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Hara Yuichiro  原 雄一郎

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HARA Yuichiro  原 雄一郎

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Researcher Number 70709708
Other IDs
Affiliation (Current) 2025: 北里大学, 未来工学部, 准教授
2025: 公益財団法人東京都医学総合研究所, ゲノム医学研究センター, 研究員
Affiliation (based on the past Project Information) *help 2020 – 2023: 公益財団法人東京都医学総合研究所, ゲノム医学研究センター, 主席研究員
2019: 名古屋大学, 環境医学研究所, 特任講師
2013: 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 43050:Genome biology-related
Except Principal Investigator
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Evolutionary biology
Keywords
Principal Investigator
de novo gene / 偽遺伝子化 / 遺伝子レパートリー / シスエレメント / de novo 遺伝子 / 祖先配列 / エンハンサー / プロモーター / 超並列レポーターアッセイ / 偽遺伝子 / de novo遺伝子 … More
Except Principal Investigator
… More 慢性炎症 / リピドーム解析 / 慢性炎症生疾患 / 慢性炎症性疾患 / 自己免疫 / 脂質代謝 / 免疫代謝 / 分子進化 / バイオインフォマティクス / 突然変異 / 生物進化 / 超微小逆位 / 比較ゲノム Less
  • Research Projects

    (3 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (8 People)
  •  Elucidation of de novo gene birth and pseudogenization processes via reconstruction of ancestral transcriptional regulationPrincipal Investigator

    • Principal Investigator
      HARA Yuichiro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43050:Genome biology-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Immune cell lipid reprogramming in chronic inflammatory diseases

    • Principal Investigator
      Ito Ayaka
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Nagoya University
  •  Evolutionary genomics of ultramicro inversions.

    • Principal Investigator
      IMANISHI Tadashi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Evolutionary biology
    • Research Institution
      Tokai University

All 2024 2023 2022 2021 2014 2013 2012

All Journal Article Presentation Book

  • [Book] ヒトゲノム事典 12章 「12.3 遺伝子変換」, 「12.6 逆位」2021

    • Author(s)
      原 雄一郎; (編) 井ノ上 逸朗, 今西 規, 河村 正二, 斎藤 成也, 颯田 葉子, 田嶋 敦
    • Total Pages
      448
    • Publisher
      一色出版
    • ISBN
      9784910389127
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Journal Article] The impact of local genomic properties on the evolutionary fate of genes2023

    • Author(s)
      Hara Yuichiro、Kuraku Shigehiro
    • Journal Title

      eLife

      Volume: 12 Pages: 82290-82290

    • DOI

      10.7554/elife.82290

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Journal Article] Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis2023

    • Author(s)
      Inoue Takayuki、Fu Bin、Nishio Miwako、Tanaka Miyako、Kato Hisashi、Tanaka Masashi、Itoh Michiko、Yamakage Hajime、Ochi Kozue、Ito Ayaka、Shiraki Yukihiro、Saito Satoshi、Ihara Masafumi、Nishimura Hideo、Kawamoto Atsuhiko、Inoue Shian、Saeki Kumiko、Enomoto Atsushi、Suganami Takayoshi、Satoh-Asahara Noriko
    • Journal Title

      Nutrients

      Volume: 15 Issue: 2 Pages: 350-350

    • DOI

      10.3390/nu15020350

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08526, KAKENHI-PROJECT-21K08571, KAKENHI-PROJECT-22K07456, KAKENHI-PROJECT-22K08667, KAKENHI-PROJECT-22K11700, KAKENHI-PROJECT-22K11720, KAKENHI-PROJECT-22K19524, KAKENHI-PROJECT-22K19723, KAKENHI-PROJECT-21K17557, KAKENHI-PROJECT-19KK0249, KAKENHI-PUBLICLY-21H05625, KAKENHI-PROJECT-20H03447, KAKENHI-PROJECT-21H02835, KAKENHI-PROJECT-19K07905, KAKENHI-PROJECT-19K07927, KAKENHI-PUBLICLY-22H04806
  • [Journal Article] Gene fate spectrum as a reflection of local genomic properties2022

    • Author(s)
      Hara Yuichiro、Kuraku Shigehiro
    • Journal Title

      biorXiv

      Volume: -

    • DOI

      10.1101/2022.08.08.502781

    • Open Access
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Journal Article] Ten years of collaborative progress in the Quest for Orthologs2021

    • Author(s)
      Linard Benjamin、Ebersberger Ingo、McGlynn Shawn E、Glover Natasha、Mochizuki Tomohiro、Patricio Mateus、Lecompte Odile、Nevers Yannis、Thomas Paul D、Gabaldon Toni、Sonnhammer Erik、Dessimoz Christophe、Uchiyama Ikuo、QFO Consortium
    • Journal Title

      Molecular Biology and Evolution

      Volume: - Issue: 8 Pages: 3033-3045

    • DOI

      10.1093/molbev/msab098

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H01325, KAKENHI-PROJECT-21K06132, KAKENHI-PROJECT-16H06279
  • [Journal Article] Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer2021

    • Author(s)
      Hara Yuichiro、Shibahara Reira、Kondo Koyuki、Abe Wataru、Kunieda Takekazu
    • Journal Title

      Open Biology

      Volume: 11 Issue: 7 Pages: 200413-200413

    • DOI

      10.1098/rsob.200413

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H04332, KAKENHI-PROJECT-21K06132, KAKENHI-PROJECT-20K20580
  • [Journal Article] Reconstructing the Demographic History of the Human Lineage Using Whole-Genome Sequences from Human and Three Great Apes2012

    • Author(s)
      Hara Y, Imanishi T, and Satta Y.
    • Journal Title

      Genome Biology and Evolution,(この論文はGenome Biology and Evolution, Volume 4 Issue 11のハイライト論文として掲載された。Highlight : Family Ties—New Evidence Simplifies Human Evolutionary Tree. Genome Biology and Evolution, 4:1146-1147, 2012.)

      Volume: 4 Pages: 1133-1145

    • Data Source
      KAKENHI-PROJECT-24657168
  • [Journal Article] Reconstructing the Demographic History of the Human Lineage Using Whole-Genome Sequences from Human and Three Great Apes.2012

    • Author(s)
      Hara Y., Imanishi, T., and Satta, Y.
    • Journal Title

      Genome Biology and Evolution

      Volume: 4 Issue: 11 Pages: 1133-1145

    • DOI

      10.1093/gbe/evs075

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] Activation of α7 nicotinic acetylcholine receptor attenuates inflammation through decreasing cellular glutathione levels2024

    • Author(s)
      Ito A, Nanahara Y, Shirakawa I, Kobayashi M, Arima H, Suganami T
    • Organizer
      Keystone Symposia, Immunometabolism: From Mechanisms to Pathways to Therapies
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0249
  • [Presentation] 祖先転写制御の実験的復元から遺伝子が生まれる・消える過程を探る2023

    • Author(s)
      原 雄一郎、吉沢 直子、豊田 敦、川路 英哉
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] Single cell analysis of non-model organisms and cross-species comparison2023

    • Author(s)
      原 雄一郎
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] 祖先転写制御の実験的復元に基づく遺伝子の創成・消失過程の解明2023

    • Author(s)
      原 雄一郎
    • Organizer
      先進ゲノム支援 2023年度拡大班会議
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] Gene fate spectrum as a reflection of local genomic properties2023

    • Author(s)
      Yuichiro Hara, Shigehiro Kuraku
    • Organizer
      SMBE 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] 遺伝子の運命を左右するゲノムの場2022

    • Author(s)
      原 雄一郎
    • Organizer
      国立遺伝学研究所 研究会 「生命科学を支える分子系統学」
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] 不均一なゲノムの場での突然変異と遺伝子進化のモード2022

    • Author(s)
      原 雄一郎
    • Organizer
      日本進化学会年大会 第24回沼津大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] FLAT-seq: Full-Length cDNA sequencing with Adaptive sampling of TSS2022

    • Author(s)
      原 雄一郎、齊藤紗希、和田涼子、川路英哉
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] 種間比較から明らかにされる遺伝子欠失を受容するゲノム領域2021

    • Author(s)
      原 雄一郎、工樂樹洋
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] Parallel evolution of trehalose biosynthesis machinery in metazoans.2021

    • Author(s)
      Hara Yuichiro、Shibahara Reira、Kondo Koyuki、Abe Wataru、Kunieda Takekazu
    • Organizer
      The 2nd AsiaEvo Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06132
  • [Presentation] Search for germline mutations from next-generation sequencing analysis2014

    • Author(s)
      Hara Y
    • Organizer
      International Symposium on "Germline Mutagenesis and Biodiversification
    • Place of Presentation
      九州大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] Search for germline mutations from next-generation sequencing analysis2014

    • Author(s)
      Hara Y
    • Organizer
      International Symposium on "Germline Mutagenesis and Biodiversification"
    • Place of Presentation
      Kyushu University Oral Presentation
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] Identification and characterization of ultramicro inversions within local alignments between closely related species2013

    • Author(s)
      Hara Y and Imanishi T
    • Organizer
      Cold Spring Harbor Meetings, GENOME INFORMATICS
    • Place of Presentation
      Cold Spring Harbor Laboratory, USA
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] Identification and characterization of ultramicro inversions within local alignments between closely related species2013

    • Author(s)
      Hara Y and Imanishi T
    • Organizer
      Cold Spring Harbor Meetings, GENOME INFORMATICS Cold Spring Harbor Laboratory
    • Place of Presentation
      USA Oral Presentation
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] 近縁種間の全ゲノムアラインメント内に同定された多数の微小な逆位2012

    • Author(s)
      原雄一郎、今西規
    • Organizer
      日本進化学会第14回大会
    • Place of Presentation
      首都大学東京南大沢キャンパス
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] 近縁種間の全ゲノム比較による超微小逆位の同定とその生成機構2012

    • Author(s)
      原雄一郎、今西規
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] Abundance of ultramicro inversions within local alignments between closely related species.2012

    • Author(s)
      Hara Y. and Imanishi T.
    • Organizer
      Molecular Biology and Evolution Conference 2012 (SMBE2012)
    • Place of Presentation
      Dublin Convention Centre, Dublin, Ireland
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] ヒトゲノム配列中に同定された多数の超微小逆位2012

    • Author(s)
      原雄一郎
    • Organizer
      NGS現場の会・第二回研究会
    • Place of Presentation
      ホテル阪急エキスポパーク
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] Abundance of ultramicro inversions within local alignments between closely related species2012

    • Author(s)
      Hara Y and Imanishi T
    • Organizer
      SMBE2012
    • Place of Presentation
      Dublin, Ireland(ポスター発表)
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] 近縁種ゲノム比較によって明らかにされる超微小逆位2012

    • Author(s)
      原雄一郎、今西規
    • Organizer
      日本進化学会第14回大会
    • Place of Presentation
      東京(ワークショップでの口頭発表)
    • Data Source
      KAKENHI-PROJECT-24657168
  • [Presentation] 近縁種間の全ゲノム比較による超微小逆位の同定とその生成機構2012

    • Author(s)
      原雄一郎,今西規
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡(ワークショップでの口頭発表およびポスター発表)
    • Data Source
      KAKENHI-PROJECT-24657168
  • 1.  IMANISHI Tadashi (80270461)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 2.  Ito Ayaka (80508333)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  菅波 孝祥 (50343752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  吉沢 直子 (30344071)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  McGlynn Shawn・E.
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  須賀田 直子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  國枝 武和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  田中 都
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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