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KUBOTA SHO  久保田 翔

… Alternative Names

Kubota Sho  久保田 翔

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Researcher Number 70747831
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6119-1259
Affiliation (Current) 2025: 岡山大学, 医歯薬学域, 助教
Affiliation (based on the past Project Information) *help 2023 – 2024: 岡山大学, 医歯薬学域, 助教
2022: 熊本大学, 国際先端医学研究機構, 特任助教
2020 – 2021: 熊本大学, 国際先端医学研究機構, 特定事業研究員
2018 – 2019: 熊本大学, 国際先端医学研究機構, 特別研究員(SPD・PD・RPD)
2017: 熊本大学, 国際先端医学研究機構, 特別研究員(PD・RPD)
2016: 熊本大学, 国際先端医学研究機構, 特定事業研究員
2015: 熊本大学, 国際先端医学研究機構, 特別研究員(PD)
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Hematology
Except Principal Investigator
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Keywords
Principal Investigator
エピゲノム / 白血病 / 造血幹細胞 / エピジェネティクス / バイオインフォマティクス / DNAメチル化 / 環境化学物質 / 造血 / がん / 年齢依存 … More / 小児 / MLL / enhancer hijacking / Super-enhancer / MYC / RUNX2 / スーパーエンハンサー / 染色体転座 / エンハンサー / BPDCN / チロシンリン酸化 / 血液学 / 造血器腫瘍 / TIF1 / TIF1beta / KAP1 / CML / BCR-ABL … More
Except Principal Investigator
病態形成 / エピゲノム / 一酸化窒素 / 健康維持 / 酸化ストレス / 健康 / DNAメチル化 Less
  • Research Projects

    (6 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (18 People)
  •  Elucidation of the mechanism of epigenome dysregulation by environmental chemicalsPrincipal Investigator

    • Principal Investigator
      久保田 翔
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Okayama University
  •  Integrated understanding of the mechanisms of maintenance and breakdown of epigenomic resilience for health

    • Principal Investigator
      上原 孝
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Okayama University
  •  健康・老化・老人性疾患における酸化ストレス依存的エピゲノム変化の意義

    • Principal Investigator
      上原 孝
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Fund for the Promotion of Joint International Research (International Collaborative Research)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Okayama University
  •  Age dependent MLL-fusion leukemia developmentPrincipal Investigator

    • Principal Investigator
      Kubota Sho
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Okayama University
      Kumamoto University
  •  Leukemic development through chromosomal translocation with super-enhancer exchangePrincipal Investigator

    • Principal Investigator
      Kubota Sho
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  Roles of tyrosine phosphorylation of KAP1 in leukemogenesisPrincipal Investigator

    • Principal Investigator
      Kubota Sho
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2015

All Journal Article Presentation

  • [Journal Article] Multiple myeloma?associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis2024

    • Author(s)
      Ohguchi Hiroto、Ohguchi Yasuyo、Kubota Sho、Etoh Kan、Hamashima Ai、Usuki Shingo、Yokomizo-Nakano Takako、Bai Jie、Masuda Takeshi、Kawano Yawara、Harada Takeshi、Nakao Mitsuyoshi、Minami Takashi、Hideshima Teru、Araki Kimi、Sashida Goro
    • Journal Title

      Blood Neoplasia

      Volume: 1 Issue: 1 Pages: 100005-100005

    • DOI

      10.1016/j.bneo.2024.100005

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07862, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-22H04922
  • [Journal Article] Attenuation of protein arginine dimethylation via S-nitrosylation of protein arginine methyltransferase 12024

    • Author(s)
      Rikako Taniguchi, Yuto Moriya, Naoshi Dohmae, Takehiro Suzuki, Kengo Nakahara, Sho Kubota, Nobumasa Takasugi, Takashi Uehara.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 154 Issue: 3 Pages: 209-217

    • DOI

      10.1016/j.jphs.2023.12.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08421
  • [Journal Article] Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling2024

    • Author(s)
      Morimoto Atsushi、Takasugi Nobumasa、Pan Yuexuan、Kubota Sho、Dohmae Naoshi、Abiko Yumi、Uchida Koji、Kumagai Yoshito、Uehara Takashi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 300 Issue: 3 Pages: 105679-105679

    • DOI

      10.1016/j.jbc.2024.105679

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K12180, KAKENHI-PROJECT-21K08421
  • [Journal Article] Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs2023

    • Author(s)
      Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Iimori M, Morii M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G.
    • Journal Title

      Journal of Experimental Medicine (JEM)

      Volume: 220 (7) Issue: 7 Pages: 9999-9999

    • DOI

      10.1084/jem.20220962

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KJ2522, KAKENHI-PROJECT-21K19512, KAKENHI-PROJECT-22K16304, KAKENHI-PROJECT-21K06870, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K08421, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21H02952
  • [Journal Article] ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration2022

    • Author(s)
      Umemoto Terumasa、Johansson Alban、Ahmad Shah Adil Ishtiyaq、Hashimoto Michihiro、Kubota Sho、Kikuchi Kenta、Odaka Haruki、Era Takumi、Kurotaki Daisuke、Sashida Goro、Suda Toshio
    • Journal Title

      The EMBO Journal

      Volume: 41 Issue: 8 Pages: 1-20

    • DOI

      10.15252/embj.2021109463

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-22K15660, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-21K16272
  • [Journal Article] The acidic domain of Hmga2 and the domain's linker region are critical for driving self-renewal of hematopoietic stem cell.2022

    • Author(s)
      Sun Y, Kubota S, Iimori M, Hamashima A, Murakami H, Bai J, Morii M, Yokomizo-Nakano T, Osato M, Araki K, Sashida G.
    • Journal Title

      Int J Hematol.

      Volume: 115 Issue: 4 Pages: 553-562

    • DOI

      10.1007/s12185-021-03274-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-21H02952, KAKENHI-PROJECT-21K19512, KAKENHI-PROJECT-23K21285
  • [Journal Article] CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma2022

    • Author(s)
      Takuro Kameda, ...Sho Kubota.... , Kazuya Shimoda
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 1309-1309

    • DOI

      10.1038/s42003-022-04284-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-20K08715, KAKENHI-PROJECT-23K24079
  • [Journal Article] HMGN3 represses transcription of epithelial regulators to promote migration of cholangiocarcinoma in a SNAI2-dependent manner2022

    • Author(s)
      Supannika Sorin, Sho Kubota, Sofiane Hamidi, Takako Yokomizo-Nakano, Kulthida Vaeteewoottacharn, Sopit Wongkham, Sakda Waraasawapati, Chawalit Pairojkul, Jie Bai, Mariko Morii, Guojun Sheng, Kanlayanee Sawanyawisuth, Goro Sashida
    • Journal Title

      The FASEB Journal

      Volume: 36 Issue: 7

    • DOI

      10.1096/fj.202200386r

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-21H02490, KAKENHI-PROJECT-21H02952
  • [Journal Article] Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome2020

    • Author(s)
      Yokomizo-Nakano Takako、Kubota Sho、Bai Jie、Hamashima Ai、Morii Mariko、Sun Yuqi、Katagiri Seiichiro、Iimori Mihoko、Kanai Akinori、Tanaka Daiki、Oshima Motohiko、Harada Yuka、Ohyashiki Kazuma、Iwama Atsushi、Harada Hironori、Osato Motomi、Sashida Goro
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 12 Pages: 2523-2536

    • DOI

      10.1158/0008-5472.can-19-3167

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K07840, KAKENHI-PROJECT-19K16811, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196
  • [Journal Article] Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak.2020

    • Author(s)
      Kuan JW, Su AT, Tay SP, Fong IL, Kubota S, Su'ut L, Osato M, Sashida G.
    • Journal Title

      International Journal of Hematology

      Volume: 111 Issue: 2 Pages: 217-224

    • DOI

      10.1007/s12185-019-02768-x

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
  • [Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm2019

    • Author(s)
      Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
    • Journal Title

      Nat Commun

      Volume: 10 Issue: 1 Pages: 1653-1653

    • DOI

      10.1038/s41467-019-09710-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K07244, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
  • [Journal Article] Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology2019

    • Author(s)
      Tenjin Yuki、Kudoh Shinji、Kubota Sho、Yamada Tatsuya、Matsuo Akira、Sato Younosuke、Ichimura Takaya、Kohrogi Hirotsugu、Sashida Goro、Sakagami Takuro、Ito Takaaki
    • Journal Title

      Laboratory Investigation

      Volume: 99 Issue: 11 Pages: 1622-1635

    • DOI

      10.1038/s41374-019-0277-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08655, KAKENHI-PROJECT-18K19480, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
  • [Journal Article] Src acts as an effector for Ku70-dependent suppression of apoptosis through phosphorylation of Ku70 at Tyr-5302017

    • Author(s)
      Morii, M., Kubota, S., Honda, T., Yuki, R., Morinaga, T., Kuga, T., Tomonaga, T., Yamaguchi, N.-t., and Yamaguchi, N.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 5 Pages: 1648-1665

    • DOI

      10.1074/jbc.m116.753202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H06672, KAKENHI-PROJECT-16J04141, KAKENHI-PROJECT-16J04363, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-16K08227, KAKENHI-PROJECT-17J02389, KAKENHI-PROJECT-15K19545
  • [Journal Article] Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in its Dissociation from Chromatin and the Nuclear Matrix2015

    • Author(s)
      Kubota S, Morii M, Yuki R, Yamaguchi N, Yamaguchi H, Aoyama K, Kuga T, Tomonaga T, Yamaguchi N.
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 17 Pages: 10891-904

    • DOI

      10.1074/jbc.m115.643882

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K19545, KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
  • [Journal Article] c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21.2015

    • Author(s)
      Noritaka Yamaguchi, Ryuzaburo Yuki, Sho Kubota, Kazumasa Aoyama, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi.
    • Journal Title

      Biochemical Journal

      Volume: 471 Issue: 1 Pages: 67-77

    • DOI

      10.1042/bj20150372

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K19545, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-25460356, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
  • [Presentation] HMGA による造血幹細胞制御機構の解析2023

    • Author(s)
      久保田翔、白潔、森井真理子 、平山真弓 、指田吾郎
    • Organizer
      第 27 回造血器腫瘍研究会
    • Data Source
      KAKENHI-PROJECT-21K08421
  • [Presentation] Hmga2による炎症応答制御を介した造血幹細胞再生機構と骨髄異形成症候群2023

    • Author(s)
      久保田 翔
    • Organizer
      第97回日本薬理学会年会 シンポジウム講演
    • Data Source
      KAKENHI-PROJECT-21K08421
  • [Presentation] Inflammatory stress tolerance of hematopoietic stem cell is activated by Hmga22022

    • Author(s)
      Sho Kubota
    • Organizer
      The 5th KU-KAIST Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08421
  • [Presentation] HMGA2 maintains hematopoietic stem cell via pleiotropic regulation of the transcription in stress conditions2021

    • Author(s)
      Sho Kubota, Yuqi Sun, Jie Bai, Takako Yokomizo-Nakano, Mariko Morii, Takako Ideue, Motomi Osato, Terumasa Umemoto, Kimi Araki, and Goro Sashida
    • Organizer
      Annual meeting of American Society of Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08421
  • [Presentation] The age-specific induction of MLL-AF9 regulates the leukemic transformation2019

    • Author(s)
      Ayaka Maeda, Sho Kubota, Yuqi Sun, Kimi Araki, Motomi Osato, and Goro Sashida
    • Organizer
      日本血液学会
    • Data Source
      KAKENHI-PROJECT-18K16090
  • [Presentation] 樹状細胞特異的RUNX2スーパーエンハンサーによるMYCの活性化を介したBPDCNの発症メカニズムの解析2018

    • Author(s)
      久保田翔, 梅津知宏, 岩間厚志, 大屋敷一馬, 大里元美, 指田吾郎
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K16090
  • [Presentation] RUNX2 super enhancer promotes the development of blastic plasmacytoid dendritic cell neoplasm2017

    • Author(s)
      Sho Kubota, Kenji Tokunaga, Motohiko Oshima, Tomohiro Umezu, Akinori Kanai, Kar Ton Tan, Henry Yang, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, and Goro Sashida
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K19545
  • [Presentation] がん遺伝子v-Srcによる細胞周期進行抑制の分子機構2017

    • Author(s)
      本田 拓也、鈴木 亘、森井 真理子、添田 修平、阿部 紘平、山口 千尋、久保田 翔、青山 和正、中山 祐治、山口 憲孝、山口 直人
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K19545
  • [Presentation] UV照射によるアポトーシス誘導におけるSrcシグナリングの役割.2015

    • Author(s)
      森井真理子, 久保田 翔, 本田拓也, 青山和正, 幸 龍三郎, 米谷詩織, 山口憲孝, 山口直人.
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K19545
  • [Presentation] Src型チロシンキナーゼによるBaxを介したアポトーシス誘導の制御.2015

    • Author(s)
      森井真理子, 久保田 翔, 本田拓也, 青山和正, 幸 龍三郎, 米谷詩織, 山口憲孝, 山口直人.
    • Organizer
      第14回次世代を担う若手ファーマ・バイオフォーラム2015
    • Place of Presentation
      千葉大学
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-15K19545
  • 1.  上原 孝 (00261321)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  Sashida Goro (70349447)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  筒井 正人 (70309962)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  座間味 義人 (70550250)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  柳田 翔太 (20995493)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  諫田 泰成 (70510387)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HARADA Yuka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  OSHIMA Masanobu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  YAMAGUCHI Noritaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  幸 龍三郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  青山 和正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  原田 浩徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  松尾 顕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  梅本 晃正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  大里 元美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  大口 裕人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  山口 直人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  安孫子 ユミ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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