hirai toshihito 平井敏仁

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Hirai Toshihito 平井敏仁

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Researcher Number	70722693
Affiliation (Current)	2026: 東京女子医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 東京女子医科大学, 医学部, 准教授 2021 – 2022: 東京女子医科大学, 医学部, 講師 2015 – 2019: 東京女子医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery
Keywords	Principal Investigator 調節性T細胞 / 免疫寛容 / 糖尿病 / IL-2 / iNKT細胞 / 移植免疫寛容 / AI画像診断 / 遺伝子空間解析 / 免疫抑制 / 細胞エンジニアリング … More / Treg細胞 / 移植臓器拒絶反応 / 臓器移植 / 骨髄移植 / natural killer T細胞 / α-galactosylceramide / 膵島移植 / 臓器拒絶 / ナチュラルキラーT細部 / 自然免疫 / 臓器移植拒絶 / OX40 / IL2 / 調整性T細胞 / 細胞工学療法 / 遺伝子導入 / 細胞工学 / 移植片対宿主病 / 制御性T細胞 Less

Toshihito HiraiPrincipal Investigator
- Principal Investigator
  
  平井敏仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Tokyo Women's Medical University
IL-2 Receptor Gene Editing Enables Regulatory T Cell-Selective Activation and Immune TolerancePrincipal Investigator
- Principal Investigator
  
  Hirai Toshihito
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Tokyo Women's Medical University
A novel strategy for treatment of diabetes by immuneregulation(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  Hirai Toshihito
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Women's Medical University
Lifelong cure of diabetes by novel approach utilizing immune regulatory systemPrincipal Investigator
- Principal Investigator
  
  Hirai Toshihito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Women's Medical University

All 2024 2023 2022 2020 2018 2017 2016

All Journal Article Presentation

[Journal Article] Unveiling Spatial Immune Cell Profile in Kidney Allograft Rejections Using 36-plex Immunofluorescence Imaging2024
- Author(s)
  Hirai Toshihito、Kondo Ayano、Shimizu Tomokazu、Fukuda Hironori、Tokita Daisuke、Takagi Toshio、Mayer Aaron T.、Ishida Hideki
- Journal Title
  
  Transplantation
  
  Volume: 108 Issue: 12 Pages: 2446-2457
- DOI
  10.1097/tp.0000000000005107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16409, KAKENHI-PROJECT-22K08723
[Journal Article] Higher Donor Age and Severe Microvascular Inflammation Are Risk Factors for Chronic Rejection After Treatment of Active Antibody-Mediated Rejection2024
- Author(s)
  Banno Taro、Hirai Toshihito、Oki Rikako、Yagisawa Takafumi、Unagami Kohei、Kanzawa Taichi、Omoto Kazuya、Shimizu Tomokazu、Ishida Hideki、Takagi Toshio
- Journal Title
  
  Transplant International
  
  Volume: 37
- DOI
  10.3389/ti.2024.11960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16409
[Journal Article] Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo2023
- Author(s)
  Ramos Teresa L.、Bolivar-Wagers Sara、Hirai Toshihito、et. al
- Journal Title
  
  Blood
  
  Volume: 141 Issue: 11 Pages: 1337-1352
- DOI
  10.1182/blood.2022018440
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Journal Article] Analysis of the T-cell repertoire and transcriptome identifies mechanisms of regulatory T-cell suppression of GVHD2023
- Author(s)
  Lohmeyer Juliane K.、Hirai Toshihito、Turkoz Mustafa、Buhler Stephane、Lopes Ramos Teresa、K?hler Natalie、Baker Jeanette、Melotti Astrid、Wagner Ingrid、Pradier Amandine、Wang Sisi、Ji Xuhuai、Becattini Simone、Villard Jean、Merkler Doron、Chalandon Yves、Negrin Robert S.、Simonetta Federico
- Journal Title
  
  Blood
  
  Volume: 141 Issue: 14 Pages: 1755-1767
- DOI
  10.1182/blood.2022017982
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Journal Article] IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor2022
- Author(s)
  Hirai Toshihito、Lin Po-Yu、Ramos Teresa L.、Simonetta Federico、Su Leon L.、Picton Lora K.、Baker Jeanette、Lohmeyer Juliane K.、Garcia K. Christopher、Negrin Robert S.
- Journal Title
  
  American Journal of Transplantation
  
  Volume: 22 Issue: 12 Pages: 3061-3068
- DOI
  10.1111/ajt.17181
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] Urology beyond Europe - Joint Session of the European Association of Urology (EAU) and the Japanese Urological Association (JUA)2024
- Author(s)
  ◎HIRAI Toshihito
- Organizer
  European Association of Urology 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] Spatial transcriptomic analysis uncovers gene expression profiles in peritubular capillaritis in antibody-mediated rejection.2024
- Author(s)
  HIRAI Toshihito, SHIMIZU Tomokazu, ISHIDA Hideki, TAKAGI Toshio
- Organizer
  2024 American Transplant Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] IL-2 receptor engineering and treg cell.2024
- Author(s)
  ◎HIRAI Toshihito, Federico Simonetta , Leon L Su , Lora Picton , Po-Yu Lin , Teresa L Ramos , Jeanette Baker , K. Christopher Garcia , TAKAGI Toshio, Robert S Negrin
- Organizer
  Asian Transplantaion Week 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] Computational analysis of multiplex immunofluorescence imaging identifies endothelial cell-macrophage interaction as a potential novel spatial biomarker in antibody mediated kidney rejection.2023
- Author(s)
  HIRAI Toshihito, KONDO Ayano, SHIMIZU Tomokazu, HORITA Shigeru, TOKITA Daisuke, MAYER Aaron, ISHIDA Hideki
- Organizer
  2023 American Transplant Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] Engineered IL-2 plus calcineurin inhibitor synergistically expands regulatory t cells transduced with engineered IL-2 receptor and facilitates establishment of transplantation tolerance.2023
- Author(s)
  HIRAI Toshihito
- Organizer
  18th Congress of the Asian Society of Transplantation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] CODEX多重免疫染色が明らかとする抗体関連型拒絶反応診断のための新しい空間インデックス2023
- Author(s)
  平井敏仁, AyanoKondo, AaronMayer, 清水朋一, 堀田茂, 福田洋典, 石井瑠美, 時田大輔, 石田英樹, 高木敏男
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] 免疫多重染色のコンピューター解析が明らかにする急性腎拒絶反応の空間インデックス2023
- Author(s)
  平井敏仁, KONDO Ayano, MAYER Aaron, 清水朋一, 堀田茂, 石田英樹, 時田大輔
- Organizer
  移植腎病理研究会・第26回学術集会
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] Computational analysis of multiplex immunofluorescence imaging identifies endothelial cell-macrophage interaction as a potential novel spatial biomarker in antibody mediated kidney rejection.2023
- Author(s)
  HIRAI Toshihito
- Organizer
  18th Congress of the Asian Society of Transplantation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] Donor-derived cell-free DNA analysis is capable of detecting antibody-mediated rejection in one-year biopsy of living kidney transplantation.2023
- Author(s)
  BANNO Taro, HIRAI Toshihito, OKI Rikako, YAGISAWA Takafumi, UNAGAMI Kohei, KANZAWA Taichi, ISHIDA Hideki, TAKAGI Toshio
- Organizer
  2023 American Transplant Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] 制御性 T 細胞を利用した中枢性免疫寛容誘導2022
- Author(s)
  平井　敏仁
- Organizer
  第48回日本臓器保存生物医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance2022
- Author(s)
  T. Hirai, P. Lin, T. L Ramos, K. Garcia, R. S Negrin,
- Organizer
  American Transplantation Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] 細胞エンジニアリングを取り入れたTreg細胞療法の新しい試み2022
- Author(s)
  平井　敏仁
- Organizer
  第21回WAKO Web受託セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K16409
[Presentation] Imaging OX40+Alloreactive T Cells Provides Early Warning Of Organ Transplant Rejection2020
- Author(s)
  T.Hirai, A.Mayer, T.W.Nobashi. et al.
- Organizer
  アメリカ移植学会2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0355
[Presentation] Engineered IL-2 Cytokine-Cytokine Receptor Complex Enables Selective Expansion of Regulatory T Cells and Facilitates Establishment of Organ Transplantation Tolerance2020
- Author(s)
  T.Hirai, F.Simonetta, L.L.Su, et al
- Organizer
  アメリカ骨髄移植移植、細胞治療学会2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0355
[Presentation] Orthogonal IL-2 Cytokine-receptor Pair Capable Of Selective Expansion Of Regulatory T Cells Facilitates Alloengraftment2020
- Author(s)
  T.Hirai, F.Simonetta, L.L.Su, et al
- Organizer
  アメリカ移植学会2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0355
[Presentation] iNKT cell stimulation with liposomal alpha/Gal/Cer amplifies proliferation of adoptively transferred regulatory T cells in vivo and reduces GVHD2018
- Author(s)
  Toshihito Hirai, Federico Simonetta, Kristina Maas-Bauer, Melissa Mavers, Jeanette Baker, and Robert S Negrin
- Organizer
  61st ASH meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0355
[Presentation] Islet Allografts Survive Permanently by Inducing Hematopoietic Chimerism with Activating Invariant Natural Killer T Cells and CD40-CD154 Signal Blockade2017
- Author(s)
  神澤太一、平井敏仁、福田洋典、勝俣陽貴、石井瑠美、宮入聡嗣、池宮城雅子、奥見雅由、石井保之、田邉一成
- Organizer
  2017 American Transplant Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19864
[Presentation] Islet Allografts Survive Permanently by Inducing Hematopoietic Chimerism with Activating Invariant Natural Killer T Cells and CD40-CD154 Signal Blockade2017
- Author(s)
  神澤　太一、平井　敏仁、福田　洋典、勝俣　陽貴、石井　瑠美、宮入　聡嗣、池宮城　雅子、奥見　雅由、石井　保之、田邉　一成
- Organizer
  2017 American Transplant Congress
- Place of Presentation
  シカゴ（アメリカ）
- Year and Date
  2017-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19864
[Presentation] Treatment of donors with liposomal alpha-galactosylceramide results in the in vivo expansion of invariant natural killer T cells and reduced incidence of acute graft versus host disease2017
- Author(s)
  Toshihito Hirai, Federico Simonetta, Kristina Mass-Bauer, Jeanette Baker, Mustafa Tukoz, Maite Alvarez, Melissa Mavers, Robert S Negrin
- Organizer
  The American Society of Hematology (ASH) 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0355
[Presentation] Islet Allografts Survive Permanently by Inducing Hematopoietic Chimerism with Activating Invariant Natural Killer T Cells and CD40-CD154 Signal Blockade2016
- Author(s)
  神澤　太一、平井　敏仁、福田　洋典、勝俣　陽貴、石井　瑠美、宮入　聡嗣、池宮城　雅子、奥見　雅由、石井　保之、田邉　一成
- Organizer
  第４５回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K19864

1. ISHII Yasuyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. Negrin Robert S

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Meyer Evertt

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Cruz Magdiel Perez

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

hirai toshihito 平井 敏仁

Hirai Toshihito 平井 敏仁

Research Projects

Research Products

Co-Researchers

Toshihito HiraiPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IL-2 Receptor Gene Editing Enables Regulatory T Cell-Selective Activation and Immune TolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel strategy for treatment of diabetes by immuneregulation(Fostering Joint International Research)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lifelong cure of diabetes by novel approach utilizing immune regulatory systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Unveiling Spatial Immune Cell Profile in Kidney Allograft Rejections Using 36-plex Immunofluorescence Imaging2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Higher Donor Age and Severe Microvascular Inflammation Are Risk Factors for Chronic Rejection After Treatment of Active Antibody-Mediated Rejection2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the T-cell repertoire and transcriptome identifies mechanisms of regulatory T-cell suppression of GVHD2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Urology beyond Europe - Joint Session of the European Association of Urology (EAU) and the Japanese Urological Association (JUA)2024

Author(s)

Organizer

Data Source

[Presentation] Spatial transcriptomic analysis uncovers gene expression profiles in peritubular capillaritis in antibody-mediated rejection.2024

Author(s)

Organizer

Data Source

[Presentation] IL-2 receptor engineering and treg cell.2024

Author(s)

Organizer

Data Source

[Presentation] Computational analysis of multiplex immunofluorescence imaging identifies endothelial cell-macrophage interaction as a potential novel spatial biomarker in antibody mediated kidney rejection.2023

Author(s)

Organizer

Data Source

[Presentation] Engineered IL-2 plus calcineurin inhibitor synergistically expands regulatory t cells transduced with engineered IL-2 receptor and facilitates establishment of transplantation tolerance.2023

Author(s)

Organizer

Data Source

[Presentation] CODEX多重免疫染色が明らかとする抗体関連型拒絶反応診断のための新しい空間インデックス2023

Author(s)

Organizer

Data Source

[Presentation] 免疫多重染色のコンピューター解析が明らかにする急性腎拒絶反応の空間インデックス2023

Author(s)

hirai toshihito 平井敏仁

Hirai Toshihito 平井敏仁