Oue Hiroshi 大上博史

Researcher Number	70711307
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(歯), 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 広島大学, 医系科学研究科(歯), 助教 2017 – 2018: 広島大学, 医歯薬保健学研究科(歯), 助教 2015 – 2016: 広島大学, 医歯薬保健学研究院(歯), 助教 2014 – 2016: 広島大学, 医歯薬保健学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 57050:Prosthodontics-related / Prosthodontics/ Dental materials science and Except Principal Investigator Basic Section 57050:Prosthodontics-related / Prosthodontics/ Dental materials science and
Keywords	Principal Investigator 歯の喪失 / 脳由来神経栄養因子 Except Principal Investigator 認知機能 / 骨質改善 / 骨粗鬆症 / 高齢者 / 舌運動訓練 / 低舌圧 / 舌圧 / 口腔機能低下症 … More / 代謝物質 / 腸内細菌 / 歯の欠損 / 機能低下 / 骨質改善療法 / 咀嚼機能 / 骨質低下 / 神経細胞死 / 認知機能障害 / 粉末食 / 抜歯 / 鼻閉 / 歯科疾患 / BDNF / 咀嚼機能低下 / 歯牙欠損 / 認知症 / インプラント支持 / 骨再生 / 糖尿病 / インプラント / 骨メタボリズム Less

メタボローム解析を用いた歯の喪失による認知機能低下メカニズムの解明Principal Investigator
- Principal Investigator
  
  大上博史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Hiroshima University
Elucidating the mechanism of cognitive decline caused by tooth loss through metabolome analysis
- Principal Investigator
  
  横井美有希
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Fujita Health University
Can diagnosis of low tongue pressure and early intervention in younger elderly prevent oral dysfunction?
- Principal Investigator
  
  津賀一弘
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Hiroshima University
Elucidation of the mechanism by which tooth loss causes cognitive declinePrincipal Investigator
- Principal Investigator
  
  Oue Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Hiroshima University
骨質改善療法が咀嚼機能および認知機能におよぼす影響の探索
- Principal Investigator
  
  久保隆靖
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Hiroshima University
脳と口腔のクロストーク破綻の分子生物学的解明Principal Investigator
- Principal Investigator
  
  大上博史
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Hiroshima University
Establishment of implant treatment with acceleration of bone metabolism
- Principal Investigator
  
  KUBO TAKAYASU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Hiroshima University
Study on mastication dysfunction-induced memory impairment
- Principal Investigator
  
  Michikawa Makoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Nagoya City University
Biologic elucidation of memory deficits by tooth lossPrincipal Investigator
- Principal Investigator
  
  Oue Hiroshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Hiroshima University

All 2022 2021 2020 2016 2015

All Journal Article Presentation

[Journal Article] Experimental tooth loss affects spatial learning function and blood-brain barrier of mice2022
- Author(s)
  Oue Hiroshi、Hatakeyama Rie、Ishida Eri、Yokoi Miyuki、Tsuga Kazuhiro
- Journal Title
  
  Oral Diseases
  
  Volume: - Issue: 7 Pages: 2907-2916
- DOI
  10.1111/odi.14379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10035
[Journal Article] Osseointegration aspects of placed implant in bone reconstruction with newly developed block-type interconnected porous calcium hydroxyapatite.2016
- Author(s)
  Doi K, Kubo T, Makihara Y, Oue H, Morita K, Oki Y, Kajihara S, Tsuga K.
- Journal Title
  
  J Appl Oral Sci
  
  Volume: 24 Issue: 4 Pages: 325-31
- DOI
  10.1590/1678-775720150597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11594, KAKENHI-PROJECT-16K11595
[Journal Article] Intermittent administration of parathyroid hormone enhances primary stability of dental implants in a bone-reduced rabbit model2016
- Author(s)
  Oki Y., Doi K., Makihara Y., Kubo T., Oue H., Tsuga K
- Journal Title
  
  Journal of Oral Science
  
  Volume: 58 Issue: 2 Pages: 241-246
- DOI
  10.2334/josnusd.15-0717
- NAID
  130005158879
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11595
[Journal Article] Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice.2016
- Author(s)
  Takeda Y, Oue H, Okada S, Kawano A, Koretake K, Michikawa M, Akagawa Y, Tsuga K.
- Journal Title
  
  BMC Neurosci.
  
  Volume: ５ Issue: 1 Pages: 81-81
- DOI
  10.1186/s12868-016-0319-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K20501, KAKENHI-PROJECT-15K15712
[Journal Article] Tooth loss might not alter molecular pathogenesis in an aged transgenic Alzheimer's disease model mouse2015
- Author(s)
  Oue H, Miyamoto Y, Koretake K, Okada S, Doi K, Jung CG, Michikawa M and Akagawa Y
- Journal Title
  
  Gerodontology
  
  Volume: in press Issue: 3 Pages: 308-14
- DOI
  10.1111/ger.12153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500402, KAKENHI-PROJECT-25670820, KAKENHI-PROJECT-16H05559, KAKENHI-PROJECT-15K15712
[Presentation] マウスの歯の喪失が脳血管に与える影響2021
- Author(s)
  大上博史，横井美有希，石田えり，津賀一弘
- Organizer
  日本補綴歯科学会　第130回記念学術大会
- Data Source
  KAKENHI-PROJECT-20K10035
[Presentation] マウスの歯の喪失が脳血管障害に与える影響2020
- Author(s)
  大上博史，横井美有希，石田えり，西端秀典，志渡澤正治，津賀一弘
- Organizer
  日本補綴歯科学会　中国・四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K10035
[Presentation] Evaluation of Implant Stability in Implant/Interconnected Porous Hydroxyapatite Complex Under Functional Loading Location2016
- Author(s)
  Doi K., Makihara Y., Oue H., Morita K., Kubo T., Tsuga K
- Organizer
  The 94th General Session and Exihibition of the International Association for Dental Research
- Place of Presentation
  Soul, Korea
- Year and Date
  2016-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11595
[Presentation] 臼歯喪失および食餌性状の違いがマウスの学習・記憶能に及ぼす影響2015
- Author(s)
  竹田洋輔，大上博史，是竹克紀，岡田信輔，河野聖，呉本晃一，山中威典，守谷直史，赤川安正，津賀一弘
- Organizer
  平成２７年度公益社団法人日本補綴歯科学会中国・四国支部学術大会
- Place of Presentation
  くにびきメッセ（松江市）
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-26861641

1. 横井美有希 (90826869)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. KUBO TAKAYASU (60240876)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 土井一矢 (80444686)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 吉田光由 (50284211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Michikawa Makoto (40270912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 赤川安正 (00127599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小野卓史 (30221857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 竹田洋輔 (80812560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石田えり (50974648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小田凌也 (10853682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 津賀一弘 (60217289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 竹内真帆 (00397944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 吉川峰加 (00444688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森田晃司 (30555149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 丸山真理子 (80613041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 岡田信輔 (20736558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 森隆浩 (70760007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. JUNG Cha-Gyun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oue Hiroshi 大上 博史

Research Projects

Research Products

Co-Researchers

メタボローム解析を用いた歯の喪失による認知機能低下メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the mechanism of cognitive decline caused by tooth loss through metabolome analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Can diagnosis of low tongue pressure and early intervention in younger elderly prevent oral dysfunction?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism by which tooth loss causes cognitive declinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨質改善療法が咀嚼機能および認知機能におよぼす影響の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳と口腔のクロストーク破綻の分子生物学的解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of implant treatment with acceleration of bone metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on mastication dysfunction-induced memory impairment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biologic elucidation of memory deficits by tooth lossPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Experimental tooth loss affects spatial learning function and blood-brain barrier of mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Osseointegration aspects of placed implant in bone reconstruction with newly developed block-type interconnected porous calcium hydroxyapatite.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intermittent administration of parathyroid hormone enhances primary stability of dental implants in a bone-reduced rabbit model2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice.2016

Author(s)

Journal Title

DOI

Oue Hiroshi 大上博史