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Kakuki Takuya  角木 拓也

ORCIDConnect your ORCID iD *help
… Alternative Names

角木 拓也  カクキ タクヤ

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Researcher Number 70706548
Affiliation (Current) 2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2025: 札幌医科大学, 医学部, 助教
2020 – 2023: 札幌医科大学, 医学部, 助教
2015 – 2017: 札幌医科大学, 医学部, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 56050:Otorhinolaryngology-related
Except Principal Investigator
Otorhinolaryngology
Keywords
Principal Investigator
Foxo3 / 繊毛形成 / 平面内細胞極性 / 内耳有毛細胞 / 薬剤性難聴 / HDAC inhibitor / 三細胞間タイト結合 / タイト結合 / 細胞極性 / FOXO3 / TGF-β … More
Except Principal Investigator
… More 導管上皮細胞 / 細胞・組織 / タイト結合 / 導管上皮 / 顎下腺 / サイトカイン / IgG4関連涙腺・唾液腺炎 / IL-6 / 繊維芽細胞 / 線維化 / IgG4関連疾患 / 唾液腺 Less
  • Research Projects

    (4 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (7 People)
  •  内耳性難聴の再生医療への応用に向けた不死化内耳有毛前駆細胞を用いた基礎的研究Principal Investigator

    • Principal Investigator
      角木 拓也
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Sapporo Medical University
  •  Establishment of drug-induced hearing loss model and investigation of new therapeutic drugsPrincipal Investigator

    • Principal Investigator
      Kakuki Takuya
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Sapporo Medical University
  •  Elucidation of new pathological mechanism of healing loss mediated by FOXO3/TGF-beta signaling pathwayPrincipal Investigator

    • Principal Investigator
      Kakuki Takuya
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Sapporo Medical University
  •  Investigation of the mechanism of fibrosis in IgG4-related disease

    • Principal Investigator
      Takano Kenichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Sapporo Medical University

All 2022 2021 2020 2016 2015

All Journal Article Presentation

  • [Journal Article] FOXO3/TGF-β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells2022

    • Author(s)
      Kakuki T, Kohno T, Nishida S, Konno T, Kikuchi S, Ohwada K, Nakano M, Tezuka M, Takano K, Kojima T.
    • Journal Title

      Histochem Cell Biol.

      Volume: 157(4) Issue: 4 Pages: 415-426

    • DOI

      10.1007/s00418-021-02068-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07464, KAKENHI-PROJECT-20K18319, KAKENHI-PROJECT-22K05357, KAKENHI-PROJECT-22K11315, KAKENHI-PROJECT-18K10678
  • [Journal Article] Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium.2016

    • Author(s)
      Abe A, Takano K, Kojima T, Nomura K, Kakuki T, Kaneko Y, Yamamoto M, Takahashi H, Himi T
    • Journal Title

      J Mol Histol

      Volume: 未定 Issue: 3 Pages: 353-363

    • DOI

      10.1007/s10735-016-9667-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-26861401, KAKENHI-PROJECT-15K08350
  • [Journal Article] The Behavior and Role of Lipolysis-stimulated Lipoprotein Receptor, a Component of Tricellular Tight Junctions, in Head and Neck Squamous Cell Carcinomas2016

    • Author(s)
      Takano K, Kakuki T, Obata K, Nomura K, Miyata R, Kondo A, Kurose M, Kakiuchi A, Kaneko Y, Kohno T, Himi T, Kojima T
    • Journal Title

      Anticancer Res

      Volume: 36 Issue: 11 Pages: 5895-5904

    • DOI

      10.21873/anticanres.11176

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10818
  • [Journal Article] Clinical Evaluation of Sinonasal Lesions in Patients With Immunoglobulin G4-Related Disease.2015

    • Author(s)
      Takano K, Abe A, Yajima R, Kakuki T, Jitsukawa S, Nomura K, Himi T
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 124 Issue: 12 Pages: 965-971

    • DOI

      10.1177/0003489415593557

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-26861401
  • [Presentation] マウス内耳有毛細胞における繊毛形成、タイト結合分子の動態変化2022

    • Author(s)
      角木 拓也
    • Organizer
      第32回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-22K16901
  • [Presentation] FOXO3-mediated ciliogenesis during differentiation of temperature-sensitive mouse cochlear precursor hair cells.2022

    • Author(s)
      Kakuki Takuya
    • Organizer
      4th World Congress on Endoscopic Ear Surgery
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16901
  • [Presentation] 内耳有毛前駆細胞(UB/OC-2)における増殖因子シグナルを介した繊毛形成の亢進2021

    • Author(s)
      角木 拓也
    • Organizer
      第31回日本耳科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20K18319
  • [Presentation] 内耳有毛前駆細胞におけるFoxo3および増殖因子シグナルを介した繊毛形成の亢進2021

    • Author(s)
      角木 拓也
    • Organizer
      第38回耳鼻咽喉科ニューロサイエンス研究会
    • Data Source
      KAKENHI-PROJECT-20K18319
  • [Presentation] TGF-βシグナルを介した難聴の新規病態メカニズムの解明2020

    • Author(s)
      角木 拓也
    • Organizer
      第38回日本耳鼻咽喉科免疫アレルギー学会
    • Data Source
      KAKENHI-PROJECT-20K18319
  • [Presentation] Foxo3/TGF-βシグナルを介した内耳性難聴における新規病態メカニズムの解明2020

    • Author(s)
      角木 拓也
    • Organizer
      第52回日本臨床分子形態学会
    • Data Source
      KAKENHI-PROJECT-20K18319
  • [Presentation] 内耳性難聴におけるFoxo3/TGF-βシグナルを介した新規病態メカニズムの解明2020

    • Author(s)
      角木 拓也
    • Organizer
      第30回日本耳科学会
    • Data Source
      KAKENHI-PROJECT-20K18319
  • 1.  Takano Kenichi (70404689)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  松宮 弘 (80517904)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  金子 躍人 (90738874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  矢島 諒人 (90722455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  垣内 晃人 (60722436)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  小島 隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  幸野 貴之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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