AKIBA HIROKI 秋葉宏樹

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Akiba Hiroki 秋葉宏樹

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Researcher Number	70739945
Other IDs
Affiliation (Current)	2026: 京都大学, 薬学研究科, 講師 2026: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬デザイン研究センター, 研究員
Affiliation (based on the past Project Information) *help	2024: 京都大学, 薬学研究科, 講師 2021 – 2023: 京都大学, 薬学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 27040:Biofunction and bioprocess engineering-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator 抗体工学 / コンジュゲート化学 / 蛋白質工学 / 抗体医薬品 / リンカー / 二重特異性抗体 / 抗体薬物複合体 / 蛍光 / クリックケミストリー / 低分子抗体 / テンプレート反応 / 抗体 … More Except Principal Investigator … More がん治療モダリティ / ワクチンアジュバント / 低分子リガンド / 構造活性相関 / コンジュゲート化 / MR1リガンド / MAIT細胞 / 自然免疫型T細胞 Less

Redesign of biparatopic antibodies through introduction of functional linkersPrincipal Investigator
- Principal Investigator
  
  秋葉宏樹
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Kyoto University
自然免疫型T細胞の機能を利用した新たな創薬モダリティの創出
- Principal Investigator
  
  井貫晋輔
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  The University of Tokushima
Development of fragment antibody targeting system based on antigen-templated chemical reactionPrincipal Investigator
- Principal Investigator
  
  Akiba Hiroki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kyoto University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule2025
- Author(s)
  Akiba Hiroki、Ise Tomoko、Satoh Reiko、Abe Yasuhiro、Tsumoto Kouhei、Ohno Hiroaki、Kamada Haruhiko、Nagata Satoshi
- Journal Title
  
  Antibody Therapeutics
  
  Volume: 8 Issue: 1 Pages: 56-67
- DOI
  10.1093/abt/tbaf002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24196, KAKENHI-PROJECT-24K01270
[Journal Article] Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling2025
- Author(s)
  Matsuoka Takuro、Takasaki Ryosuke、Akiba Hiroki、Ogata Kosuke、Hattori Akira、Arichi Norihito、Kakeya Hideaki、Yamasaki Sho、Ishihama Yasushi、Ohno Hiroaki、Inuki Shinsuke
- Journal Title
  
  Chemical Communications
  
  Volume: 61 Issue: 34 Pages: 6320-6323
- DOI
  10.1039/d4cc04452e
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24H01769, KAKENHI-PROJECT-23K17975, KAKENHI-PROJECT-24K02147
[Journal Article] Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection2023
- Author(s)
  Akiba Hiroki、Fujita Junso、Ise Tomoko、Nishiyama Kentaro、Miyata Tomoko、Kato Takayuki、Namba Keiichi、Ohno Hiroaki、Kamada Haruhiko、Nagata Satoshi、Tsumoto Kouhei
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 987-987
- DOI
  10.1038/s42003-023-05326-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06453, KAKENHI-PLANNED-19H05766
[Journal Article] A Proximity‐Induced Fluorogenic Reaction Triggered by Antibody?Antigen Interactions with Adjacent Epitopes2023
- Author(s)
  Nishiyama Kentaro、Akiba Hiroki、Nagata Satoshi、Tsumoto Kouhei、Kamada Haruhiko、Ohno Hiroaki
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 62 Issue: 30
- DOI
  10.1002/anie.202306431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06453, KAKENHI-PROJECT-23K27294
[Presentation] CD1aに提示されるリポペプチドDDM-838の構造活性相関研究2025
- Author(s)
  岡本将志、森田大輔、秋葉宏樹、服部明、有地法人、掛谷秀昭、大野浩章、井貫晋輔
- Organizer
  日本薬学会第145年会
- Data Source
  KAKENHI-PROJECT-24K02147
[Presentation] Development of a proximity-induced chemical reaction triggered by antibody-antigen interaction2024
- Author(s)
  Kentaro Nishiyama, Hiroki Akiba, Satoshi Nagata, Kouhei Tsumoto, Haruhiko Kamada, Hiroaki Ohno
- Organizer
  ISBC2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01270
[Presentation] ヒンジ領域の伸長による抗TNFR2アゴニストバイパラトピック抗体の機能変換2024
- Author(s)
  大槻拓也、松本篤幸, 金田亮, 奥野恭史, 鎌田春彦, 大野浩章, 秋葉宏樹
- Organizer
  第3回日本抗体学会
- Data Source
  KAKENHI-PROJECT-24K01270
[Presentation] 抗原テンプレート反応におけるリンカー部分の影響2024
- Author(s)
  秋葉宏樹、西山健太郎、鎌田春彦、大野浩章
- Organizer
  第18回バイオ関連科学シンポジウム
- Data Source
  KAKENHI-PROJECT-24K01270
[Presentation] 抗原?抗体相互作用をトリガーとする近接誘導型化学反応の開発2024
- Author(s)
  西山健太郎、秋葉宏樹、鎌田春彦、大野浩章
- Organizer
  第3回日本抗体学会学術大会
- Data Source
  KAKENHI-PROJECT-24K01270
[Presentation] Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by structural modification2024
- Author(s)
  Otsuki Takuya, Hiroki Akiba, Shigeyuki Matsumoto, Ryo Kanada, Junso Fujita, Keiichi Namba, Yasushi Okuno, Haruhiko Kamada, Hiroaki Ohno
- Organizer
  ISBC2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01270
[Presentation] Development of a Proximity-Driven Chemical Reactions Mediated by Antibody-Antigen Interaction2024
- Author(s)
  Kentaro Nishiyama, Hiroki Akiba, Haruhiko Kamada, Hiroaki Ohno
- Organizer
  4th Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01270
[Presentation] CD30に対するバイパラトピック抗体の網羅的評価2024
- Author(s)
  秋葉宏樹、伊勢知子、永田諭志、大野浩章、鎌田春彦
- Organizer
  第２４回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-24K01270
[Presentation] CD1a拘束性T細胞を制御する結核菌由来リポペプチドDDM-838の構造活性相関研究2024
- Author(s)
  岡本将志、森田大輔、秋葉宏樹、服部明、有地法人、掛谷秀昭、大野浩章、井貫晋輔
- Organizer
  第41回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-24K02147
[Presentation] 基礎研究と実用化研究のあいだに2023
- Author(s)
  秋葉宏樹
- Organizer
  第３回蛋白質科学会若手の会研究交流会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] 立体構造情報に基づいた抗原テンプレート反応の開発2023
- Author(s)
  秋葉宏樹、西山健太郎、永田諭志、津本浩平、鎌田春彦、大野浩章
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] 1:1結合型バイパラトピック抗体によるTNFR2アンタゴニストの開発2023
- Author(s)
  秋葉宏樹、藤田純三、伊勢知子、西山健太郎、宮田知子、加藤貴之、難波啓一、大野浩章、鎌田春彦、永田諭志、津本浩平
- Organizer
  第２回日本抗体学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] 抗 TNFR2バイパラトピックアンタゴニスト抗体の特性解析2023
- Author(s)
  秋葉宏樹、藤田純三、伊勢知子、西山健太郎、宮田知子、加藤貴之、難波啓一、大野浩章、鎌田春彦、永田諭志、津本浩平
- Organizer
  日本薬学会第１４３年会
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] 1:1結合型バイパラトピック抗体の創出と利用2023
- Author(s)
  秋葉宏樹、大槻拓也、藤田純三、伊勢知子、永田諭志、津本浩平、難波啓一、鎌田春彦、大野浩章
- Organizer
  第１７回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] 1:1結合型バイパラトピック抗体による機能開拓2023
- Author(s)
  秋葉宏樹
- Organizer
  日本薬学会第144年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] 抗原テンプレート反応を利用するための抗体選択の戦略2023
- Author(s)
  西山健太郎、秋葉宏樹、鎌田春彦、大野浩章
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] PEG リンカーの伸長による抗原テンプレート反応の促進2023
- Author(s)
  西山健太郎、秋葉宏樹、永田諭志、津本浩平、鎌田春彦、大野浩章
- Organizer
  第１７回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] クリックケミストリーによるTNFR2分子上での蛍光性バイパラトピック抗体の形成2022
- Author(s)
  西山健太郎、秋葉宏樹、永田諭志、津本浩平、鎌田春彦、大野浩章
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] Fluorogenic click reactionを用いた抗原上でのバイパラトピック抗体形成の可視化2022
- Author(s)
  西山健太郎、秋葉宏樹、永田諭志、津本浩平、鎌田春彦、大野浩章
- Organizer
  日本ケミカルバイオロジー学会　第１６回年会
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] 近接する抗体エピトープを蛍光により可視化する技術の開発2022
- Author(s)
  秋葉宏樹、西山健太郎、永田諭志、津本浩平、鎌田春彦、大野浩章
- Organizer
  日本分子イメージング学会第１６回学術集会
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] 抗体抗原間の相互作用により加速されるひずみ解消型Click反応2022
- Author(s)
  西山健太郎、秋葉宏樹、永田諭志、津本浩平、鎌田春彦、大野浩章
- Organizer
  第１６回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06453
[Presentation] Visualization of Antigen Binding on DNA Origami Using Atomic Force Microscopy2021
- Author(s)
  Yuki Minamide, Kentaro Nishiyama, Tomoya Niki, Hiroki Akiba, Satoshi Nagata, Haruhiko Kamada, Hiroaki Ohno, Akinori Kuzuya
- Organizer
  CBI学会2021年大会
- Data Source
  KAKENHI-PROJECT-21K06453

1. 中山泰亮 (90467598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 井貫晋輔 (70736272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 高橋有己 (00547870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 鎌田春彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 永田諭志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKIBA HIROKI 秋葉 宏樹

Akiba Hiroki 秋葉 宏樹

Research Projects

Research Products

Co-Researchers

Redesign of biparatopic antibodies through introduction of functional linkersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自然免疫型T細胞の機能を利用した新たな創薬モダリティの創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of fragment antibody targeting system based on antigen-templated chemical reactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Proximity‐Induced Fluorogenic Reaction Triggered by Antibody?Antigen Interactions with Adjacent Epitopes2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] CD1aに提示されるリポペプチドDDM-838の構造活性相関研究2025

Author(s)

Organizer

Data Source

[Presentation] Development of a proximity-induced chemical reaction triggered by antibody-antigen interaction2024

Author(s)

Organizer

Data Source

[Presentation] ヒンジ領域の伸長による抗TNFR2アゴニストバイパラトピック抗体の機能変換2024

Author(s)

Organizer

Data Source

[Presentation] 抗原テンプレート反応におけるリンカー部分の影響2024

Author(s)

Organizer

Data Source

[Presentation] 抗原?抗体相互作用をトリガーとする近接誘導型化学反応の開発2024

Author(s)

Organizer

Data Source

[Presentation] Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by structural modification2024

Author(s)

Organizer

Data Source

[Presentation] Development of a Proximity-Driven Chemical Reactions Mediated by Antibody-Antigen Interaction2024

Author(s)

Organizer

Data Source

[Presentation] CD30に対するバイパラトピック抗体の網羅的評価2024

Author(s)

Organizer

Data Source

[Presentation] CD1a拘束性T細胞を制御する結核菌由来リポペプチドDDM-838の構造活性相関研究2024

Author(s)

Organizer

Data Source

[Presentation] 基礎研究と実用化研究のあいだに2023

AKIBA HIROKI 秋葉宏樹

Akiba Hiroki 秋葉宏樹