Nosaka Takuto 野阪拓人

Researcher Number	70748441
Other IDs	https://orcid.org/0000-0002-1929-7305
Affiliation (Current)	2024: 福井大学, 学術研究院医学系部門(附属病院部), 講師
Affiliation (based on the past Project Information) *help	2024: 福井大学, 学術研究院医学系部門(附属病院部), 講師 2019 – 2023: 福井大学, 学術研究院医学系部門, 助教 2019: 福井大学, 学術研究院医学系部門(附属病院部), 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator エイコサノイド / 肝細胞がん / 腫瘍関連マクロファージ / 免疫療法 / がん免疫微小環境 / 免疫微小環境 / 5-LOX / マクロファージ / アラキドン酸 / 内科 … More / GM-CSF / がん微小環境 / ロイコトリエン / 癌 … More Except Principal Investigator 循環腫瘍細胞 / 肝細胞がん / 免疫チェックポイント阻害薬 / ドライバー遺伝子 / 転移 / 創薬シーズ / シングルセル解析 / がん幹細胞 Less

Development of Novel Immunotherapeutic Strategies Targeting Eicosanoids that Regulate Hepatocellular Carcinoma Immune MechanismsPrincipal Investigator
- Principal Investigator
  
  野阪拓人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Fukui
Identification of driver genes controlling metastatic potential in the evolution of hepatocellular carcinoma
- Principal Investigator
  
  中本安成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Fukui
Elucidation of eicosanoid-related tumor progression mechanism in hepatocellular carcinoma microenvironment and research on novel treatmentPrincipal Investigator
- Principal Investigator
  
  Nosaka Takuto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Fukui
Identification of liver cancer stem cell-like clones causing treatment resistance by cancer evolution
- Principal Investigator
  
  Nakamoto Yasunari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Fukui

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Longer survival and preserved liver function after proton beam therapy for patients with unresectable hepatocellular carcinoma.2023
- Author(s)
  Nosaka T, Matsuda H, Sugata R, Akazawa Y, Takahashi K, Naito T, Ohtani M, Kinoshita K, Tsujikawa T, Sato Y, Maeda Y, Tamamura H, Nakamoto Y.
- Journal Title
  
  Curr Oncol.
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24317
[Journal Article] Hepatocellular carcinoma progression promoted by 5-lipoxygenase activity in CD163(+) tumor-associated macrophages.2023
- Author(s)
  Nosaka T, Murata Y, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Imamura Y, Goi T, Nakamoto Y
- Journal Title
  
  Biomed Pharmacother.
  
  Volume: 162 Pages: 114592-114592
- DOI
  10.1016/j.biopha.2023.114592
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08008, KAKENHI-PROJECT-21K15944, KAKENHI-PROJECT-22K15992, KAKENHI-PROJECT-23K24317
[Journal Article] Longer Survival and Preserved Liver Function after Proton Beam Therapy for Patients with Unresectable Hepatocellular Carcinoma2023
- Author(s)
  Nosaka Takuto、Matsuda Hidetaka、Sugata Ryotaro、Akazawa Yu、Takahashi Kazuto、Naito Tatsushi、Ohtani Masahiro、Kinoshita Kazuyuki、Tsujikawa Tetsuya、Sato Yoshitaka、Maeda Yoshikazu、Tamamura Hiroyasu、Nakamoto Yasunari
- Journal Title
  
  Current Oncology
  
  Volume: 30 Issue: 4 Pages: 3915-3926
- DOI
  10.3390/curroncol30040296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07788, KAKENHI-PROJECT-22K15992
[Journal Article] Elderly onset congenital hepatic fibrosis with portal hypertension diagnosed after recurrent cholangitis: a case report2022
- Author(s)
  Takahashi Kazuto、Ofuji Kazuya、Nosaka Takuto、Naito Tatsushi、Matsuda Hidetaka、Ohtani Masahiro、Hiramatsu Katsushi、Harada Kenichi、Naiki Hironobu、Nakamoto Yasunari
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 15 Issue: 3 Pages: 611-616
- DOI
  10.1007/s12328-022-01620-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17456, KAKENHI-PROJECT-21K06967, KAKENHI-PROJECT-22K08008, KAKENHI-PROJECT-21K15944, KAKENHI-PROJECT-20K17018
[Journal Article] Cholesterol crystal embolism in multiple organs after transarterial chemoembolization for hepatocellular carcinoma: An autopsy case report.2022
- Author(s)
  Yamashita J, Nosaka T, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Kobayashi M, Nakamoto Y.
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 101(39) Issue: 39 Pages: e30769-e30769
- DOI
  10.1097/md.0000000000030769
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08008, KAKENHI-PROJECT-21K15944, KAKENHI-PROJECT-21H02702, KAKENHI-PROJECT-20K17018, KAKENHI-PROJECT-23K24317
[Journal Article] Clinical Usefulness of [18F]-Fluoro-2-Deoxy-d-Glucose?Positron Emission Tomography/Computed Tomography for Distinguishing Between Autoimmune Pancreatitis and Pancreatic Cancer2021
- Author(s)
  Ohtani Masahiro、Ofuji Kazuya、Akazawa Yu、Saito Yasushi、Nosaka Takuto、Ozaki Yoshihiko、Takahashi Kazuto、Naito Tatsushi、Matsuda Hidetaka、Hiramatsu Katsushi、Nakamoto Yasunari
- Journal Title
  
  Pancreas
  
  Volume: 50 Issue: 7 Pages: 1014-1019
- DOI
  10.1097/mpa.0000000000001873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17456
[Journal Article] Circulating tumor cells detected with a microcavity array predict clinical outcome in hepatocellular carcinoma2021
- Author(s)
  Takahashi Kazuto、Ofuji Kazuya、Hiramatsu Katsushi、Nosaka Takuto、Naito Tatsushi、Matsuda Hidetaka、Endo Katsuya、Higuchi Masayuki、Ohtani Masahiro、Nemoto Tomoyuki、Nakamoto Yasunari
- Journal Title
  
  Cancer Medicine
  
  Volume: 10 Issue: 7 Pages: 2300-2309
- DOI
  10.1002/cam4.3790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15808, KAKENHI-PROJECT-19K17456, KAKENHI-PROJECT-19H03637
[Journal Article] A case of immune checkpoint inhibitor-related colitis with a distinctive endoscopic finding of colonic pseudolipomatosis2021
- Author(s)
  Naito Tatsushi、Nosaka Takuto、Takahashi Kazuto、Ofuji Kazuya、Matsuda Hidetaka、Ohtani Masahiro、Hiramatsu Katsushi、Imamura Yoshiaki、Ishizuka Tamotsu、Nakamoto Yasunari
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 5 Pages: 1431-1436
- DOI
  10.1007/s12328-021-01459-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456, KAKENHI-PROJECT-20K17018
[Journal Article] Regulatory function of interferon‐inducible 44‐like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes2021
- Author(s)
  Nosaka Takuto、Naito Tatsushi、Murata Yosuke、Matsuda Hidetaka、Ohtani Masahiro、Hiramatsu Katsushi、Nishizawa Tsutomu、Okamoto Hiroaki、Nakamoto Yasunari
- Journal Title
  
  Hepatology Research
  
  Volume: 52 Issue: 2 Pages: 141-152
- DOI
  10.1111/hepr.13722
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17456, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-22K08008, KAKENHI-PROJECT-23K24317
[Journal Article] Pembrolizumab-induced autoimmune side effects of colon and pancreas in a patient with lung cancer2021
- Author(s)
  Ofuji Kazuya、Hiramatsu Katsushi、Nosaka Takuto、Naito Tatsushi、Takahashi Kazuto、Matsuda Hidetaka、Ohtani Masahiro、Imamura Yoshiaki、Ishizuka Tamotsu、Nakamoto Yasunari
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 6 Pages: 1692-1699
- DOI
  10.1007/s12328-021-01499-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17456
[Journal Article] A case of idiopathic portal hypertension accompanying multiple hepatic nodular regenerative hyperplasia in a patient with systemic sclerosis2021
- Author(s)
  Yamamoto Arisa、Matsuda Hidetaka、Hiramatsu Katsushi、Tsuji Arisa、Midori Yohei、Murata Yosuke、Tanaka Tomoko、Tohda Gen、Nosaka Takuto、Takahashi Kazuto、Naito Tatsushi、Ofuji Kazuya、Ohtani Masahiro、Imamura Yoshiaki、Nakamoto Yasunari
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 3 Pages: 820-826
- DOI
  10.1007/s12328-021-01348-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17456
[Journal Article] Severe necrotizing pancreatitis immediately after non-abdominal surgery under general anesthesia with propofol2021
- Author(s)
  Akazawa Yu、Ohtani Masahiro、Namikawa Shoichi、Nosaka Takuto、Takahashi Kazuto、Naito Tatsushi、Ofuji Kazuya、Matsuda Hidetaka、Hiramatsu Katsushi、Nakamoto Yasunari
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 6 Pages: 1798-1803
- DOI
  10.1007/s12328-021-01504-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17456
[Journal Article] Advanced primary adenosquamous carcinoma of the liver with a small cell carcinoma component: an autopsy case report2021
- Author(s)
  Nosaka Takuto、Ohtani Masahiro、Namikawa Shouichi、Takahashi Kazuto、Naito Tatsushi、Ofuji Kazuya、Matsuda Hidetaka、Hiramatsu Katsushi、Imamura Yoshiaki、Nakamoto Yasunari
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 5 Pages: 1496-1502
- DOI
  10.1007/s12328-021-01474-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17456
[Journal Article] Gastrointestinal AA amyloidosis secondary to chronic pyelonephritis presenting with refractory diarrhea and severe hypoalbuminemia2021
- Author(s)
  Tanaka Tomoko、Naito Tatsushi、Midori Yohei、Nosaka Takuto、Takahashi Kazuto、Ofuji Kazuya、Matsuda Hidetaka、Ohtani Masahiro、Hiramatsu Katsushi、Imamura Yoshiaki、Yokoyama Osamu、Naiki Hironobu、Nakamoto Yasunari
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 6 Pages: 1642-1648
- DOI
  10.1007/s12328-021-01508-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17456, KAKENHI-PROJECT-21K06967
[Journal Article] Daily Usage of Proton Pump Inhibitors May Reduce the Severity of Critical Upper Gastrointestinal Bleeding in Elderly Patients2020
- Author(s)
  Matsuda Hidetaka、Nosaka Takuto、Akazawa Yu、Saito Yasushi、Ozaki Yoshihiko、Takahashi Kazuto、Naito Tatsushi、Ofuji Kazuya、Ohtani Masahiro、Hiramatsu Katsushi、Nakamoto Yasunari
- Journal Title
  
  Gastroenterology Research and Practice
  
  Volume: 2020 Pages: 1-8
- DOI
  10.1155/2020/7168621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17456, KAKENHI-PROJECT-19H03637
[Journal Article] 免疫チェックポイント阻害薬による肝障害―リスク因子―2020
- Author(s)
  大藤和也, 野阪拓人, 中本安成
- Journal Title
  
  Kanzo
  
  Volume: 61 Issue: 3 Pages: 95-96
- DOI
  10.2957/kanzo.61.95
- NAID
  130007806188
- ISSN
  0451-4203, 1881-3593
- Year and Date
  2020-03-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17456
[Journal Article] Bipolar-current needle-knife with a water jet function (Jet B-knife) shortens the procedure time of endoscopic submucosal dissection for colorectal tumors.2020
- Author(s)
  Hiramatsu K, Naito T, Akazawa Y, Saito Y, Nosaka T, Takahashi K, Ofuji K, Matsuda H, Ohtani M, Matsuda M, Sakai A, Nakamoto Y.
- Journal Title
  
  Surg Endosc.
  
  Volume: - Issue: 7 Pages: 3600-3606
- DOI
  10.1007/s00464-020-07832-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-19K17456
[Journal Article] Molecular signature of hepatitis?B virus regulation by interferon‐γ in primary human hepatocytes2019
- Author(s)
  Nosaka Takuto、Naito Tatsushi、Matsuda Hidetaka、Ohtani Masahiro、Hiramatsu Katsushi、Nemoto Tomoyuki、Nishizawa Tsutomu、Okamoto Hiroaki、Nakamoto Yasunari
- Journal Title
  
  Hepatology Research
  
  Volume: 50 Issue: 3 Pages: 292-302
- DOI
  10.1111/hepr.13450
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17456, KAKENHI-PROJECT-19H03637
[Journal Article] The Usefulness of Video Capsule Endoscopy in Evaluating Gastrointestinal Manifestations of Immunoglobulin A Vasculitis2019
- Author(s)
  Tanaka Tomoko、Hiramatsu Katsushi、Saito Yasushi、Nosaka Takuto、Takahashi Kazuto、Naito Tatsushi、Ofuji Kazuya、Matsuda Hidetaka、Ohtani Masahiro、Nemoto Tomoyuki、Suto Hiroyuki、Nakamoto Yasunari
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 14 Pages: 1979-1985
- DOI
  10.2169/internalmedicine.2097-18
- NAID
  130007679538
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-07-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17456
[Journal Article] Reactivation of intraabdominal tuberculous lymphadenopathy after drug-eluting beads transcatheter arterial chemoembolization in a patient with hepatocellular carcinoma.2019
- Author(s)
  Murata Y, Hiramatsu K, Yoshida Y, Akazawa Y, Saito Y, Nosaka T, Ozaki Y, Hayama R, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Nemoto T, Nakamoto Y.
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: 12 Issue: 1 Pages: 76-81
- DOI
  10.1007/s12328-018-0894-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] Analysis of Mucosa-Associated Dysbiosis Related to Bile Acid Metabolism in Post-SVR Hepatitis C Patients Complicated with Esophageal Varices2022
- Author(s)
  Midori Y, Hiramatsu K, Nosaka T, Akazawa Y, Takahashi K, Naito T, Matsuda H, Ohtani M, Nakamoto Y
- Organizer
  AASLD The Liver Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24317
[Presentation] Hepatocellular Carcinoma-Derived GM-CSF Induces Leukotriene Production in Tumor-Associated Macrophages Contributing to Tumor Progression2022
- Author(s)
  Nosaka T, Murata Y, Akazawa Y, Naito T, Takahashi K, Matsuda H, Ohtani M, Nakamoto Y
- Organizer
  AASLD The Liver Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24317
[Presentation] 腫瘍関連マクロファージ由来ロイコトリエンによる肝癌進展機構の解析2022
- Author(s)
  野阪拓人，村田陽介，中本安成
- Organizer
  第30回日本消化器関連学会週間（JDDW 2022）
- Data Source
  KAKENHI-PROJECT-22K15992
[Presentation] Usefulness of Hepatic Shear Wave Velocity for Noninvasive Prediction of Esophageal Varices in Patients with Chronic Liver Diseases2022
- Author(s)
  Namikawa S, Nosaka T, Akazawa Y, Naito T, Takahashi K, Matsuda H, Ohtani M, Nakamoto Y
- Organizer
  AASLD The Liver Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24317
[Presentation] Influence of Lifestyle-Related Factors on Hypervascularization in Preneoplastic Nodules of Hepatocellular Carcinoma after HCV Eradication2022
- Author(s)
  Tanaka T, Nosaka T, Murata Y, Akazawa Y, Takahashi K, Naito T, Matsuda H, Ohtani M, Nakamoto Y
- Organizer
  AASLD The Liver Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24317
[Presentation] 腫瘍関連マクロファージ由来ロイコトリエンによる肝癌進展機構と治療標的の可能性2022
- Author(s)
  野阪拓人，村田陽介，中本安成
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K15992
[Presentation] イメージング計測AIを用いた肝癌腫瘍内M2 Tumor-Associated Macrophageの細胞形状解析と細胞内脂質代謝の検討2022
- Author(s)
  平松活志、野阪拓人、中本安成
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-22K15992
[Presentation] Stem Cell Signature of Peripheral Circulating Tumor Cells correlated with therapeutic effects of Atezolizumab plus Bevacizumab in unresectable HCC patients2022
- Author(s)
  Murata Y, Nosaka T, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Nakamoto Y
- Organizer
  AASLD The Liver Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24317
[Presentation] HEPATOCELLULAR CARCINOMA-DERIVED GM-CSF INDUCES LEUKOTRIENE PRODUCTION IN TUMOR-ASSOCIATED MACROPHAGES CONTRIBUTING TO TUMOR PROGRESSION2022
- Author(s)
  Takuto Nosaka, Yosuke Murata, Yu Akazawa, Tatsushi Naito, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani and Yasunari Nakamoto
- Organizer
  米国肝臓学会議（AASLD）2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15992
[Presentation] 機械学習アルゴリズムを用いた腫瘍関連マクロファージの形態解析と肝癌臨床病態に関する検討2021
- Author(s)
  平松活志, 野阪拓人, 中本安成
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 軽症・中等症COVID-19感染病態における肝障害の臨床的意義に関する検討2021
- Author(s)
  松田秀岳, 野阪拓人, 中本安成
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 免疫チェックポイント阻害剤投与後肝障害のリスク因子の検討2021
- Author(s)
  大藤和也、野阪拓人、中本安成
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Identification of an Interferon-Inducible Regulatory Molecule, IFI44L, for Hepatitis B Virus cccDNA in Primary Human Hepatocytes2021
- Author(s)
  Takuto Nosaka, Tatsushi Naito, Yasunari Nakamoto
- Organizer
  第63回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 肝癌局所治療困難例における陽子線治療の有効性に関する検討2021
- Author(s)
  野阪拓人, 松田秀岳, 高橋和人, 内藤達志, 大藤和也, 大谷昌弘, 平松活志, 佐藤義高, 玉村裕保, 中本安成
- Organizer
  第57回肝癌研究会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 抗HBV効果を制御する細胞内宿主因子を用いた新たな分子免疫戦略の検討2021
- Author(s)
  野阪拓人, 内藤達志, 中本安成
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Leukotrienes Derived from Tumor-Infiltrating M2 Macrophages Promote the Progression of Hepatocellular Carcinoma2021
- Author(s)
  Takuto Nosaka, Yasunari Nakamoto
- Organizer
  APASL(Asian Pacific Association for the Study of the Liver) Oncology 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Leukotrienes Derived from Tumor-Infiltrating Macrophages Promote Hepatocellular Carcinoma Progression2021
- Author(s)
  Takuto Nosaka, Yosuke Murata, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto
- Organizer
  AASLD(American Association for the Study of Liver Diseases) The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] ロイコトリエンによる肝癌進展機構の解析と新規治療標的の可能性2021
- Author(s)
  野阪拓人、村田陽介、中本安成
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Comparison of Circulating Tumor Cells in Hepatocellular Carcinoma Patients Treated by Atezolizumab-Bevacizumab and Transcatheter Arterial Chemoembolization.2021
- Author(s)
  Murata Y, Nosaka T, Naito T, Takahashi K, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Nakamoto Y.
- Organizer
  AASLD The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] Leukotrienes Derived from Tumor-Infiltrating Macrophages Enhance the Progression of Hepatocellular Carcinoma2021
- Author(s)
  Takuto Nosaka, Yosuke Murata, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto
- Organizer
  JSH International Liver Conference 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Morphological Analysis of M2 Tumor-Associated Macrophage Subsets in Patients with Hepatocellular Carcinoma using Machine Learning Algorithm.2021
- Author(s)
  Hiramatsu K, Nosaka T, Yamamoto A, Saito Y, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Nakamoto Y.
- Organizer
  AASLD The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] 局所治療困難な高齢者肝癌における陽子線治療の有効性と安全性の検討2021
- Author(s)
  菅田亮太郎、野阪拓人, 村田陽介, 高橋和人, 内藤達志, 大藤和也, 松田秀岳, 大谷昌弘, 平松活志, 中本安成
- Organizer
  第25回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Analysis of Mucosa-Associated Dysbiosis Related to Portal Hypertension and Liver Fibrosis in Hepatitis C Patients.2021
- Author(s)
  Yohei Midori, Katsushi Hiramatsu, Takuto Nosaka, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani and Yasunari Nakamoto.
- Organizer
  AASLD The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] Baseline FIB4 Index, Albumin, and ALBI Scores Predict Hypervascularization in Preneoplastic Nodules of Hepatocellular Carcinoma after HCV Eradication.2021
- Author(s)
  Tanaka T, Murata Y, Nosaka T, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Nakamoto Y.
- Organizer
  AASLD The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] 抗癌剤併用免疫チェックポイント阻害剤治療後に発症する肝障害の検討2021
- Author(s)
  大藤和也、野阪拓人、中本安成
- Organizer
  第63回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Leukotrienes Derived from Tumor-Infiltrating Macrophages Promote Hepatocellular Carcinoma Progression.2021
- Author(s)
  Nosaka T, Murata Y, Naito T, Takahashi K, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Nakamoto Y.
- Organizer
  AASLD The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] 肝細胞癌の循環腫瘍細胞が発現する癌幹細胞マーカーの意義に関する検討2021
- Author(s)
  村田陽介, 野阪拓人, 中本安成
- Organizer
  第63回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 高度進行肝癌に対する多剤sequential治療におけるHAICの有用性に関する検討2021
- Author(s)
  村田陽介, 野阪拓人, 中本安成
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] HBV感染系におけるcccDNA制御をめざしたIFN-γシグナル経路の検討2020
- Author(s)
  野阪　拓人、内藤　達志、中本　安成
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 免疫チェックポイント阻害剤による肝障害発症様式の検討2020
- Author(s)
  大藤和也, 野阪拓人, 中本安成
- Organizer
  第62回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Circulating Tumor Cells Detected with Microcavity Array Predict Clinical Outcome in Patients with Hepatocellular Carcinoma2020
- Author(s)
  Kazuto Takahashi, Kazuya Ofuji, Katsushi Hiramatsu, Takuto Nosaka, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto
- Organizer
  AASLD The Liver Meeting 2020
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Analysis of Immune Microenvironment of Hepatocellular Carcinoma after Hepatitis C Virus Eradication2020
- Author(s)
  Katsushi Hiramatsu, Takuto Nosaka, Yasushi Saito, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto
- Organizer
  AASLD The Liver Meeting 2020
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Signal Changes in Preneoplastic Nodules on DWI of Gd-EOB-DTPA MRI in Patients at Risk for Hypervascular Hepatocellular Carcinoma2020
- Author(s)
  Tomoko Tanaka, Yosuke Murata, Takuto Nosaka, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto
- Organizer
  AASLD The Liver Meeting 2020
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 肝癌局所治療困難例における陽子線治療の有効性と安全性に関する検討2020
- Author(s)
  野阪　拓人、松田　秀岳、中本　安成
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Efficacy of Early Initiation of Anticoagulant Therapy for Portal Vein Thrombosis in Chronic Liver Disease Patients with Hyponatremia2020
- Author(s)
  Yosuke Murata, Hidetaka Matsuda, Takuto Nosaka, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto
- Organizer
  AASLD The Liver Meeting 2020
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Signal Changes in Preneoplastic Nodules on DWI of Gd-EOB-DTPA MRI in Patients at Risk for Hypervascular Hepatocellular Carcinoma.2020
- Author(s)
  Tanaka T, Murata Y, Nosaka T, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Nakamoto Y.
- Organizer
  AASLD THE LIVER MEETING 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] Analysis of Immune Microenvironment of Hepatocellular Carcinoma after Hepatitis C Virus Eradication.2020
- Author(s)
  Hiramatsu K, Nosaka T, Saito Y, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Nakamoto Y.
- Organizer
  AASLD THE LIVER MEETING 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] Identification of IFN-γ Mediated Regulatory Molecules for Hepatitis B Virus Clones in Primary Human Hepatocytes2020
- Author(s)
  Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto
- Organizer
  第24回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Investigation of IFN-γ Mediated Regulatory Molecules for Hepatitis B Virus Clones in Primary Human Hepatocyte2020
- Author(s)
  Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto
- Organizer
  AASLD The Liver Meeting 2020
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Circulating Tumor Cells Detected with Microcavity Array Predict Clinical Outcome in Patients with Hepatocellular Carcinoma.2020
- Author(s)
  Takahashi K, Ofuji K, Hiramatsu K, Nosaka T, Naito T, Matsuda H, Ohtani M, Nakamoto Y.
- Organizer
  AASLD THE LIVER MEETING 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637
[Presentation] 臨床応用に向けた肝癌の病態解明 HLA発現解析および新規蛍光多重免疫染色による肝癌の免疫病態に関する検討2020
- Author(s)
  平松活志, 野阪拓人, 中本安成
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 高度進行肝癌における肝外転移臓器別の集学的治療戦略2020
- Author(s)
  野阪　拓人、松田　秀岳、中本　安成
- Organizer
  第56回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] CLINICAL USEFULNESS OF HIGH-SENSITIVITY HEPATITIS B SURFACE ANTIGEN ASSAYS AND GENOTYPING FOR HLA-DPB1 SNP FOR DETECTION OF VIRAL REACTIVATION IN EARLY PHASE OF IMMUNOSUPPRESSIVE TREATMENTS2019
- Author(s)
  Hidetaka Matsuda, Katsushi Hiramatsu, Yumi Yoshida, Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Masahiro Ohtani, Yasunari Nakamoto
- Organizer
  第70回米国肝臓病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] HIGH INCIDENCE OF CHOLESTATIC TYPE IRAE LIVER INJURY CAUSED BY IMMUNE CHECKPOINT INHIBITORS IN JAPANESE PATIENTS WITH ADVANCED SOLID TUMORS2019
- Author(s)
  Kazuya Ofuji, Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto
- Organizer
  第70回米国肝臓病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] B型肝炎診療;未来への展望を踏まえた現在の在り方 HBV感染系におけるcccDNA排除をめざしたIFNα/IFNγシグナルの検討2019
- Author(s)
  野阪拓人, 内藤達志, 中本安成
- Organizer
  第23回肝臓学会大会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] TOLEROGENIC MACROPHAGES AND DENDRITIC CELLS ARE RECRUITED IN MICROENVIRONMENT OF HEPATOCELLULAR CARCINOMA IN NON-CIRRHOTIC PATIENTS WITH HEPATITIS C VIRUS INFECTION2019
- Author(s)
  Katsushi Hiramatsu, Hidetaka Matsuda, Yasushi Saito, Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Masahiro Ohtani, Yasunari Nakamoto
- Organizer
  第70回米国肝臓病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Molecular signature of hepatitis B virus regulation by IFN-γ in primary human hepatocyte2019
- Author(s)
  Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto
- Organizer
  第70回米国肝臓病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 新たなB型肝炎治療薬:創薬の現況 HBV感染系におけるcccDNA排除をめざした自然・獲得免疫シグナルの検討2019
- Author(s)
  野阪拓人, 内藤達志, 中本安成
- Organizer
  第55回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] HBV cccDNAの制御に関わる肝細胞内獲得免疫シグナルの検討(Investigation of intrahepatic acquired immune signal involved in regulation of HBV cccDNA)2019
- Author(s)
  野阪拓人, 内藤達志, 高橋和人, 大藤和也, 松田秀岳, 大谷昌弘, 平松活志, 中本安成
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 脈管侵襲を伴う肝細胞癌に対する1次治療法選択に有効なスコアリングの選定と治療戦略2019
- Author(s)
  野阪拓人、松田秀岳、村田陽介、内藤達志、大藤和也、大谷昌弘、平松活志、根本朋幸、中本安成
- Organizer
  第55回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 薬物性肝障害:臨床・研究のUp to Date 免疫チェックポイント阻害剤による肝障害の検討2019
- Author(s)
  大藤和也, 野阪拓人, 中本安成
- Organizer
  第61回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Sensitive Detection of Circulating Tumor Cells in Patients with Chronic Liver Disease and Hepatocellular Carcinoma Using a Microcavity Array2019
- Author(s)
  Kazuto Takahashi, Kazuya Ofuji, Katsushi Hiramatsu, Takuto Nosaka, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Tomoyuki Nemoto, Yasunari Nakamoto
- Organizer
  The Asian Pacific Association for the Study of the Liver 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] NASHとASH、その診断と治療への対応血清IgAを用いたNAFLDにおける肝癌高リスク群の囲い込みの検討2019
- Author(s)
  根本朋幸, 野阪拓人, 中本安成
- Organizer
  第43回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 胃炎の京都分類の新展開 H.pylori既感染症例における胃炎京都分類の適用についての臨床的検討2019
- Author(s)
  松田秀岳, 野阪拓人, 中本安成
- Organizer
  第97回日本内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] B型肝炎の根治を目指した臨床及び創薬研究最前線 HBV感染系を用いた自然・獲得免疫によるcccDNA制御シグナルの検討2019
- Author(s)
  野阪拓人, 内藤達志, 中本安成
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Genetic Polymorphism and Reduced mRNA Expression of HLA Class II DP Genes are Associated with Hepatitis B Virus Reactivation in Japanese Patients Treated with Immunomodulatory Agents2019
- Author(s)
  Hidetaka Matsuda, Katsushi Hiramatsu, Takuto Nosaka, Tatsushi Naito, Kazuya Ofuji, Masahiro Ohtani, Tomoyuki Nemoto, Yasunari Nakamoto
- Organizer
  The Asian Pacific Association for the Study of the Liver 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 消化器領域における免疫療法の開発と未来肝がん肺転移を制御するマクロファージの病態解明と標的治療の可能性2019
- Author(s)
  野阪拓人, 向田直史, 中本安成
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] 免疫チェックポイント阻害剤による肝障害の臨床的特徴の検討2019
- Author(s)
  大藤和也, 野阪拓人, 中本安成
- Organizer
  第55回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17456
[Presentation] Sensitive detection of circulating tumor cells in patients with chronic liver disease and hepatocellular carcinoma using a microcavity array.2019
- Author(s)
  Takahashi K, Ofuji K, Hiramatsu K, Nosaka T, Naito T, Matsuda H, Ohtani M, Nemoto T, Nakamoto Y.
- Organizer
  The Asian Pacific Association for the Study of the Liver single Topic Conference(APASL STC Tokyo 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03637

1. Nakamoto Yasunari (40293352)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. 平松活志 (30646849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. 山下太郎 (90377432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 島上哲朗 (50436820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大藤和也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 高橋泰岳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 佐藤義高

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nosaka Takuto 野阪 拓人

Research Projects

Research Products

Co-Researchers

Development of Novel Immunotherapeutic Strategies Targeting Eicosanoids that Regulate Hepatocellular Carcinoma Immune MechanismsPrincipal Investigator

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Identification of driver genes controlling metastatic potential in the evolution of hepatocellular carcinoma

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Elucidation of eicosanoid-related tumor progression mechanism in hepatocellular carcinoma microenvironment and research on novel treatmentPrincipal Investigator

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Identification of liver cancer stem cell-like clones causing treatment resistance by cancer evolution

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[Journal Article] Longer survival and preserved liver function after proton beam therapy for patients with unresectable hepatocellular carcinoma.2023

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[Journal Article] Hepatocellular carcinoma progression promoted by 5-lipoxygenase activity in CD163(+) tumor-associated macrophages.2023

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[Journal Article] Longer Survival and Preserved Liver Function after Proton Beam Therapy for Patients with Unresectable Hepatocellular Carcinoma2023

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[Journal Article] Elderly onset congenital hepatic fibrosis with portal hypertension diagnosed after recurrent cholangitis: a case report2022

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[Journal Article] Cholesterol crystal embolism in multiple organs after transarterial chemoembolization for hepatocellular carcinoma: An autopsy case report.2022

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[Journal Article] Clinical Usefulness of [18F]-Fluoro-2-Deoxy-d-Glucose?Positron Emission Tomography/Computed Tomography for Distinguishing Between Autoimmune Pancreatitis and Pancreatic Cancer2021

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[Journal Article] Circulating tumor cells detected with a microcavity array predict clinical outcome in hepatocellular carcinoma2021

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[Journal Article] A case of immune checkpoint inhibitor-related colitis with a distinctive endoscopic finding of colonic pseudolipomatosis2021

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[Journal Article] Regulatory function of interferon‐inducible 44‐like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes2021

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[Journal Article] Pembrolizumab-induced autoimmune side effects of colon and pancreas in a patient with lung cancer2021

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[Journal Article] A case of idiopathic portal hypertension accompanying multiple hepatic nodular regenerative hyperplasia in a patient with systemic sclerosis2021

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Nosaka Takuto 野阪拓人