OZURU Ryou 尾鶴亮

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OZURU Ryo 尾鶴亮

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Researcher Number	70763035
Other IDs	https://orcid.org/0000-0002-0616-0190
Affiliation (Current)	2026: 福岡大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 福岡大学, 医学部, 講師 2021: 福岡大学, 医学部, 助教 2018 – 2020: 鳥取大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Basic Section 54030:Infectious disease medicine-related Except Principal Investigator Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Keywords	Principal Investigator レプトスピラ / 脂肪組織 / レプトスピラ症 / 人獣共通感染症 / 脂質代謝 / 脂肪分解 / 脂肪細胞 / アディポカイン / 脂質代謝異常症 / バイオマーカー … More / ワクチン / 感染症 / 鞭毛 / オルガノイド / ワイル病 … More Except Principal Investigator 腸内細菌 / HTLV-1感染症 / 成人T細胞性白血病 Less

成人T細胞性白血病の病態解明のための腸内細菌の解析
- Principal Investigator
  
  前田俊樹
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Fukuoka University
人獣共通感染症の感染制御への応用を目指した病原体代謝標的の網羅的同定Principal Investigator
- Principal Investigator
  
  尾鶴亮
- Project Period (FY)
  2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Fukuoka University
Identification and Functional Analysis of Host Lipolysis Factors Derived from Pathogenic Leptospira: Aimed at Application to Inhibition of Severe LeptospirosisPrincipal Investigator
- Principal Investigator
  
  尾鶴亮
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Fukuoka University
Creation of a novel biomarker for leptospirosis using the adipose tissue colonization mechanism.Principal Investigator
- Principal Investigator
  
  Ozuru Ryo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Fukuoka University
Elucidation of the molecular mechanism by which Leptospira colonizes on host adipose tissue blood vesselsPrincipal Investigator
- Principal Investigator
  
  OZURU Ryo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Tottori University

All 2025 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Mycobacterium abscessus resides within lipid droplets and acquires a dormancy-like phenotype in adipocytes2025
- Author(s)
  Kurihara Yusuke、Shimizu Akinori、Ozuru Ryo、Yoshimura Michinobu、Chou Bin、Itoh Ryota、Ishii Kazunari、Hirota Yuko、Takagi Satoshi、Fujita Masaki、Inoue Masahiro、Hiromatsu Kenji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 758 Pages: 151645-151645
- DOI
  10.1016/j.bbrc.2025.151645
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16329, KAKENHI-PROJECT-24K10225, KAKENHI-PROJECT-24K11646
[Journal Article] Objectification of evaluation criteria in microscopic agglutination test using deep learning2024
- Author(s)
  Nakano Risa、Oyamada Yuji、Ozuru Ryo、Yoshimura Michinobu、Hiromatsu Kenji
- Journal Title
  
  Journal of Microbiological Methods
  
  Volume: 222 Pages: 106955-106955
- DOI
  10.1016/j.mimet.2024.106955
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16329, KAKENHI-PROJECT-24K10225, KAKENHI-PROJECT-24K11646
[Journal Article] The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines2024
- Author(s)
  Yoshimura Michinobu、Sakamoto Atsuhiko、Ozuru Ryo、Kurihara Yusuke、Itoh Ryota、Ishii Kazunari、Shimizu Akinori、Chou Bin、Nabeshima Shigeki、Hiromatsu Kenji
- Journal Title
  
  International Journal of Infectious Diseases
  
  Volume: 139 Pages: 1-5
- DOI
  10.1016/j.ijid.2023.11.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16329, KAKENHI-PROJECT-22K08614, KAKENHI-PROJECT-19K16659, KAKENHI-PROJECT-19K16660, KAKENHI-PROJECT-21K16320
[Journal Article] Insufficient anti-spike RBD IgA responses after triple vaccination with intramuscular mRNA BNT162b2 vaccine against SARS-CoV-22024
- Author(s)
  Yoshimura Michinobu、Sakamoto Atsuhiko、Ozuru Ryo、Kurihara Yusuke、Itoh Ryota、Ishii Kazunari、Shimizu Akinori、Chou Bin、Sechi Yusuke、Fujikane Aya、Nabeshima Shigeki、Hiromatsu Kenji
- Journal Title
  
  Heliyon
  
  Volume: 10 Issue: 1 Pages: e23595-e23595
- DOI
  10.1016/j.heliyon.2023.e23595
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16329, KAKENHI-PROJECT-22K08614, KAKENHI-PROJECT-19K16659, KAKENHI-PROJECT-19K16660, KAKENHI-PROJECT-21K16320
[Journal Article] Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan2022
- Author(s)
  Sakamoto Atsuhiko、Yoshimura Michinobu、Itoh Ryota、Ozuru Ryo、Ishii Kazunari、Sechi Yusuke、Nabeshima Shigeki、Hiromatsu Kenji
- Journal Title
  
  Vaccines
  
  Volume: 10 Issue: 6 Pages: 830-830
- DOI
  10.3390/vaccines10060830
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08614, KAKENHI-PROJECT-21K16320, KAKENHI-PROJECT-21K16329
[Journal Article] A machine learning model of microscopic agglutination test for diagnosis of leptospirosis2021
- Author(s)
  Oyamada Yuji、Ozuru Ryo、Masuzawa Toshiyuki、Miyahara Satoshi、Nikaido Yasuhiko、Obata Fumiko、Saito Mitsumasa、Villanueva Sharon Yvette Angelina M.、Fujii Jun
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 11 Pages: e0259907-e0259907
- DOI
  10.1371/journal.pone.0259907
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22942, KAKENHI-PROJECT-21K16320
[Journal Article] Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice.2020
- Author(s)
  Ozuru R, Wakao S, Tsuji T, Ohara N, Matsuba T, Amuran MY, Isobe J, Iino M, Nishida N, Matsumoto S, Iwadate K, Konishi N, Yasuda K, Tashiro K, Hida M, Yadoiwa A, Kato S, Yamashita E, Matsumoto S, Kurozawa Y, Dezawa M, Fujii J.
- Journal Title
  
  Mol Ther.
  
  Volume: 28(1) Issue: 1 Pages: 100-118
- DOI
  10.1016/j.ymthe.2019.09.023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22648, KAKENHI-PROJECT-18K16174
[Journal Article] A Machine Learning Approach Towards Standardizing Microscopic Agglutination Test for Diagnosis of Leptospirosis2020
- Author(s)
  Oyamada Yuji、Ozuru Ryo、Masuzawa Toshiyuki、Miyahara Satoshi、Nikaido Yasuhiko、Obata Fumiko、Saito Mitsumasa、Villanueva Sharon Yvette Angelina M.、Fujii Jun
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 410712-410712
- DOI
  10.1101/2020.12.08.410712
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22942, KAKENHI-PROJECT-18K16174
[Patent] 顕微鏡下凝集試験のための感染診断装置および方法2019
- Inventor(s)
  尾鶴亮、小山田雄仁
- Industrial Property Rights Holder
  国立大学法人鳥取大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K16174
[Presentation] ゲノムスケール代謝ネットワーク再構築を用いたレプトスピラの病原性株特異的代謝経路の特定2025
- Author(s)
  園田卓己、尾鶴亮、吉村芳修、Jason A. Papin、小幡史子、Glynis L. Kolling、廣松賢治
- Organizer
  第19回日本ゲノム微生物学会年会
- Data Source
  KAKENHI-PROJECT-24K10225
[Presentation] Leptospirosis: Why Is Diagnosis So Difficult and How Can We Improve It?2025
- Author(s)
  Ryo Ozuru
- Organizer
  The 1st International Online Conference on Clinical Reports
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K10225
[Presentation] Pangenome-scale Metabolic Network Reconstruction Uncovered Pathogenicity-Specific Pathways in Leptospira2025
- Author(s)
  Takumi Sonoda, Ryo Ozuru, Michinobu Yoshimura, Jason A. Papin, Fumiko Obata, Glynis L. Kolling, Kenji Hiromatsu
- Organizer
  25th International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K10225
[Presentation] 深層学習による感染症検査の自動化2024
- Author(s)
  尾鶴亮
- Organizer
  Laboratory Automation Developers Conference 2024
- Data Source
  KAKENHI-PROJECT-24K10225
[Presentation] 環境と宿主を移行する病原細菌の代謝変化の定量と可視化2024
- Author(s)
  尾鶴亮
- Organizer
  定量生物学の会九州キャラバン2025
- Data Source
  KAKENHI-PROJECT-24K10225
[Presentation] Percutaneously Infected Leptospira Induces Lipolysis in the Host Adipose Tissue.2024
- Author(s)
  Ryo Ozuru, Michinobu Yoshimura, Shotaro Fujiki, Kazunari Ishii, Akinori Shimizu, Yusuke Kurihara, Shuntaro Kuwahara, and Kenji Hiromatsu
- Organizer
  The 13th Conference of the International Leptospirosis Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] A unique strategy for acquiring carbon sources: Leptospira induces lipolysis in the host adipocytes via adrenergic receptors.2024
- Author(s)
  Ryo Ozuru, Yusuke Kurihara, Kazunari Ishii, Shotaro Fujiki, Michinobu Yoshimura and Kenji Hiromatsu
- Organizer
  Gordon Research Conference 2024 Biology of Spirochetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] 温度依存的代謝シフトを標的とする病原性レプトスピラ増殖抑制因子の発見2024
- Author(s)
  尾鶴亮、園田卓己、吉村芳修、Jason A. Papin、小幡史子、Glynis L. Kolling、廣松賢治
- Organizer
  第60回レプトスピラ・シンポジウム
- Data Source
  KAKENHI-PROJECT-24K10225
[Presentation] Temperature-Dependent Glycometabolic Shifts in Pathogenic Leptospira As Potential Therapeutic Targets2024
- Author(s)
  Ryo Ozuru, Takumi Sonoda, Michinobu Yoshimura, Jason A. Papin, Fumiko Obata, Glynis L. Kolling, Kenji Hiromatsu
- Organizer
  9th Conference on Constraint-Based Reconstruction and Analysis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K10225
[Presentation] Pathogenic Leptospira induces lipolysis in the murine adipocytes in vitro and in vivo2024
- Author(s)
  Ryo Ozuru, Michinobu Yoshimura, Shotaro Fujiki, Kazunari Ishii, Akinori Shimizu, Yusuke Kurihara, Shuntaro Kuwahara, Kenji Hiromatsu
- Organizer
  第97回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] Objectification of Evaluation Criteria in MAT Using Deep Learning2024
- Author(s)
  Risa Nakano, Yuji Oyamada, Ryo Ozuru
- Organizer
  The 13th Conference of the International Leptospirosis Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K10225
[Presentation] Automating tests for leptospirosis with deep learning -Seeing "by computer" is believing-2024
- Author(s)
  Ryo Ozuru
- Organizer
  The PSM Cluster 1 Symposium with the theme “Computational Microbiology and Biotechnology in an Evolving Microbial World”
- Invited
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] Pathogenic leptospires induce lipolysis in the host adipocytes via adrenergic receptors to obtain their carbon sources.2023
- Author(s)
  Ryo Ozuru, Kazunari Ishii, Shotaro Fujiki and Kenji Hiromatsu
- Organizer
  The 21st Awaji International Forum on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] 機械学習による感染症検査の自動化・標準化2023
- Author(s)
  尾鶴亮
- Organizer
  第17回細菌学若手コロッセウム
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] アドレナリン受容体を介したレプトスピラの宿主脂質分解2023
- Author(s)
  尾鶴亮、石井一成、栗原悠介、藤木正太郎、吉村芳修、廣松賢治
- Organizer
  第59回レプトスピラ・シンポジウム
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] 病原性レプトスピラ感染による宿主の免疫応答と脂質代謝変化2022
- Author(s)
  尾鶴亮、石井一成、廣松賢治
- Organizer
  第16回細菌学若手コロッセウム
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] レプトスピラ感染による宿主の脂質代謝変化2022
- Author(s)
  尾鶴亮、石井一成、廣松賢治
- Organizer
  第58回レプトスピラシンポジウム
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] PATHOGENIC LEPTOSPIRES INDUCE LIPOLYSIS IN HOST ADIPOCYTES TO OBTAIN THEIR CARBON SOURCES.2022
- Author(s)
  Ryo Ozuru, Michinobu Yoshimura, Yusuke Kurihara, Kazunari Ishii, Kenji Hiromatsu
- Organizer
  12th International Leptospirosis Society Conference 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] 若手から見た異分野融合とその難しさ~現場の声~ 2. 細菌学的に見た再生医療との異分野融合2021
- Author(s)
  尾鶴亮，藤井潤
- Organizer
  第94回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K16174
[Presentation] 鳥取県米子市に生息する2種のヌカカ(トクナガクロヌカカ・イソヌカカ)のメタゲノム比較解析2021
- Author(s)
  尾鶴亮、山岸潤也、青木薫、伊達勇介、藤井貴敏、竹内彩結実、遠藤綾乃、須崎萌実、日野英壱、大峯正人、藤井潤、松葉隆司
- Organizer
  第15回日本ゲノム微生物学会年会
- Data Source
  KAKENHI-PROJECT-18K16174
[Presentation] 細菌検査を自動化する－レプトスピラ症の顕微鏡下凝集試験 (Microscopic Agglutination Test; MAT)を例に2021
- Author(s)
  尾鶴亮，小山田雄仁，増澤俊之，宮原敏，二階堂靖彦，齋藤光正，Sharon Y. A. M. Villanueva，藤井潤
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K16174
[Presentation] 凝集反応検査を自動化する－レプトスピラ症における顕微鏡下凝集試験の深層学習判定モデルを基に－2021
- Author(s)
  尾鶴亮、中野里咲、小山田雄仁
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K16320
[Presentation] サポートベクターマシンを用いた顕微鏡下凝集試験 (MAT) の自動化2020
- Author(s)
  小山田雄仁, 二階堂靖彦, 宮原敏, 齋藤光正, Sharon Y.A.M. Villanueva, 増澤俊幸, 尾鶴亮
- Organizer
  2020年日本バイオインフォマティクス学会年会
- Data Source
  KAKENHI-PROJECT-18K16174
[Presentation] 機械学習による感染症診断支援システム構築の試み～レプトスピラ感染症を例に～2020
- Author(s)
  尾鶴亮，増澤俊之，宮原敏，二階堂靖彦，齋藤光正，藤井潤
- Organizer
  第73回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-18K16174
[Presentation] An Artificial Intelligence Approach Towards a Computer-Aided Microscopic Agglutination Test2019
- Author(s)
  Yuji Oyamada , Sharon Y. A. M. Villanueva , Ryo Ozuru
- Organizer
  10th International Leptospirosis Society Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16174
[Presentation] 顕微鏡下凝集試験（MAT）の自動化を目指した機械学習モデルの構築2019
- Author(s)
  尾鶴亮、小山田雄仁
- Organizer
  第56回レプトスピラシンポジウム
- Data Source
  KAKENHI-PROJECT-18K16174
[Presentation] レプトスピラの病原性と菌体回転運動の関わり2018
- Author(s)
  尾鶴亮
- Organizer
  バイオメカニクス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K16174

1. 前田俊樹 (50555555)

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2. 有馬久富 (20437784)

# of Collaborated Projects: 1 results

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3. 石田晋太郎 (20899695)

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4. 石津昌直 (50526415)

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5. 西巧 (20760739)

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6. 松本晃太郎 (60932217)

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7. 出沢真理

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8. 宮原敏

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# of Collaborated Products: 2 results
9. 石井一成

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10. 吉村芳修

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# of Collaborated Products: 4 results

OZURU Ryou 尾鶴 亮

OZURU Ryo 尾鶴 亮

Research Projects

Research Products

Co-Researchers

成人T細胞性白血病の病態解明のための腸内細菌の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

人獣共通感染症の感染制御への応用を目指した病原体代謝標的の網羅的同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and Functional Analysis of Host Lipolysis Factors Derived from Pathogenic Leptospira: Aimed at Application to Inhibition of Severe LeptospirosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation of a novel biomarker for leptospirosis using the adipose tissue colonization mechanism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism by which Leptospira colonizes on host adipose tissue blood vesselsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mycobacterium abscessus resides within lipid droplets and acquires a dormancy-like phenotype in adipocytes2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Objectification of evaluation criteria in microscopic agglutination test using deep learning2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insufficient anti-spike RBD IgA responses after triple vaccination with intramuscular mRNA BNT162b2 vaccine against SARS-CoV-22024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A machine learning model of microscopic agglutination test for diagnosis of leptospirosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Machine Learning Approach Towards Standardizing Microscopic Agglutination Test for Diagnosis of Leptospirosis2020

Author(s)

Journal Title

DOI

Data Source

[Patent] 顕微鏡下凝集試験のための感染診断装置および方法2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

OZURU Ryou 尾鶴亮

OZURU Ryo 尾鶴亮

[Presentation] ゲノムスケール代謝ネットワーク再構築を用いたレプトスピラの病原性株特異的代謝経路の特定2025