Kakuki Takuya 角木拓也

… Alternative Names

角木拓也カクキタクヤ

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Researcher Number	70706548
Affiliation (Current)	2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 札幌医科大学, 医学部, 助教 2020 – 2023: 札幌医科大学, 医学部, 助教 2015 – 2017: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator 内耳有毛細胞 / 細胞極性 / Foxo3 / 繊毛形成 / 平面内細胞極性 / 上皮バリア機能 / アポトーシス / 内耳性難聴 / 薬剤性難聴 / HDAC inhibitor … More / 三細胞間タイト結合 / タイト結合 / FOXO3 / TGF-β … More Except Principal Investigator 導管上皮細胞 / 細胞・組織 / タイト結合 / 導管上皮 / 顎下腺 / サイトカイン / IgG4関連涙腺・唾液腺炎 / IL-6 / 繊維芽細胞 / 線維化 / IgG4関連疾患 / 唾液腺 Less

内耳性難聴の再生医療への応用に向けた不死化内耳有毛前駆細胞を用いた基礎的研究Principal Investigator
- Principal Investigator
  
  角木拓也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Sapporo Medical University
Establishment of drug-induced hearing loss model and investigation of new therapeutic drugsPrincipal Investigator
- Principal Investigator
  
  Kakuki Takuya
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Sapporo Medical University
Elucidation of new pathological mechanism of healing loss mediated by FOXO3/TGF-beta signaling pathwayPrincipal Investigator
- Principal Investigator
  
  Kakuki Takuya
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Sapporo Medical University
Investigation of the mechanism of fibrosis in IgG4-related disease
- Principal Investigator
  
  Takano Kenichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University

All 2022 2021 2020 2016 2015

All Journal Article Presentation

[Journal Article] FOXO3/TGF-β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells2022
- Author(s)
  Kakuki T, Kohno T, Nishida S, Konno T, Kikuchi S, Ohwada K, Nakano M, Tezuka M, Takano K, Kojima T.
- Journal Title
  
  Histochem Cell Biol.
  
  Volume: 157(4) Issue: 4 Pages: 415-426
- DOI
  10.1007/s00418-021-02068-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07464, KAKENHI-PROJECT-20K18319, KAKENHI-PROJECT-22K05357, KAKENHI-PROJECT-22K11315, KAKENHI-PROJECT-18K10678
[Journal Article] Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium.2016
- Author(s)
  Abe A, Takano K, Kojima T, Nomura K, Kakuki T, Kaneko Y, Yamamoto M, Takahashi H, Himi T
- Journal Title
  
  J Mol Histol
  
  Volume: 未定 Issue: 3 Pages: 353-363
- DOI
  10.1007/s10735-016-9667-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-26861401, KAKENHI-PROJECT-15K08350
[Journal Article] The Behavior and Role of Lipolysis-stimulated Lipoprotein Receptor, a Component of Tricellular Tight Junctions, in Head and Neck Squamous Cell Carcinomas2016
- Author(s)
  Takano K, Kakuki T, Obata K, Nomura K, Miyata R, Kondo A, Kurose M, Kakiuchi A, Kaneko Y, Kohno T, Himi T, Kojima T
- Journal Title
  
  Anticancer Res
  
  Volume: 36 Issue: 11 Pages: 5895-5904
- DOI
  10.21873/anticanres.11176
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10818
[Journal Article] Clinical Evaluation of Sinonasal Lesions in Patients With Immunoglobulin G4-Related Disease.2015
- Author(s)
  Takano K, Abe A, Yajima R, Kakuki T, Jitsukawa S, Nomura K, Himi T
- Journal Title
  
  Ann Otol Rhinol Laryngol
  
  Volume: 124 Issue: 12 Pages: 965-971
- DOI
  10.1177/0003489415593557
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-26861401
[Presentation] マウス内耳有毛細胞における繊毛形成、タイト結合分子の動態変化2022
- Author(s)
  角木　拓也
- Organizer
  第32回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K16901
[Presentation] FOXO3-mediated ciliogenesis during differentiation of temperature-sensitive mouse cochlear precursor hair cells.2022
- Author(s)
  Kakuki Takuya
- Organizer
  4th World Congress on Endoscopic Ear Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16901
[Presentation] 内耳有毛前駆細胞（UB/OC-2）における増殖因子シグナルを介した繊毛形成の亢進2021
- Author(s)
  角木　拓也
- Organizer
  第31回日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K18319
[Presentation] 内耳有毛前駆細胞におけるFoxo3および増殖因子シグナルを介した繊毛形成の亢進2021
- Author(s)
  角木　拓也
- Organizer
  第38回耳鼻咽喉科ニューロサイエンス研究会
- Data Source
  KAKENHI-PROJECT-20K18319
[Presentation] TGF-βシグナルを介した難聴の新規病態メカニズムの解明2020
- Author(s)
  角木　拓也
- Organizer
  第38回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-20K18319
[Presentation] Foxo3/TGF-βシグナルを介した内耳性難聴における新規病態メカニズムの解明2020
- Author(s)
  角木　拓也
- Organizer
  第52回日本臨床分子形態学会
- Data Source
  KAKENHI-PROJECT-20K18319
[Presentation] 内耳性難聴におけるFoxo3/TGF-βシグナルを介した新規病態メカニズムの解明2020
- Author(s)
  角木　拓也
- Organizer
  第30回日本耳科学会
- Data Source
  KAKENHI-PROJECT-20K18319

1. Takano Kenichi (70404689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 松宮弘 (80517904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 金子躍人 (90738874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 矢島諒人 (90722455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 垣内晃人 (60722436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 小島隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 幸野貴之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kakuki Takuya 角木 拓也

角木 拓也 カクキ タクヤ

Research Projects

Research Products

Co-Researchers

内耳性難聴の再生医療への応用に向けた不死化内耳有毛前駆細胞を用いた基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of drug-induced hearing loss model and investigation of new therapeutic drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of new pathological mechanism of healing loss mediated by FOXO3/TGF-beta signaling pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism of fibrosis in IgG4-related disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] FOXO3/TGF-β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Behavior and Role of Lipolysis-stimulated Lipoprotein Receptor, a Component of Tricellular Tight Junctions, in Head and Neck Squamous Cell Carcinomas2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Evaluation of Sinonasal Lesions in Patients With Immunoglobulin G4-Related Disease.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] マウス内耳有毛細胞における繊毛形成、タイト結合分子の動態変化2022

Author(s)

Organizer

Data Source

[Presentation] FOXO3-mediated ciliogenesis during differentiation of temperature-sensitive mouse cochlear precursor hair cells.2022

Author(s)

Organizer

Data Source

[Presentation] 内耳有毛前駆細胞（UB/OC-2）における増殖因子シグナルを介した繊毛形成の亢進2021

Author(s)

Organizer

Data Source

[Presentation] 内耳有毛前駆細胞におけるFoxo3および増殖因子シグナルを介した繊毛形成の亢進2021

Author(s)

Organizer

Data Source

[Presentation] TGF-βシグナルを介した難聴の新規病態メカニズムの解明2020

Author(s)

Organizer

Data Source

[Presentation] Foxo3/TGF-βシグナルを介した内耳性難聴における新規病態メカニズムの解明2020

Author(s)

Organizer

Data Source

[Presentation] 内耳性難聴におけるFoxo3/TGF-βシグナルを介した新規病態メカニズムの解明2020

Author(s)

Organizer

Data Source

Kakuki Takuya 角木拓也

角木拓也カクキタクヤ