Shimizu Yoshimi 清水芳実

Researcher Number	70633931
Other IDs	https://orcid.org/0000-0001-6829-7259
Affiliation (Current)	2026: 昭和医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 昭和大学, 医学部, 講師 2023: 帝京平成大学, 薬学部, 講師 2019 – 2022: 帝京平成大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 低酸素環境 / 遺伝子治療 / イムノトキシン / 薬物送達システム / ビフィズス菌 / 低分子抗体 / 一本鎖抗体 / メソテリン / がん治療 / 偏性嫌気性細菌 … More / 遺伝子組換え技術 / 抗悪性腫瘍薬 / 膵臓がん / 抗体療法 / 悪性胸膜中皮腫 / 偏性嫌気性菌 / 膜タンパク質 / トリプルネガティブ乳癌 / 膜蛋白質 / クローディン / クローディン-4 / トリプルネガティブ乳がん … More Except Principal Investigator 光遺伝学 / チャネル Less

Development of therapy for pancreatic cancer using genetically modified BifidobacteriumPrincipal Investigator
- Principal Investigator
  
  清水芳実
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa University
近赤外光活性化人工チャネルの創生による抗がん治療法の開発
- Principal Investigator
  
  吉田卓史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo Heisei University
Development of a novel anti-malignat mesothelioma agent using intestinal bacteriaPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Yoshimi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo Heisei University
Development of therapy for triple negative breast cancer using anaerobic bacteriaPrincipal Investigator
- Principal Investigator
  
  Shimizu Yoshimi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo Heisei University

All 2025 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] BIO Clinica 2023年 11月臨時増刊号　遺伝子診療ホットトピックス2023
- Author(s)
  清水芳実、平裕一郎
- Total Pages
  88
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-21K15301
[Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学2021
- Author(s)
  清水芳実、深澤征義、執筆他99名、技術情報協会
- Total Pages
  602
- Publisher
  技術情報協会
- ISBN
  9784861048555
- Data Source
  KAKENHI-PROJECT-21K15301
[Book] 医薬品モダリティの特許戦略と技術開発動向2019
- Author(s)
  清水芳実、平裕一郎、平郁子、石田功
- Total Pages
  676
- Publisher
  技術情報協会
- ISBN
  9784861047497
- Data Source
  KAKENHI-PROJECT-19K16452
[Journal Article] Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals2024
- Author(s)
  Sakaguchi R, Takahashi N, Yoshida T, Ogawa N, Ueda Y, Hamano S, Yamaguchi K, Sawamura S, Yamamoto S, Hara Y, Kawamoto T, Suzuki R, Nakao A, Mori MX, Furukawa T, Shimizu S, Inoue R, Mori Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 300 Issue: 9 Pages: 107705-107705
- DOI
  10.1016/j.jbc.2024.107705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24078, KAKENHI-PROJECT-21K05272, KAKENHI-PROJECT-24K01976, KAKENHI-PROJECT-23K06215, KAKENHI-PROJECT-24K08607, KAKENHI-PROJECT-24K22034
[Journal Article] Potential Anti-Cancer Therapeutic Agents: Effects of VHH Antibodies on Mesothelin Binding Affinity in Cancer2024
- Author(s)
  Shimizu Yoshimi、Isoda Katsuhiro、Shinohara Kaho、Nakayama Miki、Taira Ikuko、Taira Yuichiro
- Journal Title
  
  BPB Reports
  
  Volume: 7 Issue: 4 Pages: 141-146
- DOI
  10.1248/bpbreports.7.4_141
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K09894
[Journal Article] Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation2024
- Author(s)
  Shinichiro Yamamoto, Naoto Kiyatake, Akihiro Kaneko, Masanao Shimamura, Takashi Yoshida, Shunichi Shimizu
- Journal Title
  
  Genes to Cells
  
  Volume: 29 Issue: 3 Pages: 254-269
- DOI
  10.1111/gtc.13097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06215, KAKENHI-PROJECT-20K07256
[Journal Article] Anti-tumor effect of a recombinant Bifidobacterium strain secreting a claudin-targeting molecule in a mouse breast cancer model2020
- Author(s)
  Yoshimi Shimizu, Katsuhiro Isoda, Yuichiro Taira, Ikuko Taira, Masuo Kondoh, Isao Ishida
- Journal Title
  
  Eur J Pharmacol .
  
  Volume: 887 Pages: 173596-173596
- DOI
  10.1016/j.ejphar.2020.173596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07172, KAKENHI-PROJECT-19K16452
[Presentation] Ca2+-NO 間シグナルのポジティブフィードバックを増強するTRPC5-カベオリン-1-eNOSタンパク質複合体の動的なリモデリング機構2025
- Author(s)
  坂口怜子、髙橋重成、吉田卓史、小川臨、植田誉志史、浜野智、山口佳織、澤村晴志朗、山本伸一郎、原雄二、川本倫也、鈴木椋介、中尾章人、森誠之、古川哲史、清水俊一、井上隆司、森泰生
- Organizer
  第98回日本薬理学会
- Data Source
  KAKENHI-PROJECT-23K06215
[Presentation] Effects of VHH antibodies on mesothelin binding affinity in pancreatic cancer2024
- Author(s)
  Yoshimi Shimizu, Katsuhiro Isoda, Kaho Shinohara, Miki Nakayama, Ikuko Taira, and Yuichiro Taira
- Organizer
  Antibody Engineering & Therapeutics US 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K09894
[Presentation] 膵臓がん細胞株に対する抗MSLN VHHイムノトキシンの有用性評価2023
- Author(s)
  清水芳実、古川祥平、氏家丈瑠、平郁子、磯田勝広、平裕一郎
- Organizer
  第96回日本生化学大会
- Data Source
  KAKENHI-PROJECT-21K15301
[Presentation] 抗メソテリン-VHH抗体の性状解析とがん細胞株を用いた評価2023
- Author(s)
  清水芳実、常行航平、古川祥平、磯田勝広、平裕一郎、平郁子、石田功
- Organizer
  第143年回日本薬学会
- Data Source
  KAKENHI-PROJECT-21K15301
[Presentation] 組換えビフィズス菌を利用した抗がん剤開発2023
- Author(s)
  清水芳実、平裕一郎
- Organizer
  第2回日本抗体学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15301
[Presentation] 抗メソテリン-VHH抗体のイムノトキシン化と中皮細胞株に対する細胞傷害活性の評価2022
- Author(s)
  清水芳実、菊本裕子、古川祥平、磯田勝広、平裕一郎、平郁子、石田功
- Organizer
  第95回日本生化学大会
- Data Source
  KAKENHI-PROJECT-21K15301
[Presentation] メソテリンの立体構造を認識する抗メソテリン-VHH抗体の精製と性状解析2021
- Author(s)
  清水芳実、篠原華穂、佐藤泰成、磯田勝広、平裕一郎、平郁子、石田功
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-21K15301
[Presentation] 偏性嫌気性細菌を用いたトリプルネガティブ乳がん治療薬の開発2021
- Author(s)
  清水芳実、中山未希、篠原華穂、磯田勝広、平裕一郎、平郁子、斎藤浩美、石田功
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16452
[Presentation] 乳がんに対する組換えビフィズス菌の腫瘍集積性と抗腫瘍効果の評価2020
- Author(s)
  清水芳実、島岡真理亜、中山未希、磯田勝広、平裕一郎、平郁子、斎藤浩美、石田功
- Organizer
  日本DDS学会　第36回
- Data Source
  KAKENHI-PROJECT-19K16452
[Presentation] 組換えビフィズス菌を用いた乳がん治療薬開発に向けた検討2019
- Author(s)
  清水芳実、島岡真理亜、藤岡野々花、磯田勝広、平裕一郎、平郁子、斎藤浩美、石田功
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-19K16452

1. 吉田卓史 (30455795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 村田喜理 (60455780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAIRA Ikuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 石田功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 平裕一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 森泰生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Yoshimi 清水 芳実

Research Projects

Research Products

Co-Researchers

Development of therapy for pancreatic cancer using genetically modified BifidobacteriumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

近赤外光活性化人工チャネルの創生による抗がん治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel anti-malignat mesothelioma agent using intestinal bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapy for triple negative breast cancer using anaerobic bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] BIO Clinica 2023年 11月臨時増刊号 遺伝子診療ホットトピックス2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 医薬品モダリティの特許戦略と技術開発動向2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential Anti-Cancer Therapeutic Agents: Effects of VHH Antibodies on Mesothelin Binding Affinity in Cancer2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-tumor effect of a recombinant Bifidobacterium strain secreting a claudin-targeting molecule in a mouse breast cancer model2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Ca2+-NO 間シグナルのポジティブフィードバックを増強するTRPC5-カベオリン-1-eNOSタンパク質複合体の 動的なリモデリング機構2025

Author(s)

Organizer

Data Source

[Presentation] Effects of VHH antibodies on mesothelin binding affinity in pancreatic cancer2024

Author(s)

Organizer

Data Source

[Presentation] 膵臓がん細胞株に対する抗MSLN VHHイムノトキシンの有用性評価2023

Author(s)

Organizer

Data Source

[Presentation] 抗メソテリン-VHH抗体の性状解析とがん細胞株を用いた評価2023

Shimizu Yoshimi 清水芳実

[Book] BIO Clinica 2023年 11月臨時増刊号　遺伝子診療ホットトピックス2023

[Presentation] Ca2+-NO 間シグナルのポジティブフィードバックを増強するTRPC5-カベオリン-1-eNOSタンパク質複合体の動的なリモデリング機構2025