Lee Ji-Won 李智媛

Researcher Number	70711274
Other IDs
Affiliation (Current)	2025: 北海道大学, 歯学研究院, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 北海道大学, 歯学研究院, 助教 2021: 愛媛大学, プロテオサイエンスセンター, 助教(特定教員) 2016 – 2019: 愛媛大学, プロテオサイエンスセンター, 助教(特定教員) 2014 – 2016: 愛媛大学, プロテオサイエンスセンター, 助教(特命教員)
Review Section/Research Field	Principal Investigator Basic Section 57010:Oral biological science-related / Morphological basic dentistry Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Basic Section 57040:Regenerative dentistry and dental engineering-related / Morphological basic dentistry
Keywords	Principal Investigator osteoclast / bone / RANKL / CCR5 / chemokine / PTK2B / Alzheimer's disease / osteoporosis / ontogeny / microglia … More / osteoclasts / Pyk2 / Lysosome / Rank / Histomorphometry / Smarcc1 / SWI/SNF / Bone / sexual dimorphism / Chromatin remodeler / Baf155 / Osteoclast / BAF155 / chromatin remodeler / histomorphometry / RNA-sequence / chemokine receptor / bone metabolism / chemokine receptor 5 / osteoblast / small GTPase / cytoskeleton … More Except Principal Investigator 骨 / 骨再生 / 血管 / イメージング / 骨粗鬆症 / 骨代謝 / 微小循環 / 顎骨 / 骨壊死 / CCR5 / 放射線性顎骨骨髄炎 / 頭蓋顎顔面 / 再生 / 神経再構成 / 三叉神経 / 概日リズム / 神経 / 骨リモデリング / PTH / 骨形成 / 発生 / 恒常性 / 老化 / シミュレーション / 骨吸収性疾患 / 骨格形成 / 形態形成 / 軟骨 / ケモカイン / 骨芽細胞 / 骨格 / シグナル / HIV / 破骨細胞 Less

A drug development study for radiation osteonecrosis of jaw with improving micro vascular-skeletal structure
- Principal Investigator
  
  飯村忠浩
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Hokkaido University
Pharmacological study of a shared genetic risk factor for osteoporosis and Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  李智媛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Hokkaido University
Investigation of chromatic remodeling in osteoclast function for therapeutic targeting of bone remodeling balancePrincipal Investigator
- Principal Investigator
  
  Lee Ji-Won
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Hokkaido University
  Ehime University
Study on mature bone formation and regeneration by Nuero-Skeletal regulations
- Principal Investigator
  
  IImura Tadahiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Hokkaido University
  Ehime University
Morphometrical and quantitative transcriptome analyses of C-C chemokine receptor 5 in functional structure of osteoclastsPrincipal Investigator
- Principal Investigator
  
  LEE JIWON
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Ehime University
Multimode analyses of skeletogenesis by imaging, simulation and omics
- Principal Investigator
  
  Iimura Tadahiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Ehime University
Pathophysiological investigation of bone cell communications regulated by chemokine networkPrincipal Investigator
- Principal Investigator
  
  Lee Ji-Won
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Ehime University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Association between an increased serum CCL5 level and pathophysiology of degenerative joint disease in the temporomandibular joint in females2023
- Author(s)
  H Watanabe, T Iori, Ji-Won Lee, T Kajii, A Takakura, T Takao-Kawabata, Y Kitagawa, Y Maruoka, T Iimura
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 24 Issue: 3 Pages: 2775-2775
- DOI
  10.3390/ijms24032775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10044, KAKENHI-PROJECT-23K18347
[Journal Article] Centrosome clustering control in osteoclasts through CCR5-mediated signaling2023
- Author(s)
  Lee Ji-Won、Lee In-Hee、Watanabe Haruhisa、Liu Yunqing、Sawada Kazuaki、Maekawa Masashi、Uehara Shunsuke、Kobayashi Yasuhiro、Imai Yuuki、Kong Sek Won、Iimura Tadahiro
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 20813-20813
- DOI
  10.1038/s41598-023-48140-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18402, KAKENHI-PROJECT-23K18347, KAKENHI-PROJECT-23K16013, KAKENHI-PROJECT-23K09116, KAKENHI-PROJECT-21K09373, KAKENHI-PROJECT-23K24462
[Journal Article] Evolution of multiple comics approaches to define pathophysiology of pediatric acute respiratory distress syndrome2022
- Author(s)
  Jane E Whitney, In-Hee Lee, Ji-Won Lee, Sek Won Kong
- Journal Title
  
  Elife
  
  Volume: 11
- DOI
  10.7554/elife.77405
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10044
[Journal Article] Histone H3K27 demethylase, Utx, regulates osteoblast-to-osteocyte differentiation2022
- Author(s)
  Xia Yuhan、Ikedo Aoi、Lee Ji-Won、Iimura Tadahiro、Inoue Kazuki、Imai Yuuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 590 Pages: 132-138
- DOI
  10.1016/j.bbrc.2021.12.102
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19649, KAKENHI-PROJECT-18H02983, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-21K09373, KAKENHI-PROJECT-19K10044, KAKENHI-PROJECT-23K24462
[Journal Article] Expansion of the osteocytic lacunar-canalicular system involved in pharmacological action of PTH revealed by AI-driven fluorescence morphometry in female rabbits2022
- Author(s)
  A Takakura, T Sato, Ji-Won Lee, K Hirano, R Takao-Kawabata, T Ishizuka, T Iimura
- Journal Title
  
  Scientific reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-20793-5
- Data Source
  KAKENHI-PROJECT-19K10044
[Journal Article] The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes2022
- Author(s)
  Hamasaki Eriko、Wakita Natsuki、Yasuoka Hiroki、Nagaoka Hikaru、Morita Masayuki、Takashima Eizo、Uchihashi Takayuki、Takeda Tetsuya、Abe Tadashi、Lee Ji-Won、Iimura Tadahiro、Saleem Moin A、Ogo Naohisa、Asai Akira、Narita Akihiro、Takei Kohji、Yamada Hiroshi
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10 Pages: 884509-884509
- DOI
  10.3389/fcell.2022.884509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06990, KAKENHI-PROJECT-22K06580, KAKENHI-PROJECT-19K10044, KAKENHI-PROJECT-20K08591
[Journal Article] Genetic variation analyses indicate conserved SARS‐CoV‐2-host interaction and varied genetic adaptation in immune response factors in modern human evolution2021
- Author(s)
  Lee Ji‐Won、Lee In‐Hee、Sato Takanori、Kong Sek Won、Iimura Tadahiro
- Journal Title
  
  Development, Growth & Differentiation
  
  Volume: 63 Issue: 3 Pages: 219-227
- DOI
  10.1111/dgd.12717
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19649, KAKENHI-PROJECT-18H02983, KAKENHI-PROJECT-19K10044
[Journal Article] Two macrophages, osteoclasts and microglia: from development to pleiotropy2021
- Author(s)
  Lee Ji-Won、Lee In-Hee、Iimura Tadahiro、Kong Sek Won
- Journal Title
  
  Bone Research
  
  Volume: 9 Issue: 1 Pages: 11-11
- DOI
  10.1038/s41413-020-00134-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19649, KAKENHI-PROJECT-18H02983, KAKENHI-PROJECT-19K10044
[Journal Article] A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys2021
- Author(s)
  Sato Takanori、Takakura Aya、Lee Ji-Won、Tokunaga Kazuaki、Matsumori Haruka、Takao-Kawabata Ryoko、Iimura Tadahiro
- Journal Title
  
  Microscopy
  
  Volume: 70 Issue: 6 Pages: 498-509
- DOI
  10.1093/jmicro/dfab020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19649, KAKENHI-PROJECT-18H02983, KAKENHI-PROJECT-19K10044
[Journal Article] Teriparatide relieves ovariectomy-induced hyperalgesia in rats, suggesting the involvement of functional regulation in primary sensory neurons by PTH-mediated signaling.2020
- Author(s)
  Tanaka T, Takao-Kawabata R, Takakura A, Shimazu Y, Nakatsugawa M, Ito A, Lee JW, Kawasaki K, Iimura T.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 5346-5346
- DOI
  10.1038/s41598-020-62045-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19649, KAKENHI-PROJECT-18H02983, KAKENHI-PROJECT-19K10044
[Journal Article] A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3/7/8/ across populations2020
- Author(s)
  In-Hee Lee, Ji-Won Lee, Sek Won Kong
- Journal Title
  
  Infection, Genetics and Evolution
  
  Volume: 85 Pages: 104507-104507
- DOI
  10.1016/j.meegid.2020.104507
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10044
[Journal Article] Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin.2019
- Author(s)
  Yanagihara Y, Inoue K, Saeki N, Sawada Y, Yoshida S, Lee JW, Iimura T and Imai Y.
- Journal Title
  
  Bone
  
  Volume: 122 Pages: 93-100
- DOI
  10.1016/j.bone.2019.02.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19728, KAKENHI-PROJECT-17K17929, KAKENHI-PROJECT-18K19649, KAKENHI-PROJECT-18H02983, KAKENHI-PROJECT-19H03786
[Journal Article] 骨組織の顕微鏡研究2018
- Author(s)
  李智媛、飯村忠浩
- Journal Title
  
  顕微鏡
  
  Volume: 23 Pages: 24-28
- NAID
  130007686936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293392
[Journal Article] Harmine promotes molar root development via SMAD1/5/8 phosphorylation.2018
- Author(s)
  Fujiwara N, Lee JW, Kumakami-Sakano M, Otsu K, Woo JT, Iseki S, Ota
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 497 Issue: 3 Pages: 924-929
- DOI
  10.1016/j.bbrc.2017.12.062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01810, KAKENHI-PROJECT-17K08499, KAKENHI-PROJECT-17K19774, KAKENHI-PROJECT-26293392, KAKENHI-PROJECT-16K20412
[Journal Article] テリパラチドの高頻度投与は皮質骨空隙形成を誘導する2018
- Author(s)
  高倉綾、李智媛、山根宏志、高尾亮子、飯村忠浩
- Journal Title
  
  日本骨形態計測学会雑誌
  
  Volume: 28 Pages: 31-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293392
[Journal Article] PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes2018
- Author(s)
  Morita Masayuki、Nagaoka Hikaru、Ntege Edward H.、Kanoi Bernard N.、Ito Daisuke、Nakata Takahiro、Lee Ji-Won、Tokunaga Kazuaki、Iimura Tadahiro、Torii Motomi、Tsuboi Takafumi、Takashima Eizo
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 3696-3696
- DOI
  10.1038/s41598-018-22026-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06873, KAKENHI-PROJECT-17K15678, KAKENHI-PROJECT-16K20412
[Journal Article] 骨組織の顕微鏡研究2018
- Author(s)
  飯村忠浩、李　智媛
- Journal Title
  
  顕微鏡
  
  Volume: 23 Pages: 24-28
- NAID
  130007686936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20412
[Journal Article] テリパラチドの高頻度投与は皮質骨空隙形成を誘導する2018
- Author(s)
  高倉綾、李智媛、山根宏志、高尾亮子、飯村忠浩
- Journal Title
  
  日本骨形態計測学会雑誌
  
  Volume: 28 Pages: 31-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20412
[Journal Article] Uhrf1 is indispensable for normal limb growth by regulating chondrocyte differentiation through specific gene expression2017
- Author(s)
  Yamashita Michiko、Inoue Kazuki、Saeki Noritaka、Ideta-Otsuka Maky、Yanagihara Yuta、Sawada Yuichiro、Sakakibara Iori、Lee Jiwon、Ichikawa Koichi、Kamei Yoshiaki、Iimura Tadahiro、Igarashi Katsuhide、Takada Yasutsugu、Imai Yuuki
- Journal Title
  
  Development
  
  Volume: 145 Issue: 1 Pages: 157412-157412
- DOI
  10.1242/dev.157412
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19728, KAKENHI-PROJECT-26293392, KAKENHI-PROJECT-15H04961, KAKENHI-PROJECT-17H01882, KAKENHI-PROJECT-16K20412
[Journal Article] Japanse Dental Science Review2017
- Author(s)
  Ji-Won Lee, Tadahiro Iimura
- Journal Title
  
  Shedding quantitative fluorescence light on novel regulatory mechanisms in skeletal biomedicine and biodentistry
  
  Volume: 53 Pages: 2-10
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412
[Journal Article] Shedding quantitative fluorescence light on novel regulatory mechanisms in skeletal biomedicine and biodentistry.2017
- Author(s)
  Lee JW, Iimura T
- Journal Title
  
  Japanese of Dental Science Review
  
  Volume: 53 Issue: 1 Pages: 2-10
- DOI
  10.1016/j.jdsr.2016.04.005
- NAID
  50012041274
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412, KAKENHI-PROJECT-26293392
[Journal Article] Shedding quantitative fluorescence light on novel regulatory mechanisms in skeletal biomedicine and biodentistry.2017
- Author(s)
  Lee JW, Iimura T.
- Journal Title
  
  Jpn Dent Sci Rev.
  
  Volume: 53 Pages: 2-10
- NAID
  50012041274
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293392
[Journal Article] Acute development of cortical porosity and endosteal naive bone formation from the daily but not weekly short-term administration of PTH in rabbit.2017
- Author(s)
  Yamane H, Takakura A, Shimadzu Y, Kodama T, Lee JW, Isogai Y, Ishizuya T, Takao-Kawabata R, Iimura T.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 4 Pages: e0175329-e0175329
- DOI
  10.1371/journal.pone.0175329
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293392, KAKENHI-PROJECT-16K20412
[Journal Article] Bone Research2017
- Author(s)
  Aya Tanaka, Ji-Won Lee, Kyoko Hirano, Yukihiro Isogai, Toshinori Ishizuya, Rhoko Takao-Kawabata, Tadahiro Iimura
- Journal Title
  
  Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariwctomized rats
  
  Volume: 5 Issue: 1 Pages: 17002-17002
- DOI
  10.1038/boneres.2017.2
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412, KAKENHI-PROJECT-26293392
[Journal Article] The HIV co-receptor CCR5 regulates osteoclast function.2017
- Author(s)
  Lee JW, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, Ueha S, Matsushima K, Yamaguchi A, Imai Y, Iimura T.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 2226-2226
- DOI
  10.1038/s41467-017-02368-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08730, KAKENHI-PROJECT-16K11494, KAKENHI-PROJECT-17K19546, KAKENHI-PROJECT-17K19728, KAKENHI-PROJECT-16K20412, KAKENHI-PROJECT-26293392, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-15H04961, KAKENHI-PROJECT-16H05203, KAKENHI-PROJECT-15F15113, KAKENHI-PROJECT-16K15791, KAKENHI-PROJECT-16K18578
[Journal Article] Journal of Oral Biosciences2017
- Author(s)
  Tadahiro Iimura, Ji-Won Lee
- Journal Title
  
  Unveiling a rhythmic regulatory mode hidden in developmental tissue growth by fluorescence live imaging-based mathematical modeling
  
  Volume: 59 Issue: 1 Pages: 6-11
- DOI
  10.1016/j.job.2016.09.001
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412, KAKENHI-PROJECT-26293392
[Journal Article] Changes in the spatial distribution of sclerostin in the osteocytic lacuno-canalicular system in alveolar bone due to orthodontic forces, as detected on multimodal confocal fluorescence imaging analyses.2015
- Author(s)
  Nishiyama Y, Matsumoto T, Lee JW, Saitou T, Imamura T, Moriyama K, Yamaguchi A, Iimura T.
- Journal Title
  
  Arch Oral Biol.
  
  Volume: 60 Issue: 1 Pages: 45-54
- DOI
  10.1016/j.archoralbio.2014.08.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293392, KAKENHI-PROJECT-26861549, KAKENHI-PROJECT-26861772
[Journal Article] Quantitative in situ fluorescence imaging to unveil the morphological and function heterogeneity of osteocytes2015
- Author(s)
  Ji-Won Lee, Tadahiro Iimura
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: e-pub Issue: 2 Pages: 76-79
- DOI
  10.1016/j.job.2015.02.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26861549, KAKENHI-PROJECT-26293392
[Journal Article] Functional heterogeneity of osteocytes in FGF23 production: the possible involvement of DMP1 as a direct negative regulator.2014
- Author(s)
  Lee JW, Yamaguchi A, Iimura T.
- Journal Title
  
  Bonekey Rep.
  
  Volume: 3 Pages: 543-543
- DOI
  10.1038/bonekey.2014.38
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293392, KAKENHI-PROJECT-26861549
[Journal Article] Rosmarinic acid exerts an anti-osteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation.2014
- Author(s)
  Lee JW, Asai M, Jeon SK, Iimura T, Yonezawa T, Cha BY, Woo JT, Yamaguchi A
- Journal Title
  
  Mol Nutr Food Res
  
  Volume: 59 Issue: 3 Pages: 386-400
- DOI
  10.1002/mnfr.201400164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253098, KAKENHI-PROJECT-25870188, KAKENHI-PROJECT-26293024, KAKENHI-PROJECT-26670657, KAKENHI-PROJECT-26861549, KAKENHI-PROJECT-26293392
[Presentation] RAW264.7細胞において Calcitriolがアポトーシスを誘導する2023
- Author(s)
  笠井満知子、中村圭佑、李智媛、長谷部晃
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09116
[Presentation] 女性における血清CCL5値の上昇と顎関節の退行性病変の病態との関連性2023
- Author(s)
  渡辺陽久、庵　敬、李智媛、丸岡豊、飯村忠浩
- Organizer
  第43回日本骨形態計測学会
- Data Source
  KAKENHI-PROJECT-23K18347
[Presentation] 破骨細胞の分化成熟におけるPyk2の役割2023
- Author(s)
  西浦まい、八若保孝、飯村忠浩、李　智媛
- Organizer
  第43回日本骨形態計測学会
- Data Source
  KAKENHI-PROJECT-23K18347
[Presentation] The role of centrosome clustering in CCR5-medaited cell polarity2023
- Author(s)
  李智媛
- Organizer
  第43回日本骨形態計測学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K09116
[Presentation] AI駆動型形態計測を用いたイヌ皮質骨ハバース管リモデリングに対する骨形成促進薬テリパラチドの薬理作用2023
- Author(s)
  星（沼端）麻里絵、高倉　綾、中西（木村）徳子、李　智媛、佐藤嘉晃、高尾亮子、飯村忠浩
- Organizer
  第43回日本骨形態計測学会
- Data Source
  KAKENHI-PROJECT-23K18347
[Presentation] Candida albicans 臨床分離株の抗真菌薬感受性の比較・検討2023
- Author(s)
  中村圭佑、笠井満知子、李智媛、長谷部晃
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09116
[Presentation] SARS-CoV-2の相互作用分子ACE2, TMPRSS2およびTLR3/7/8における人口集団の遺伝的変異調査2021
- Author(s)
  李　智媛、In-Hee Lee, Sek Won Kong, 飯村　忠浩
- Organizer
  日本薬理学会
- Data Source
  KAKENHI-PROJECT-19K10044
[Presentation] The HIV co-receptor CCR5 regulates cellular pathways required for osteoclast function2018
- Author(s)
  Lee JW
- Organizer
  第３回日本骨免疫学会ウィンターセミナー
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] マルチモード蛍光観察による新規の骨代謝病態機能探索2018
- Author(s)
  飯村忠浩　李　智媛
- Organizer
  第123回日本解剖学会総会・全国学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] The HIV co-receptor CCR5 regulates cellular pathways required for osteoclast function2018
- Author(s)
  Lee JW
- Organizer
  The 370th Matsumoto University
- Invited
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] CCR5 is required for osteoclast function through regulating lysosomal vesicle trafficking2018
- Author(s)
  LEe JW, Iami Y, Iimura T
- Organizer
  Annual meeting of American Society for Bone and Mineral Research, Montreal, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] The HIV co-receptor CCR5 regulates cellular pathways required for osteoclast function2018
- Author(s)
  Ji-Won Lee, Shunsuke Uehara, Yasuhiro Kobayashi, Yuuki Imai and Tadahiro Iimura
- Organizer
  第3回日本骨免疫学会　ウィンターセミナー
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] CCケモカイン受容体のゲノム進化と骨代謝における病態機能解析2018
- Author(s)
  飯村忠浩、李智媛
- Organizer
  第189回日仏生物学会総会
- Data Source
  KAKENHI-PROJECT-18H02983
[Presentation] HIV, co-receptor, CCR5 plays an essential role in bone-destructive conditions through the functional regulation of osteoclast2018
- Author(s)
  Lee JW
- Organizer
  The 36th annual meeting of the Japanese society for bone and mineral research
- Invited
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] CCR5, a therapeutic target of HIV infection, is required for osteoclast differentiation and function, suggesting a skeletal merit of the CCR5 targeting HIV therapy.2018
- Author(s)
  Lee JW
- Organizer
  BioForum@Dental School, Okayama University
- Invited
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] HIV治療薬標的分子CCR5の破骨細胞機能分化における必須の機能－CCR5を標的としたHIV治療は骨吸収性疾患に対してもメリットをもたらす可能性がある－2017
- Author(s)
  李　智媛、飯村　忠浩
- Organizer
  第３５回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] Requirement of CCR5, a co-receptor of HIV, for the functional cellular architecture of osteoclasts, providing experimental evidences for the direct association between loss of CCR5 and resistance to bone loss2017
- Author(s)
  Lee JW, Inoue K, Uehara, S, Kobayashi Y, Imai Y, Iimura T
- Organizer
  Joint meeting of the Australian and New Zealand Bone and Mineral Society (ANZBMS) and the International Federation of Musculoskeletal Research Societies (IFMRS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] 骨形態計測法で明らかになったHIV治療薬標的分子CCR5の破骨細胞機能分化における必須の機能2017
- Author(s)
  李　智媛　飯村忠浩
- Organizer
  第37回　日本骨形態計測学会
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Novel regulatory mechanisms of osteoclast function, as revealed by combinatorial approaches of functional live-imaging and molecular omics2017
- Author(s)
  Lee JW
- Organizer
  The 39th Annual meeting of the molecular biology society of Japan
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] Requirement of CCR5, a co-receptor of HIV, for the functional cellular architecture of osteoclasts, providing experimental evidences for the direct association between loss of CCR5 and resistance to bone loss2017
- Author(s)
  Lee JW, Inoue K, Uehara S, Kobayashi Y, Imai Y, Iimura T
- Organizer
  Australian and New Zealand Bone and Mineral Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] マウスジェネティクスを用いたHIV感染患者の骨病態解明2017
- Author(s)
  飯村忠浩　李智媛
- Organizer
  第59回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Role of chemokine-mediated signaling in architectural function of osteoclasts2016
- Author(s)
  Ji-Won Lee
- Organizer
  34th 日本骨代謝学会
- Place of Presentation
  大阪、日本
- Year and Date
  2016-07-21
- Invited
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] 機能的生細胞イメージングとオミクス解析による破骨細胞調節機能の解明2016
- Author(s)
  李智媛　飯村忠浩
- Organizer
  第58回　歯科基礎医学会学術大会サテライトシンポジウム10
- Place of Presentation
  札幌市　札幌コンベンションセンター
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Roles of Chemokine-mediated signaling in architectual funstion of osteoclasts2016
- Author(s)
  李智媛、星野昭芳、井上和樹、上原俊輔、小林康浩、山口朗、今井祐記、飯村忠浩
- Organizer
  第34回日本骨代謝学会学術集会・第3回アジア太平洋骨代謝会議　若手シンポジウム　基礎
- Place of Presentation
  大阪市　大阪国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Essential role of C-C chemokine-mediated signaling in mature osteoclast function2016
- Author(s)
  Ji-Won Lee
- Organizer
  7th 骨バイオサイエンス研究会
- Place of Presentation
  岡山、日本
- Invited
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal is required for geometric architecture and function of osteoclasts, thus for RANKL-induced bone destruction2016
- Author(s)
  Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Shunsuke Uehara, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai, Tadahiro Iimura
- Organizer
  43rd Annual European Calcified Tissue Society Congress
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] Essential roles of C-C chemokine signaling in mature osteoclast function2016
- Author(s)
  Lee JW, Hoshino A, Kobayashi Y, Uehara, S, Imai Y, Iimura T.
- Organizer
  International Osteoporosis Foundation (IOF) 2016
- Place of Presentation
  Suntec Singapore Convention and Exhibition Centre, Sigapore
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal is required for geometric architecture and function of osteoclasts, thus for RANKL-induced bone destruction2016
- Author(s)
  Lee JW, Hoshino A, Saitou T, Inoue K, Uehara, S, Kobayashi Y, Matsushima K, Imai Y, Iimura T.
- Organizer
  43rd Annual European Calcified Tissue Society Congress
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal is required for architectural function of osteoclasts, thus for RANKL-induced bone destruction2016
- Author(s)
  Ji-Won Lee, Akiyoshi Hoshino, Yasuhiro Kobayashi, Shunsuke Uehara, Yuuki Imai, Tadahiro Iimura
- Organizer
  1st Skeletal Science Retreat
- Place of Presentation
  熱海、日本
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] Unveiling novel regulatory mechanisms of osteoclasts by integrative approaches of bio-imaging and molecular comics2016
- Author(s)
  Ji-Won Lee
- Organizer
  Protein Island Matsuyama (PIM) International symposium 2016
- Place of Presentation
  松山、日本
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] マルチモーダル超解像法を用いた骨系細胞の機能解析2016
- Author(s)
  飯村忠浩　李智媛
- Organizer
  第58回　歯科基礎医学会学術大会メインシンポジウムA
- Place of Presentation
  札幌市　札幌コンベンションセンター
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] 機能的生細胞イメージングとオミックス解析による破骨細胞調節機能の解明2016
- Author(s)
  Ji-Won Lee
- Organizer
  58th 歯科基礎医学会学術大会
- Place of Presentation
  札幌、日本
- Year and Date
  2016-08-24
- Invited
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] Novel regulatory mechanisms of osteoclast function, as revealed by combinatorial approaches of functional live-imaging and molecular comics2016
- Author(s)
  Ji-Won Lee
- Organizer
  39th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  横浜、日本
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] Novel regulatory mechanisms of osteoclast function, as revealed by combinatorial approaches of functional live-imaging and molevular omics2016
- Author(s)
  Lee JW, Hoshino A, Uehara, S, Kobayashi Y, Imai Y, Iimura T.
- Organizer
  第39回　日本分子生物学会年会　シンポジウム
- Place of Presentation
  横浜市　パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Essential roles of C-C chemokine-mediated signaling in mature osteoclast function2016
- Author(s)
  Ji-Won Lee, Akiyoshi Hoshino, Yasuhiro Kobayashi, Shunsuke Uehara, Yuuki Imai, Tadahiro Iimura
- Organizer
  6th Asia-Pacific Osteoporosis Meeting
- Place of Presentation
  Signapore
- Year and Date
  2016-11-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20412
[Presentation] Essential role of C-C chemokine-mediated signaling in mature osteoclast function2016
- Author(s)
  李智媛　飯村忠浩
- Organizer
  第７回　骨バイオサイエンス研究会
- Place of Presentation
  岡山市　岡山コンベンションセンター
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] マルチスケール画像解析の骨生物医学への応用展開2015
- Author(s)
  飯村忠浩　李智媛
- Organizer
  第35回　日本骨形態計測学会
- Place of Presentation
  岡山県倉敷市　倉敷芸文館
- Year and Date
  2015-06-04
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] 蛍光細胞イメージングと骨形態計測で見る骨代謝におけるケモカインシグナルの役割2015
- Author(s)
  Ji-Won Lee
- Organizer
  第57回歯科基礎医学会学術大会
- Place of Presentation
  新潟県新潟市　朱鷺メッセ（新潟コンベンションセンター）
- Year and Date
  2015-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] Quantitative illumination of bone histology and cell biology by fluorescence imaging2015
- Author(s)
  Ji-Won Lee, Tadahiro Iimura
- Organizer
  International Symposium on Bio-imaging and Gene Targeting Sciences
- Place of Presentation
  Okayama, Japan
- Year and Date
  2015-02-15
- Invited
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Ji-Won Lee, Hoshino Akiyoshi, Saitou Takashi, Inoue Kazuki, Uehara Shunsuke, Kobayashi Yasuhiro, Ueha Satoshi, Matsushima Kouji, Ito Masako, Yamaguchi Akira, Imai Yuuki, Iimura Tadahiro2015
- Author(s)
  Ji-Won LeeJi-Won Lee, Hoshino Akiyoshi, Saitou Takashi, Inoue Kazuki, Uehara Shunsuke, Kobayashi Yasuhiro, Ueha Satoshi, Matsushima Kouji, Ito Masako, Yamaguchi Akira, Imai Yuuki, Iimura Tadahiro
- Organizer
  the ASBMR 2015 Annual Meeting
- Place of Presentation
  Washington StateConvention Center, Seattle, USA
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] Roles of CCR5, a co-receptor of HIV, in regulation of functional motility of osteoclasts2015
- Author(s)
  Ji-Won Lee, Hoshino Akiyoshi, Saitou Takashi, Inoue Kazuki, Uehara Shunsuke, Kobayashi Yasuhiro, Ueha Satoshi, Matsushima Kouji, Ito Masako, Yamaguchi Akira, Imai Yuuki, Iimura Tadahiro
- Organizer
  第1回日本骨免疫学会
- Place of Presentation
  沖縄県宮古島市　ホテルブリーズベイマリーナ
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal　regulates bone resorption via locomotion of osteoclasts2015
- Author(s)
  Lee JW et al.
- Organizer
  the ASBMR 2015 Annual Meeting
- Place of Presentation
  Washington State Convention Center, Seattle, Washington, USA
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Quantitative illumination on bone histology and cell biology by fluorescence imaging2015
- Author(s)
  Ji-Won Lee, Tadahiro Iimura
- Organizer
  International Symposium on Bio-imaging and Gene Targeting Sciences
- Place of Presentation
  Okayama, Japan
- Year and Date
  2015-02-15
- Invited
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] Roles of C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal in locomotion of osteoclasts and bone resorption2015
- Author(s)
  Ji-Won Lee
- Organizer
  第33回日本骨代謝学会
- Place of Presentation
  東京都新宿区　京王プラザホテル
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] Super-resolution analyses of Cell cycle phase-dependent phosphorylation of Smads
- Author(s)
  i-Won Lee, Takeshi Imamura, Tadahiro Iimura
- Organizer
  Joint International Symposium on TGF-beta Family and Cancer
- Place of Presentation
  Tsukuba,Japan
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Three-dimensional fluorescence morphometry reveals functional heterogeneity of osteocytes in FGF23 production　regulated by DMP1
- Author(s)
  Ji-Won Lee, Akira Yamaguchi, Tadahiro Iimura
- Organizer
  第34回日本骨形態計測学会
- Place of Presentation
  札幌市　札幌芸文館
- Year and Date
  2014-06-12 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] DMP1は骨細胞におけるFGF23産生の抑制因子である－蛍光3次元形態計測と細胞生物学的アプローチ－
- Author(s)
  李智媛、山口朗、飯村忠浩
- Organizer
  第32回日本骨代謝学会学術集会
- Place of Presentation
  大阪市　大阪国際会議場
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] A possible role of DMP1 as a negative regulator of FGF23 production in functional heterogeneity osteocytes: Three-dimensional morphological approaches
- Author(s)
  Ji-Won Lee, Akira Yamaguchi, Tadahiro Iimura
- Organizer
  The American Society of Bone and Mineral Research 2014 Annual Meeting
- Place of Presentation
  Houston, Texas, USA
- Year and Date
  2014-09-12 – 2014-09-15
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] DMP1は骨細胞におけるFGF23産生の抑制因子である－蛍光3次元形態計測と細胞生物学的アプローチ－
- Author(s)
  李智媛、山口朗、飯村忠浩
- Organizer
  第32回日本骨代謝学会学術集会
- Place of Presentation
  Osaka, Japan
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] A possible role of DMP1 as a negative regulator of FGF23 production in functional heterogeneity osteocytes: Three-dimensional morphological approaches
- Author(s)
  Ji-Won Lee, Akira Yamaguchi, Tadahiro Iimura
- Organizer
  The American Society of Bone and Mineral Research
- Place of Presentation
  Houston, Texas
- Year and Date
  2014-09-12 – 2014-09-15
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] Cell cycle phase-dependent phosphorylation of Smads in skeletal cells
- Author(s)
  Ji-Won Lee, Takeshi Imamura, Tadahiro Iimura
- Organizer
  10th International BMP Conference
- Place of Presentation
  Berlin, Germany
- Year and Date
  2014-09-16 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] Three-dimensional fluorescence morphometry reveals functional heterogeneity of osteocytes in FGF23 production regulated by DMP1
- Author(s)
  Ji-Won Lee, Tadahiro Iimura
- Organizer
  The 34th Annual Meeting of Japanese Society for Bone Morphometry
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2014-06-12 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26861549
[Presentation] Cell cycle phase-dependent phosphorylation of Smads in skeletal cells
- Author(s)
  Ji-Won Lee, Takeshi Imamura, Tadahiro Iimura
- Organizer
  The 10th International BMP Conference
- Place of Presentation
  Berlin, Germany
- Year and Date
  2014-09-12 – 2014-09-15
- Data Source
  KAKENHI-PROJECT-26293392
[Presentation] Super-resolution analysis of cell cycle phase-dependent phosphorylation of Smads
- Author(s)
  Ji-Won Lee, Takeshi Imamura, Tadahiro Iimura
- Organizer
  Joint International Symposium on TGF-β Family and Cancer
- Place of Presentation
  Tsukuba, Japan
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PROJECT-26861549

1. Iimura Tadahiro (20282775)

# of Collaborated Projects: 5 results

# of Collaborated Products: 47 results
2. 疋田温彦 (60443397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 沼野利佳 (30462716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 丸岡豊 (10323726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 樋田京子 (40399952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IMAI Yuuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. Yanagihara Yuta

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. Saeki Noritaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. UEHA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. Matsushima Kouji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 禹済泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 伊藤大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 上原俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 小林泰浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 山口朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 長岡ひかる

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Lee Ji-Won 李 智媛

Research Projects

Research Products

Co-Researchers

A drug development study for radiation osteonecrosis of jaw with improving micro vascular-skeletal structure

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Pharmacological study of a shared genetic risk factor for osteoporosis and Alzheimer's diseasePrincipal Investigator

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Investigation of chromatic remodeling in osteoclast function for therapeutic targeting of bone remodeling balancePrincipal Investigator

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Study on mature bone formation and regeneration by Nuero-Skeletal regulations

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Morphometrical and quantitative transcriptome analyses of C-C chemokine receptor 5 in functional structure of osteoclastsPrincipal Investigator

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Multimode analyses of skeletogenesis by imaging, simulation and omics

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Pathophysiological investigation of bone cell communications regulated by chemokine networkPrincipal Investigator

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[Journal Article] Association between an increased serum CCL5 level and pathophysiology of degenerative joint disease in the temporomandibular joint in females2023

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[Journal Article] Centrosome clustering control in osteoclasts through CCR5-mediated signaling2023

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[Journal Article] Evolution of multiple comics approaches to define pathophysiology of pediatric acute respiratory distress syndrome2022

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[Journal Article] Histone H3K27 demethylase, Utx, regulates osteoblast-to-osteocyte differentiation2022

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[Journal Article] Expansion of the osteocytic lacunar-canalicular system involved in pharmacological action of PTH revealed by AI-driven fluorescence morphometry in female rabbits2022

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[Journal Article] The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes2022

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[Journal Article] Genetic variation analyses indicate conserved SARS‐CoV‐2-host interaction and varied genetic adaptation in immune response factors in modern human evolution2021

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Lee Ji-Won 李智媛