Koike Shin 小池伸

Researcher Number	70751014
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2025: 明治薬科大学, 薬学部, 講師 2017 – 2020: 明治薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator 精神疾患 / 終末糖化産物 / メチルグリオキサール / 統合失調症 / カルボニルストレス / 神経変性疾患 / カルボニル化タンパク質 / Sestrin2 / タンパク質分解 / オートファジー … More / プロテアソーム / タンパク質分解系 / AGEs / メイラード反応 / LC-MS/MS / モデルマウス / 神経伝達物質 / 老齢マウス / グリオキサラーゼ / 老化 / グルタチオン / Nrf2 … More Except Principal Investigator アルツハイマー病 Less

老化依存的な脳異常タンパク質蓄積の末梢－脳連関を介した制御とメカニズムの解明
- Principal Investigator
  
  若林朋子
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Meiji Pharmaceutical University
Sestrin2が制御する脳内カルボニル化タンパク質の分解と、その中枢疾患への関与Principal Investigator
- Principal Investigator
  
  小池伸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
Elucidation of the onset mechanism of schizophrenia by focusing on the degradation system of carbonylated proteins.Principal Investigator
- Principal Investigator
  
  Koike Shin
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
Analysis of the reactivity of methylglyoxal and neurotransmitters and its involvement in treatment-resistant schizophreniaPrincipal Investigator
- Principal Investigator
  
  Koike Shin
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
Inhibition of carbonyl stress via Nrf2 activation and its application for the treatment-resistant schizophreniaPrincipal Investigator
- Principal Investigator
  
  Koike Shin
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Meiji Pharmaceutical University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Novel Fluorometric Assay of Antiglycation Activity Based on Methylglyoxal-Induced Protein Carbonylation2023
- Author(s)
  Koike Shin, Saito Yuna, Ogasawara Yuki
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 12 Pages: 2030-2030
- DOI
  10.3390/antiox12122030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06780, KAKENHI-PROJECT-21K06652
[Journal Article] Plasma unconjugated bile acids as novel biomarker for schizophrenia2022
- Author(s)
  Koike Shin、Miyaji Yusuke、Suzuki Kazuhiro、Miyashita Mitsuhiro、Itokawa Masanari、Arai Makoto、Ogasawara Yuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 634 Pages: 70-74
- DOI
  10.1016/j.bbrc.2022.09.110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06652, KAKENHI-PROJECT-20H03608
[Journal Article] Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits2021
- Author(s)
  Koike Shin、Toriumi Kazuya、Kasahara Sakura、Kibune Yosuke、Ishida Yo-ichi、Dan Takashi、Miyata Toshio、Arai Makoto、Ogasawara Yuki
- Journal Title
  
  Antioxidants
  
  Volume: 10 Issue: 4 Pages: 574-574
- DOI
  10.3390/antiox10040574
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04887, KAKENHI-PROJECT-18K06977, KAKENHI-PROJECT-19K07208, KAKENHI-PROJECT-21K06652
[Journal Article] Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma2021
- Author(s)
  Koike Shin、Miyaji Yusuke、Sano Hinako、Aikawa Natsuki、Kai Masayuki、Kasahara Sakura、Suzuki Toshihiro、Nishimoto-Kusunose Shoichi、Ogasawara Yuki
- Journal Title
  
  Anal. Sci.
  
  Volume: 37 Issue: 8 Pages: 1165-1170
- DOI
  10.2116/analsci.20P429
- NAID
  130008072575
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2021-08-10
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16425
[Journal Article] Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex2021
- Author(s)
  Toriumi Kazuya、Berto Stefano、Koike Shin、Usui Noriyoshi、Dan Takashi、Suzuki Kazuhiro、Miyashita Mitsuhiro、Horiuchi Yasue、Yoshikawa Akane、Asakura Mai、Nagahama Kenichiro、Lin Hsiao-Chun、Sugaya Yuki、Watanabe Takaki、Kano Masanobu、Ogasawara Yuki、Miyata Toshio、Itokawa Masanari、Konopka Genevieve、Arai Makoto
- Journal Title
  
  Redox Biology
  
  Volume: 45 Pages: 102057-102057
- DOI
  10.1016/j.redox.2021.102057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06977, KAKENHI-PROJECT-19K07208, KAKENHI-PLANNED-20H05915, KAKENHI-PROJECT-19H03589, KAKENHI-PROJECT-20H03608, KAKENHI-PROJECT-20K06872, KAKENHI-PROJECT-21K06652
[Journal Article] Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage2020
- Author(s)
  Sugiura K, Koike S, Suzuki T, Ogasawara Y.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 5 Pages: 879-883
- DOI
  10.1248/bpb.b19-01120
- NAID
  130007839310
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-05-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07208, KAKENHI-PROJECT-19K16425
[Journal Article] Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain2019
- Author(s)
  Koike S, Ando C, Usui Y, Kibune Y, Nishimoto S, Suzuki T, Ogasawara Y.
- Journal Title
  
  Brain Research Bulletin
  
  Volume: 144 Pages: 164-170
- DOI
  10.1016/j.brainresbull.2018.11.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08383, KAKENHI-PROJECT-17K15525, KAKENHI-PROJECT-19K07208
[Journal Article] Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation.2017
- Author(s)
  Koike S, Nishimoto S, Ogasawara Y.
- Journal Title
  
  Redox Biol.
  
  Volume: 12 Pages: 530-539
- DOI
  10.1016/j.redox.2017.03.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08383, KAKENHI-PROJECT-17K15525
[Journal Article] Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress2017
- Author(s)
  Ishida Y.I, Kayama T, Kibune Y, Nishimoto S, Koike S, Suzuki T, Horiuchi Y, Miyashita M, Itokawa M, Arai M, Ogasawara Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 493 Issue: 1 Pages: 573-577
- DOI
  10.1016/j.bbrc.2017.08.150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15525, KAKENHI-PROJECT-16H05380
[Presentation] Nrf2活性化剤によるメチルグリオキサール誘導性カルボニルストレスの軽減作用2024
- Author(s)
  鶴留里梨、小池伸、鈴木俊宏、小笠原裕樹
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-21K06652
[Presentation] メチルグリオキサール解毒障害による統合失調症様行動異常発現の分子機序解明2022
- Author(s)
  鳥海和也、小池伸、段孝、鈴木一浩、宮下光弘、堀内泰江、小笠原裕樹、宮田敏男、糸川昌成、新井誠
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06652
[Presentation] メチルグリオキサール解毒障害による統合失調症様行動異常発現の分子機序解明2022
- Author(s)
  鳥海和也、小池伸、段孝、鈴木一浩、宮下光弘、堀内泰江、小笠原裕樹、宮田敏男、糸川昌成、新井誠
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06652
[Presentation] Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits2021
- Author(s)
  Shin Koike, Sakura Kasahara, Kazuya Toriumi, Takashi Dan, Toshio Miyata, Makoto Arai, Yuki Ogasawara
- Organizer
  日本メイラード学会
- Data Source
  KAKENHI-PROJECT-21K06652
[Presentation] 疾患モデルマウスを用いたカルボニルストレス性統合失調症に関する研究2019
- Author(s)
  木船陽介、小池伸、鈴木俊宏、石田洋一、鳥海和也、新井誠、小笠原裕樹
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15525
[Presentation] 疾患モデルマウスを用いたカルボニルストレス性統合失調症に関する研究2019
- Author(s)
  木船陽介、小池伸、鈴木俊宏、石田洋一、鳥海和也、新井誠、小笠原裕樹
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-19K16425
[Presentation] グリセリン製剤中において生成されるメチルグリオキサールの測定2019
- Author(s)
  杉浦江、小池伸、鈴木俊宏、小笠原裕樹
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15525
[Presentation] 疾患モデルマウスの海馬に蓄積するAGEs含有タンパク質の解析2019
- Author(s)
  笠原桜、小池伸、鳥海和也、新井誠、鈴木俊宏、小笠原裕樹
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K16425
[Presentation] Glo1遺伝子欠損とビタミン B6欠乏がマウスの精神行動に与える影響2019
- Author(s)
  鳥海和也、鈴木一浩、小池伸、宮下光弘、堀内泰江、吉川茜、小笠原裕樹、糸川昌成、新井誠
- Organizer
  第29回日本メイラード学会
- Data Source
  KAKENHI-PROJECT-19K16425
[Presentation] メチルグリオキサールに着目した統合失調症の AGEs上昇メカニズムの検討2019
- Author(s)
  鈴木一浩、鳥海和也、宮下光弘、堀内泰江、吉川茜、小池伸、小笠原裕樹、鷲塚伸介、糸川昌成、新井誠
- Organizer
  第29回日本メイラード学会
- Data Source
  KAKENHI-PROJECT-19K16425
[Presentation] グリセリン製剤中において生成されるメチルグリオキサールの測定2019
- Author(s)
  杉浦江、小池伸、鈴木俊宏、小笠原裕樹
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-19K16425
[Presentation] カルボニルストレス性統合失調症患者由来 iPS細胞の解析2019
- Author(s)
  堀内泰江, 石川充, 小幡菜々子, 畠中真依, 許絲茵, 小池伸, 鳥海和也、宮下光弘、宮岡祐一郎, 小笠原裕樹, 勝田奈那, 永井竜児, 岡野栄之, 糸川昌成, 新井誠
- Organizer
  第29回日本メイラード学会
- Data Source
  KAKENHI-PROJECT-19K16425
[Presentation] 統合失調症患者赤血球中のアルグピリミジン化タンパク質の同定2018
- Author(s)
  木船陽介、鹿山将、小池伸、鈴木俊宏、石田洋一、堀内泰江、宮下光弘、新井誠、小笠原裕樹
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K15525
[Presentation] 老齢マウス脳内におけるメチルグリオキサール濃度の測定2018
- Author(s)
  小池伸、安藤千尋、臼井遥祐、小笠原裕樹
- Organizer
  第48回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-17K15525
[Presentation] グリオキサラーゼ1欠損マウス脳内のメチルグリオキサールの測定2017
- Author(s)
  小池伸、西本翔一、川村久美子、鳥海和也、新井誠、小笠原裕樹
- Organizer
  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-17K15525

1. 若林朋子 (20530330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 橋本唯史 (30334337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 新井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小笠原裕樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Koike Shin 小池 伸

Research Projects

Research Products

Co-Researchers

老化依存的な脳異常タンパク質蓄積の末梢－脳連関を介した制御とメカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Sestrin2が制御する脳内カルボニル化タンパク質の分解と、その中枢疾患への関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the onset mechanism of schizophrenia by focusing on the degradation system of carbonylated proteins.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the reactivity of methylglyoxal and neurotransmitters and its involvement in treatment-resistant schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibition of carbonyl stress via Nrf2 activation and its application for the treatment-resistant schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Novel Fluorometric Assay of Antiglycation Activity Based on Methylglyoxal-Induced Protein Carbonylation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma unconjugated bile acids as novel biomarker for schizophrenia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation.2017

Author(s)

Journal Title

Koike Shin 小池伸