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Yamada Hiroyuki  山田 博之

ORCIDConnect your ORCID iD *help
Researcher Number 70713650
Other IDs
Affiliation (Current) 2026: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help 2021 – 2025: 京都大学, 医学研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53040:Nephrology-related
Except Principal Investigator
Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 53040:Nephrology-related
Keywords
Principal Investigator
p38 / ポドサイト / p38 MAPK / オードファジー / 細胞死 / MAPK / 巣状糸球体硬化症 / p3 MAPK / 糸球体上皮細胞 / ハンプ / 内皮障害 / ANP / ナトリウム利尿ペプチド … More
Except Principal Investigator
… More 救急医療 / 敗血症 / 低代謝 / 休眠 / 冬眠 / 糸球体 / PAI-1 / 血栓 / p38 MAPK / ナトリウム利尿ペプチド / アルドステロン / ポドサイト Less
  • Research Projects

    (5 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (15 People)
  •  ポドサイト障害におけるp38 MAPKを介した細胞内タンパク分解機構の解明Principal Investigator

    • Principal Investigator
      山田 博之
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyoto University
  •  The Impact of Hibernation-like States on Sepsis: An Investigation

    • Principal Investigator
      大鶴 繁
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Kyoto University
  •  ポドサイト障害におけるp38 MAPKの意義の解明Principal Investigator

    • Principal Investigator
      山田 博之
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyoto University
  •  Role of PAI-1 and Mechanism of intracapillary throbi induced by podocyte damage

    • Principal Investigator
      横井 秀基
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kumamoto University
      Kyoto University
  •  Association of p38 MAPK with natriuretic peptide receptors in renal glomeruliPrincipal Investigator

    • Principal Investigator
      Yamada Hiroyuki
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyoto University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

  • [Journal Article] Frequency of Acute Kidney Injury After the Initiation of Vitamin D Receptor Activators: A Multicenter Retrospective Observational Study.2025

    • Author(s)
      Nakanishi M, Mizuno T, Sakai S, Hira D, Koseki T, Matsubara T, Yokoi H, Yanagita M, Terada T, Yamada S, Tsuboi N.
    • Journal Title

      Clin Drug Investig

      Volume: 45 Issue: 4 Pages: 191-199

    • DOI

      10.1007/s40261-025-01429-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08350, KAKENHI-PROJECT-23K07717
  • [Journal Article] Diuretics for preventing and treating acute kidney injury.2025

    • Author(s)
      Hiroyuki Hashimoto; Hiroyuki Yamada; Maki Murata; Norio Watanabe
    • Journal Title

      The Cochrane database of systematic reviews

      Volume: 1 Issue: 1

    • DOI

      10.1002/14651858.cd014937.pub2

    • Data Source
      KAKENHI-PROJECT-23K15227
  • [Journal Article] Ultrasound renal denervation in hypertensive patients: A systematic review and meta-analysis2025

    • Author(s)
      Roy Novri Ramadhan; Derren David Christian Homenta Rampengan; Felicia Angelica Gunawan; Nathania; Sebastian Emmanuel Willyanto; Hiroyuki Yamada; Mochammad Thaha; Satriyo Dwi Suryantoro; Maulana Antiyan Empitu
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 1 Pages: e0311191-e0311191

    • DOI

      10.1371/journal.pone.0311191

    • Data Source
      KAKENHI-PROJECT-23K15227
  • [Journal Article] 【AKIの病態の理解と集中治療】集中治療における急性血液浄化の最新動向2024

    • Author(s)
      山田 博之
    • Journal Title

      ICUとCCU

      Volume: 48 Pages: 199-205

    • Data Source
      KAKENHI-PROJECT-23K15227
  • [Journal Article] 日本版敗血症診療ガイドラインでのCKRT開始基準 2020から2024へ2024

    • Author(s)
      山田 博之
    • Journal Title

      日本急性血液浄化学会雑誌

      Volume: 15 Pages: 105-110

    • Data Source
      KAKENHI-PROJECT-23K15227
  • [Journal Article] 【急性腎障害の最新トレンド】急性腎障害に対する腎代替療法2024

    • Author(s)
      山田 博之
    • Journal Title

      臨床透析

      Volume: 40 Pages: 422-427

    • Data Source
      KAKENHI-PROJECT-23K15227
  • [Journal Article] Successful Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus with Celecoxib: A Promising Therapeutic Option.2024

    • Author(s)
      Ryunosuke Hahsikawa; Hiroyuki Yamada; Toshihito Fujii; Shigeru Ohtsuru
    • Journal Title

      The American journal of case reports

      Volume: 25

    • DOI

      10.12659/ajcr.943244

    • Data Source
      KAKENHI-PROJECT-23K15227
  • [Journal Article] Deletion of p38 MAPK in macrophages ameliorates peritoneal fibrosis and inflammation in peritoneal dialysis2024

    • Author(s)
      Ikushima Akie、Ishimura Takuya、Mori Keita P.、Yamada Hiroyuki、Sugioka Sayaka、Ishii Akira、Toda Naohiro、Ohno Shoko、Kato Yukiko、Handa Takaya、Yanagita Motoko、Yokoi Hideki
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 21220-21220

    • DOI

      10.1038/s41598-024-71859-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08310, KAKENHI-PROJECT-23K15226, KAKENHI-PROJECT-23K07717, KAKENHI-PROJECT-23K15227, KAKENHI-PROJECT-24K19129
  • [Journal Article] 【もっと知りたいあなたのための「日本版敗血症診療ガイドライン2024」読本】推奨の背景を知りたい!急性血液浄化2024

    • Author(s)
      山田 博之
    • Journal Title

      救急医学

      Volume: 48 Pages: 1158-1162

    • Data Source
      KAKENHI-PROJECT-23K15227
  • [Journal Article] Beyond 2D: A scalable and highly sensitive method for a comprehensive 3D analysis of kidney biopsy tissue2023

    • Author(s)
      Yamada Hiroyuki、Makino Shin-ichi、Okunaga Issei、Miyake Takafumi、Yamamoto-Nonaka Kanae、Oliva Trejo Juan Alejandro、Tominaga Takahiro、Empitu Maulana A、Kadariswantiningsih Ika N、Kerever Aurelien、Komiya Akira、Ichikawa Tomohiko、Arikawa-Hirasawa Eri、Yanagita Motoko、Asanuma Katsuhiko
    • Journal Title

      PNAS Nexus

      Volume: 3 Issue: 1 Pages: 433-445

    • DOI

      10.1093/pnasnexus/pgad433

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07543, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K27616, KAKENHI-PROJECT-23K15227
  • [Journal Article] Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi2023

    • Author(s)
      Sugioka Sayaka、Yamada Hiroyuki、Ishii Akira、Kato Yukiko、Yamada Ryo、Mori Keita P.、Ohno Shoko、Handa Takaya、Ikushima Akie、Ishimura Takuya、Osaki Keisuke、Tokudome Takeshi、Matsusaka Taiji、Nebreda Angel R.、Yanagita Motoko、Yokoi Hideki
    • Journal Title

      Kidney International

      Volume: 104 Issue: 3 Pages: 508-525

    • DOI

      10.1016/j.kint.2023.06.007

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K15226, KAKENHI-PROJECT-23K15227, KAKENHI-PROJECT-22K08310, KAKENHI-PROJECT-23K07717, KAKENHI-PROJECT-20K08505, KAKENHI-PROJECT-23K21437
  • [Journal Article] Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFκΒ pathway inhibition2023

    • Author(s)
      Ishimura Takuya、Ishii Akira、Yamada Hiroyuki、Osaki Keisuke、Toda Naohiro、Mori Keita P.、Ohno Shoko、Kato Yukiko、Handa Takaya、Sugioka Sayaka、Ikushima Akie、Nishio Haruomi、Yanagita Motoko、Yokoi Hideki
    • Journal Title

      Kidney International

      Volume: 104 Issue: 5 Pages: 929-942

    • DOI

      10.1016/j.kint.2023.08.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K15226, KAKENHI-PROJECT-23K15227, KAKENHI-PROJECT-22K08310, KAKENHI-PROJECT-23K07717, KAKENHI-PROJECT-23K27616
  • [Journal Article] Inhibition of Importin-α?Mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis2023

    • Author(s)
      Empitu Maulana A.、Kikyo Mitsuhiro、Shirata Naritoshi、Yamada Hiroyuki、Makino Shin-ichi、Kadariswantiningsih Ika N.、Aizawa Masashi、Patrakka Jaakko、Nishimori Katsuhiko、Asanuma Katsuhiko
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 34 Issue: 7 Pages: 1222-1239

    • DOI

      10.1681/asn.0000000000000150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K15227, KAKENHI-PROJECT-23K27614
  • [Journal Article] Nephrotoxicity associated with anticancer agents: perspective on onconephrology from nephrologists2023

    • Author(s)
      Takeshi Matsubara, Hideki Yokoi, Hiroyuki Yamada, Motoko Yanagita
    • Journal Title

      Int J Clin Oncol

      Volume: なし Issue: 5 Pages: 1-12

    • DOI

      10.1007/s10147-023-02307-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08350, KAKENHI-PROJECT-23K15227, KAKENHI-PROJECT-21K16188
  • [Journal Article] Sacubitril/valsartan ameliorates renal tubulointerstitial injury through increasing renal plasma flow in a mouse model of type 2 diabetes with aldosterone excess2023

    • Author(s)
      Nishio Haruomi、Ishii Akira、Yamada Hiroyuki、Mori Keita P、Kato Yukiko、Ohno Shoko、Handa Takaya、Sugioka Sayaka、Ishimura Takuya、Ikushima Akie、Inoue Yui、Minamino Naoto、Mukoyama Masashi、Yanagita Motoko、Yokoi Hideki
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 38 Issue: 11 Pages: 2517-2527

    • DOI

      10.1093/ndt/gfad098

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K18291, KAKENHI-PROJECT-23K15226, KAKENHI-PROJECT-23K15227, KAKENHI-PROJECT-22K08310, KAKENHI-PROJECT-23K07717
  • [Journal Article] Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease.2022

    • Author(s)
      Linh HT, Iwata Y, Senda Y, Sakai-Takemori Y, Nakade Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Sakai N, Yamada H, Asanuma K, Matsushima K, Wada T.
    • Journal Title

      J Am Soc Nephrol.

      Volume: - Issue: 6 Pages: 1105-1119

    • DOI

      10.1681/asn.2021060843

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06394, KAKENHI-PROJECT-21K08224, KAKENHI-PROJECT-21K16188, KAKENHI-PROJECT-20KK0191, KAKENHI-PROJECT-19H03557, KAKENHI-PROJECT-21K19479, KAKENHI-WRAPUP-22H04906
  • [Journal Article] Optimal Evidence Grading of Simultaneous Use of Hypertonic Saline and Furosemide for Fluid Overload2022

    • Author(s)
      Kitajima Naoki、Yamada Hiroyuki、Minami Takuma、Ohtsuru Shigeru
    • Journal Title

      Critical Care Medicine

      Volume: 50 Issue: 4 Pages: 405-406

    • DOI

      10.1097/ccm.0000000000005419

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K17860, KAKENHI-PROJECT-21K16188
  • [Journal Article] Global Perspectives in Acute Kidney Injury: Japan2022

    • Author(s)
      Hiroyuki Yamada , Motoko Yanagita
    • Journal Title

      Kidney360

      Volume: 5 Issue: 6 Pages: 1099-1104

    • DOI

      10.34067/kid.0007892021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Journal Article] 【腎疾患治療薬update】(第5章)期待される薬剤 急性腎障害の予防 低用量カルペリチド(心房性ナトリウム利尿ペプチド:ANP)2021

    • Author(s)
      山田博之
    • Journal Title

      腎と透析

      Volume: 91 Pages: 765-768

    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Journal Article] Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model2021

    • Author(s)
      Fukuta M, Suzuki K, Kojima S, Yabe Y, Suzuki K, Iida K, Yamada H, Makino S, Iwata A, Tanaka S, Iwamoto T, Suto A, Nakagomi D, Wakashin H, Maezawa Y, Maezawa Y, Takemoto M, Asanuma K, Nakajima H.
    • Journal Title

      Lupus Sci Med.

      Volume: 8 Issue: 1 Pages: 426-426

    • DOI

      10.1136/lupus-2020-000426

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08797, KAKENHI-PROJECT-21K16188, KAKENHI-PROJECT-21K16297, KAKENHI-PROJECT-20H03572
  • [Journal Article] 特集 腎疾患-エキスパートへの質問で学ぶ診療のキホンと最新情報 利尿薬やその他の新薬の有効性と注意すべき副作用 心不全やAKIにANP(心房性ナトリウム利尿ペプチド)を投与すべきか否か? またその効果はあるのか? について教えてください2021

    • Author(s)
      山田 博之、横井 秀基
    • Journal Title

      medicina

      Volume: 58 Issue: 10 Pages: 1636-1640

    • DOI

      10.11477/mf.1402227821

    • ISSN
      0025-7699, 1882-1189
    • Year and Date
      2021-09-10
    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Presentation] ポドサイト特異的p38 MAPK欠失は、FSGSモデルマウスの腎障害を増悪させる2024

    • Author(s)
      岩木亮介、山田博之、杉岡清香、石村拓也、松阪泰二、柳田素子、横井秀基
    • Organizer
      第67回 日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07717
  • [Presentation] Sacubitril/valsartanはアルドステロン負荷糖尿病マウスでの尿細管間質障害を改善 する2023

    • Author(s)
      西尾治臣、石井輝、山田博之、杉岡清香、加藤有希子、向山政志、柳田素子、横井秀基
    • Organizer
      第66回 日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07717
  • [Presentation] ポドサイト特異的GC-A & p38 MAPKダブルノックアウトマウスの腎病変におけるPAI-1 阻害の役割2023

    • Author(s)
      杉岡清香、山田博之、加藤有希子、石井輝、森慶太、大﨑啓介、徳留健、松阪泰二、柳田素子、横井秀基
    • Organizer
      第66回 日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07717
  • [Presentation] 全身性GC-Aノックアウトマウスでは、高蛋白食負荷下にストレプトゾトシン誘導糖尿 病性腎臓病が増悪する2023

    • Author(s)
      井上唯衣、石井輝、西尾治臣、生島昭恵、石村拓也、杉岡清香、半田貴也、山田博之、柳田素子、横井秀基
    • Organizer
      第66回 日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07717
  • [Presentation] ポドサイトにおけるp38MAPKの欠失はFSGSモデルにおける腎障害を増悪させる2023

    • Author(s)
      岩木亮介、山田博之、杉岡清香、石井輝、松阪泰二、柳田素子、横井秀基
    • Organizer
      第66回 日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07717
  • [Presentation] ポドサイト特異的p38 MAPK & GC-Aダブルノックアウトマウスの腎病変におけるポドサイト-内皮連関の解明2022

    • Author(s)
      杉岡 清香 , 山田 博之 , 加藤 有希子 , 石井 輝 , 森 慶太 , 大崎 啓介 , 徳留 健 , 松阪 泰二 , 柳田 素子 , 横井 秀基
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Presentation] 拡張型心筋症モデルマウスを用いた心腎連関の機序解明2022

    • Author(s)
      石村 拓也 , 石井 輝 , 山田 博之 , 中川 靖章 , 大野 祥子 , 生島 昭恵 , 杉岡 清香 , 半田 貴也 , 桑原 宏一郎 , 柳田 素子 , 横井 秀基
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Presentation] Subcellular localization of dendrin modulates the fate of podocyte injury and glomerulosclerosis2022

    • Author(s)
      Empitu Maulana A. , Makino Shin-ichi , Yamada Hiroyuki , Kadariswantiningsih Ika N. , Aizawa Masashi , Asanuma Katsuhiko
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Presentation] The Ambivalent Role of Ccl5 in Podocyte Injury and Glomerular Disease2022

    • Author(s)
      Kadariswantiningsih Ika N. , Empitu Maulana A. , Yamada Hiroyuki , Makino Shin-Ichi , Aizawa Masashi , Tatsumoto Narihito , Asanuma Katsuhiko
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Presentation] 組織透明化による糸球体およびポドサイトの3次元病理診断2022

    • Author(s)
      山田 博之 , 牧野 慎市 , 柳田 素子 , 淺沼 克彦
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Presentation] Membrane-Associated Guanylate Kinase Inverted 2は、腎糸球体ポドサイトのスリット膜構造維持に必須である2021

    • Author(s)
      山田博之
    • Organizer
      日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K16188
  • [Presentation] 未踏の頂き AKIへの挑戦 ICUにおけるケアバンドル2021

    • Author(s)
      山田博之
    • Organizer
      日本腎臓学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K16188
  • 1.  横井 秀基 (90378779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  杉岡 清香 (60986545)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 3.  大鶴 繁 (60437225)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  砂川 玄志郎 (70710250)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  高谷 悠大 (60828903)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MATSUBARA Takeshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  SUTO Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  SUZUKI Kotaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  平沢 恵理
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  加藤 有希子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  松島 綱治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  岩本 太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  南 卓馬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  石井 輝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  向山 政志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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