Kubo Asako 久保亜抄子

… Alternative Names

KUBO Asako 久保亜抄子

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Researcher Number	70733202
Other IDs
Affiliation (Current)	2025: 新潟医療福祉大学, リハビリテーション学部, 教授 2025: 生理学研究所, 生体機能調節研究領域, 特別協力研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 新潟医療福祉大学, リハビリテーション学部, 教授 2020 – 2022: 生理学研究所, 生体機能調節研究領域, 特別協力研究員 2015 – 2021: 日本大学, 歯学部, ポスト・ドクトラル・フェロー
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Basic Section 59010:Rehabilitation science-related / Surgical dentistry Except Principal Investigator Surgical dentistry / Basic Section 57010:Oral biological science-related / Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator 三叉神経節 / パッチクランプ / サテライトグリア / 温熱刺激 / 筋 / TRPチャネル / 鎮痛 / 細胞内環境 / 細胞環境 / 酸性化 … More / 三叉神経 / 光刺激 / 痛覚過敏 / 衛星細胞 / ATP / 光遺伝学 / 三叉神経節細胞 / P2X7 / パッチクランプ法 / 痛み / 中枢神経機構 / 筋性疼痛 / 延髄 / 機械痛覚過敏 / 神経成長因子 / 顎関節症 / 咬筋痛 … More Except Principal Investigator 下歯槽神経損傷 / 三叉神経節 / 異所性疼痛 / 三叉神経脊髄路核尾側亜核 / マクロファージ / 三叉神経障害性疼痛 / IFN-gamma / 一酸化窒素 / サテライト細胞 / 下行性抑制機構 / 侵害情報伝達機構 / 背側三叉神経傍核 / 孤束核 / Aδ線維 / C線維 / 視床内側核群 / Aδ-fiber / C-fiber / 橋結合腕傍核 / 視床内側各群 / 視床後内側腹側核 / 三叉神経脊髄路核 / 投射ニューロン / 神経障害性疼痛 / GDNF / 神経再生 Less

筋／筋膜の温受容をトリガーとする中枢性鎮痛機構の解明Principal Investigator
- Principal Investigator
  
  久保亜抄子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Niigata University of Health and Welfare
神経障害後の細胞環境依存的な衛星細胞の機能変化と三叉神経の興奮性変調機構の解明Principal Investigator
- Principal Investigator
  
  久保亜抄子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Niigata University of Health and Welfare
  National Institute for Physiological Sciences
Macrophages in trigeminal ganglion contributes to the ectopic orofacial pain following inferior alveolar nerve injury
- Principal Investigator
  
  SHINODA Masamichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Nihon University
Involvement of non-neuronal cell activation in the development of pain following nerve injury.Principal Investigator
- Principal Investigator
  
  Kubo Asako
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  National Institute for Physiological Sciences
  Nihon University
Ectopic orofacial pain mechanisms following inferior alveolar injury
- Principal Investigator
  
  SHIBUTA Ikuko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nihon University
Neuroplastic changes in trigeminal nociceptive pathways following trigeminal nerve injury
- Principal Investigator
  
  Katagiri Ayano
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Osaka University
Neural mechanism for developing therapy for masseter muscle pain triggered by myofascial pain in the neck shoulderPrincipal Investigator
- Principal Investigator
  
  KUBO Asako
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nihon University
Functional recovery of injured inferior alveolar nerve using peripheral glial cell line-derived neurotrophic factor
- Principal Investigator
  
  SHINODA Masamichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Nihon University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] 筋筋膜性疼痛の基礎 up to date2023
- Author(s)
  久保亜抄子
- Journal Title
  
  Journal of Japanese Society of Oriental Physiotherapy
  
  Volume: 48 Issue: 2 Pages: 11-16
- DOI
  10.32255/jjsop.48.2_11
- ISSN
  2187-5316, 2434-5644
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-21K09867
[Journal Article] Masseter muscle contraction and cervical muscle sensitization by nerve growth factor cause mechanical hyperalgesia in masticatory muscle with activation of the trigemino-lateral parabrachial nucleus system in female rats2022
- Author(s)
  Asako Kubo, Shiori Sugawara, Koichi Iwata, Satoru Yamaguchi, Kazue Mizumura
- Journal Title
  
  Headache
  
  Volume: 62 Issue: 10 Pages: 1365-1375
- DOI
  10.1111/head.14406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09867
[Journal Article] Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity2020
- Author(s)
  Lee Jun、Ohara Kinuyo、Shinoda Masamichi、Hayashi Yoshinori、Kubo Asako、Sugawara Shiori、Asano Sayaka、Soma Kumi、Kanno Kohei、Ando Masatoshi、Koyama Ryo、Kimura Yuki、Sakanashi Kousuke、Iinuma Toshimitsu、Iwata Koichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 4 Pages: 1252-1252
- DOI
  10.3390/ijms21041252
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09732, KAKENHI-PROJECT-19K10049, KAKENHI-PROJECT-18K17077, KAKENHI-PROJECT-16K11477
[Journal Article] Pathophysiological mechanisms of persistent orofacial pain2020
- Author(s)
  Shinoda Masamichi、Hayashi Yoshinori、Kubo Asako、Iwata Koichi
- Journal Title
  
  Journal of Oral Science
  
  Volume: 62 Issue: 2 Pages: 131-135
- DOI
  10.2334/josnusd.19-0373
- NAID
  130007821522
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09541, KAKENHI-PROJECT-16K11477, KAKENHI-PROJECT-17K11654, KAKENHI-PROJECT-20K09896
[Journal Article] Oxytocin-dependent regulation of TRPs expression in trigeminal ganglion neurons attenuates orofacial neuropathic pain following intraorbital nerve injury in rats2020
- Author(s)
  Ando M, Hayashi Y, Hitomi S, Shibuta I, Furukawa A, Oto T, Inada T, Matsui T, Fukaya C, Noma N, Okubo M, Yonehara Y, Kaneko T, Iwata K, Shinoda M
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 23 Pages: 9173-9190
- DOI
  10.3390/ijms21239173
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09466, KAKENHI-PROJECT-20K09896, KAKENHI-PROJECT-18K09732
[Journal Article] Peripheral and Central Mechanisms of Persistent Orofacial Pain2019
- Author(s)
  Shinoda Masamichi、Kubo Asako、Hayashi Yoshinori、Iwata Koichi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 13 Pages: 1-10
- DOI
  10.3389/fnins.2019.01227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09541, KAKENHI-PROJECT-16K11477, KAKENHI-PROJECT-17K11654
[Journal Article] Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain2019
- Author(s)
  Sugawara Shiori、Shinoda Masamichi、Hayashi Yoshinori、Saito Hiroto、Asano Sayaka、Kubo Asako、Shibuta Ikuko、Furukawa Akihiko、Toyofuku Akira、Iwata Koichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 24 Pages: 6360-6360
- DOI
  10.3390/ijms20246360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09732, KAKENHI-PROJECT-19K10328, KAKENHI-PROJECT-16K11477
[Journal Article] Phenotypic change in trigeminal ganglion neurons associated with satellite cell activation via extracellular signal-regulated kinase phosphorylation is involved in lingual neuropathic pain2017
- Author(s)
  Mikuzuki Lou、Saito Hiroto、Katagiri Ayano、Okada Shinji、Sugawara Shiori、Kubo Asako、Ohara Kinuyo、Lee Jun、Toyofuku Akira、Iwata Koichi
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 46 Issue: 6 Pages: 2190-2202
- DOI
  10.1111/ejn.13667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11881, KAKENHI-PROJECT-17K11855, KAKENHI-PROJECT-16K20466
[Journal Article] Oxytocin alleviates orofacial mechanical hypersensitivity associated with infraorbital nerve injury via vasopressin 1A receptors of the rat trigeminal ganglia.2017
- Author(s)
  Kubo A, Shinoda M, Katagiri A, Takeda M, Suzuki T, Asaka J, Yeomans D, Iwata K.
- Journal Title
  
  Pain
  
  Volume: 158(4) Issue: 4 Pages: 649-659
- DOI
  10.1097/j.pain.0000000000000808
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21410, KAKENHI-PROJECT-15K11272, KAKENHI-PROJECT-17K11654
[Journal Article] Ascending projections of nociceptive neurons from trigeminal subnucleus caudalis: A population approach.2017
- Author(s)
  Saito H, Katagiri A, Okada S, Mikuzuki L, Kubo A, Suzuki T, Ohara K, Lee J, Gionhaku N, Iinuma T, Bereiter DA, Iwata K.
- Journal Title
  
  Experimantal Neurology
  
  Volume: 293 Pages: 124-136
- DOI
  10.1016/j.expneurol.2017.03.024
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21410, KAKENHI-PROJECT-15K11272, KAKENHI-PROJECT-16K11636, KAKENHI-PROJECT-16K20466, KAKENHI-PROJECT-17K11855
[Journal Article] ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue2016
- Author(s)
  Nakaya Y, Tsuboi Y, Okada-Ogawa A, Shinoda M, Kubo A, Chen JY, Noma N, Batbold D, Imamura Y, Sessle BJ, Iwata K
- Journal Title
  
  Molecular Pain
  
  Volume: - Pages: 12-12
- DOI
  10.1177/1744806916641680
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460708, KAKENHI-PROJECT-15K11272, KAKENHI-PROJECT-16K11766
[Presentation] Mechanisms of chronic muscle hyperalgesia -from studies using animal models-2024
- Author(s)
  Asako Kubo
- Organizer
  第101回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09867
[Presentation] 痛みと鍼治療2023
- Author(s)
  久保亜抄子
- Organizer
  第41回日本歯科東洋医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09867
[Presentation] 頭痛に対する鍼治療の効果とその作用機序2023
- Author(s)
  久保亜抄子、菊池友和、山口智
- Organizer
  第88回日本温泉気候物理医学会総会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09867
[Presentation] 雌ラット咀嚼筋における機械痛覚過敏発症には外側腕傍核の活性化が関連する2022
- Author(s)
  久保亜抄子、菅原詩織、岩田幸一、山口智、水村和枝
- Organizer
  第４４回日本疼痛学会
- Data Source
  KAKENHI-PROJECT-21K09867
[Presentation] Sex differences in the development of masticatory muscle pain in rats.2021
- Author(s)
  Asako Kubo, Shiori Sugawara, Koichi Iwata
- Organizer
  IASP 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09541
[Presentation] Electrophysiological approach with ex vivo trigeminal ganglia to clarify neuron-glia interactions2019
- Author(s)
  A Kubo, S Sugawara, K Iwata
- Organizer
  9th Federation of the Asian and Oceanian Physiological Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09541
[Presentation] Ex vivo electrophysiological evaluation of the involvement of glia-neuron interactions within the trigeminal ganglion in orofacial pain mechanisms2018
- Author(s)
  A　Kubo, K Iwata
- Organizer
  International Association for the Study of Pain (IASP) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09541
[Presentation] Oxytocin suppresses facial mechanical hypersensitivity following nerve injury via voltage-gated potassium channel mechanisms in the rat trigeminal ganglia2017
- Author(s)
  Asako Kubo, Masamichi Shinoda, David C. Yeomans, Koichi Iwata
- Organizer
  10th Congress of the European Pain Federation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11272
[Presentation] Chondroitin sulfate suppresses the low-pH induced mechanical response in thin muscle afferents of rats2017
- Author(s)
  Norio Hotta, Asako Kubo, Kazue Mizumura
- Organizer
  International Society for Autonomic Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11272
[Presentation] Orofacial cutaneous mechanical hypersensitivity following infraorbital nerve injury is attenuated by peripheral Oxytocin in rats.2016
- Author(s)
  A Kubo, M Shinoda, D Yeomans, K Iwata
- Organizer
  International Association for the Study of Pain (IASP)
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-09-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11272
[Presentation] Oxytocin alleviates orofacial hypersensitivity following infraorbital nerve injury in rats.2015
- Author(s)
  Asako KUBO, Masamichi SHINODA, David C. YEOMANS, Koichi IWATA
- Organizer
  Neuroscience 2015
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11272

1. SHINODA Masamichi (20362238)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. IWATA Koichi (60160115)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
3. Katagiri Ayano (40731899)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. SHIBUTA Ikuko (60459906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 本田訓也 (20548945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 林良憲 (80582717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 人見涼露 (70548924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小林真之 (00300830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 太田大樹 (10712432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 八坂敏一 (20568365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田口徹 (90464156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUZUKI Ikuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 坪井美行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 豊福明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 深谷親

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubo Asako 久保 亜抄子

KUBO Asako 久保 亜抄子

Research Projects

Research Products

Co-Researchers

筋／筋膜の温受容をトリガーとする中枢性鎮痛機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経障害後の細胞環境依存的な衛星細胞の機能変化と三叉神経の興奮性変調機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Macrophages in trigeminal ganglion contributes to the ectopic orofacial pain following inferior alveolar nerve injury

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of non-neuronal cell activation in the development of pain following nerve injury.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ectopic orofacial pain mechanisms following inferior alveolar injury

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuroplastic changes in trigeminal nociceptive pathways following trigeminal nerve injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neural mechanism for developing therapy for masseter muscle pain triggered by myofascial pain in the neck shoulderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional recovery of injured inferior alveolar nerve using peripheral glial cell line-derived neurotrophic factor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 筋筋膜性疼痛の基礎 up to date2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Masseter muscle contraction and cervical muscle sensitization by nerve growth factor cause mechanical hyperalgesia in masticatory muscle with activation of the trigemino-lateral parabrachial nucleus system in female rats2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathophysiological mechanisms of persistent orofacial pain2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Oxytocin-dependent regulation of TRPs expression in trigeminal ganglion neurons attenuates orofacial neuropathic pain following intraorbital nerve injury in rats2020

Author(s)

Kubo Asako 久保亜抄子

KUBO Asako 久保亜抄子