KUBOTA SHO 久保田翔

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Kubota Sho 久保田翔

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Researcher Number	70747831
Other IDs	https://orcid.org/0000-0001-6119-1259
Affiliation (Current)	2024: 岡山大学, 医歯薬学域, 助教
Affiliation (based on the past Project Information) *help	2024: 岡山大学, 医歯薬学域, 助教 2022: 熊本大学, 国際先端医学研究機構, 特任助教 2020 – 2021: 熊本大学, 国際先端医学研究機構, 特定事業研究員 2018 – 2019: 熊本大学, 国際先端医学研究機構, 特別研究員(SPD・PD・RPD) 2017: 熊本大学, 国際先端医学研究機構, 特別研究員(PD・RPD) 2016: 熊本大学, 国際先端医学研究機構, 特定事業研究員 2015: 熊本大学, 国際先端医学研究機構, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Hematology Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Keywords	Principal Investigator エピゲノム / 白血病 / エピジェネティクス / バイオインフォマティクス / DNAメチル化 / 環境化学物質 / 造血 / 小児 / MLL / enhancer hijacking … More / Super-enhancer / MYC / RUNX2 / スーパーエンハンサー / 染色体転座 / エンハンサー / BPDCN / チロシンリン酸化 / 造血幹細胞 / 血液学 / 造血器腫瘍 / TIF1 / TIF1beta / KAP1 / CML / BCR-ABL … More Except Principal Investigator 健康 / 病態形成 / DNAメチル化 / エピゲノム / 一酸化窒素 Less

Elucidation of the mechanism of epigenome dysregulation by environmental chemicalsPrincipal Investigator
- Principal Investigator
  
  久保田翔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Okayama University
Integrated understanding of the mechanisms of maintenance and breakdown of epigenomic resilience for health
- Principal Investigator
  
  上原孝
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Okayama University
MLL融合白血病発症を受容する胎児造血幹細胞形質の解析Principal Investigator
- Principal Investigator
  
  久保田翔
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Leukemic development through chromosomal translocation with super-enhancer exchangePrincipal Investigator
- Principal Investigator
  
  Kubota Sho
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Roles of tyrosine phosphorylation of KAP1 in leukemogenesisPrincipal Investigator
- Principal Investigator
  
  Kubota Sho
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University

All 2023 2022 2021 2020 2019 2018 2017 2015 Other

All Journal Article Presentation Other

[Journal Article] ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration2022
- Author(s)
  Umemoto Terumasa、Johansson Alban、Ahmad Shah Adil Ishtiyaq、Hashimoto Michihiro、Kubota Sho、Kikuchi Kenta、Odaka Haruki、Era Takumi、Kurotaki Daisuke、Sashida Goro、Suda Toshio
- Journal Title
  
  The EMBO Journal
  
  Volume: 41 Issue: 8 Pages: 1-20
- DOI
  10.15252/embj.2021109463
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-22K15660, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-21K16272
[Journal Article] CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma2022
- Author(s)
  Takuro Kameda, ...Sho Kubota.... , Kazuya Shimoda
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 1309-1309
- DOI
  10.1038/s42003-022-04284-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-20K08715, KAKENHI-PROJECT-23K24079
[Journal Article] HMGN3 represses transcription of epithelial regulators to promote migration of cholangiocarcinoma in a SNAI2-dependent manner2022
- Author(s)
  Supannika Sorin, Sho Kubota, Sofiane Hamidi, Takako Yokomizo-Nakano, Kulthida Vaeteewoottacharn, Sopit Wongkham, Sakda Waraasawapati, Chawalit Pairojkul, Jie Bai, Mariko Morii, Guojun Sheng, Kanlayanee Sawanyawisuth, Goro Sashida
- Journal Title
  
  The FASEB Journal
  
  Volume: 36 Issue: 7
- DOI
  10.1096/fj.202200386r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-21H02490, KAKENHI-PROJECT-21H02952
[Journal Article] Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome2020
- Author(s)
  Yokomizo-Nakano Takako、Kubota Sho、Bai Jie、Hamashima Ai、Morii Mariko、Sun Yuqi、Katagiri Seiichiro、Iimori Mihoko、Kanai Akinori、Tanaka Daiki、Oshima Motohiko、Harada Yuka、Ohyashiki Kazuma、Iwama Atsushi、Harada Hironori、Osato Motomi、Sashida Goro
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 12 Pages: 2523-2536
- DOI
  10.1158/0008-5472.can-19-3167
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K07840, KAKENHI-PROJECT-19K16811, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196
[Journal Article] Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak.2020
- Author(s)
  Kuan JW, Su AT, Tay SP, Fong IL, Kubota S, Su'ut L, Osato M, Sashida G.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 111 Issue: 2 Pages: 217-224
- DOI
  10.1007/s12185-019-02768-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
[Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm2019
- Author(s)
  Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
- Journal Title
  
  Nat Commun
  
  Volume: 10 Issue: 1 Pages: 1653-1653
- DOI
  10.1038/s41467-019-09710-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K07244, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
[Journal Article] Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology2019
- Author(s)
  Tenjin Yuki、Kudoh Shinji、Kubota Sho、Yamada Tatsuya、Matsuo Akira、Sato Younosuke、Ichimura Takaya、Kohrogi Hirotsugu、Sashida Goro、Sakagami Takuro、Ito Takaaki
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 11 Pages: 1622-1635
- DOI
  10.1038/s41374-019-0277-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08655, KAKENHI-PROJECT-18K19480, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
[Journal Article] Src acts as an effector for Ku70-dependent suppression of apoptosis through phosphorylation of Ku70 at Tyr-5302017
- Author(s)
  Morii, M., Kubota, S., Honda, T., Yuki, R., Morinaga, T., Kuga, T., Tomonaga, T., Yamaguchi, N.-t., and Yamaguchi, N.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 5 Pages: 1648-1665
- DOI
  10.1074/jbc.m116.753202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06672, KAKENHI-PROJECT-16J04141, KAKENHI-PROJECT-16J04363, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-16K08227, KAKENHI-PROJECT-17J02389, KAKENHI-PROJECT-15K19545
[Journal Article] Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in its Dissociation from Chromatin and the Nuclear Matrix2015
- Author(s)
  Kubota S, Morii M, Yuki R, Yamaguchi N, Yamaguchi H, Aoyama K, Kuga T, Tomonaga T, Yamaguchi N.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 17 Pages: 10891-904
- DOI
  10.1074/jbc.m115.643882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K19545, KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
[Journal Article] c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21.2015
- Author(s)
  Noritaka Yamaguchi, Ryuzaburo Yuki, Sho Kubota, Kazumasa Aoyama, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi.
- Journal Title
  
  Biochemical Journal
  
  Volume: 471 Issue: 1 Pages: 67-77
- DOI
  10.1042/bj20150372
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K19545, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-25460356, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
[Presentation] HMGA による造血幹細胞制御機構の解析2023
- Author(s)
  久保田翔、白潔、森井真理子、平山真弓、指田吾郎
- Organizer
  第 27 回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-21K08421
[Presentation] Inflammatory stress tolerance of hematopoietic stem cell is activated by Hmga22022
- Author(s)
  Sho Kubota
- Organizer
  The 5th KU-KAIST Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08421
[Presentation] HMGA2 maintains hematopoietic stem cell via pleiotropic regulation of the transcription in stress conditions2021
- Author(s)
  Sho Kubota, Yuqi Sun, Jie Bai, Takako Yokomizo-Nakano, Mariko Morii, Takako Ideue, Motomi Osato, Terumasa Umemoto, Kimi Araki, and Goro Sashida
- Organizer
  Annual meeting of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08421
[Presentation] The age-specific induction of MLL-AF9 regulates the leukemic transformation2019
- Author(s)
  Ayaka Maeda, Sho Kubota, Yuqi Sun, Kimi Araki, Motomi Osato, and Goro Sashida
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K16090
[Presentation] 樹状細胞特異的RUNX2スーパーエンハンサーによるMYCの活性化を介したBPDCNの発症メカニズムの解析2018
- Author(s)
  久保田翔, 梅津知宏, 岩間厚志, 大屋敷一馬, 大里元美, 指田吾郎
- Organizer
  第７７回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16090
[Presentation] RUNX2 super enhancer promotes the development of blastic plasmacytoid dendritic cell neoplasm2017
- Author(s)
  Sho Kubota, Kenji Tokunaga, Motohiko Oshima, Tomohiro Umezu, Akinori Kanai, Kar Ton Tan, Henry Yang, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, and Goro Sashida
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K19545
[Presentation] がん遺伝子v-Srcによる細胞周期進行抑制の分子機構2017
- Author(s)
  本田拓也、鈴木亘、森井真理子、添田修平、阿部紘平、山口千尋、久保田翔、青山和正、中山祐治、山口憲孝、山口直人
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K19545
[Presentation] UV照射によるアポトーシス誘導におけるSrcシグナリングの役割.2015
- Author(s)
  森井真理子, 久保田翔, 本田拓也, 青山和正, 幸龍三郎, 米谷詩織, 山口憲孝, 山口直人.
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K19545
[Presentation] Src型チロシンキナーゼによるBaxを介したアポトーシス誘導の制御.2015
- Author(s)
  森井真理子, 久保田翔, 本田拓也, 青山和正, 幸龍三郎, 米谷詩織, 山口憲孝, 山口直人.
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K19545
[]

1. Sashida Goro (70349447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 上原孝 (00261321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 筒井正人 (70309962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 座間味義人 (70550250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. OSHIMA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. YAMAGUCHI Noritaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 幸龍三郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 青山和正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 松尾顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 梅本晃正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山口直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 大里元美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBOTA SHO 久保田 翔

Kubota Sho 久保田 翔

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of epigenome dysregulation by environmental chemicalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated understanding of the mechanisms of maintenance and breakdown of epigenomic resilience for health

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MLL融合白血病発症を受容する胎児造血幹細胞形質の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Leukemic development through chromosomal translocation with super-enhancer exchangePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of tyrosine phosphorylation of KAP1 in leukemogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HMGN3 represses transcription of epithelial regulators to promote migration of cholangiocarcinoma in a SNAI2-dependent manner2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Src acts as an effector for Ku70-dependent suppression of apoptosis through phosphorylation of Ku70 at Tyr-5302017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in its Dissociation from Chromatin and the Nuclear Matrix2015

Author(s)

Journal Title

DOI

Data Source

KUBOTA SHO 久保田翔

Kubota Sho 久保田翔