Toshimoto Kota 年本広太

Researcher Number	70740504
Affiliation (based on the past Project Information) *help	2022: 国立研究開発法人理化学研究所, 科技ハブ産連本部, 特別研究員 2018 – 2019: 国立研究開発法人理化学研究所, 科技ハブ産連本部, 特別研究員 2016 – 2017: 国立研究開発法人理化学研究所, イノベーション推進センター, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 仮想臨床試験 / 遺伝子多型 / モデリング＆シミュレーション / 薬物動態学 / 分子標的薬 / 個人間変動 / モデリング＆シミュテーション / 薬物相互作用 / 生理学的薬物速度論モデル / 個別医療 … More Except Principal Investigator … More アルブミン介在性輸送 / トランスポータ / 仮想臨床試験 / モデリング＆シミュレーション / 個人間変動 / 薬物動態 / 内在性バイオマーカー / 生理学的薬物速度論モデル（PBPK） / 薬物間相互作用 / In vitroからin vivoへの予測 / 薬物間相互作用　（DDI） / 生理学的薬物速度論（PBPKモデル） Less

Establishment of a virtual clinical trial system considering variations in factors governing drug tissue distribution, efficacy, and side effects.
- Principal Investigator
  
  Sugiyama Yuichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Josai International University
  Institute of Physical and Chemical Research
Prediction of interindividual variability about adverse effect caused by molecular target drugs using physiologacal mechanism based mathematical modelPrincipal Investigator
- Principal Investigator
  
  Toshimoto Kota
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Institute of Physical and Chemical Research
Comprehensive analysis of influencing factor of effect/adverse effect for anti-cancer drug using virtual clinical studyPrincipal Investigator
- Principal Investigator
  
  Toshimoto Kota
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Institute of Physical and Chemical Research

All 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B2021
- Author(s)
  Park Ji Eun、Shitara Yoshihisa、Lee Wooin、Morita Shigemichi、Sahi Jasminder、Toshimoto Kota、Sugiyama Yuichi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 110 Issue: 1 Pages: 517-528
- DOI
  10.1016/j.xphs.2020.10.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes2021
- Author(s)
  Yoshikado Takashi、Lee Wooin、Toshimoto Kota、Morita Kiyoe、Kiriake Aya、Chu Xiaoyan、Lee Nora、Kimoto Emi、Varma Manthena V.S.、Kikuchi Ryota、Scialis Renato J.、Shen Hong、Ishiguro Naoki、Lotz Ralf、Li Albert P.、Maeda Kazuya、Kusuhara Hiroyuki、Sugiyama Yuichi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 110 Issue: 1 Pages: 376-387
- DOI
  10.1016/j.xphs.2020.10.041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine2019
- Author(s)
  Nishiyama K, Toshimoto K, Lee W, Ishiguro N, Bister B, Sugiyama Y
- Journal Title
  
  CPT Pharmacometrics Syst Pharmacol
  
  Volume: 8 Issue: 6 Pages: 396-406
- DOI
  10.1002/psp4.12398
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03392
[Journal Article] Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics2018
- Author(s)
  Sato M, Toshimoto K, Tomaru A, Yoshikado T, Tanaka Y, Hisaka A, Lee W, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 46 Issue: 5 Pages: 740-748
- DOI
  10.1124/dmd.117.078972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18972
[Journal Article] Application of PBPK modeling and virtual clinical study approaches to predict the outcomes of CYP2D6 genotype-guided dosing of tamoxifen2018
- Author(s)
  Nakamura T, Toshimoto K, Lee W, Imamura CK, Tanigawara Y, Sugiyma Y
- Journal Title
  
  CPT Pharmacometrics Syst Pharmacol
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18972
[Journal Article] Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin2018
- Author(s)
  Futatsugi Azusa、Toshimoto Kota、Yoshikado Takashi、Sugiyama Yuichi、Kato Yukio
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 46 Issue: 5 Pages: 749-757
- DOI
  10.1124/dmd.117.078816
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04664, KAKENHI-PROJECT-16K18972, KAKENHI-PROJECT-18H02584
[Journal Article] Is ethnic variability in the exposure to rosuvastatin explained only by genetic polymorphisms in OATP1B1 and BCRP or should the contribution of intrinsic ethnic differences in OATP1B1 be considered?2017
- Author(s)
  Sugiyama Y, Maeda K, Toshimoto K.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中 Issue: 9 Pages: 2227-2230
- DOI
  10.1016/j.xphs.2017.04.074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-16K18972
[Journal Article] Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects.2017
- Author(s)
  Toshimoto K, Tomaru A, Hosokawa M, Sugiyama Y.
- Journal Title
  
  Pharm Res
  
  Volume: 印刷中 Issue: 8 Pages: 1584-1600
- DOI
  10.1007/s11095-017-2153-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-16K18972
[Journal Article] Analysis of the change in the blood concentration-time profile caused by complex drug-drug interactions in the liver considering the enterohepatic circulation: Examining whether the inhibition constants for uptake, metabolism and biliary excretion can be recovered by the analyses using physiologically based pharmacokinetic modeling.2017
- Author(s)
  Toshimoto K, Tomoda Y, Chiba K, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中 Issue: 9 Pages: 2727-2738
- DOI
  10.1016/j.xphs.2017.04.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-16K18972
[Presentation] PBPK modeling and virtual clinical study for drug-drug interactions (DDI) between repaglinide and gemfibrozil: Variability in OATP1B1 activity impacting AUC changes for repaglinide2019
- Author(s)
  Sato M, Lee W, Toshimoto K, Sugiyama Y
- Organizer
  日本薬物動態学会第愛34回年会
- Data Source
  KAKENHI-PROJECT-18K14971
[Presentation] PBPKモデルを用いたパラメータ最適化で得られた薬物阻害定数の妥当性検証2017
- Author(s)
  年本　広太、友田　有加菜、千葉　康司、杉山　雄一
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-16K18972
[Presentation] Prospective prediction of the clinical efficacy of tamoxifen: application of a virtual clinical study2017
- Author(s)
  Nakamura T, Toshimoto K, Imamura CK, Tanigawara Y, Sugiyma Y
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-16K18972
[Presentation] Virtual Clinical Studyを用いた効率的な医薬品開発の提案2017
- Author(s)
  年本　広太
- Organizer
  第２４回ＨＡＢ研究機構　学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18972
[Presentation] Application of virtual clinical studies using physiologically-based pharmacokinetic modeling to analyses of the association of side effects of CPT-11 with genetic polymorphism of enzymes and transporters.2017
- Author(s)
  Toshimoto K, Sugiyama Y
- Organizer
  6th FIP Pharmaceutical Sciences World Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18972
[Presentation] Are inhibition constants (Ki) correctly estimated using only the blood concentration time profile of substrate drugs with and without co-administration of inhibitor drugs?2016
- Author(s)
  Toshimoto K, Tomoda Y, Chiba K, Sugiyama Y
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K18972
[Presentation] The novel physiologically based pharmacoki- netics (PBPK) model to investigate transporter-mediated disposition and clearance of metformin in humans.2016
- Author(s)
  Nishiyama K, Toshimoto K, Ishiguro N, Sugiyama Y
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K18972
[Presentation] Prediction of inter-individual differences in pharmacokinetics and drug interactions of pravastatin using physiologically based pharmacokinetics model with Monte Carlo simulation.2016
- Author(s)
  Matsumoto T, Toshimoto K, Chiba K, Sugiyama Y
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K18972

1. Sugiyama Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 吉門崇 (70535096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 速水謙 (20251358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小山智志 (60805761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 加藤将夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 前田和哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Toshimoto Kota 年本 広太

Research Projects

Research Products

Co-Researchers

Establishment of a virtual clinical trial system considering variations in factors governing drug tissue distribution, efficacy, and side effects.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction of interindividual variability about adverse effect caused by molecular target drugs using physiologacal mechanism based mathematical modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of influencing factor of effect/adverse effect for anti-cancer drug using virtual clinical studyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of PBPK modeling and virtual clinical study approaches to predict the outcomes of CYP2D6 genotype-guided dosing of tamoxifen2018

Author(s)

Journal Title

Data Source

[Journal Article] Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Is ethnic variability in the exposure to rosuvastatin explained only by genetic polymorphisms in OATP1B1 and BCRP or should the contribution of intrinsic ethnic differences in OATP1B1 be considered?2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects.2017

Author(s)

Journal Title

DOI

Data Source

Author(s)

Journal Title

DOI

Data Source

[Presentation] PBPK modeling and virtual clinical study for drug-drug interactions (DDI) between repaglinide and gemfibrozil: Variability in OATP1B1 activity impacting AUC changes for repaglinide2019

Author(s)

Organizer

Data Source

[Presentation] PBPKモデルを用いたパラメータ最適化で得られた薬物阻害定数の妥当性検証2017

Author(s)

Organizer

Data Source

[Presentation] Prospective prediction of the clinical efficacy of tamoxifen: application of a virtual clinical study2017

Author(s)

Organizer

Data Source

[Presentation] Virtual Clinical Studyを用いた効率的な医薬品開発の提案2017

Author(s)

Organizer

Toshimoto Kota 年本広太