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Kobayashi Hisato  小林 久人

… Alternative Names

KOBAYASHI Hisato  小林 久人

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Researcher Number 70632727
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3800-4691
Affiliation (Current) 2025: 獨協医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2025: 獨協医科大学, 医学部, 教授
2021 – 2024: 奈良県立医科大学, 医学部, 准教授
2015 – 2018: 東京農業大学, その他部局等, 准教授
2014: 東京農業大学, 応用生物科学部・生物資源ゲノム解析センター, 准教授
2013 – 2014: 東京農業大学, 応用生物科学部, 准教授
Review Section/Research Field
Principal Investigator
Basic Section 42030:Animal life science-related / Genome biology
Except Principal Investigator
Animal production science / Applied animal science
Keywords
Principal Investigator
エピゲノム / DNAメチル化 / ゲノム刷り込み / 種間比較 / 非コードRNA / 発生・分化 / ウサギ / ラット / 胚発生 / 胎盤 … More / 応用動物 / 遺伝学 / ゲノム / DNAメチル化 / エピジェネティクス / ゲノム刷り込み機構 / Placenta / Embryogenesis / lncRNA / Epigenetics / DNA methylation / Genomic imprinting … More
Except Principal Investigator
エピゲノム / 始原生殖細胞 / トランスクリプトーム / 次世代シークエンサー / 性転換マウス / ゲノム編集 / 発生・分化 / 3Dイメージング / トランスクリプトーム解析 / Sry欠損性転換マウス / 生殖系列細胞 / 卵母細胞 / Sry欠損 / 生殖細胞形成異常 / CRISPR/Cas9 / 性転換 / ChIP-seq / ヒストン修飾 / 性分化 / エピジェネティクス / イピゲノム / メチローム / DNAメチル化 / 脱メチル化 / DNAメチローム / リプログラミング / 生殖細胞 / 生殖系列 / DNA メチローム Less
  • Research Projects

    (6 results)
  • Research Products

    (78 results)
  • Co-Researchers

    (18 People)
  •  Phylogenetic comparative analysis of imprintomes in mammals: A reappraisal of the parental conflict hypothesisPrincipal Investigator

    • Principal Investigator
      小林 久人
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Dokkyo Medical University
  •  Comparative imprintome analysis between mammalian species reveals functional diversity of genomic imprintingPrincipal Investigator

    • Principal Investigator
      小林 久人
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Nara Medical University
  •  Sex specification of germline cells by epigenetic regulation in mice

    • Principal Investigator
      Kono Tomohiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Animal production science
    • Research Institution
      Tokyo University of Agriculture
  •  New paradigm of genomic imprinting at Gpr1/Zdbf2 locusPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Hisato
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Genome biology
    • Research Institution
      Tokyo University of Agriculture
  •  Mechanisms of epigenetic regulation via lncRNA transcription at the imprinted Zdbf2 locusPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Hisato
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Genome biology
    • Research Institution
      Tokyo University of Agriculture
  •  Analysis of Epigenome Marks and Transcriptome in the Germ Line by the Next Generation Sequencer

    • Principal Investigator
      KONO Tomohiro
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Applied animal science
    • Research Institution
      Tokyo University of Agriculture

All 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] ADAD2 functions in spermiogenesis and piRNA biogenesis in mice2023

    • Author(s)
      Lu Yonggang、Nagamori Ippei、Kobayashi Hisato、Kojima‐Kita Kanako、Shirane Kenjiro、Chang Hsin‐Yi、Nishimura Toru、Koyano Takayuki、Yu Zhifeng、Castaneda Julio M.、Matsuyama Makoto、Kuramochi‐Miyagawa Satomi、Matzuk Martin M.、Ikawa Masahito
    • Journal Title

      Andrology

      Volume: 11 Issue: 4 Pages: 698-709

    • DOI

      10.1111/andr.13400

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H05033, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-22K15125, KAKENHI-PROJECT-23K21282
  • [Journal Article] Upregulated Ribosomal Pathway Impairs Follicle Development in a Polycystic Ovary Syndrome Mouse Model: Differential Gene Expression Analysis of Oocytes2023

    • Author(s)
      Nakanishi N, Osuka S, Kono T, Kobayashi H, Ikeda S, Bayasula B, Sonehara R, Murakami M, Yoshita S, Miyake N, Muraoka A, Kasahara Y, Murase T, Nakamura T, Goto M, Iwase A, Kajiyama H.
    • Journal Title

      Reprod Sci

      Volume: 30 Issue: 4 Pages: 1306-1315

    • DOI

      10.1007/s43032-022-01095-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K18217, KAKENHI-PROJECT-23K21282
  • [Journal Article] Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells2023

    • Author(s)
      Iwatsuki Kenyu、Oikawa Mami、Kobayashi Hisato、Penfold Christopher A.、Sanbo Makoto、Yamamoto Takuya、Hochi Shinichi、Kurimoto Kazuki、Hirabayashi Masumi、Kobayashi Toshihiro
    • Journal Title

      Cell Reports Methods

      Volume: 3 Issue: 8 Pages: 100542-100542

    • DOI

      10.1016/j.crmeth.2023.100542

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06364, KAKENHI-PROJECT-22KJ1490, KAKENHI-PROJECT-20H00471, KAKENHI-PROJECT-23K21282
  • [Journal Article] Conservation and divergence of canonical and non-canonical imprinting in murids2023

    • Author(s)
      Richard Albert Julien、Kobayashi Toshihiro、Inoue Azusa、Monteagudo-S?nchez Ana、Kumamoto Soichiro、Takashima Tomoya、Miura Asuka、Oikawa Mami、Miura Fumihito、Takada Shuji、Hirabayashi Masumi、Korthauer Keegan、Kurimoto Kazuki、Greenberg Maxim V. C.、Lorincz Matthew、Kobayashi Hisato
    • Journal Title

      Genome Biology

      Volume: 24 Issue: 1 Pages: 48-48

    • DOI

      10.1186/s13059-023-02869-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H00471, KAKENHI-PLANNED-18H05553, KAKENHI-PROJECT-23K21282, KAKENHI-PROJECT-22K17837, KAKENHI-PLANNED-19H05754
  • [Journal Article] Functional primordial germ cell?like cells from pluripotent stem cells in rats2022

    • Author(s)
      Oikawa Mami、Kobayashi Hisato、Sanbo Makoto、Mizuno Naoaki、Iwatsuki Kenyu、Takashima Tomoya、Yamauchi Keiko、Yoshida Fumika、Yamamoto Takuya、Shinohara Takashi、Nakauchi Hiromitsu、Kurimoto Kazuki、Hirabayashi Masumi、Kobayashi Toshihiro
    • Journal Title

      Science

      Volume: 376 Issue: 6589 Pages: 176-179

    • DOI

      10.1126/science.abl4412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H00471, KAKENHI-PLANNED-18H05553, KAKENHI-PROJECT-23K21282
  • [Journal Article] Repeated translocation of a supergene underlying rapid sex chromosome turnover in <i>Takifugu</i> pufferfish2022

    • Author(s)
      Kabir Ahammad、Ieda Risa、Hosoya Sho、Fujikawa Daigaku、Atsumi Kazufumi、Tajima Shota、Nozawa Aoi、Koyama Takashi、Hirase Shotaro、Nakamura Osamu、Kadota Mitsutaka、Nishimura Osamu、Kuraku Shigehiro、Nakamura Yasukazu、Kobayashi Hisato、Toyoda Atsushi、Tasumi Satoshi、Kikuchi Kiyoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 23 Pages: 1901-1909

    • DOI

      10.1073/pnas.2121469119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K05833, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K21282
  • [Journal Article] Deciphering two rounds of cell lineage segregations during bovine preimplantation development2021

    • Author(s)
      Akizawa Hiroki, Saito Shun, Kohri Nanami, Furukawa Eri, Hayashi Yoshihiro, Bai Hanako, Nagano Masashi, Yanagawa Yojiro, Tsukahara Hayato, Takahashi Masashi, Kagawa Shinjiro, Kawahara‐Miki Ryouka, Kobayashi Hisato、Kono Tomohiro、Kawahara Manabu
    • Journal Title

      The FASEB Journal

      Volume: 35 Issue: 10

    • DOI

      10.1096/fj.202002762rr

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K15644, KAKENHI-PROJECT-21H02336, KAKENHI-PROJECT-23K21282
  • [Journal Article] Loop-mediated isothermal amplification (LAMP) and machine learning application for early pregnancy detection using bovine vaginal mucosal membrane2021

    • Author(s)
      Kunii Hiroki, Kubo Tomoaki, Asaoka Natsuki, Balboula Ahmed Z, Hamaguchi Yu, Shimasaki Tomoya, Bai Hanako, Kawahara Manabu, Kobayashi Hisato, Ogawa Hidehiko, Takahashi Masashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 569 Pages: 179-186

    • DOI

      10.1016/j.bbrc.2021.07.015

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15644, KAKENHI-PROJECT-21H02336, KAKENHI-PROJECT-20J11776, KAKENHI-PROJECT-23K21282
  • [Journal Article] Canonical and Non-canonical Genomic Imprinting in Rodents2021

    • Author(s)
      Kobayashi Hisato
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 713878-713878

    • DOI

      10.3389/fcell.2021.713878

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K21282
  • [Journal Article] Characterization of Frond and Flower Development and Identification of FT and FD Genes From Duckweed Lemna aequinoctialis Nd2021

    • Author(s)
      Yoshida Akiko、Taoka Ken-ichiro、Hosaka Aoi、Tanaka Keisuke、Kobayashi Hisato、Muranaka Tomoaki、Toyooka Kiminori、Oyama Tokitaka、Tsuji Hiroyuki
    • Journal Title

      Frontiers in Plant Science

      Volume: 12 Pages: 697206-697206

    • DOI

      10.3389/fpls.2021.697206

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19J40259, KAKENHI-PROJECT-21H04728, KAKENHI-PROJECT-23K21282
  • [Journal Article] Dorso-ventral heterogeneity in tracheal basal stem cells.2021

    • Author(s)
      Tadokoro T, Tanaka K, Osakabe S, Kato M, Kobayashi H, Hogan BLM, Taniguchi H.
    • Journal Title

      Biology Open

      Volume: 10 Issue: 9

    • DOI

      10.1242/bio.058676

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04830, KAKENHI-PROJECT-21H02991, KAKENHI-PROJECT-21K08208, KAKENHI-PROJECT-23K21282
  • [Journal Article] Sex-specific histone modifications in mouse fetal and neonatal germ cells2019

    • Author(s)
      Kawabata Yukiko、Kamio Asuka、Jincho Yuko、Sakashita Akihiko、Takashima Tomoya、Kobayashi Hisato、Matsui Yasuhisa、Kono Tomohiro
    • Journal Title

      Epigenomics

      Volume: 11 Issue: 5 Pages: 543-561

    • DOI

      10.2217/epi-2018-0193

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Journal Article] LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation2018

    • Author(s)
      Brind’Amour Julie、Kobayashi Hisato、Richard Albert Julien、Shirane Kenjiro、Sakashita Akihiko、Kamio Asuka、Bogutz Aaron、Koike Tasuku、Karimi Mohammad M.、Lefebvre Louis、Kono Tomohiro、Lorincz Matthew C.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 3331-3331

    • DOI

      10.1038/s41467-018-05841-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Journal Article] SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling2018

    • Author(s)
      Mochizuki Kentaro, Tando Yukio, Sekinaka Tamotsu, Otsuka Kei, Hayashi Yohei, Kobayashi Misato, Kamio Asuka, Ito-Matsuoka Yumi, Takehara Asuka, Kono Tomohiro, Osumi Noriko, Matsui Yasuhisa
    • Journal Title

      Development

      Volume: 145 Issue: 23 Pages: 1-10

    • DOI

      10.1242/dev.164160

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K17594, KAKENHI-PROJECT-18K15001, KAKENHI-PROJECT-17J02039, KAKENHI-PROJECT-17K19372, KAKENHI-PROJECT-15H05579, KAKENHI-PUBLICLY-18H04875
  • [Journal Article] Repression of somatic genes by selective recruitment of HDAC3 by BLIMP1 is essential for mouse primordial germ cell fate determination2018

    • Author(s)
      Mochizuki Kentaro, Hayashi Yohei, Sekinaka Tamotsu, Otsuka Kei, Ito-Matsuoka Yumi, Kobayashi Misato, Oki Shinya, Takehara Asuka, Kono Tomohiro, Osumi Noriko, Matsui Yasuhisa
    • Journal Title

      Cell Reports

      Volume: 24 Issue: 10 Pages: 2682-2693

    • DOI

      10.1016/j.celrep.2018.07.108

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K17594, KAKENHI-PLANNED-16H06530, KAKENHI-PROJECT-17J02039, KAKENHI-PROJECT-17K19372, KAKENHI-PROJECT-15H05579, KAKENHI-PUBLICLY-18H04875, KAKENHI-PROJECT-18KT0024
  • [Journal Article] DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells2018

    • Author(s)
      Tatsumi Daiki、Hayashi Yohei、Endo Mai、Kobayashi Hisato、Yoshioka Takumi、Kiso Kohei、Kanno Shinichiro、Nakai Yuji、Maeda Ikuma、Mochizuki Kentaro、Tachibana Makoto、Koseki Haruhiko、Okuda Akihiko、Yasui Akira、Kono Tomohiro、Matsui Yasuhisa
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: e0205969-e0205969

    • DOI

      10.1371/journal.pone.0205969

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07726, KAKENHI-ORGANIZER-17H06423, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16H05143, KAKENHI-PROJECT-18H02419, KAKENHI-PROJECT-15H05579, KAKENHI-PLANNED-17H06424, KAKENHI-PUBLICLY-18H04875
  • [Journal Article] Relationship between PIWIL4-mediated H3K4me2 demethylation and piRNA-dependent DNA methylation.2018

    • Author(s)
      Nagamori, I., Kobayashi, H., Nishimura, T., Yamagishi, R., Katahira, J., Kuramochi-Miyagawa, S., Kono, T., Nakano, T.
    • Journal Title

      Cell Reports

      Volume: 25 Issue: 2 Pages: 350-356

    • DOI

      10.1016/j.celrep.2018.09.017

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08630, KAKENHI-PROJECT-15H02509, KAKENHI-PROJECT-15H05579
  • [Journal Article] Inducible Transposition of a Heat-Activated Retrotransposon in Tissue Culture2017

    • Author(s)
      Masuta Y, Nozawa K, Takagi H, Yaegashi H, Tanaka K, Ito T, Saito H, Kobayashi H, Matsunaga W, Masuda S, Kato A, Ito H
    • Journal Title

      Plant and Cell Physiology

      Volume: 58 Pages: 375-384

    • DOI

      10.1093/pcp/pcw202

    • NAID

      120006382279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05579, KAKENHI-PLANNED-15H05960
  • [Journal Article] Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas2017

    • Author(s)
      Fukushima S, Yamashita S, Kobayashi H, et al.; Intracranial Germ Cell Tumor Genome Analysis Consortium (The iGCTConsortium).
    • Journal Title

      Acta Neuropathologica

      Volume: 133 Issue: 3 Pages: 445-462

    • DOI

      10.1007/s00401-017-1673-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05579, KAKENHI-PROJECT-15K10346, KAKENHI-PROJECT-15K10349, KAKENHI-PROJECT-15K15534, KAKENHI-PROJECT-17K10865
  • [Journal Article] DNA Methylation Errors in Cloned Mouse Sperm by Germ Line Barrier Evasion2016

    • Author(s)
      Koike T, Wakai T, Jincho Y, Sakashita A, Kobayashi H, Mizutani E, Wakayama S, Miura F, Ito T, Kono T
    • Journal Title

      Biol Reprod

      Volume: 94 Issue: 6 Pages: 1-7

    • DOI

      10.1095/biolreprod.116.138677

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02472, KAKENHI-PROJECT-15H05579, KAKENHI-PROJECT-26506006, KAKENHI-PROJECT-26250038
  • [Journal Article] Spatiotemporal dynamics of OCT4 protein localization during preimplantation development in mice2016

    • Author(s)
      Fukuda A, Mitani A, Miyashita T, Kobayashi H, Umezawa A, Akutsu H
    • Journal Title

      Reproduction

      Volume: 152 Issue: 5 Pages: 417-30

    • DOI

      10.1530/rep-16-0277

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05579, KAKENHI-PROJECT-26293364, KAKENHI-PROJECT-26861350, KAKENHI-PROJECT-16K15716
  • [Journal Article] Repetitive DNA methylome analysis by small-scale and single-cell shotgun bisulfite sequencing.2016

    • Author(s)
      Kobayashi H, Koike T, Sakashita A, Tanaka K, Kumamoto S, Kono T
    • Journal Title

      Genes Cells

      Volume: 21 Issue: 11 Pages: 1209-1222

    • DOI

      10.1111/gtc.12440

    • NAID

      130007024787

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02472, KAKENHI-PROJECT-15H05579, KAKENHI-PROJECT-15J08690
  • [Journal Article] Sex Specification and Heterogeneity of Primordial Germ Cells in Mice.2015

    • Author(s)
      Sakashita, A., Kawabata, Y., Jincho, Y., Tajima, S., Kumamoto, S., Kobayashi, H., Matsui, Y. and Kono, T.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 12 Pages: 1-21

    • DOI

      10.1371/journal.pone.0144836

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25114003, KAKENHI-PROJECT-15H02472, KAKENHI-PROJECT-15H05579, KAKENHI-PROJECT-15J08690, KAKENHI-PROJECT-25650104
  • [Journal Article] Comprehensive DNA Methylation Analysis of Retrotransposons in Male Germ Cells2015

    • Author(s)
      Nagamori I, Kobayashi H, Shiromoto Y, Nishimura T, Kuramochi-Miyagawa S, Kono T, Nakano T.
    • Journal Title

      Cell Rep.

      Volume: 12 Issue: 10 Pages: 1541-1547

    • DOI

      10.1016/j.celrep.2015.07.060

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-26112511, KAKENHI-PROJECT-24249018, KAKENHI-PROJECT-15H05579, KAKENHI-PROJECT-24370074, KAKENHI-PROJECT-15H04699
  • [Journal Article] Sunflower centromeres consist of a centromere-specific LINE and a chromosome-specific tandem repeat2015

    • Author(s)
      Nagaki K, Tanaka K, Yamaji N, Kobayashi H, Murata M
    • Journal Title

      Frontiers in Plant Science

      Volume: 6 Pages: 12-12

    • DOI

      10.3389/fpls.2015.00912

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Journal Article] DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.2015

    • Author(s)
      Kubo N, Toh H, Shirane K, Shirakawa T, Kobayashi H, Sato T, Sone H, Sato Y, Tomizawa S, Tsurusaki Y, Shibata H, Saitsu H, Suzuki Y, Matsumoto N, Suyama M, Kono T, Ohbo K, Sasaki H.
    • Journal Title

      BMC Genomics.

      Volume: 16 Issue: 1 Pages: 624-624

    • DOI

      10.1186/s12864-015-1833-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19660, KAKENHI-PROJECT-26860137, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118007, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112010, KAKENHI-PROJECT-15H05579, KAKENHI-PROJECT-14J04310, KAKENHI-PLANNED-25114004
  • [Journal Article] Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth2014

    • Author(s)
      Akihito Sakashita, Hisato Kobayashi, Takuya Wakai, Yuusuke Sotomaru, Kenichiro Hata, Tomohiro Kono
    • Journal Title

      Genes Cells

      Volume: 19 Issue: 8 Pages: 629-636

    • DOI

      10.1111/gtc.12164

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-22228004, KAKENHI-PROJECT-25640051, KAKENHI-PROJECT-25870766
  • [Journal Article] Effect of feeding behavior on circadian regulation of endothelin expression in mouse colon2014

    • Author(s)
      Kozakai T, Sakate M, Takizawa S, Uchide T, Kobayashi H, Oishi K, Ishida N, Saida K
    • Journal Title

      Life Sciences

      Volume: 118 Issue: 2 Pages: 232-237

    • DOI

      10.1016/j.lfs.2014.06.022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25350179, KAKENHI-PROJECT-25870766
  • [Journal Article] Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc.2013

    • Author(s)
      Kobayashi H, Yanagisawa E, Sakashita A, Sugawara N, Kumakura S, Ogawa H, Akutsu H, Hata K, Nakabayashi K, Kono T.
    • Journal Title

      Epigenetics

      Volume: 8 (6) Issue: 6 Pages: 635-645

    • DOI

      10.4161/epi.24887

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22228004, KAKENHI-PROJECT-25450470, KAKENHI-PROJECT-25460409, KAKENHI-PROJECT-25870766
  • [Journal Article] Mouse oocyte methylomes at base resolution reveal genome- wide accumulation of non-CpG methylation and role of DNA methyltransferases2013

    • Author(s)
      Shirane K, Toh H, Kobayashi H, Miura F, Chiba H, Ito T, Kono T, Sasaki H
    • Journal Title

      PLoS Genet

      Volume: 9(4) Issue: 4 Pages: 303-306

    • DOI

      10.1371/journal.pgen.1003439

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062009, KAKENHI-PLANNED-20062010, KAKENHI-PROJECT-22228004, KAKENHI-PROJECT-23590657, KAKENHI-PUBLICLY-25129702, KAKENHI-PROJECT-25870766
  • [Journal Article] Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency2012

    • Author(s)
      Wang L, Aburatani H, et al.
    • Journal Title

      Genome Research

      Volume: 22 Issue: 3 Pages: 208-219

    • DOI

      10.1101/gr

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20221009, KAKENHI-PROJECT-22228004
  • [Journal Article] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks2012

    • Author(s)
      Kobayashi, Hisato.
    • Journal Title

      PLoS GENETICS

      Volume: 8

    • NAID

      120005300482

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Journal Article] Imprinted DNA methylation reprogramming during early mouse embryogenesis at the Gprl-Zdbf2 locus is linked to long cis-intergenic transcription2012

    • Author(s)
      Kobayashi, Hisato.
    • Journal Title

      FEBS Letters

      Volume: 586 Pages: 827-833

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Journal Article] DNA methylation analysis of germ cells by using bisulfite-based sequencing methods2012

    • Author(s)
      Kobayashi, Hisato.
    • Journal Title

      Methods in Molecular Biology

      Volume: 825 Pages: 223-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] ZDBF2遺伝子刷り込みの起源を探るLTR介在型転写物の種間比較2023

    • Author(s)
      小林久人
    • Organizer
      第46回日本分子生物学会大会
    • Data Source
      KAKENHI-PROJECT-23K21282
  • [Presentation] ZDBF2遺伝子刷り込みの起源を探るLTR介在型転写物の種間比較2023

    • Author(s)
      小林久人
    • Organizer
      第116回日本繁殖生物学会大会
    • Data Source
      KAKENHI-PROJECT-23K21282
  • [Presentation] マウス・ラット間におけるカノニカル・非カノニカル型刷り込み機構の保存性と多様性2022

    • Author(s)
      小林久人
    • Organizer
      第45回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-23K21282
  • [Presentation] ラットのゲノムワイドなインプリントーム解析2022

    • Author(s)
      小林久人
    • Organizer
      第115回 日本繁殖生物学会大会
    • Data Source
      KAKENHI-PROJECT-23K21282
  • [Presentation] ヒト・ラット,マウス卵子のDNAメチローム比較解析2018

    • Author(s)
      小林久人、Brind’Amour J, Richard Albert J, 白根健次郎, 坂下陽彦, 神尾明日香, Karimi MM, Lefebvre L, 河野友宏, Lorincz MC
    • Organizer
      第111回日本繁殖生物学会大会
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Presentation] 内在性レトロトランスポゾンが哺乳動物卵子DNAメチロームの多様性を生み出す2018

    • Author(s)
      小林久人、Brind’Amour J, Richard Albert J, 白根健次郎, 坂下陽彦, 神尾明日香, Karimi MM, Lefebvre L, 河野友宏, Lorincz MC
    • Organizer
      第12回エピジェネティクス研究会
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Presentation] マウスのゲノム包括的なアレル特異的DNAメチローム解析2017

    • Author(s)
      小林久人
    • Organizer
      第5回NGS現場の会
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Presentation] DNA methylome analysis in mouse germ cells and early embryos2016

    • Author(s)
      Tomohiro Kono, Hisato Kobayashi, Tasuku Koike, Akihiko Sakashita, Haruka Tsuno, Soichiro Kumamoto, Takuya Wakai, Satoshi Sano
    • Organizer
      ESHRE
    • Place of Presentation
      Finland, Helsinki, Mussukeskus
    • Year and Date
      2016-07-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02472
  • [Presentation] XY oocytes of sex-reversed mice with Sry mutation deviate from the differentiation process at initial stages2016

    • Author(s)
      Akihiko SAKASHITA, Chiaki NISHIMURA, Hisato KOBAYASHI, Yusuke SOTOMARU, Tomohiro KONO
    • Organizer
      分子生物学会
    • Place of Presentation
      神奈川県、横浜、パシフィコ横浜
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-15H02472
  • [Presentation] 脱メチル化完了後のマウス始原生殖細胞におけるヒストン修飾の役割2016

    • Author(s)
      川畑順子、神尾明日香、神長祐子、高島友弥、坂下陽彦、小林久人、河野友宏
    • Organizer
      分子生物学会
    • Place of Presentation
      神奈川県、横浜、パシフィコ横浜
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-15H02472
  • [Presentation] マウス生殖細胞および初期発生胚のDNAメチローム解析2016

    • Author(s)
      小林 久人、小池 佐、坂下 陽彦、都能 遼、隈本 宗一郎、若井 拓也、佐野 賢、河野 友宏
    • Organizer
      分子生物学会
    • Place of Presentation
      神奈川県、横浜、パシフィコ横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H02472
  • [Presentation] ゲノミックインプリンティング~全ゲノムバイサルファイトシーケンス解析から“目印”として働くDNAメチル化の本質を探る~2016

    • Author(s)
      小林久人
    • Organizer
      第5回生命医薬情報学連合大会
    • Place of Presentation
      東京国際交流館プラザ平成、東京都江東区、日本
    • Year and Date
      2016-09-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Presentation] DNA methylome analysis in mouse germ cells and early embryos2016

    • Author(s)
      小林久人
    • Organizer
      Genomic Imprinting, Epigenetics and Physiological Functions
    • Place of Presentation
      エーリチェ・シチリア州、イタリア
    • Year and Date
      2016-10-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Presentation] Regulation of Gender Specific Gene Expression in mouse Primordial Germ Cells2015

    • Author(s)
      Akihiko Sakashita, Yukiko Kawabata, Yuko Jincho, Shiun Tajima, Souichiro Kumamoto, Hisato Kobayashi, Yasuhisa Matsui, Tomohiro Kono
    • Organizer
      Epigenetics 2015
    • Place of Presentation
      Tasmania, Australia
    • Year and Date
      2015-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02472
  • [Presentation] 小規模およびシングルセルショットガンバイサルファイトシーケンス解析による生殖細胞系列における反復配列特性の解明2015

    • Author(s)
      小林久人、小池佐、坂下陽彦、田中啓介、河野友宏
    • Organizer
      第108回 日本繁殖生物学会大会
    • Place of Presentation
      宮崎大学
    • Year and Date
      2015-09-16
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Presentation] 小規模およびシングルセルショットガンバイサルファイトシーケンス解析による生殖細胞系列における反復配列特性の解明2015

    • Author(s)
      小林久人、小池佐、坂下陽彦、田中啓介、河野友宏
    • Organizer
      第38回日本分子生物学会・BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Presentation] マウス始原生殖細胞の遺伝子発現を制御するエピゲノム修飾2015

    • Author(s)
      神長祐子, 川畑順子, 坂下陽彦, 小林久人、河野友宏
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      宮崎大学
    • Year and Date
      2015-10-17
    • Data Source
      KAKENHI-PROJECT-15H02472
  • [Presentation] マウス始原生殖細胞におけるDNAメチル化非依存的な性特異的遺伝子発現機構2015

    • Author(s)
      坂下 陽彦, 田島 紫雲, 川畑 順子, 神長 裕子, 小林 久人, 河野 友宏
    • Organizer
      日本卵子学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2015-05-30
    • Data Source
      KAKENHI-PROJECT-15H02472
  • [Presentation] 次世代シーケンサーを利用した新しい農学研究分野の開拓2015

    • Author(s)
      小林久人
    • Organizer
      日本動物遺伝育種学会第16回大会
    • Place of Presentation
      神戸大学
    • Year and Date
      2015-11-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05579
  • [Presentation] 体細胞クローンマウス精子のDNAメチレーションエラー2014

    • Author(s)
      河野友宏, 若井拓也, 水谷英二, 小林久人, 若山清香, 坂下陽彦, 三浦史仁, 伊藤隆司
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      帯広畜産大学
    • Year and Date
      2014-09-22
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス生殖細胞・初期胚のDNAメチローム解析2014

    • Author(s)
      小林久人、坂下陽彦、若井拓哉、小池佐、佐野賢、河野友宏
    • Organizer
      日本分子生物学会大会
    • Place of Presentation
      横浜国際展示場
    • Year and Date
      2014-11-27
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] 体細胞クローンマウス精子のDNAメチル化リプログラミング2014

    • Author(s)
      若井 拓哉、水谷英二、小林久人、若山 清香、坂下 陽彦、伊藤 隆司、 三浦 史仁、河野 友
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜国際展示場
    • Year and Date
      2014-11-27
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス初期胚における5hmCおよびH3K9me2の挙動とDNA脱メチル化制御機構2014

    • Author(s)
      坂下 陽彦、中島 芽生、若井 拓哉、小林 久人、井関陽介、河野 友宏
    • Organizer
      本哺乳動物卵子学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2014-05-17
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] Genome-wide reprogramming by DNA demethylation during mouse oocyte growth and early development2014

    • Author(s)
      Akihiko SAKASHITA, Yosuke ISEKI, Mei NAKAJIMA, Takuya WAKAI, Hisato KOBAYASHI, Tomohiro KONO
    • Organizer
      World Congress of Reproductive Biology
    • Place of Presentation
      Edinburgh (UK)
    • Year and Date
      2014-09-03
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] 刷り込み遺伝子クラスター領域GPR1-ZDBF2におけるlncRNAを介したエピジェネティクス制御機構とヒト・マウスゲノム間の保存性2013

    • Author(s)
      小林久人、柳澤永吉、坂下陽彦、菅原直子、熊倉紫織、小川英彦、阿久津英憲、秦健一郎、中林一彦、河野友宏
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-25870766
  • [Presentation] マウス生殖細胞の全ゲノム包括的DNAメチローム解析2013

    • Author(s)
      小林久人
    • Organizer
      大阪大学蛋白質研究所セミナー DNAメチル化の制御機構-メチル化模様形成、維持と消去-
    • Place of Presentation
      大阪大学蛋白質研究所
    • Data Source
      KAKENHI-PROJECT-25870766
  • [Presentation] マウス生殖細胞の全ゲノム包括的DNAメチローム解析2013

    • Author(s)
      小林久人
    • Organizer
      第7回日本エピジェネティクス研究会年会
    • Place of Presentation
      奈良県新公会堂
    • Data Source
      KAKENHI-PROJECT-25870766
  • [Presentation] Mouse genomic DNA methylomes show the role of intergenic DNA methylation in the establishment of oocyte-specific heritable marks2011

    • Author(s)
      Kobayashi Hisato.
    • Organizer
      World Congress on Reproductive Biology & Society for Reproductive Biology
    • Place of Presentation
      オーストラリア・ケアンズ
    • Year and Date
      2011-10-12
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] エピゲノム解析(DNAメチローム解析)による卵子正常性の評価2011

    • Author(s)
      小林久人
    • Organizer
      第52回日本哺乳動物卵子学会
    • Place of Presentation
      国際医療福祉大学本校(栃木)(招待講演)
    • Year and Date
      2011-05-21
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス配偶子における全ゲノム包括的DNAメチローム解析2011

    • Author(s)
      小林久人
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス配偶子における全ゲノム包括的DNAメチローム解析2011

    • Author(s)
      小林久人
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      いわて県民情報交流センター・アイーナ(盛岡)
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] Whole genome bisulphite shotgun sequencing in mouse germ cells2010

    • Author(s)
      Kobayashi, Hisato.
    • Organizer
      International Symposium on "Epigenome Network, Development and Reprogramming of Germ Cells"
    • Place of Presentation
      九州大学医学部百年講堂(福岡市)
    • Year and Date
      2010-11-22
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] Bisulphite Shotgun Sequencing法によるマウス生殖細胞の包括的DNAメチル化解析2010

    • Author(s)
      小林久人
    • Organizer
      第33回日本分子生物学会年会(BMB2010)
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス生殖細胞における全ゲノム包括的DNAメチローム解析

    • Author(s)
      小林久人
    • Organizer
      第7回 日本エピジェネティクス研究会
    • Place of Presentation
      奈良県新公会堂
    • Invited
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス始原生殖細胞におけるDNAメチローム解析

    • Author(s)
      小林久人
    • Organizer
      第105回日本繁殖生物学会
    • Place of Presentation
      筑波大学大学会館
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス始原生殖細胞におけるDNAメチローム解析

    • Author(s)
      小林久人
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] Whole-genome profiling of cytosine methylation in mouse primordial germ cells

    • Author(s)
      小林久人
    • Organizer
      Next Generation Sequencing Asia Congress 2012,
    • Place of Presentation
      Singapore
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] Methylomes and transcriptomes in mouse germ cells

    • Author(s)
      Hisato Kobayashi
    • Organizer
      International Symposium on “Epigenome Network, Development and Reprogramming of Germ Cells”
    • Place of Presentation
      イギリス、エジンバラ
    • Year and Date
      2014-09-01 – 2014-09-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-25870766
  • [Presentation] マウス生殖細胞における全ゲノム包括的DNAメチローム解析

    • Author(s)
      小林久人、坂下陽彦、若井拓哉、小池佐、佐野賢、河野友宏
    • Organizer
      第37回日本分子生物学会大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25870766
  • [Presentation] 1番染色体におけるインプリント発現する大型介在性ノンコーディングRNA:Zdbf2lincの同定

    • Author(s)
      小林久人
    • Organizer
      第6回エピジェネティクス研究会
    • Place of Presentation
      学術総合センター
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス卵子形成過程における5ヒドロキシメチル化シトシンのダイナミクス

    • Author(s)
      坂下陽彦, 小林久人, 井関陽介、若井拓也、外丸祐介、 河野友宏
    • Organizer
      第106回日本繁殖生物学会
    • Place of Presentation
      東京農工大学
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] Amplification-free whole-genome shotgun bisulfite sequencing of mouse primordial germ cells

    • Author(s)
      Kobayashi H, Sakurai T, Miura F, Imai M, Mochiduki K, Yanagisawa E,Sakashita A, Wakai T, Suzuki Y, Ito T, Matsui Y, Kono T.
    • Organizer
      Non-coding RNA, epigenetics and transgenerational inheritance 2013
    • Place of Presentation
      ケンブリッジ、イギリス
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] Amplification-free whole-genome shotgun bisulfite sequencing of mouse primordial germ cells

    • Author(s)
      小林久人
    • Organizer
      Epigenetics & Chromatin: Interactions and Processes 2013
    • Place of Presentation
      ハーバードメディカルセンター、ボストン・アメリカ
    • Data Source
      KAKENHI-PROJECT-22228004
  • [Presentation] マウス卵子形成過程における5-hydroxymethylcytosine のダイナミク ス

    • Author(s)
      坂下陽彦、小林久人, 井関陽介、若井拓也、外丸祐介、 河野友宏
    • Organizer
      第36回 日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド国際会議場
    • Data Source
      KAKENHI-PROJECT-22228004
  • 1.  KONO Tomohiro (80153485)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 20 results
  • 2.  SOTOMARU Yusuke (90309352)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  SUZUKI Yutaka (40323646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  NAKAI Yuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  望月 研太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 6.  松居 靖久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  唄 花子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  倉持 敏美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  油谷 浩幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  栗本 一基
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  大須賀 智子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  保地 眞一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  片平 じゅん
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  大石 勝隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  鶴崎 美徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  小山 喬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  谷口 英樹
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    # of Collaborated Products: 1 results

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