BLYTH BENJAMIN ブライスベンジャミン

Researcher Number	70642289
Affiliation (based on the past Project Information) *help	2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 主任研究員
Review Section/Research Field	Except Principal Investigator Childhood science (childhood environment science)
Keywords	Except Principal Investigator 子ども / 放射線発がん / ゲノム変異 / 発がん / 放射線 / 子ども被ばく

What causes the susceptibility to carcinogenesis after childhood radiation exposure? ~ Exploring the mechanism of genomic mutation unique to childhood~
- Principal Investigator
  
  Kakinuma Shizuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Childhood science (childhood environment science)
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology

All 2017 2016 2015 Other

All Journal Article Presentation Book Other

[Book] Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation2016
- Author(s)
  Shizuko Kakinuma , Benjamin Blyth , Yoshiya Shimada
- Total Pages
  8
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-15H01834
[Journal Article] Effect of Age at Exposure on the Incidence of Lung and Mammary Cancer after Thoracic X-Ray Irradiation in Wistar Rats.2017
- Author(s)
  Yutaka Yamada , Ken-Ichi Iwata , Benjamin J Blyth , Kazutaka Doi , Takamitsu Morioka , Kazuhiro Daino , Mayumi Nishimura , Shizuko Kakinuma , Yoshiya Shimada
- Journal Title
  
  Radiation Research
  
  Volume: 187 Issue: 2 Pages: 210-220
- DOI
  10.1667/rr14478.1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01654, KAKENHI-PROJECT-15H01834, KAKENHI-PROJECT-26350955
[Journal Article] Tissue-specific and time-dependent clonal expansion of ENU-induced mutant cells in gpt delta mice2017
- Author(s)
  Nakayama Takafumi、Sawai Tomoko、Masuda Ikuko、Kaneko Shinya、Yamauchi Kazumi、Blyth Benjamin J.、Shimada Yoshiya、Tachibana Akira、Kakinuma Shizuko
- Journal Title
  
  Environmental and Molecular Mutagenesis
  
  Volume: 58 Issue: 8 Pages: 592-606
- DOI
  10.1002/em.22132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25220102, KAKENHI-PROJECT-15H01834
[Journal Article] DNA Methylation Patterns in Rat Mammary Carcinomas Induced by Pre- and Post-Pubertal Irradiation2016
- Author(s)
  Masaru Takabatake , Benjamin J. Blyth , Kazuhiro Daino , Tatsuhiko Imaoka , Mayumi Nishimura , Masahiro Fukushi , Yoshiya Shimada
- Journal Title
  
  PLoS One
  
  Volume: - Issue: 10 Pages: e0164194-e0164194
- DOI
  10.1371/journal.pone.0164194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H01834
[Journal Article] Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas2016
- Author(s)
  Kaye Showler , Mayumi Nishimura , Kazuhiro Daino , Tatsuhiko Imaoka , Yukiko Nishimura , Takamitsu Morioka , Benjamin J. Blyth , Toshiaki Kokubo , Masaru Takabatake , Maki Fukuda , Hitomi Moriyama , Shizuko Kakinuma , Masahiro Fukushi , Yoshiya Shimada
- Journal Title
  
  Journal of radiation research
  
  Volume: 58 Issue: 2 Pages: 183-194
- DOI
  10.1093/jrr/rrw097
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01834, KAKENHI-PROJECT-26670217, KAKENHI-PROJECT-26740022, KAKENHI-PROJECT-26350955
[Journal Article] The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas,2015
- Author(s)
  M. Sunaoshi, Y. Amasaki, S. Hirano-Sakairi, B.J. Blyth, T. Morioka, M. Kaminishi, Y. Shang, M. Nishimura, Y. Shimada, A. Tachibana, S. Kakinuma
- Journal Title
  
  Mutat Res
  
  Volume: 779 Pages: 58-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H01834
[Journal Article] Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion Radiotherapy,2015
- Author(s)
  B.J. Blyth, S. Kakinuma, M. Sunaoshi, Y. Amasaki, S. Hirano-Sakairi, K. Ogawa, A. Shirakami, Y. Shang, C. Tsuruoka, M. Nishimura, Y. Shimada,
- Journal Title
  
  PLoS One
  
  Volume: 10 Pages: 1-17
- NAID
  120006578898
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] 放射線誘発胸腺リンパ腫におけるがん抑制遺伝子の変異に対するカロリー制限の影響2017
- Author(s)
  高橋　みずき, 甘崎　佳子, 中山　貴文, 砂押　正章, Benjamin J Blyth, 尚　奕, 臺野　和広, 島田　義也, 立花　章, 柿沼　志津子
- Organizer
  日本放射線影響学会第60回大会, 一般社団法人日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] Detection of radiation signature in medulloblastoma after protracted gamma-ray exposure in Ptch1 heterozygous mice2017
- Author(s)
  鶴岡　千鶴, Blyth J. Benjamin, 森岡　孝満, 上西　睦美, 品川　まゆみ, 島田　義也, 柿沼　志津子
- Organizer
  63rd Annual Radiation Research Society Meeting, Radiation Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] Age-dependent thymus regeneration after irradiation may change the initiating cells for radiation-induced lymphomagenesis2017
- Author(s)
  Masaaki Sunaoshi, Blyth J. Benjamin, Yi Shang, Chizuru Tsuruoka, Shinobu Sakairi, Takamitsu Morioka, Mayumi Shinagawa, Mari Ogawa, Atsuko Ishikawa, Kazuhiro Daino, Keiji Suzuki, Yoshiya Shimada, Akira Tachibana, Shizuko Kakinuma
- Organizer
  63rd Annual Radiation Research Society Meeting, Radiation Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] 放射線誘発変異シグネチャーを用いた低線量率被ばくによる発がんリスク評価2017
- Author(s)
  鶴岡　千鶴, Blyth J. Benjamin, 森岡　孝満, 上西　睦美, 品川　まゆみ, 島田　義也, 柿沼　志津子
- Organizer
  日本放射線影響学会第60回大会, 日本放射線影響学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] 放射線の被ばく時年齢に依存した発がんメカニズム –放射線誘発マウス胸腺リンパ腫発生モデルを用いた解析から–2016
- Author(s)
  砂押正章, 甘崎佳子, 坂入しのぶ, Blyth Benjamin, 森岡孝満, 上西睦美, 尚奕, 西村まゆみ, 島田義也, 立花章, 柿沼志津子
- Organizer
  第32回日本毒性病理学会総会及び学術集会
- Place of Presentation
  サンポートホール高松（高松市）
- Year and Date
  2016-01-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] Detecting Cancer-Relevant DNA Damage Due to Heavy Ion Exposure2016
- Author(s)
  Blyth Benjamin, Chizuru Tsuruoka, Yutaka Yamada, Shizuko Kakinuma, Yoshiya Shimada
- Organizer
  14th International Workshop on Radiation Damage to DNA
- Place of Presentation
  Victorian Treasury Theatre, East Melbourne
- Year and Date
  2016-03-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] 柿沼志津子, Blyth Benjamin, 砂押正章, 甘崎佳子, 尚奕, 鶴岡千鶴, 森岡孝満, 中山貴文, 島田義也2015
- Author(s)
  柿沼志津子, Blyth Benjamin, 砂押正章, 甘崎佳子, 尚奕, 鶴岡千鶴, 森岡孝満, 中山貴文, 島田義也
- Organizer
  日本放射線影響学会放射線ワークショップ
- Place of Presentation
  富山大学五福キャンパス (富山市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] 放射線誘発マウスTリンパ腫における標的遺伝子は、被ばく時年齢に依存して変化する2015
- Author(s)
  砂押正章, 甘崎佳子, 坂入しのぶ, Blyth Benjamin, 森岡孝満, 上西睦美, 尚奕, 西村まゆみ, 島田義也, 立花章, 柿沼志津子
- Organizer
  日本放射線影響学会放射線ワークショップ
- Place of Presentation
  富山大学五福キャンパス (富山市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] Discovering the role of Pten in protecting from tumours induced by childhood irradiation2015
- Author(s)
  Benjamin Blyth, Takamitsu Morioka, Chizuru Tsuruoka, Yoshiya Shimada, Shizuko Kakinuma
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto International Conference Center(Kyoto)
- Year and Date
  2015-05-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] 放射線と化学発がん物質の複合ばく露による発がんリスクとメカニズム～解析技術の進歩で見えてきたこと～2015
- Author(s)
  柿沼志津子, 甘崎佳子, 砂押正章, 中山貴文, 鶴岡千鶴, Blyth Benjamin, 尚奕, 臺野和広, 西村まゆみ, 島田義也
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂（金沢市）
- Year and Date
  2015-07-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] 放医研における放射線生物影響研究資源アーカイブの構築2015
- Author(s)
  森岡孝満, 山田裕, Blyth Benjamin, 今岡達彦, 石田敦郎, 大竹淳, 下村岳夫, 竹下洋, 島田義也, 柿沼志津子
- Organizer
  日本放射線影響学会放射線ワークショップ
- Place of Presentation
  富山大学五福キャンパス (富山市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] Effect of calorie restriction on genomic alterations in radiation-induced thymic lymphoma and lung cancer2015
- Author(s)
  中山貴文, 尚奕, 砂押正章, Blyth Benjamin, 甘崎佳子, 臺野和広, 小川佳那依, 島田義也, 立花章, 柿沼志津子
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto International Conference Center(Kyoto)
- Year and Date
  2015-05-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01834
[Presentation] The Molecular Mechanisms Underlying The Induction of T-cell Lymphomas by Combined Exposure to Ionizing Radiation and A Chemical Carcinogen in B6C3F1 Mice2015
- Author(s)
  Shizuko kakinuma, Yoshiko Amasaki, Yi Shang, Shinobu Sakairi, Chizuru Tsuruoka, Masaaki Sunaoshi, Benjamin Blyth, Tomoko Sawai, Kazumi Yamauchi, Takamitsu Morioka, Mayumi Nishimura, Yoshiya Shimada
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto International Conference Center(Kyoto)
- Year and Date
  2015-05-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01834
[]

1. Kakinuma Shizuko (20392219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
2. SHIMADA YOHSIYA (10201550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
3. NISHIMURA MAYUMI (70218204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. AMASAKI YOSHIKO (80435700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. IMAOKA TATSUHIKO (40356134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 尚奕 (50533189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
7. 森岡孝満 (70253961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. 臺野和広 (90543299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. 立花章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

BLYTH BENJAMIN ブライス ベンジャミン

Research Projects

Research Products

Co-Researchers

What causes the susceptibility to carcinogenesis after childhood radiation exposure? ~ Exploring the mechanism of genomic mutation unique to childhood~

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Effect of Age at Exposure on the Incidence of Lung and Mammary Cancer after Thoracic X-Ray Irradiation in Wistar Rats.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tissue-specific and time-dependent clonal expansion of ENU-induced mutant cells in gpt delta mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA Methylation Patterns in Rat Mammary Carcinomas Induced by Pre- and Post-Pubertal Irradiation2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas,2015

Author(s)

Journal Title

Data Source

[Journal Article] Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion Radiotherapy,2015

Author(s)

Journal Title

NAID

Data Source

[Presentation] 放射線誘発胸腺リンパ腫におけるがん抑制遺伝子の変異に対するカロリー制限の影響2017

Author(s)

Organizer

Data Source

[Presentation] Detection of radiation signature in medulloblastoma after protracted gamma-ray exposure in Ptch1 heterozygous mice2017

Author(s)

Organizer

Data Source

[Presentation] Age-dependent thymus regeneration after irradiation may change the initiating cells for radiation-induced lymphomagenesis2017

Author(s)

Organizer

Data Source

[Presentation] 放射線誘発変異シグネチャーを用いた低線量率被ばくによる発がんリスク評価2017

Author(s)

Organizer

Data Source

[Presentation] 放射線の被ばく時年齢に依存した発がんメカニズム &#8211;放射線誘発マウス胸腺リンパ腫発生モデルを用いた解析から&#8211;2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Detecting Cancer-Relevant DNA Damage Due to Heavy Ion Exposure2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 柿沼志津子, Blyth Benjamin, 砂押正章, 甘崎佳子, 尚奕, 鶴岡千鶴, 森岡孝満, 中山貴文, 島田義也2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 放射線誘発マウスTリンパ腫における標的遺伝子は、被ばく時年齢に依存して変化する2015

Author(s)

BLYTH BENJAMIN ブライスベンジャミン

[Presentation] 放射線の被ばく時年齢に依存した発がんメカニズム –放射線誘発マウス胸腺リンパ腫発生モデルを用いた解析から–2016

[Presentation] 放射線と化学発がん物質の複合ばく露による発がんリスクとメカニズム～解析技術の進歩で見えてきたこと～2015