Kumazoe Motofumi 熊添基文

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KUMAZOE Motofumi 熊添基文

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Researcher Number	70737212
Other IDs
Affiliation (Current)	2025: 九州大学, 農学研究院, 助教
Affiliation (based on the past Project Information) *help	2024: 九州大学, 農学研究院, 助教 2022: 九州大学, 農学研究院, 助教 2018 – 2020: 九州大学, 農学研究院, 学術研究員 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 2016: 九州大学, 大学院農学研究院, 学術研究員 2015 – 2016: 九州大学, 農学研究院, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Basic Section 38060:Applied molecular and cellular biology-related / Applied molecular and cellular biology Except Principal Investigator Basic Section 48030:Pharmacology-related / Eating habits
Keywords	Principal Investigator cGMP / ケミカルバイオロジー / がん / microRNA / NASH / fibrosis / 食生活 / 抗炎症 / 細胞間シグナル / 内皮細胞 … More / 炎症 / 食品成分 / 病態モデル / 分子細胞生物学 / がん細胞 / CD44 / 抗がん作用 / 67LR / がん幹細胞 / 天然物 / FOXO3 / PDE3 / EGCG / Caner … More Except Principal Investigator cGMP / アクチン細胞骨格 / 細胞骨格 / ANP / アクチン / PAK4 / YAP / 組織繊維化 / Hippo経路 / ナトリウム利尿ペプチド / コホート / 組み合わせ / 食品因子感知遺伝子 / 食品摂取パターン / 健康長寿 / 日本型食事パターン / 食事摂取パターン / バイカレイン / トコトリエノール / 機能性増強 / 掛川コホート / 日本食 / 食事習慣 / Food Factor-Sensing / 食品因子センシング Less

Anti-fibrotic effect of microRNAs in NASH modelsPrincipal Investigator
- Principal Investigator
  
  熊添基文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Kyushu University
The role of endothelial cells in regulation of inflammationPrincipal Investigator
- Principal Investigator
  
  Kumazoe Motofumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Kyushu University
The mechanism of the inhibitory effect of cGMP on cancer stem cell propertiesPrincipal Investigator
- Principal Investigator
  
  Kumazoe Motofumi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Kyushu University
Suppression of tissue fibrosis by ANP and treatment for pulmonary fibrosis
- Principal Investigator
  
  Miura Koichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyushu University
Screening of the novel target for cancer therapy based on the mechanisms of natural compoundsPrincipal Investigator
- Principal Investigator
  
  Kumazoe Motofumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Cardiovascular Center Research Institute
  Kyushu University
Research on food interaction through food factor-sensing
- Principal Investigator
  
  Yamashita Shuya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits
- Research Institution
  National Agriculture and Food Research Organization
  Kyushu University

All 2017 2016 2015 2014

All Journal Article

[Journal Article] PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma2017
- Author(s)
  Kumazoe M. et al
- Journal Title
  
  Scientific Reports
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18821
[Journal Article] γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein2016
- Author(s)
  Yamashita S, Baba K, Makio A, Kumazoe M, Huang Y, Lin IC, Bae J, Murata M, Yamada S, Tachibana H
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: S0006-291X Issue: 4 Pages: 30424-7
- DOI
  10.1016/j.bbrc.2016.03.111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16231, KAKENHI-PROJECT-15H02448
[Journal Article] Anti-cancer effect of EGCG and its mechanisms.2016
- Author(s)
  Kumazoe M., Tachibana T.
- Journal Title
  
  Functional Foods in Health & Disease
  
  Volume: 6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18821
[Journal Article] FOXO3 is essential for CD44 expression in pancreatic cancer cells2016
- Author(s)
  Kumazoe M. et al
- Journal Title
  
  Oncogene
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18821
[Journal Article] Metabolic Profiling-based Data-mining for an Effective Chemical Combination to Induce Apoptosis of Cancer Cells.2015
- Author(s)
  Kumazoe M, Fujimura Y, Hidaka S, Kim Y, Murayama K, Takai M, Huang Y, Yamashita S, Murata M, Miura D, Wariishi H, Maeda-Yamamoto M, Tachibana H.
- Journal Title
  
  Sci Rep.
  
  Volume: 31 Issue: 1 Pages: 9474-9474
- DOI
  10.1038/srep09474
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J03437, KAKENHI-PROJECT-26462066, KAKENHI-PROJECT-15K18821, KAKENHI-PROJECT-14J30004, KAKENHI-PROJECT-15H02448
[Journal Article] Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells.2015
- Author(s)
  Huang Y., Kumazoe M. et. al.(equal contribution)
- Journal Title
  
  Oncology Reports
  
  Volume: 34 Issue: 3 Pages: 1162-1168
- DOI
  10.3892/or.2015.4086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18821, KAKENHI-PROJECT-13J03437, KAKENHI-PROJECT-14J30004, KAKENHI-PROJECT-15H02448
[Journal Article] Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells.2014
- Author(s)
  Kumazoe, M., Tsukamoto, S., Lesnick, C., Kay, N. E. Yamada, K., Shanafelt T. D. and Tachibana, H.
- Journal Title
  
  Br. J. Haematol.
  
  Volume: 168 Issue: 4 Pages: 610-613
- DOI
  10.1111/bjh.13135
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22228002, KAKENHI-PROJECT-15K18821, KAKENHI-PROJECT-14J30004

1. Yamashita Shuya (40706355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. TACHIBANA Hirofumi (70236545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. Miura Koichi (20360349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 錦織充広 (00633645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 野尻崇 (50570553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 藤村由紀 (20390304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAHARA Kanami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. WON Yeong Seon

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MURATA Motoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. LIN I-Chian

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Kumazoe Motofumi 熊添 基文

KUMAZOE Motofumi 熊添 基文

Research Projects

Research Products

Co-Researchers

Anti-fibrotic effect of microRNAs in NASH modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of endothelial cells in regulation of inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of the inhibitory effect of cGMP on cancer stem cell propertiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Suppression of tissue fibrosis by ANP and treatment for pulmonary fibrosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening of the novel target for cancer therapy based on the mechanisms of natural compoundsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on food interaction through food factor-sensing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma2017

Author(s)

Journal Title

Data Source

[Journal Article] γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-cancer effect of EGCG and its mechanisms.2016

Author(s)

Journal Title

Data Source

[Journal Article] FOXO3 is essential for CD44 expression in pancreatic cancer cells2016

Author(s)

Journal Title

Data Source

[Journal Article] Metabolic Profiling-based Data-mining for an Effective Chemical Combination to Induce Apoptosis of Cancer Cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells.2014

Author(s)

Journal Title

DOI

Data Source

Kumazoe Motofumi 熊添基文

KUMAZOE Motofumi 熊添基文