sugai, akihiro 須貝章弘

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Sugai Akihiro 須貝章弘

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Researcher Number	70758903
Other IDs
Affiliation (Current)	2025: 新潟大学, 医歯学総合病院, 講師
Affiliation (based on the past Project Information) *help	2024 – 2025: 新潟大学, 医歯学総合病院, 講師 2019 – 2023: 新潟大学, 脳研究所, 助教 2015 – 2018: 新潟大学, 医歯学総合病院, 特任助教
Review Section/Research Field	Principal Investigator Neurology / Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator TDP-43 / 筋萎縮性側索硬化症 / アンチセンスオリゴ / 選択的スプライシング / ALS / 進化 / 隠れエキソン / シナプス / 神経変性疾患 / 相分離 … More / アンチセンスオリゴヌクレオチド / 天然変性領域 / アンチセンス核酸 / スプライシング / 病態モデル / RNA代謝 / iPS細胞モデル / マウスモデル / 自己制御機構 … More Except Principal Investigator 細胞外マトリクス / シングルセルRNA-seq / 細胞老化 / 細胞外マトリックス / 病因形質獲得細胞 / シングルRNA-seq / カンデサルタン / CARASIL / 老化 / シングルセルトランスクリプトーム / 脳小血管病 Less

TDP-43病態の多因子性をふまえた孤発性神経変性疾患の核新的治療の検証Principal Investigator
- Principal Investigator
  
  須貝章弘
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Niigata University
Deciphering Synaptic Pruning and Neurodegeneration from Human Cryptic ExonsPrincipal Investigator
- Principal Investigator
  
  須貝章弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Niigata University
脳小血管線維化促進細胞の同定による脳小血管老化の解明
- Principal Investigator
  
  加藤泰介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Assessing the Therapeutic Potential of Alternative Splicing Manipulation in ALS Treatment for Intrinsically Disordered RegionsPrincipal Investigator
- Principal Investigator
  
  SUGAI Akihiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Therapeutic strategy for ALS with nucleic acid technology focusing on the vulnerability of TDP-43 autoregulationPrincipal Investigator
- Principal Investigator
  
  Sugai Akihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Modeling ALS with TDP-43 proteinopathyPrincipal Investigator
- Principal Investigator
  
  Sugai Akihiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Niigata University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] 【ALS-どこまでわかり,どこまで治るか】原因と発症機序　TDP-432023
- Author(s)
  小出眞悟, 須貝章弘, 小野寺理
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 41 Pages: 338-341
- Data Source
  KAKENHI-PROJECT-20K07880
[Journal Article] 運動ニューロン疾患の新規治療とエビデンス　筋萎縮性側索硬化症に対するアンチセンス核酸治療薬の可能性2022
- Author(s)
  須貝章弘
- Journal Title
  
  神経治療学
  
  Volume: 39 Pages: 311-314
- Data Source
  KAKENHI-PROJECT-20K07880
[Journal Article] Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex2021
- Author(s)
  Koike Yuka、Sugai Akihiro、Hara Norikazu、Ito Junko、Yokoseki Akio、Ishihara Tomohiko、Yamagishi Takuma、Tsuboguchi Shintaro、Tada Mari、Ikeuchi Takeshi、Kakita Akiyoshi、Onodera Osamu
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1107-1107
- DOI
  10.1038/s42003-021-02621-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K07880
[Journal Article] Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model2021
- Author(s)
  Kato T, Manabe RI, Igarashi H, Kametani F, Hirokawa S, Sekine Y, Fujita N, Saito S, Kawashima Y, Hatano Y, Ando S, Nozaki H, Sugai A, Uemura M, Fukunaga M, Sato T, Koyama A, Saito R, Sugie A, Toyoshima Y, Kawata H, Murayama S, Matsumoto M, Kakita A, Hasegawa M, Ihara M, Kanazawa M, Nishizawa M, Tsuji S, Onodera O.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 131 Issue: 22
- DOI
  10.1172/jci140555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-19H01043, KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-20K07880
[Journal Article] 相分離メガネをかけて見直す神経変性疾患 (相分離生物学の全貌)2020
- Author(s)
  山岸拓磨、須貝章弘
- Journal Title
  
  現代化学
  
  Volume: 増刊(46) Pages: 68-71
- Data Source
  KAKENHI-PROJECT-20K07880
[Journal Article] Molecular mechanism of amyotrophic lateral sclerosis (ALS) from the viewpoint of the formation and degeneration of transactive response DNA-binding protein 43 kDa (TDP-43) inclusions2020
- Author(s)
  Kasahara Sou、Ishihara Tomohiko、Koike Yuka、Sugai Akihiro、Onodera Osamu
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 60 Issue: 2 Pages: 109-116
- DOI
  10.5692/clinicalneurol.cn-001362
- NAID
  130007802650
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09751, KAKENHI-PROJECT-19H01043
[Journal Article] Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation2019
- Author(s)
  Sugai Akihiro、Kato Taisuke、Koyama Akihide、Koike Yuka、Konno Takuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 130 Pages: 104534-104534
- DOI
  10.1016/j.nbd.2019.104534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751, KAKENHI-PROJECT-19H01043
[Journal Article] 増大特集 ALS2019 TDP-43封入体から解くALSの分子病態2019
- Author(s)
  坪口晋太朗、石原智彦、須貝章弘、横関明男、小野寺理
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 11 Pages: 1183-1189
- DOI
  10.11477/mf.1416201428
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-11-01
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751
[Journal Article] Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based on in Silico Data2018
- Author(s)
  Sugai Akihiro、Kato Taisuke、Koyama Akihide、Koike Yuka、Kasahara Sou、Konno Takuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 12 Pages: 0-0
- DOI
  10.3389/fnins.2018.00028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751, KAKENHI-PLANNED-26117006
[Journal Article] Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43.2016
- Author(s)
  Koyama A, Sugai A, Kato T, Ishihara T, Shiga A, Toyoshima Y, Koyama M, Konno T, Hirokawa S, Yokoseki A, Nishizawa M, Kakita A, Takahashi H, Onodera O.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 44 Issue: 12 Pages: 5820-5836
- DOI
  10.1093/nar/gkw499
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26250017, KAKENHI-PROJECT-15H06225, KAKENHI-PROJECT-15K19479, KAKENHI-PLANNED-26117006
[Patent] ＴＤＰ－４３の凝集抑制剤及び医薬組成物2022
- Inventor(s)
  須貝章弘, 山岸拓磨, 山田友美, 小野寺理
- Industrial Property Rights Holder
  須貝章弘, 山岸拓磨, 山田友美, 小野寺理
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-070532
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K07880
[Patent] アンチセンス核酸及びその使用2021
- Inventor(s)
  須貝章弘、小野寺理
- Industrial Property Rights Holder
  須貝章弘、小野寺理
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K07880
[Patent] アンチセンス核酸及びその使用2020
- Inventor(s)
  須貝章弘、小野寺理
- Industrial Property Rights Holder
  須貝章弘、小野寺理
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-198595
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07880
[Presentation] TDP isoform lacking the intrinsically disordered region alleviates in vitro TDP-43 aggregation and restores aberrant splicing in TDP-43 overexpression mice2022
- Author(s)
  Takuma Yamagishi, Shingo Koide, Yumi Yamada, Akihiro Sugai, Osamu Onodera
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07880
[Presentation] Antisense oligonucleotides that prevent impaired splicing of TARDBP exitron caused by loss of nuclear TDP-43 function2022
- Author(s)
  Akihiro Sugai, Takuma Yamagishi, Shingo Koide, Osamu Onodera
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07880
[Presentation] TDP isoform lacking the intrinsically disordered region alleviates TDP-43 LLPS and aggregation2022
- Author(s)
  Yamagishi Takuma, Sugai Akihiro, Yamada Yumi, Onodera Osamu
- Organizer
  63rd Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K07880
[Presentation] Antisense nucleotides that promote splicing of the exitron encoding the prion-like domain of TDP-432022
- Author(s)
  Toyama Genri, Sugai Akihiro, Yamada Yumi, Yamagishi Takuma, Kato Taisuke, Onodera Osamu
- Organizer
  63rd Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K07880
[Presentation] 天然変性領域の発現制御と破綻から捉えるALS病態2021
- Author(s)
  須貝章弘
- Organizer
  第62回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07880
[Presentation] 筋萎縮性側索硬化症に対するアンチセンス核酸治療薬の可能性2021
- Author(s)
  須貝章弘
- Organizer
  第39回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07880
[Presentation] Alteration of DNA methylation status of TARDBP 3 'UTR in sporadic ALS brain2019
- Author(s)
  Yuka Koike, Akihiro Sugai , Akio Yokoseki, Tomohiko Ishihara, Norikazu Hara, Junko Ito Ikeuchi, Takeshi, Akiyoshi Kakita, Osamu Onodera
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] TARDBP mutations distort autoregulation-relevant splicing especially under excess hnRNPA1 expression2019
- Author(s)
  Genri Toyama, Akihiro Sugai, Yuka Koike, Akihide Koyama, Takuya Konno, Osamu Onodera
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] TARDBP mutations and ALS-related splicing factors that cause disturbances in TDP-43 autoregulation2018
- Author(s)
  Akihiro Sugai，Takuya Konno, Akihide Koyama，Osamu Onodera
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] TARDBP pre-mRNA with a mutation causes disturbance of TDP-43 autoregulation via altered interaction with ALS-related splicing factors2018
- Author(s)
  Akihiro Sugai, Takuya Konno, Akihide Koyama, Osamu Onodera
- Organizer
  29th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] ALS原因遺伝子TDP-43の点変異によるアレル特異的遺伝子発現の変化2017
- Author(s)
  須貝章弘, 廣川祥子, 小山哲秀, 今野卓哉, 小野寺理
- Organizer
  2017年度命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] A non-genetically modified iPSC-derived neuron model with an increased expression of intrinsic TDP-432017
- Author(s)
  Akihiro Sugai, Genri Tohyama, Taisuke Kato, Tomohiko Ishihara, Osamu Onodera
- Organizer
  Gordon Research Conferences 2017 Amyotrophic Lateral Sclerosis (ALS) & Related Motor Neuron Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] A non-genetically modified human neuronal model of ALS with an increased expression of intrinsic TDP-432017
- Author(s)
  Akihiro Sugai, Taisuke Kato, Tomohiko Ishihara, Osamu Onodera
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09751
[Presentation] Fragility of TDP-43 autoregulation facilitates ALS pathology: an in silico study2016
- Author(s)
  Akihiro Sugai， Taisuke Kato， Masatoyo Nishizawa， Osamu Onodera
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15H06225
[Presentation] A trade-off theory for TDP-43 proteinopathy; a 'robust yet fragile' nature of the autoregulation2016
- Author(s)
  Akihiro Sugai, Osamu Onodera
- Organizer
  11th Brain Research Conference, 4th RNA Metabolism in Neurological Disease
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06225

1. 石原智彦 (70612232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 加藤泰介 (30598496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 三橋佑佳 (60844488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TOYOSHIMA Yasuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 柿田明美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 池内健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 他田真理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松本雅記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 高橋均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 小野寺理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sugai, akihiro 須貝 章弘

Sugai Akihiro 須貝 章弘

Research Projects

Research Products

Co-Researchers

TDP-43病態の多因子性をふまえた孤発性神経変性疾患の核新的治療の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deciphering Synaptic Pruning and Neurodegeneration from Human Cryptic ExonsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳小血管線維化促進細胞の同定による脳小血管老化の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Assessing the Therapeutic Potential of Alternative Splicing Manipulation in ALS Treatment for Intrinsically Disordered RegionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic strategy for ALS with nucleic acid technology focusing on the vulnerability of TDP-43 autoregulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modeling ALS with TDP-43 proteinopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 【ALS-どこまでわかり,どこまで治るか】原因と発症機序 TDP-432023

Author(s)

Journal Title

Data Source

[Journal Article] 運動ニューロン疾患の新規治療とエビデンス 筋萎縮性側索硬化症に対するアンチセンス核酸治療薬の可能性2022

Author(s)

Journal Title

Data Source

[Journal Article] Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 相分離メガネをかけて見直す神経変性疾患 (相分離生物学の全貌)2020

Author(s)

Journal Title

Data Source

[Journal Article] Molecular mechanism of amyotrophic lateral sclerosis (ALS) from the viewpoint of the formation and degeneration of transactive response DNA-binding protein 43 kDa (TDP-43) inclusions2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 増大特集 ALS2019 TDP-43封入体から解くALSの分子病態2019

Author(s)

Journal Title

DOI

sugai, akihiro 須貝章弘

Sugai Akihiro 須貝章弘

[Journal Article] 【ALS-どこまでわかり,どこまで治るか】原因と発症機序　TDP-432023

[Journal Article] 運動ニューロン疾患の新規治療とエビデンス　筋萎縮性側索硬化症に対するアンチセンス核酸治療薬の可能性2022