Morihiro Kunihiko 森廣邦彦

… Alternative Names

MORIHIRO Kunihiko 森廣邦彦

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Researcher Number	70713890
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院工学系研究科(工学部), 准教授
Affiliation (based on the past Project Information) *help	2025: 東京大学, 大学院工学系研究科(工学部), 准教授 2019 – 2024: 東京大学, 大学院工学系研究科(工学部), 助教 2023: 東京大学, 大学院工学系研究科(工学部), 准教授 2015: 医薬基盤研究所, 研究員 2013 – 2014: 独立行政法人医薬基盤研究所, 創薬支援スクリーニングセンター, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Science and Engineering / Basic Section 28040:Nanobioscience-related / Chemical pharmacy Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Drug development chemistry
Keywords	Principal Investigator 核酸化学 / がん / HCR / 化学療法 / 抗がん剤 / マイクロRNA / Staudinger還元 / 生体直交型反応 / DNAナノテクノロジー / ルシフェラーゼ … More / プロドラッグ / siRNA / 銅イオン / Lab on Paper / CHA / リキッドバイオプシー / 診断薬 / 蛍光 / オリゴヌクレオチド / 遺伝子発現制御 / エントロピー / ノルボルナン / 人工核酸 … More Except Principal Investigator ユビキチン / 核酸集合体 / マイクロRNA / ハイブリダイゼーション / 集合体 / 化学合成 / 核酸 / アンチセンス医薬 / バイオコンジュゲート / アンチセンス核酸 / ゲノム創薬 / 核酸医薬 Less

Unprecedented and potent immunoregulation provided by protein capture with functionalized small synthetic nucleic acids
- Principal Investigator
  
  岡本晃充
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  The University of Tokyo
siRNA prodrugs activated by Cu(I) in cancer cellsPrincipal Investigator
- Principal Investigator
  
  Morihiro Kunihiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  The University of Tokyo
microRNA-responsive liquid biopsy in a crowded environmentPrincipal Investigator
- Principal Investigator
  
  森廣邦彦
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Cancer-selective chemotherapy using DNA nanotechnologyPrincipal Investigator
- Principal Investigator
  
  Morihiro Kunihiko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  The University of Tokyo
Development of highly constrained nucleic acid analogue based on norbornane structurePrincipal Investigator
- Principal Investigator
  
  MORIHIRO Kunihiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Chemical pharmacy
- Research Institution
  独立行政法人医薬基盤研究所
Development of platform technologies for antisense oligonucleotide-based therapeutics by a combination of nucleic acids chemistry and information sciences
- Principal Investigator
  
  Satoshi Obika
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Copper-mediated siRNA activation for conditional control of gene expression2024
- Author(s)
  Morihiro Kunihiko、Tomida Yasuhiro、Ando Honami、Okamoto Akimitsu
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 104 Pages: 129738-129738
- DOI
  10.1016/j.bmcl.2024.129738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06449
[Journal Article] RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality2023
- Author(s)
  Morihiro, K.; Morita, S.; Harada, N.; Baba, M.; Yum, J.; Naito, M.; Miyata, K.; Nagae, G.; Okamoto, A.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 146 Issue: 2 Pages: 1346-1355
- DOI
  10.1021/jacs.3c09524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17969, KAKENHI-PROJECT-23H00317, KAKENHI-PROJECT-23K21431
[Journal Article] Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery2023
- Author(s)
  Takatsu, M.; Morihiro, K.; Watanabe, H.; Yuki, M.; Hattori, T.; Noi, K.; Aikawa, K.; Noguchi, K.; Yohda, M.; Okazoe, T.; Okamoto, A.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 18 Issue: 12 Pages: 2590-2598
- DOI
  10.1021/acschembio.3c00612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17969, KAKENHI-PROJECT-23K04717, KAKENHI-PROJECT-23H00317
[Journal Article] Nucleic Acid-to-Small Molecule Converter through Amplified Hairpin DNA Circuits2023
- Author(s)
  Morihiro, K.; Tomida, Y.; Fukui, D.; Hasegawa, M.; Okamoto, A.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 62 Issue: 44
- DOI
  10.1002/anie.202306587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17969, KAKENHI-PROJECT-23H00317
[Journal Article] Floxuridine Oligomers Activated under Hypoxic Environment2021
- Author(s)
  Morihiro, K.; Ishinabe, T.; Takatsu, M.; Osumi, H.; Osawa, T.; Okamoto, A.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 143 Issue: 9 Pages: 3340-3347
- DOI
  10.1021/jacs.0c10732
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PUBLICLY-20H04698, KAKENHI-PROJECT-18H03931, KAKENHI-PROJECT-19K22245, KAKENHI-PROJECT-19K15408, KAKENHI-PUBLICLY-20H04834, KAKENHI-PROJECT-19H03496, KAKENHI-PROJECT-21K19399
[Journal Article] Wavelength-selective light-triggered strand exchange reaction2016
- Author(s)
  Morihiro K., Kodama T., Mori S., Obika S.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 14 Issue: 5 Pages: 1555-1558
- DOI
  10.1039/c5ob02369f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] C5-azobenzene-functionalized locked nucleic acid uridine: isomerization properties, hybridization ability, and enzymatic stability2015
- Author(s)
  Morihiro K., Hasegawa O., Mori S., Tsunoda S., Obika S.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Issue: 18 Pages: 5209-5209
- DOI
  10.1039/c5ob00477b
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Synthesis and Properties of 2'-Deoxyuridine Analogues Bearing Various Azobenzene Derivatives at the C5-Position2015
- Author(s)
  Shohei Mori, Kunihiko Morihiro, Yuuya Kasahara, Shin-ichi Tsunoda, Satoshi Obika
- Journal Title
  
  Chemosensors
  
  Volume: 3 Issue: 2 Pages: 36-54
- DOI
  10.3390/chemosensors3020036
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Photoinduced Changes in Hydrogen Bonding Patterns of 8-Thiopurine Nucleobase Analogues in a DNA Strand.2014
- Author(s)
  K. Morihiro, T. Kodama, S. Mori, S. Obika
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 12 Issue: 15 Pages: 2468-2473
- DOI
  10.1039/c3ob42427h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Light-triggered Strand Exchange Reaction Using the Change in the Hydrogen Bonding Pattern of the Nucleobase Analog2014
- Author(s)
  K. Morihiro, T. Kodama, R. Waki, S. Obika
- Journal Title
  
  Chem. Sci.
  
  Volume: 5 Issue: 2 Pages: 744-750
- DOI
  10.1039/c3sc51987b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Selenomethylene Locked Nucleic Acid Enables Reversible Hybridization in Response to Redox Changes2013
- Author(s)
  Kunihiko Morihiro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 52 Issue: 19 Pages: 5074-5078
- DOI
  10.1002/anie.201300555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03275, KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Synthesis of Selenomethylene-locked Nucleic Acid (SeLNA)-modified Oligonucleotides by Polymerases2012
- Author(s)
  Megan Wheeler
- Journal Title
  
  Chemical Communications
  
  Volume: 48 Issue: 89 Pages: 11020-11022
- DOI
  10.1039/c2cc36464f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03275, KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Presentation] 弱酸性微小環境応答性人工核酸塩基を用いたがん選択的DNAアプタマーの開発2024
- Author(s)
  陳鈺媛、森廣邦彦、根本祐衣、市村晃人、植木亮介、山東信介、岡本晃充
- Organizer
  日本化学会第１０４春季年会
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] 化学修飾が長鎖DNA二重鎖の細胞毒性に与える影響2024
- Author(s)
  馬場愛奈美、森廣邦彦、岡本晃充
- Organizer
  日本薬学会第１４４年会
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] 生細胞内の多種マイクロRNAの同時検出2024
- Author(s)
  徐云嵩、森廣邦彦、岡本晃充
- Organizer
  日本化学会第１０４春季年会
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] DNAナノテクノロジーCatalytic hairpin assembly (CHA) を応用したプロドラッグDNAデコイの開発2024
- Author(s)
  安田壮秀、森廣邦彦、岡本晃充
- Organizer
  日本化学会第１０４春季年会
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] 腫瘍関連miRNAが触媒するDNAデコイの腫瘍細胞内生成2024
- Author(s)
  安田壮秀、森廣邦彦、岡本晃充
- Organizer
  日本薬学会第１４４年会
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] がん細胞選択的なヘテロ二重鎖核酸構築による細胞毒性の発現2024
- Author(s)
  原田直毅、森廣邦彦、岡本晃充
- Organizer
  日本薬学会第１４４年会
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] がん細胞内に蓄積された銅イオンをトリガーとするsiRNAの活性化2023
- Author(s)
  冨田康弘、森廣邦彦、岡本晃充
- Organizer
  日本化学会第１０３春季年会
- Data Source
  KAKENHI-PROJECT-21K06449
[Presentation] Multidrug-integrated mini-nucleic acid drug platform for effective chemotherapy of refractory cancer2023
- Author(s)
  Ryosei Komiyama, Kunihiko Morihiro, Akimitsu Okamoto
- Organizer
  第50回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] 化学修飾による長鎖ＤＮＡ二重鎖の細胞毒性制御2023
- Author(s)
  馬場愛奈美、森廣　邦彦、岡本　晃充
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] siRNA Prodrugs for Selective Cancer Treatment Using Copper-Responsive Artificial Nucleic Acids2023
- Author(s)
  Yasuhiro Tomida, Honami Ando, Kunihiko Morihiro, Akimitsu Okamoto
- Organizer
  The 50th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06449
[Presentation] がん細胞選択的なDNA/RNAヘテロ二重鎖の構築2023
- Author(s)
  原田　直毅、森廣　邦彦、岡本　晃充
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] Drug Strategies for Selective Cancer Tratment Using Stimuli-Responsive Artificial Nucleic Acid2023
- Author(s)
  Yasuhiro Tomida, Kunihiko Morihiro, Akimitsu Okamoto
- Organizer
  第50回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00317
[Presentation] Activation of siRNA triggered by copper ion accumulated in cancer cells2022
- Author(s)
  Yasuhiro Tomida, Honami Ando, Kunihiko Morihiro, Akimitsu Okamoto
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06449
[Presentation] がん細胞内に蓄積した不安定な金属イオンをトリガーとする核酸医薬の活性化2021
- Author(s)
  安藤帆菜美、森廣邦彦、岡本晃充
- Organizer
  第11回CSJ化学フェスタ2021
- Data Source
  KAKENHI-PROJECT-21K06449
[Presentation] Hypoxia-Activated Floxuridine Oligomers via Bioreduction of Nitro and/or Azo Functionalities2021
- Author(s)
  Kunihiko Morihiro, Takuro Ishinabe, Masako Takatsu, Tsuyoshi Osawa, Akimitsu Okamoto
- Organizer
  日本化学会第101春季年会(2021)
- Data Source
  KAKENHI-PUBLICLY-20H04698
[Presentation] 金属イオン曝露による DNAトランスポゾンのメチル化蛍光解析2021
- Author(s)
  森廣邦彦, 劉杉, 竹内芙美香, 岡本晃充
- Organizer
  第42回日本光医学・光生物学会
- Data Source
  KAKENHI-PUBLICLY-20H04698
[Presentation] 金属イオン曝露による DNAトランスポゾンのメチル化蛍光解析2021
- Author(s)
  森廣邦彦, 劉杉, 竹内芙美香, 岡本晃充
- Organizer
  第42回日本光医学・光生物学会
- Data Source
  KAKENHI-PROJECT-19K15408
[Presentation] 核酸ナノ技術を用いたマイクロRNAの蛍光検出2021
- Author(s)
  森廣邦彦, 福井大介, 大住拓輝, 岡本晃充
- Organizer
  第43回日本光医学・光生物学会
- Data Source
  KAKENHI-PUBLICLY-20H04698
[Presentation] Hypoxia-Activated Floxuridine Oligomers via Bioreduction of Nitro and/or Azo Functionalities2021
- Author(s)
  森廣邦彦, 石鍋拓郎, 高津正子, 大澤毅, 岡本晃充
- Organizer
  日本化学会第101春季年会(2021)
- Data Source
  KAKENHI-PROJECT-19K15408
[Presentation] マイクロRNA応答型低分子多重放出システム2020
- Author(s)
  福井大介, 森廣邦彦. 岡本晃充
- Organizer
  日本化学会第100春季年会2020
- Data Source
  KAKENHI-PROJECT-19K15408
[Presentation] 低酸素環境下で活性化するFloxuridineオリゴマーの開発2020
- Author(s)
  森廣邦彦, 石鍋拓郎, 高津正子, 岡本晃充
- Organizer
  第14回バイオ関連化学シンポジウム 2020
- Data Source
  KAKENHI-PUBLICLY-20H04698
[Presentation] 低酸素環境下で活性化するFloxuridineオリゴマーの開発2020
- Author(s)
  森廣邦彦, 石鍋拓郎, 高津正子, 岡本晃充
- Organizer
  第14回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K15408
[Presentation] A Hybridization Chain Reaction (HCR)-Based MicroRNA Detection System2019
- Author(s)
  Kunihiko Morihiro, Daisuke Fukui, Akimitsu Okamoto
- Organizer
  The 46th International Symposium on Nucleic Acid Chemistry 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15408
[Presentation] セレノメチレン架橋型ピリミジンヌクレオシドで修飾したアンチセンス分子2015
- Author(s)
  兒玉哲也，百相義大，森廣邦彦，廣明秀一，小比賀聡
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都市
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Selenomethylene Locked Nucleic Acid (SeLNA) Bearing a Purine Base2013
- Author(s)
  Yoshihiro Moai, Tetsuya Kodama, Kunihiko Morihiro, Hidekazu Hiroaki, Satoshi Obika
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013
- Place of Presentation
  神奈川大学（神奈川）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] セレノメチレン架橋型人工核酸の開発と酸化還元スイッチへの応用
- Author(s)
  森廣邦彦，兒玉哲也，肯特夫，百相義大，Veedu Rakesh.N，小比賀聡
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthesis and properties of oligonucleotides containing 2’,4’-BNA/LNA-deazapurine analogues.
- Author(s)
  Hara Takashi, Kodama Tetsuya, Takegaki Yumi, Morihiro Kunihiko, Ito Kousuke R, Obika Satoshi
- Organizer
  10th Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-10-12 – 2014-10-14
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] チミン塩基をもつセレノメチレン架橋型人工核酸の合成と基本的性質
- Author(s)
  兒玉哲也，森廣邦彦，肯特夫，百相義大，VeeduR.N，小比賀聡
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム 2012
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-24249007

1. Satoshi Obika (80243252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. KODAMA Tetsuya (00432443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. TAKAGI Tatsuya (80144517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAWASHITA Norihito (00423111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 岡本晃充 (60314233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
6. 大橋瑠子 (20447600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Morihiro Kunihiko 森廣 邦彦

MORIHIRO Kunihiko 森廣 邦彦

Research Projects

Research Products

Co-Researchers

Unprecedented and potent immunoregulation provided by protein capture with functionalized small synthetic nucleic acids

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

siRNA prodrugs activated by Cu(I) in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

microRNA-responsive liquid biopsy in a crowded environmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cancer-selective chemotherapy using DNA nanotechnologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of highly constrained nucleic acid analogue based on norbornane structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of platform technologies for antisense oligonucleotide-based therapeutics by a combination of nucleic acids chemistry and information sciences

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Copper-mediated siRNA activation for conditional control of gene expression2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleic Acid-to-Small Molecule Converter through Amplified Hairpin DNA Circuits2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Floxuridine Oligomers Activated under Hypoxic Environment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wavelength-selective light-triggered strand exchange reaction2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C5-azobenzene-functionalized locked nucleic acid uridine: isomerization properties, hybridization ability, and enzymatic stability2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and Properties of 2'-Deoxyuridine Analogues Bearing Various Azobenzene Derivatives at the C5-Position2015

Author(s)

Journal Title

DOI

Morihiro Kunihiko 森廣邦彦

MORIHIRO Kunihiko 森廣邦彦