、Togashi Yu、Fukushima Setsuko、Atsumi Takuto、Sato Aoi、Tsurumoto Asuka、Sakai Chisato、Fujitani Yoshio、Terauchi Yasuo、Ito Shuichi、Shirakawa Jun
- Journal Title
  
  Endocrinology
  
  Volume: 164 Issue: 8
- DOI
  10.1210/endocr/bqad095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04801, KAKENHI-PROJECT-23K27652, KAKENHI-PROJECT-23K28014
[Journal Article] A Disproportionality Analysis of the Adverse Effect Profiles of Methimazole and Propylthiouracil in Patients with Hyperthyroidism Using the Japanese Adverse Drug Event Report Database2023
- Author(s)
  Arai Masanori、Tsuno Takahiro、Konishi Hiromi、Nishiyama Kuniyuki、Terauchi Yasuo、Inoue Ryota、Shirakawa Jun
- Journal Title
  
  Thyroid
  
  Volume: 33 Issue: 7 Pages: 804-816
- DOI
  10.1089/thy.2023.0030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K28014
[Journal Article] Validity and reliability of the Japanese version of the diabetes knowledge test among in‐patients with type 2 diabetes2022
- Author(s)
  Minami Taichi、Shirakawa Jun、Hiiragi Hiroko、Yamada Taku、Suzuki Youichi、Shirabe Shinitiro、Maeda Hajime、Terauchi Yasuo
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 13 Issue: 3 Pages: 580-587
- DOI
  10.1111/jdi.13683
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study2022
- Author(s)
  Kyohara Mayu、Miyashita Daisuke、Inoue Ryota、Nishiyama Kuniyuki、Tsuno Takahiro、Okuyama Tomoko、Togashi Yu、Terauchi Yasuo、Shirakawa Jun
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 11 Pages: e0276915-e0276915
- DOI
  10.1371/journal.pone.0276915
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance.2022
- Author(s)
  Shirakawa J, Togashi Y, Basile G, Okuyama T, Inoue R, Fernandez M, Kyohara M, De Jesus DF, Goto N, Zhang W, Tsuno T, Kin T, Pan H, Dreyfuss JM, Shapiro AMJ, Yi P, Terauchi Y, Kulkarni RN.
- Journal Title
  
  Cell Rep.
  
  Volume: 41(1) Issue: 1 Pages: 111436-111436
- DOI
  10.1016/j.celrep.2022.111436
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03733, KAKENHI-PROJECT-20K08866
[Journal Article] Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes.2022
- Author(s)
  Miyashita D, Inoue R, Tsuno T, Okuyama T, Kyohara M, Nakahashi-Oda C, Nishiyama K, Fukushima S, Inada Y, Togashi Y, Shibuya A, Terauchi Y, Shirakawa J.
- Journal Title
  
  iScience
  
  Volume: 25(12) Issue: 12 Pages: 105662-105662
- DOI
  10.1016/j.isci.2022.105662
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03733, KAKENHI-PROJECT-20K08866
[Journal Article] Insulin regulates arginine-stimulated insulin secretion in humans2022
- Author(s)
  Halperin Florencia、Mezza Teresa、Li Ping、Shirakawa Jun、Kulkarni Rohit N.、Goldfine Allison B.
- Journal Title
  
  Metabolism
  
  Volume: 128 Pages: 155117-155117
- DOI
  10.1016/j.metabol.2021.155117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Recent developments in Phos-tag electrophoresis for the analysis of phosphoproteins in proteomics2022
- Author(s)
  Hirano Hisashi、Shirakawa Jun
- Journal Title
  
  Expert Review of Proteomics
  
  Volume: 19 Issue: 2 Pages: 103-114
- DOI
  10.1080/14789450.2022.2052850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion2022
- Author(s)
  Sobajima Mitsuaki、Miyake Masato、Hamada Yoshimasa、Tsugawa Kazue、Oyadomari Miho、Inoue Ryota、Shirakawa Jun、Arima Hiroshi、Oyadomari Seiichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 611 Pages: 165-171
- DOI
  10.1016/j.bbrc.2022.04.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08866, KAKENHI-PROJECT-20K08909
[Journal Article] Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER2022
- Author(s)
  Inoue Ryota、Tsuno Takahiro、Togashi Yu、Okuyama Tomoko、Sato Aoi、Nishiyama Kuniyuki、Kyohara Mayu、Li Jinghe、Fukushima Setsuko、Kin Tatsuya、Miyashita Daisuke、Shiba Yusuke、Atobe Yoshitoshi、Kiyonari Hiroshi、Bando Kana、Shapiro A.M. James、Funakoshi Kengo、Kulkarni Rohit N.、Terauchi Yasuo、Shirakawa Jun
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 7 Pages: 104603-104603
- DOI
  10.1016/j.isci.2022.104603
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K21247, KAKENHI-PROJECT-20H03733, KAKENHI-PROJECT-20K08866
[Journal Article] Abdominal aortic calcification is associated with Fibrosis‐4 index and low body mass index in type?2 diabetes patients: A retrospective cross‐sectional study2022
- Author(s)
  Togashi Yu、Miyashita Daisuke、Tsuno Takahiro、Inoue Ryota、Okuyama Tomoko、Kyohara Mayu、Nishiyama Kuniyuki、Arai Masanori、Kanematsu Kenta、Kanataki Soichiro、Terauchi Yasuo、Shirakawa Jun
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 13 Issue: 11 Pages: 1861-1872
- DOI
  10.1111/jdi.13883
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells2021
- Author(s)
  Charoensuk Chutima、Thamtarana Prapaporn Jungtrakoon、Chanprasert Chutima、Tangjittipokin Watip、Shirakawa Jun、Togashi Yu、Orime Kazuki、Songprakhon Pucharee、Chaichana Chartchai、Abubakar Zuroida、Ouying Paweena、Sujjitjoon Jatuporn、Doria Alessandro、Plengvidhya Nattachet、Yenchitsomanus Pa-thai
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 522 Pages: 111126-111126
- DOI
  10.1016/j.mce.2020.111126
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes2021
- Author(s)
  Okuyama Tomoko、Shirakawa Jun、Nakamura Takashi、Murase Takayo、Miyashita Daisuke、Inoue Ryota、Kyohara Mayu、Togashi Yu、Terauchi Yasuo
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 3768-3768
- DOI
  10.1038/s41598-021-83234-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway2021
- Author(s)
  Li Jinghe、Inoue Ryota、Togashi Yu、Okuyama Tomoko、Satoh Aoi、Kyohara Mayu、Nishiyama Kuniyuki、Tsuno Takahiro、Miyashita Daisuke、Kin Tatsuya、Shapiro A.M. James、Chew Resilind Su Ern、Teo Adrian Kee Keong、Oyadomari Seiichi、Terauchi Yasuo、Shirakawa Jun
- Journal Title
  
  Diabetes
  
  Volume: 71 Issue: 3 Pages: 424-439
- DOI
  10.2337/db21-0123
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02853, KAKENHI-PROJECT-21K21247, KAKENHI-PROJECT-20K08866
[Journal Article] Pancreatic β‐cell fate in subjects with COVID‐192021
- Author(s)
  Shirakawa Jun
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 12 Issue: 12 Pages: 2126-2128
- DOI
  10.1111/jdi.13671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Translational research on human pancreatic β-cell mass expansion for the treatment of diabetes2021
- Author(s)
  Shirakawa Jun
- Journal Title
  
  Diabetology International
  
  Volume: 12 Issue: 4 Pages: 349-355
- DOI
  10.1007/s13340-021-00531-4
- NAID
  130008145820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice2021
- Author(s)
  Takatani Tomozumi、Shirakawa Jun、Shibue Kimitaka、Gupta Manoj K.、Kim Hyunki、Lu Shusheng、Hu Jiang、White Morris F.、Kennedy Robert T.、Kulkarni Rohit N.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100646-100646
- DOI
  10.1016/j.jbc.2021.100646
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes2021
- Author(s)
  Inoue Ryota、Nishiyama Kuniyuki、Li Jinghe、Miyashita Daisuke、Ono Masato、Terauchi Yasuo、Shirakawa Jun
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 7 Pages: 1589-1589
- DOI
  10.3390/cells10071589
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Asymptomatic meningitis diagnosed by positron emission tomography in a patient with syndrome of inappropriate antidiuretic hormone secretion: a case report2021
- Author(s)
  Hasebe Masanori、Shirakawa Jun、Miyashita Daisuke、Kunishita Rieko、Kyohara Mayu、Okuyama Tomoko、Togashi Yu、Terauchi Yasuo
- Journal Title
  
  Journal of Medical Case Reports
  
  Volume: 15 Issue: 1 Pages: 390-390
- DOI
  10.1186/s13256-021-02956-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling2021
- Author(s)
  Okuyama Tomoko、Kyohara Mayu、Terauchi Yasuo、Shirakawa Jun
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 13 Pages: 6817-6817
- DOI
  10.3390/ijms22136817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study2021
- Author(s)
  Terui Sakiko、Akamatsu Ryoichi、Arai Masanori、Inoue Ryota、Okuyama Tomoko、Kyohara Mayu、Li Jinghe、Tsuno Takahiro、Miyashita Daisuke、Togashi Yu、Terauchi Yasuo、Shirakawa Jun
- Journal Title
  
  Diabetes Therapy
  
  Volume: 12 Issue: 11 Pages: 2873-2889
- DOI
  10.1007/s13300-021-01147-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality2020
- Author(s)
  Shirakawa Jun、Terauchi Yasuo
- Journal Title
  
  Endocr J
  
  Volume: 67 Issue: 1 Pages: 1-8
- DOI
  10.1507/endocrj.EJ19-0335
- NAID
  130007790985
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] A case of an elderly patient with insulin-dependent diabetes and dementia receiving one basal insulin plus one bolus insulin injections a day for 6?months2020
- Author(s)
  Minami Taichi、Shirakawa Jun、Kameda Akiko、Suzuki Yoichi、Watanabe Kaoru、Yamada Taku、Hiiragi Hiroko、Takeda Soichiro、Takahashi Mayuko、Terauchi Yasuo
- Journal Title
  
  Diabetology International
  
  Volume: 12 Issue: 1 Pages: 135-139
- DOI
  10.1007/s13340-020-00452-8
- NAID
  40022457530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor2020
- Author(s)
  Okuyama Tomoko、Shirakawa Jun、Tajima Kazuki、Ino Yoko、Vethe Heidrun、Togashi Yu、Kyohara Mayu、Inoue Ryota、Miyashita Daisuke、Li Jinghe、Goto Nozomi、Ichikawa Taiga、Yamasaki Shingo、Ohnuma Haruka、Takayanagi Rie、Kimura Yayoi、Hirano Hisashi、Terauchi Yasuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 21 Pages: 7815-7815
- DOI
  10.3390/ijms21217815
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08866, KAKENHI-PROJECT-19H03774
[Journal Article] Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects2020
- Author(s)
  Kyohara Mayu、Shirakawa Jun、Okuyama Tomoko、Togashi Yu、Inoue Ryota、Li Jinghe、Miyashita Daisuke、Terauchi Yasuo
- Journal Title
  
  Diabetology & Metabolic Syndrome
  
  Volume: 12 Issue: 1 Pages: 83-83
- DOI
  10.1186/s13098-020-00591-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08866
[Journal Article] Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells2020
- Author(s)
  Gupta Manoj K.、Vethe Heidrun、Softic Samir、Rao Tata Nageswara、Wagh Vilas、Shirakawa Jun、Barsnes Harald、Vaudel Marc、Takatani Tomozumi、Kahraman Sevim、Sakaguchi Masaji、Martinez Rachael、Hu Jiang、Bj?rlykke Yngvild、Raeder Helge、Kulkarni Rohit N.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 15 Issue: 5 Pages: 1067-1079
- DOI
  10.1016/j.stemcr.2020.10.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08866, KAKENHI-PROJECT-18K16208
[Journal Article] Potential linkage between dipeptidyl peptidase‐4 inhibitor use and the risk of pancreatitis/pancreatic cancer2020
- Author(s)
  Shirakawa Jun、Terauchi Yasuo
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: in press Issue: 4 Pages: 789-791
- DOI
  10.1111/jdi.13192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16240, KAKENHI-PROJECT-20K08866
[Journal Article] Melanophilin accelerates insulin granule fusion without predocking to the plasma membrane.2020
- Author(s)
  Wang H, Mizuno K, Takahashi N, Kobayashi E, Shirakawa J, Terauchi Y, Kasai H, Okunishi K, Izumi T.
- Journal Title
  
  Diabetes
  
  Volume: 69 Issue: 12 Pages: 2655-2666
- DOI
  10.2337/db20-0069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07280, KAKENHI-PROJECT-20K08796, KAKENHI-PROJECT-20K08866, KAKENHI-PROJECT-20H05685, KAKENHI-PROJECT-20H00480, KAKENHI-PROJECT-19H03449, KAKENHI-PROJECT-20K15742
[Journal Article] Luseogliflozin Increases Beta Cell Proliferation Through Humoral Factors That Activate an Insulin Receptor- And IGF-1 Receptor-Independent Pathway2020
- Author(s)
  Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN, Terauchi Y.
- Journal Title
  
  Diabetologia
  
  Volume: 63 Issue: 3 Pages: 577-587
- DOI
  10.1007/s00125-019-05071-w
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16240, KAKENHI-PROJECT-20K08866
[Journal Article] Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity2019
- Author(s)
  Ji Yewei、Sun Shengyi、Shrestha Neha、Darragh Laurel B.、Shirakawa Jun、Xing Yuan、He Yi、Carboneau Bethany A.、Kim Hana、An Duo、Ma Minglin、Oberholzer Jose、Soleimanpour Scott A.、Gannon Maureen、Liu Chengyang、Naji Ali、Kulkarni Rohit N.、Wang Yong、Kersten Sander、Qi Ling
- Journal Title
  
  Nature Immunology
  
  Volume: 20 Issue: 6 Pages: 677-686
- DOI
  10.1038/s41590-019-0396-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes2019
- Author(s)
  Jungtrakoon Prapaporn、Shirakawa Jun、Buranasupkajorn Patinut、Gupta Manoj K.、De Jesus Dario F.、Pezzolesi Marcus G.、Panya Aussara、Hastings Timothy、Chanprasert Chutima、Mendonca Christine、Kulkarni Rohit N.、Doria Alessandro
- Journal Title
  
  Diabetes
  
  Volume: 68 Issue: 5 Pages: 1084-1093
- DOI
  10.2337/db17-0821
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] Influence of Timing of Insulin Initiation on Long-term Glycemic Control in Japanese Patients with Type 2 Diabetes: A Retrospective Cohort Study2019
- Author(s)
  Miyazaki Takashi、Shirakawa Jun、Nagakura Jo、Shibuya Makoto、Kyohara Mayu、Okuyama Tomoko、Togashi Yu、Nakamura Akinobu、Kondo Yoshinobu、Satoh Shinobu、Nakajima Shigeru、Taguri Masataka、Terauchi Yasuo
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 23 Pages: 3361-3367
- DOI
  10.2169/internalmedicine.3060-19
- NAID
  130007754643
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-12-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] Drug-induced hyperglycemia in the Japanese Adverse Drug Event Report database: association of evelolimus use with diabetes2019
- Author(s)
  Konishi Hiromi、Shirakawa Jun、Arai Masanori、Terauchi Yasuo
- Journal Title
  
  Endocr J
  
  Volume: 66 Issue: 6 Pages: 571-574
- DOI
  10.1507/endocrj.EJ18-0553
- NAID
  130007668508
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] A Randomized Controlled Trial of a Mini Low-Carbohydrate Diet and an Energy-Controlled Diet Among Japanese Patients With Type 2 Diabetes2018
- Author(s)
  Kimura Masayo、Kondo Yoshinobu、Aoki Kazutaka、Shirakawa Jun、Kamiyama Hiroshi、Kamiko Kazunari、Nakajima Shigeru、Terauchi Yasuo
- Journal Title
  
  Journal of Clinical Medicine Research
  
  Volume: 10 Issue: 6 Pages: 531-534
- DOI
  10.14740/jocmr3281wc1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] Bullous Pemphigoid and Dipeptidyl Peptidase 4 Inhibitors: A Disproportionality Analysis Based on the Japanese Adverse Drug Event Report Database2018
- Author(s)
  Arai Masanori、Shirakawa Jun、Konishi Hiromi、Sagawa Naoko、Terauchi Yasuo
- Journal Title
  
  Diabetes Care
  
  Volume: 41 Issue: 9 Pages: e130-e132
- DOI
  10.2337/dc18-0210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion2018
- Author(s)
  El Ouaamari Abdelfattah、O-Sullivan InSug、Shirakawa Jun、Basile Giorgio、Zhang Wenwei、Roger Sandra、Thomou Thomas、Xu Shanshan、Qiang Guifen、Liew Chong Wee、Kulkarni Rohit N.、Unterman Terry G.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 3 Pages: 1059-1069
- DOI
  10.1074/jbc.ra118.006031
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] Signaling between pancreatic beta-cells and macrophages via S100 calcium-binding protein A8 exacerbates beta-cell apoptosis and islet inflammation.2018
- Author(s)
  Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 293 Issue: 16 Pages: 5934-5946
- DOI
  10.1074/jbc.m117.809228
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-18K16240, KAKENHI-PROJECT-17K16152
[Journal Article] SUSTAINable management of type 2 diabetes: feasibility of use and safety of semaglutide2018
- Author(s)
  Shirakawa Jun、Terauchi Yasuo
- Journal Title
  
  Annals of Translational Medicine
  
  Volume: 6 Issue: 7 Pages: 129-129
- DOI
  10.21037/atm.2018.01.35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16240
[Journal Article] Rapid recovery of adipose tissue atrophy, liver steatosis, and pancreatic β cells proliferation after dual inhibition of insulin and IGF-1 receptors.2017
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Yamasaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017
- Author(s)
  Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamasaki S, Tajima K, Togashi Y, Terauchi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7(1) Issue: 1 Pages: 2345-2345
- DOI
  10.1038/s41598-017-02535-0
- NAID
  120007134459
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-17H06992
[Journal Article] Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.2017
- Author(s)
  Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A, Kulkarni RN.
- Journal Title
  
  Cell Metab.
  
  Volume: 25(4): Issue: 4 Pages: 868-882
- DOI
  10.1016/j.cmet.2017.02.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017
- Author(s)
  Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamasaki S, Tajima K, Togashi Y, Terauchi Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- NAID
  120007134459
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-9062017
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Yamazaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 4119-4119
- DOI
  10.1038/s41598-017-04304-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16152, KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-16K19542
[Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans.2017
- Author(s)
  Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 158(12) Issue: 12 Pages: 4152-4164
- DOI
  10.1210/en.2017-00339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-15K19028
[Journal Article] Glucose- or insulin resistance-mediated β-cell replication: PKCζ integrates the proliferative signaling.2016
- Author(s)
  Shirakawa J, Terauchi Y.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 8 Issue: 2 Pages: 149-151
- DOI
  10.1111/jdi.12558
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Evaluation of blood glucose meters for measuring mouse blood glucose levels.2016
- Author(s)
  Togashi Y, Shirakawa J, Okuyama T, Kyohara M, Yamazaki S, Miyazawa A, Suzuki T, Hamada M, Terauchi Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 25465-25465
- DOI
  10.1038/srep25465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice.2014
- Author(s)
  Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y.
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 305
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860754
[Journal Article] Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β cell functions, and β cell proliferation in male mice2014
- Author(s)
  Shirakawa J, Okuyama T, Yoshida E, Shimizu M, Horigome Y, Tuno T, Hayasaka M, Abe S, Fuse M, Togashi Y, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy2014
- Author(s)
  Shirakawa J, Murohashi Y, Okazaki N, Yamazaki S, Tamura T, Okuyama T, Togashi Y, Terauchi Y.
- Journal Title
  
  Endocr J
  
  Volume: 61 Issue: 11 Pages: 1115-1123
- DOI
  10.1507/endocrj.EJ14-0290
- NAID
  130004677955
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860754, KAKENHI-PROJECT-26860698
[Journal Article] β cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.2014
- Author(s)
  Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 155(5) Pages: 1643-52
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β cell functions, and β cell proliferation in male mice.2014
- Author(s)
  Shirakawa J, Okuyama T, Yoshida E, Shimizu M, Horigome Y, Tuno T, Hayasaka M, Abe S, Fuse M, Togashi Y, Terauchi Y.
- Journal Title
  
  Endocrinologｙ
  
  Volume: in press Issue: 6 Pages: 2102-11
- DOI
  10.1210/en.2013-2032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860754
[Journal Article] Selective and sequential loss of transcriptional factors: a hallmark of β cell failure in type 2 diabetes?2014
- Author(s)
  Shirakawa J, Terauchi Y
- Journal Title
  
  J Diabetes Invest.
  
  Volume: in press Issue: 4 Pages: 359-61
- DOI
  10.1111/jdi.12212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860754
[Journal Article] Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β cell functions, and β cell proliferation in male mice.2014
- Author(s)
  Shirakawa J, Okuyama T, Yoshida E, Shimizu M, Horigome Y, Tuno T, Hayasaka M, Abe S, Fuse M, Togashi Y, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 155(6) Pages: 2102-11
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] β cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.2014
- Author(s)
  Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 155 Issue: 5 Pages: 1643-52
- DOI
  10.1210/en.2013-1796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25860754, KAKENHI-PROJECT-26860698
[Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 Mice.2013
- Author(s)
  Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y.
- Journal Title
  
  Am. J. Physiol. Endocrinol. Metab.
  
  Volume: 305 Issue: 8 Pages: 987-998
- DOI
  10.1152/ajpendo.00133.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-25670455, KAKENHI-PROJECT-25860754
[Journal Article] AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration.2013
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Inoue H, Sato K, Orime K, Ito Y, Kaji M, Sakamoto E, Nakamura A, Aoki K, Goshima Y, Atsumi T, Terauchi Y.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 5 Pages: e64633-e64633
- DOI
  10.1371/journal.pone.0064633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-24390235, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25670455, KAKENHI-PROJECT-25860754
[Journal Article] Trefoil Factor 2 Promotes Cell Proliferation in Pancreaticβ-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation2013
- Author(s)
  Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi, Y
- Journal Title
  
  Endocrinology
  
  Volume: 154(1) Issue: 1 Pages: 54-64
- DOI
  10.1210/en.2012-1814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-25860754
[Journal Article] Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β cells.2013
- Author(s)
  Shirakawa J, Togashi Y, Sakamoto E, Kaji M, Tajima K, Orime K, Inoue H, Kubota N, Kadowaki T, Terauchi Y.
- Journal Title
  
  Diabetes
  
  Volume: 62 Issue: 10 Pages: 3448-58
- DOI
  10.2337/db13-0052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-24390235, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25860754
[Journal Article] Trefoil factor 2 promotes cell proliferation in pancreatic β cells through CXCR-4-mediated ERK1/2 phosphorylation.2013
- Author(s)
  Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 154 Pages: 54-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] Effects of liraglutide on B cell-specific glucokinase-deficient neonatal mice.2012
- Author(s)
  Shirakawa J, et al.
- Journal Title
  
  Endocrinology
  
  Volume: 153 Pages: 3066-3075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] 膵島腺房細胞連関を介したGLP-1による膵β細胞増殖制御機構の解明2024
- Author(s)
  京原麻由，寺内康夫，白川純
- Organizer
  第37回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K27652
[Presentation] 急性インスリン抵抗性に対する膵β 細胞量の代償性増大機構2023
- Author(s)
  白川　純
- Organizer
  第66回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K28014
[Presentation] 糖毒性下におけるUCP2およびアルドラーゼBを介した膵β細胞障害機構の解明2023
- Author(s)
  井上亮太、寺内康夫、白川　純
- Organizer
  第58回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27652
[Presentation] インスリン分泌障害の新しい機序2023
- Author(s)
  白川　純
- Organizer
  第54回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] 膵島細胞の統合的解析による糖尿病の病態解明および治療法開発2023
- Author(s)
  白川　純
- Organizer
  第36回日本糖尿病・肥満動物学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] The role of acinar cells in GLP-1R-mediated beta cell proliferation2023
- Author(s)
  Jun Shirakawa
- Organizer
  The 15th AASD Scientific Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-23K28014
[Presentation] Mechanisms underlying compensatory β cell replication in response to insulin resistance2023
- Author(s)
  Jun Shirakawa
- Organizer
  第66回日本糖尿病学会年次学術集会　Japan-Korea Diabetes Forum
- Invited
- Data Source
  KAKENHI-PROJECT-23K28014
[Presentation] Signaling pathways that regulate adaptive β-cell proliferation2022
- Author(s)
  Jun Shirakawa
- Organizer
  The 14th AASD Scientific Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] 糖尿病の合併症予防へ向けた分子機序からのアプローチ2022
- Author(s)
  白川　純
- Organizer
  第65回日本糖尿病学会年次学術集
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] 液性因子を介した膵β細胞増殖促進機構の新機軸2022
- Author(s)
  白川　純
- Organizer
  第95回　日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] ヒトの膵β細胞量増大による糖尿病治療を目指した基礎的研究2021
- Author(s)
  白川　純
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] 日本人ヒト膵島の研究転用の意義と課題2021
- Author(s)
  白川　純
- Organizer
  第57回日本移植学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] ヒトの膵β細胞量増大による糖尿病治療を目指した基礎的研究2021
- Author(s)
  白川　純
- Organizer
  第64回日本糖尿病学会年次学術集会　リリー賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-20H03733
[Presentation] 培養ヒト膵島を用いた膵β細胞機能と膵β細胞量の制御機構の解析2021
- Author(s)
  白川　純
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] 肥満・糖尿病の病態および治療における免疫と癌2021
- Author(s)
  白川　純
- Organizer
  第20回生体機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] インスリンシグナルと膵島細胞の制御2020
- Author(s)
  白川　純
- Organizer
  第55回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] 膵β細胞の再生2020
- Author(s)
  白川　純
- Organizer
  第54回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] グルコースシグナルを介した膵β細胞機能調節機構の解明2020
- Author(s)
  白川　純
- Organizer
  第96回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03733
[Presentation] Heterogeneity of pancreatic islets2020
- Author(s)
  Jun Shirakawa
- Organizer
  The 15th International Symposium of the Institute Network for Biomedical Sciences
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] 日本人膵島の特性を考慮した早期からの糖尿病治療2020
- Author(s)
  白川　純
- Organizer
  第48回日本膵・膵島移植研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08866
[Presentation] ヒト膵島研究の世界的動向2019
- Author(s)
  白川　純
- Organizer
  第62回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K16240
[Presentation] 膵島におけるS100A8/A9の発現制御機構の解析2018
- Author(s)
  奥山　朋子　白川　純　金滝聡一郎　寺内　康夫
- Organizer
  第33回日本糖尿病・肥満動物学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] Functional role and mechanism of UCP2 upregulation in pancreatic β cells2018
- Author(s)
  Ryota Inoue, Jun Shirakawa, Yu Togashi, Yasuo Terauchi
- Organizer
  78th American Diabetes Association (ADA) meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] グルコースおよびインスリンシグナルの変動に伴う膵島UCP2発現の検討．2018
- Author(s)
  井上亮太、白川　純、富樫　優、寺内　康夫．
- Organizer
  第32回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 膵β細胞におけるinsulin-like growth factor-2受容体（IGF2R）の役割．2018
- Author(s)
  白川純、寺内康夫
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 血清プロテオーム解析により同定されたsoluble EGFRの糖尿病バイオマーカーとしての検討2018
- Author(s)
  京原麻由、白川純、木村鮎子、平野久、寺内康夫
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 膵β細胞におけるUCP2発現上昇の意義の検討2018
- Author(s)
  井上亮太、白川　純、富樫　優、寺内　康夫．
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] Insulin-like growth factor-2受容体（IGF2R）の膵β細胞における役割2018
- Author(s)
  白川　純、Rohit N Kulkarni, 寺内　康夫
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 膵β細胞増殖モデルマウスを用いた糖尿病研究2017
- Author(s)
  富樫優、白川純、田島一樹、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Invited
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 細胞外弾性線維形成蛋白Fibulin-5によるインスリン抵抗性および肥満惹起機構の解明2017
- Author(s)
  奥山朋子、白川純、柳沢裕美、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] メトホルミンは、インスリン抵抗性とは独立して、膵β細胞に保護的に作用する2017
- Author(s)
  田島一樹、白川純、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] Heterogeneity of pancreatic islets.2017
- Author(s)
  Shirakawa j, Terauchi Y.
- Organizer
  The 60th Annual Meeting of the Japan Diabetes Society
- Invited
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] OSI-906投与マウスモデルにおけるDPP-4阻害薬およびSGLT-2阻害薬の膵β細胞、肝臓、脂肪組織へ効果2017
- Author(s)
  市川大河、山崎伸悟、白川純、田島一樹、奥山朋子、山崎俊介、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] db/dbマウスの血清プロテオミクスより同定されたsoluble EGFRは新たな糖尿病マーカー候補である2017
- Author(s)
  京原　麻由、白川　純、寺内　康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017
- Author(s)
  Okuyama T, Shirakawa J, Yanagisawa H, Terauchi Y.
- Organizer
  77th American Diabetes Association (ADA) meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] Identification of Soluble EGFR as a Serum Biomarker of Insulin Resistance by a Quantitative Proteomic Analysis Using Mice with Diabetes.2017
- Author(s)
  Kyohara M, Shirakawa J, Kimura A, Hirano H, Terauchi Y.
- Organizer
  77th American Diabetes Association (ADA) meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] リラグルチド投与による肥満糖尿病モデルdb/dbマウスにおける血清タンパク変動の網羅的解析2016
- Author(s)
  京原麻由、白川純、木村鮎子、平野久、寺内康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  京都国際会館（京都府）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 簡易血糖測定器を用いたマウスの血糖測定の評価2016
- Author(s)
  富樫　優、白川　純、鈴木　崇文、宮沢　あゆみ、浜田　麻里、寺内　康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  京都国際会館（京都府）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 細胞外弾性線維形成蛋白Fibulin-5はインスリン抵抗性および肥満惹起に関与する2016
- Author(s)
  奥山朋子、白川純、柳沢裕美、寺内康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  京都国際会館（京都府）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] A Mouse of Model of Acute Reversible Lipodystrophy with Dual Inhibition of Insulin and IGF-1 Receptors.2016
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Terauchi Y.
- Organizer
  76th American Diabetes Association (ADA) meeting
- Place of Presentation
  New Orleans，USA
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] メトホルミンによる膵β細胞保護作用の検討2016
- Author(s)
  田島一樹、白川　純、富樫　優、折目和基、寺内康夫
- Organizer
  日本臨床分子医学会
- Place of Presentation
  東京国際フォーラム（東京都）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] S100A8を介した膵島とマクロファージの相互作用による膵島炎症惹起機構の解明2016
- Author(s)
  井上英昭、白川純、折目和基、田島一樹、富樫優、京原麻由、奥山朋子、吉田瑛子、山崎俊介、小西裕美、寺内康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  京都国際会館（京都府）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] ワークショップ　膵島の単離とβ細胞の培養法2014
- Author(s)
  白川純、寺内康夫
- Organizer
  第28回　日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  宮崎市民プラザ（宮崎県宮崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-25860754
[Presentation] シンポジウム１　膵β細胞障害と再生　増殖およびアポトーシスの制御による膵β細胞量の調節機構2014
- Author(s)
  白川純、寺内康夫
- Organizer
  第28回　日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  宮崎市民プラザ（宮崎県宮崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-25860754
[Presentation] Characterization of target genes of glucokinase activator (GKA) in pancreatic islets.2013
- Author(s)
  Shirakawa J, Terauchi Y
- Organizer
  73rd American Diabetes Association (ADA) meeting
- Place of Presentation
  Chicago, USA.
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β cells.2013
- Author(s)
  Shirakawa J, Terauchi Y
- Organizer
  Beta Cell Workshop 2013 Kyoto
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] Coordinated effects of macrophages and free fatty acids on the inflammatory gene expression in pancreatic islets.2013
- Author(s)
  Inoue H, Shirakawa J, Orime K, Togashi Y, Terauchi Y
- Organizer
  49th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] シンポジウム　膵β細胞研究の進化と展望　増殖およびアポトーシスの制御による膵β細胞量の調節機構2013
- Author(s)
  白川純, 井上英明, 田島一樹, 富樫優, 寺内康夫
- Organizer
  第56回　日本糖尿病学会年次学術集会
- Place of Presentation
  ホテル日航熊本（熊本県熊本市）
- Invited
- Data Source
  KAKENHI-PROJECT-25860754
[Presentation] Characterization of target genes of glucokinase activator (GKA) in pancreatic islets.2013
- Author(s)
  Jun Shirakawa, Kazuki Orime, Yu Togashi, hideaki Inoue, Yasuo Terauchi
- Organizer
  73th American Diabetes Association (ADA) meeting
- Place of Presentation
  Chicago, IL, USA
- Data Source
  KAKENHI-PROJECT-25860754
[Presentation] Partial pancreatectomy facilitated β cell proliferation in glucokinase haploinsufficient mice and IRS-2 deficient mice.2013
- Author(s)
  Togashi Y, Shirakawa J, Orime K, Inoue H, Nakamura A, Terauchi Y.
- Organizer
  73rd American Diabetes Association (ADA) meeting
- Place of Presentation
  Chicago, USA.
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] The roles of glucokinase activation and IRS-2 in ER stress-induced apoptosis in pancreatic β cells.2013
- Author(s)
  Jun Shirakawa, Yu Togashi, Kazuki Orime, Kazuki Tajima, Mitsuyo Kaji, Eri Sakamoto, and Yasuo Terauchi
- Organizer
  第56回　日本糖尿病学会年次学術集会
- Place of Presentation
  ホテル日航熊本（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-25860754
[Presentation] β cell proliferation in glucokinase haploinsufficient mice and IRS-2 deficient mice after a partial pancreatectomy.2013
- Author(s)
  Togashi Y, Shirakawa J, Terauchi Y
- Organizer
  Beta Cell Workshop 2013 Kyoto
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] Glucokinase activator ameliorates B cell ER stress and apoptosis by both IRS-2-dependent and -independent pathways.2012
- Author(s)
  Shirakawa J, et al.
- Organizer
  第72回米国糖尿病学会
- Place of Presentation
  フィラデルフィア(米国)
- Year and Date
  2012-06-10
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] Effects of glucokinase activator (GKA)on the regulation of B cell ER stress and incretin receptor expressions.2012
- Author(s)
  白川純
- Organizer
  第55回日本糖尿病学会
- Place of Presentation
  パシフィコ横浜(神奈川県)(招待講演)
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] The role of S100A8 and S100A9 in inflammatory interaction between pancreatic islets and macrophages.
- Author(s)
  Inoue H, Shirakawa J, Orime K, Togashi Y, Tajima K, Terauchi Y
- Organizer
  50th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Vienna, Austria.
- Year and Date
  2014-09-15 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] Isolation of target genes of liraglutide, a GLP-1 receptor agonist, in pancreatic islets by using nano-LC-MS/MS system.
- Author(s)
  Yoshida E, Shirakawa J, Okuyama T, Kyohara M, Togashi Y, Kimura A, Hirano H, Terauchi Y
- Organizer
  50th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Vienna, Austria.
- Year and Date
  2014-09-15 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-24390235

1. TERAUCHI Yasuo (40359609)

# of Collaborated Projects: 5 results

# of Collaborated Products: 47 results
2. TOGASHI Yu (10710444)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
3. Tajima Kazuki (00725236)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. 奥山朋子 (90806928)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 木村真理 (40363840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 中村昭伸 (70552420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 伊藤譲 (00512980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 京原麻由 (20828545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 井上亮太 (40902763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. FUKUNAKA Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. OYADOMARI Seiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. YAMADA koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 伊藤讓

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 親泊美帆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高橋倫子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 山田健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shirakawa Jun 白川 純

SHIRAKAWA Jun 白川 純

Research Projects

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Co-Researchers

機能的な膵β細胞量を増加させる「膵β細胞のhealthy expansion」の分子機構の解明

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Exploring inter-organ crosstalk to uncover mechanisms that regulate islet function under insulin resistance or obesityPrincipal Investigator

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Regulation of beta cell fate during dedifferentiationPrincipal Investigator

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Elucidation of pathogenesis and treatment of islet mitochondrial dysfunction and inflammation under glucolipotoxicity

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A novel sarcopenia model by insulin / IGF-1 receptor inhibition

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Heterogeneity of pancreatic isletsPrincipal Investigator

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Fate determination of pancreatic beta cells by glucokinase activation

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Glucokinase Activation Ameliorates ER Stress-Induced Apoptosis in Pancreatic Beta-CellsPrincipal Investigator

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Establishing a base for tailor-made therapy on diabetes from the view point of the pancreatic beta cell mass

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[Journal Article] Encapsulated human islets in alginate fiber maintain long-term functionality2024

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[Journal Article] Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion2023

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[Journal Article] Signaling pathways that regulate adaptive β‐cell proliferation for the treatment of diabetes2023

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[Journal Article] Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice2023

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Shirakawa Jun 白川純

SHIRAKAWA Jun 白川純