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Gosho Masahiko  五所 正彦

ORCIDConnect your ORCID iD *help
Researcher Number 70701019
Other IDs
Affiliation (Current) 2025: 筑波大学, 医学医療系, 教授
Affiliation (based on the past Project Information) *help 2017 – 2024: 筑波大学, 医学医療系, 教授
2015 – 2016: 筑波大学, 医学医療系, 准教授
Review Section/Research Field
Principal Investigator
Basic Section 58010:Medical management and medical sociology-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 60030:Statistical science-related / Epidemiology and preventive medicine
Except Principal Investigator
Basic Section 60030:Statistical science-related / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Basic Section 58010:Medical management and medical sociology-related
Keywords
Principal Investigator
シグナル検出 / スパースデータ / データベース / 副作用 / 薬物相互作用 / データベース研究 / レアイベント / 小標本バイアス補正 / グローバル検定 / 外部対照 … More / アダプティブデザイン / 統計モデル / 医薬品データベース / ロバスト推測 / 経時測定データ / 小規模臨床試験 / シミュレーション実験 / 臨床試験 / 小標本問題 / ブートストラップ法 / Bartlett補正 / 多重代入法 / 加速モデル / 混合効果モデル / 既存データ / ロジスティック回帰分析 / データ欠測 / ロバスト分散 / スパースデータバイアス / 小標本バイアス / 薬剤併用 / 相互作用 / 生活習慣病 / 安全性 / シグナル検出法 … More
Except Principal Investigator
既存データ / 臨床試験 / 医薬品開発 / リアルワールドデータ / Bayes / 産業保健 / 行動科学 / 健康増進 / 職場 / 運動 / セミパラメトリック統計理論 / 統計モデリング / 統計的予測 / 統計的推測 / Evidence-Based Medicine / 外れ値 / ロバスト推測 / 公表バイアス / 多変量メタアナリシス / 影響力解析 / モンテカルロ推測 / 高次漸近理論 / Evidence-based medicine / ネットワークメタアナリシス / 累積データ / Bayesian shrinkage prior / ヒストリカルデータ / 多重性 / 試験期間 / 2段階試験 / 事象時間データ / 3群比較試験 / 中央モニタリング / 国際データ標準 / 情報技術 / CDISC標準 / 国際標準 / 臨床研究 / データ信頼性評価 Less
  • Research Projects

    (9 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (17 People)
  •  小規模臨床試験のデザインと解析と基盤整備Principal Investigator

    • Principal Investigator
      五所 正彦
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58010:Medical management and medical sociology-related
    • Research Institution
      University of Tsukuba
  •  Effectiveness of a low-cost, multi-factor intervention program to promote physical activity among working generation

    • Principal Investigator
      中田 由夫
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
    • Research Institution
      University of Tsukuba
  •  Evaluation and construction of the Bayesian method to accelerate drug development

    • Principal Investigator
      寒水 孝司
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 60030:Statistical science-related
    • Research Institution
      Tokyo University of Science
  •  機械学習を用いた副作用自動検出アプリケーションの開発Principal Investigator

    • Principal Investigator
      五所 正彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      University of Tsukuba
  •  A statistical method for achieving efficient and rapid clinical trials

    • Principal Investigator
      Takashi Sozu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 60030:Statistical science-related
    • Research Institution
      Tokyo University of Science
  •  Developments of statistical inference, prediction, and modeling methods for network meta-analysis

    • Principal Investigator
      Noma Hisashi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 60030:Statistical science-related
    • Research Institution
      The Institute of Statistical Mathematics
  •  Development of central monitoring method to improve clinical trial efficiency

    • Principal Investigator
      Ueno Satoshi
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58010:Medical management and medical sociology-related
    • Research Institution
      National Institute of Public Health
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  Development and application of statistical methods for small clinical trialsPrincipal Investigator

    • Principal Investigator
      Gosho Masahiko
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 60030:Statistical science-related
    • Research Institution
      University of Tsukuba
  •  Analysis of adverse event after concomitant use of lifestyle disease medications using spontaneous reporting system databasePrincipal Investigator

    • Principal Investigator
      Gosho Masahiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Epidemiology and preventive medicine
    • Research Institution
      University of Tsukuba

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Multivariate generalized mixed-effects models for screening multiple adverse drug reactions in spontaneous reporting systems2024

    • Author(s)
      Gosho Masahiko、Ishii Ryota、Ohigashi Tomohiro、Maruo Kazushi
    • Journal Title

      Frontiers in Pharmacology

      Volume: 15

    • DOI

      10.3389/fphar.2024.1312803

    • Open Access
    • Data Source
      KAKENHI-PROJECT-22K19682
  • [Journal Article] Bias in Odds Ratios From Logistic Regression Methods With Sparse Data Sets2023

    • Author(s)
      Gosho Masahiko、Ohigashi Tomohiro、Nagashima Kengo、Ito Yuri、Maruo Kazushi
    • Journal Title

      Journal of Epidemiology

      Volume: 33 Issue: 6 Pages: 265-275

    • DOI

      10.2188/jea.JE20210089

    • NAID

      130008091644

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2023-06-05
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] A comparison of bias‐adjusted generalized estimating equations for sparse binary data in small‐sample longitudinal studies2023

    • Author(s)
      Gosho Masahiko、Ishii Ryota、Noma Hisashi、Maruo Kazushi
    • Journal Title

      Statistics in Medicine

      Volume: 42 Issue: 15 Pages: 2711-2727

    • DOI

      10.1002/sim.9744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19682
  • [Journal Article] Using horseshoe prior for incorporating multiple historical control data in randomized controlled trials2022

    • Author(s)
      Ohigashi Tomohiro、Maruo Kazushi、Sozu Takashi、Gosho Masahiko
    • Journal Title

      Statistical Methods in Medical Research

      Volume: - Issue: 7 Pages: 1392-1404

    • DOI

      10.1177/09622802221090752

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187, KAKENHI-PROJECT-20K11717
  • [Journal Article] Practical Review and Comparison of Modified Covariance Estimators for Linear Mixed Models in Small‐sample Longitudinal Studies with Missing Data2021

    • Author(s)
      Gosho Masahiko、Noma Hisashi、Maruo Kazushi
    • Journal Title

      International Statistical Review

      Volume: 89 Issue: 3 Pages: 550-572

    • DOI

      10.1111/insr.12447

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] bcmixed: A Package for Median Inference on Longitudinal Data with the Box?Cox Transformation2021

    • Author(s)
      Maruo Kazushi、Ishii Ryota、Yamaguchi Yusuke、Gosho Masahiko
    • Journal Title

      The R Journal

      Volume: 13 Issue: 2 Pages: 153-153

    • DOI

      10.32614/rj-2021-083

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11187, KAKENHI-PROJECT-19K11849
  • [Journal Article] Effect of Covariate Omission in Randomised Controlled Trials: A Review and Simulation Study2021

    • Author(s)
      Ishii Ryota、Maruo Kazushi、Gosho Masahiko
    • Journal Title

      International Statistical Review

      Volume: 90 Issue: 1 Pages: 100-117

    • DOI

      10.1111/insr.12468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Methods for detecting outlying regions and influence diagnosis in multi-regional clinical trials2021

    • Author(s)
      Aoki Makoto、Noma Hisashi、Gosho Masahiko
    • Journal Title

      Biostatistics & Epidemiology

      Volume: 5 Issue: 1 Pages: 30-48

    • DOI

      10.1080/24709360.2021.1921944

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] A note on the bias of standard errors when orthogonality of mean and variance parameters is not satisfied in the mixed model for repeated measures analysis2020

    • Author(s)
      Maruo Kazushi、Ishii Ryota、Yamaguchi Yusuke、Doi Masaaki、Gosho Masahiko
    • Journal Title

      Statistics in Medicine

      Volume: 39 Issue: 9 Pages: 1264-1274

    • DOI

      10.1002/sim.8474

    • NAID

      120007132671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187, KAKENHI-PROJECT-19K11849
  • [Journal Article] An application of the mixed‐effects model and pattern mixture model to treatment groups with differential missingness suspected not‐missing‐at‐random2020

    • Author(s)
      Gosho Masahiko、Maruo Kazushi
    • Journal Title

      Pharmaceutical Statistics

      Volume: 20 Issue: 1 Pages: 93-108

    • DOI

      10.1002/pst.2058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Outlier detection and influence diagnostics in network meta‐analysis2020

    • Author(s)
      Noma Hisashi、Gosho Masahiko、Ishii Ryota、Oba Koji、Furukawa Toshi A.
    • Journal Title

      Research Synthesis Methods

      Volume: 11 Issue: 6 Pages: 891-902

    • DOI

      10.1002/jrsm.1455

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187, KAKENHI-PROJECT-19H04074
  • [Journal Article] Borrowing external information to improve Bayesian confidence propagation neural network2020

    • Author(s)
      Tada Keisuke、Maruo Kazushi、Isogawa Naoki、Yamaguchi Yusuke、Gosho Masahiko
    • Journal Title

      European Journal of Clinical Pharmacology

      Volume: 76 Issue: 9 Pages: 1311-1319

    • DOI

      10.1007/s00228-020-02909-w

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Statistical Inference Based on Accelerated Failure Time Models Under Model Misspecification and Small Samples2020

    • Author(s)
      Ishii Ryota、Maruo Kazushi、Noma Hisashi、Gosho Masahiko
    • Journal Title

      Statistics in Biopharmaceutical Research

      Volume: - Issue: 4 Pages: 384-394

    • DOI

      10.1080/19466315.2020.1752297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Assessment of Hazard Ratios in Oncology Clinical Trials Terminated Early for Superiority2020

    • Author(s)
      Shimura Masashi、Nomura Shogo、Wakabayashi Masashi、Maruo Kazushi、Gosho Masahiko
    • Journal Title

      JAMA Network Open

      Volume: 3 Issue: 6 Pages: e208633-e208633

    • DOI

      10.1001/jamanetworkopen.2020.8633

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Improved Small Sample Inference Methods for a Mixed-Effects Model for Repeated Measures Approach in Incomplete Longitudinal Data Analysis2019

    • Author(s)
      Ukyo Yoshifumi、Noma Hisashi、Maruo Kazushi、Gosho Masahiko
    • Journal Title

      Stats

      Volume: 2 Issue: 2 Pages: 174-188

    • DOI

      10.3390/stats2020013

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Multiple imputation for longitudinal data in the presence of heteroscedasticity between treatment groups2019

    • Author(s)
      Yamaguchi Yusuke、Ueno Mai、Maruo Kazushi、Gosho Masahiko
    • Journal Title

      Journal of Biopharmaceutical Statistics

      Volume: 30 Issue: 1 Pages: 178-196

    • DOI

      10.1080/10543406.2019.1632878

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Rhabdomyolysis risk from the use of two-drug combination of antidyslipidemic drugs with antihypertensive and antidiabetic medications: a signal detection analysis2018

    • Author(s)
      Gosho Masahiko
    • Journal Title

      Fundamental & Clinical Pharmacology

      Volume: 印刷中 Issue: 3 Pages: 339-346

    • DOI

      10.1111/fcp.12435

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] SignalDetDDI: An SAS macro for detecting adverse drug-drug interactions in spontaneous reporting systems2018

    • Author(s)
      Gosho Masahiko、Ohigashi Tomohiro、Maruo Kazushi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: e0207487-e0207487

    • DOI

      10.1371/journal.pone.0207487

    • NAID

      120007133525

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Effect of heteroscedasticity between treatment groups on mixed-effects models for repeated measures2018

    • Author(s)
      Gosho Masahiko、Maruo Kazushi
    • Journal Title

      Pharmaceutical Statistics

      Volume: 17 Issue: 5 Pages: 578-592

    • DOI

      10.1002/pst.1872

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Risk of Hypoglycemia After Concomitant Use of Antidiabetic, Antihypertensive, and Antihyperlipidemic Medications: A Database Study2018

    • Author(s)
      Gosho Masahiko
    • Journal Title

      The Journal of Clinical Pharmacology

      Volume: 58 Issue: 10 Pages: 1324-1331

    • DOI

      10.1002/jcph.1147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Journal Article] Risk of hypoglycemia after concomitant use of antidiabetic, antihypertensive, and antihyperlipidemic medications: A database study2018

    • Author(s)
      Gosho Masahiko
    • Journal Title

      Journal of Clinical Pharmacology

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19219
  • [Journal Article] Utilization of chi-square statistics for screening adverse drug-drug interactions in spontaneous reporting systems2017

    • Author(s)
      Gosho, M., Maruo, K., Tada, K., Hirakawa, A.
    • Journal Title

      European Journal of Clinical Pharmacology

      Volume: 73 Issue: 6 Pages: 779-786

    • DOI

      10.1007/s00228-017-2233-3

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19219
  • [Presentation] Dirichlet過程混合モデルを用いたクラスタリングによる既存データ利用法の提案2023

    • Author(s)
      大東智洋, 丸尾和司, 寒水孝司, 五所正彦
    • Organizer
      2023年度日本計量生物学会年会
    • Data Source
      KAKENHI-PROJECT-23K11015
  • [Presentation] Dirichlet過程混合モデルを用いたクラスタリングによる既存データ利用2023

    • Author(s)
      大東智洋, 丸尾和司, 寒水孝司, 五所正彦
    • Organizer
      2023年度日本計量生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K11717
  • [Presentation] 既存試験データを利用するためのBayesian shrinkage priorに基づく方法の提案2022

    • Author(s)
      大東智洋, 丸尾和司, 寒水孝司, 澤本涼, 五所正彦
    • Organizer
      2022年度日本計量生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K11717
  • [Presentation] 既存試験データを用いたhorseshoe prior に基づく二値応答の群間比較法2021

    • Author(s)
      大東智洋,丸尾和司,寒水孝司,五所正彦
    • Organizer
      2020年度日本計量生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] 薬物相互作用評価のための類薬の情報を利用したシグナル検出法の提案2021

    • Author(s)
      多田圭佑,丸尾和司,五所正彦
    • Organizer
      2020年度日本計量生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] 主要評価項目が2つの試験にglobal testを用いる際の試験データに基づく重みの最適化2021

    • Author(s)
      吉田哲,山口祐介,丸尾和司,五所正彦
    • Organizer
      2020年度日本統計関連学会連合大会
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] 既存試験データを用いたhorseshoe priorに基づく二値応答の群間比較法2021

    • Author(s)
      大東智洋, 丸尾和司, 寒水孝司, 五所正彦
    • Organizer
      2021年度日本計量生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K11717
  • [Presentation] 第1段階と第2段階の評価変数が異なるアダプティブシームレスデザインのためのmid-p値に基づく解析2021

    • Author(s)
      高橋健一,石井亮太,丸尾和司,五所正彦
    • Organizer
      2020年度日本統計関連学会連合大会
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] ランダム化比較試験における非調整解析の影響2020

    • Author(s)
      石井亮太,丸尾和司,五所正彦
    • Organizer
      日本統計関連学会連合大会
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] 評価変数が2値変数の場合のアダプティブシームレスデザインに対する解析方法の提案2020

    • Author(s)
      高橋健一,石井亮太,丸尾和司,五所正彦
    • Organizer
      日本統計関連学会連合大会
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] 医薬品副作用データ解析における外部情報を利用した薬物間相互作用の検出法2020

    • Author(s)
      多田圭佑,丸尾和司,五所正彦
    • Organizer
      日本統計関連学会連合大会
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] Modified Bayesian Confidence Propagation Neural Network for Signal Detection Analysis2019

    • Author(s)
      Tada, K., Maruo, K., Isogawa, N., Yanaguchi, Y., Gosho, M.
    • Organizer
      The 6th International Symposium on Biopharmaceutical Statistics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] 欠測データの解析のための混合効果モデル~理論,実践,課題2019

    • Author(s)
      五所正彦
    • Organizer
      2019年度統計関連学会連合大会
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] Nonparametric approach with small-sample adjustment in accelerated failure time model2019

    • Author(s)
      Ishii, R, Maruo, K., Gosho, M.
    • Organizer
      40th Annual Conference of the International Society for Clinical Biostatistics, Leuven, Belgium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] 類薬の情報を利用した Bayesian Confidence Propagation Neural Network の改良法の提案2018

    • Author(s)
      多田圭介,丸尾和司,五十川直樹,五所正彦
    • Organizer
      日本計算機統計学会 第32回シンポジウム
    • Data Source
      KAKENHI-PROJECT-18K11187
  • [Presentation] Statistical methods for screening adverse drug interactions, with an application to spontaneous reporting systems database2017

    • Author(s)
      Gosho Masahiko
    • Organizer
      28th Annual Conference of the International Society for Clinical Biostatistics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19219
  • [Presentation] A novel method for detecting adverse drug interactions in spontaneous reporting systems2016

    • Author(s)
      Gosho, M., Tada, K.
    • Organizer
      27th Annual Conference of the International Society for Clinical Biostatistics
    • Place of Presentation
      International Convention Centre (ICC), Birmingham, UK
    • Year and Date
      2016-08-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19219
  • 1.  Takashi Sozu (80408723)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 2.  石井 亮太 (40835633)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 3.  大東 智洋 (90980863)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  Ueno Satoshi (20595706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Noma Hisashi (70633486)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  岡田 昌史 (70375492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  土井 麻理子 (70636860)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  池原 由美 (70773456)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  水島 洋 (50219630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  古川 壽亮 (90275123)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  長島 健悟 (20510712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  丸尾 和司 (10777999)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  中田 由夫 (00375461)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  笹井 浩行 (60733681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  小林 裕幸 (70536218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  渡辺 和広 (60822682)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  島津 明人 (80318724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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