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Shimbo Takashi  新保 敬史

ORCIDConnect your ORCID iD *help
Researcher Number 70780609
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院 医学系研究科, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help 2025: 大阪大学, 大学院 医学系研究科, 特任准教授(常勤)
2022 – 2024: 大阪大学, 大学院医学系研究科, 特任准教授(常勤)
2020 – 2021: 大阪大学, 医学系研究科, 特任准教授(常勤)
2019: 大阪大学, 医学系研究科, 寄附講座准教授
2016 – 2018: 大阪大学, 医学系研究科, 特任助教(常勤)
Review Section/Research Field
Principal Investigator
Basic Section 53050:Dermatology-related / Dermatology
Except Principal Investigator
Basic Section 57030:Conservative dentistry-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 49030:Experimental pathology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 53050:Dermatology-related
Keywords
Principal Investigator
表皮水疱症 / 間葉系幹細胞 / 遺伝子型-表現系相関 / 劣勢栄養障害型表皮水疱症 / 遺伝子型-表現型相関 / 劣性栄養障害型表皮水疱症 / シングルセル解析 / rna-seq / single cell / 組織再生 … More / 単一細胞網羅的遺伝子発現解析 / 骨髄由来PDGFRα陽性間葉系幹細胞 / 再生医療 / シングルセルRNA-seq / 間葉系細胞 / 単一細胞遺伝子発現網羅的解析 / 遺伝子発現解析 / 遺伝病 / 皮膚科学 / 再生医学 / Pdgfra / 単一細胞 / 網羅的遺伝子発現解析 … More
Except Principal Investigator
HMGB1 / 歯根膜 / 再生誘導 / 骨破壊 / 歯周炎特異的 / 破骨細胞 / 細胞系譜解析 / シングルセル解析技 / シングルセル解析 / シングルセル解析技術 / オープンクロマチン領域 / scATAC-seq / 歯周組織再生 / シングルセル / 慢性腎障害 / 線維化 / 腎 / ノックアウトライブラリー / 再生医療 / 幹細胞 / 治療 / 気管支肺異形成症 / 幹細胞再生医学 / 間葉・上皮転換 / 外胚葉性間葉系細胞 / 表皮水疱症 / 間葉球 / 間葉系幹細胞 / 組織幹細胞 Less
  • Research Projects

    (9 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (15 People)
  •  歯周組織破壊を誘導する歯根膜細胞集団の制御と歯周炎予防への展開

    • Principal Investigator
      岩山 智明
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      The University of Osaka
  •  内因性危険シグナルHMGB1誘導性組織再生における骨髄間葉系幹細胞活性化機構解明

    • Principal Investigator
      佐賀 公太郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Osaka University
  •  HMGB1ペプチドを用いた末梢血間葉系幹細胞動員による腎線維化の抑制

    • Principal Investigator
      谷口 歩
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Osaka University
  •  細胞ダイバーシティーを基盤とした歯周組織幹細胞の運命決定機構の解明

    • Principal Investigator
      岩山 智明
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Osaka University
  •  Regeneration-inducing medicine for Bronchopulmonary displasia

    • Principal Investigator
      Endo Masayuki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  Genotype-phenotype analysis in recessive dystrophic epidermolysis bullosa using single cell analysis and mouse modelsPrincipal Investigator

    • Principal Investigator
      Shimbo Takashi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Osaka University
  •  Study for developmental origin of mesenchymal blood cells and their regenerative activity in epidermolysis bullosa

    • Principal Investigator
      Tamai Katsuto
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Osaka University
  •  Single cell transcriptome analysis on circulating mesenchymal stem cells during tissue regenerationPrincipal Investigator

    • Principal Investigator
      Shimbo Takashi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Osaka University
  •  Functions of PDGFRa positive mesenchymal stem cells during the treatment of epidermolysis bullosaPrincipal Investigator

    • Principal Investigator
      Shimbo Takashi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Dermatology
    • Research Institution
      Osaka University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] High-mobility group box-1 peptide ameliorates bronchopulmonary dysplasia by suppressing inflammation and fibrosis in a mouse model2023

    • Author(s)
      Hara Takeya、Shimbo Takashi、Masuda Tatsuo、Kitayama Tomomi、Fujii Makoto、Hanawa Morifumi、Yokota Kazuha、Endo Masayuki、Tomimatsu Takuji、Kimura Tadashi、Tamai Katsuto
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 671 Pages: 357-365

    • DOI

      10.1016/j.bbrc.2023.06.032

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09570, KAKENHI-PROJECT-21K07796
  • [Journal Article] Single-cell transcriptome analysis of a rat model of bilateral renal ischemia-reperfusion injury2023

    • Author(s)
      Taniguchi Ayumu、Miyashita Kazuya、Fukae Shota、Tanaka Ryo、Nishida Mami、Kitayama Tomomi、Ouchi Yuya、Shimbo Takashi、Nakazawa Shigeaki、Yamanaka Kazuaki、Imamura Ryoichi、Tamai Katsuto、Nonomura Norio
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 33 Pages: 101433-101433

    • DOI

      10.1016/j.bbrep.2023.101433

    • Data Source
      KAKENHI-PROJECT-22K08690
  • [Journal Article] <i>Plap-1</i> lineage tracing and single-cell transcriptomics reveal cellular dynamics in the periodontal ligament2022

    • Author(s)
      Iwayama Tomoaki、Iwashita Mizuho、Miyashita Kazuya、Sakashita Hiromi、Matsumoto Shuji、Tomita Kiwako、Bhongsatiern Phan、Kitayama Tomomi、Ikegami Kentaro、Shimbo Takashi、Tamai Katsuto、Murayama Masanori A.、Ogawa Shuhei、Iwakura Yoichiro、Yamada Satoru、Olson Lorin E.、Takedachi Masahide、Murakami Shinya
    • Journal Title

      Development

      Volume: 149 Issue: 19 Pages: 201203-201203

    • DOI

      10.1242/dev.201203

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06955, KAKENHI-PROJECT-21K16991, KAKENHI-PROJECT-19H01069, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-23K24527
  • [Journal Article] Generation of a recessive dystrophic epidermolysis bullosa mouse model with patient-derived compound heterozygous mutations.2022

    • Author(s)
      Takaki S, Shimbo T, Ikegami K, Kitayama T, Yamamoto Y, Yamazaki S, Mori S, Tamai K
    • Journal Title

      Lab Invest

      Volume: Online ahead of print Issue: 6 Pages: 574-580

    • DOI

      10.1038/s41374-022-00735-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03682, KAKENHI-PROJECT-21K08324
  • [Journal Article] Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice.2021

    • Author(s)
      Nojiri S, Tsuchiya A, Natsui K, Takeuchi S, Watanabe T, Kojima Y, Watanabe Y, Kamimura H, Ogawa M, Motegi S, Iwasawa T, Sato T, Kumagai M, Ishii Y, Kitayama T, Li YT, Ouchi Y, Shimbo T, Takamura M, Tamai K, Terai S
    • Journal Title

      Inflamm Regen

      Volume: 41(1) Issue: 1 Pages: 28-28

    • DOI

      10.1186/s41232-021-00177-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03682, KAKENHI-PROJECT-20K08326
  • [Journal Article] Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.2021

    • Author(s)
      Ho YT, Shimbo T, Wijaya E, Kitayama T, Takaki S, Ikegami K, Miyashita K, Ouchi Y, Takaki E, Yamamoto R, Kaneda Y, Tamai K
    • Journal Title

      Cell Mol Gastroenterol Hepatol

      Volume: 12(2) Issue: 2 Pages: 547-566

    • DOI

      10.1016/j.jcmgh.2021.04.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03682
  • [Journal Article] Contribution of PDGFRα lineage cells in adult mouse hematopoiesis.2020

    • Author(s)
      Miura A, Shimbo T, Kitayama T, Ouchi Y, Yamazaki S, Nishida M, Takaki E, Yamamoto R, Wijaya E, Tamai K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 534 Pages: 186-192

    • DOI

      10.1016/j.bbrc.2020.11.114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03682
  • [Journal Article] Controlled induction of immune tolerance by mesenchymal stem cells transferred by maternal microchimerism.2020

    • Author(s)
      Iwai S, Okada A, Sasano K, Endo M, Yamazaki S, Wang X, Shimbo T, Tomimatsu T, Kimura T, Tamai K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 539 Pages: 83-88

    • DOI

      10.1016/j.bbrc.2020.12.032

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03682, KAKENHI-PROJECT-18K09228
  • [Journal Article] Transcriptionally distinct mesenchymal stem/stromal cells circulate in fetus2019

    • Author(s)
      Shimbo, T., Endo, M., Iwai; S., Kitayama, T., Ouchi, Y., Yamamoto, R., Takaki, E., Yamazaki, S., Nishida, M., Wang, X., Kikuchi, Y., Tomimatsu, T., Kaneda, Y., Kimura, T. Tamai, K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: pii: S0006-291X(19) Issue: 2 Pages: 30410-3

    • DOI

      10.1016/j.bbrc.2019.03.033

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17KT0053, KAKENHI-PROJECT-18K16027, KAKENHI-PROJECT-16H04712, KAKENHI-PROJECT-16H05369, KAKENHI-PROJECT-18K09228, KAKENHI-PROJECT-19H01398, KAKENHI-PROJECT-17K11233
  • [Journal Article] Cut-C: cleavage under tethered nuclease for conformational capture.2019

    • Author(s)
      Shimbo T, Kawamura M, Wijaya E, Takaki E, Kaneda Y, Tamai K
    • Journal Title

      BMC Genomics

      Volume: 20 Issue: 1 Pages: 614-614

    • DOI

      10.1186/s12864-019-5989-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03682
  • [Presentation] Development of a method identifying revertant mosaicism in recessive dystrophic epidermolysis bullosa using long-read sequencing2023

    • Author(s)
      Takashi Shimbo, Atsushi Matsuba, Satoshi Takaki, Katsuto Tamai
    • Organizer
      International Societies for Investigative Dermatology 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08324
  • [Presentation] ラット両側腎虚血再灌流モデルに対する単一細胞トランスクリプトーム解析2023

    • Author(s)
      谷口歩, 宮下和也, 深江彰太, 田中亮, 西田真美, 北山智美, 新保敬史, 中澤成晃, 山中和明, 今村亮一, 玉井克人, 野々村祝夫
    • Organizer
      第110回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-22K08690
  • [Presentation] ラット両側腎虚血再灌流モデルに対する単一細胞トランスクリプトーム解析2023

    • Author(s)
      谷口歩, 宮下和也, 深江彰太, 田中亮, 西田真美, 北山智美, 新保敬史, 中澤成晃, 山中和明, 今村亮一, 玉井克人, 野々村祝夫
    • Organizer
      第110回日本泌尿器科学会総会 若手研究者クローズアップ企画
    • Data Source
      KAKENHI-PROJECT-22K08690
  • [Presentation] Characterization of ectomesenchyme as an original of epidermal stem cells2023

    • Author(s)
      Asaka Miura, Yuki Kobayashi, Yoshikazu Hirose, Ayako Yamanishi, Yuya Ouchi, Ryoma Yamamoto, Tomomi Kitayama, Eiichi Takaki, Takashi Shimbo, Katsuto Tamai
    • Organizer
      International Societies for Investigative Dermatology 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08324
  • [Presentation] 歯根膜一細胞アトラスの構築2022

    • Author(s)
      岩下 瑞穂, 岩山 智明, 冨田 貴和子, 松本 修治, パーン ポンサティアン, 阪下 裕美, 宮下 和也, 北山 智美, 池上 健太郎, 新保 敬史, 玉井 克人, 竹立 匡秀, 山田 聡, 村上 伸也
    • Organizer
      第65回春季日本歯周病学会学術大会
    • Data Source
      KAKENHI-PROJECT-23K24527
  • [Presentation] Rapid establishment of model mice for recessive dystrophic epidermolysis bullosa with patient-derived mutations2022

    • Author(s)
      新保敬史
    • Organizer
      日本研究皮膚科学会第47回年次学術大会・総会
    • Data Source
      KAKENHI-PROJECT-21K08324
  • [Presentation] Single cell RNA-seq and single cell ATAC-seq analyses during a treatment for dystrophic epidermolysis bullosa2019

    • Author(s)
      Takashi Shimbo, Sho Yamazaki, Tomomi Kitayama, Yuya Ouchi, Ryoma Yamamoto, Eiichi Takaki, Leena Bruckner- Tuderman, Jouni Uitto, Yasufumi Kaneda, Katsuto Tamai
    • Organizer
      Society for Investigative Dermatology 77th
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16027
  • [Presentation] 網羅的単一細胞遺伝子発現解析が明らかにしたマウス潰瘍性大腸炎増悪メカニズム2019

    • Author(s)
      新保敬史、Ho Yen-Ting、北山智美、大内雄矢、Edward Wijaya、金田安史、玉井克人
    • Organizer
      第40回日本炎症・再生医学会
    • Data Source
      KAKENHI-PROJECT-18K16027
  • [Presentation] TRANSCRIPTOME AND EPIGENOME ANALYSES FOR REGENERATED SKIN IN A RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA MOUSE MODEL2019

    • Author(s)
      Takashi Shimbo, Sho Yamazaki, Tomomi Kitayama, Yuya Ouchi, Ryoma Yamamoto, Eiichi Takaki, Leena Bruckner- Tuderman, Jouni Uitto, Yasufumi Kaneda, Katsuto Tamai
    • Organizer
      International Society for Stem Cell Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16027
  • [Presentation] Single cell transcriptome and epigenome analyses in a murine model of dystrophic epidermolysis bullosa2019

    • Author(s)
      Takashi Shimbo, Sho Yamazaki, Tomomi Kitayama, Yuya Ouchi, Ryoma Yamamoto, Eiichi Takaki, Leena Bruckner- Tuderman, Jouni Uitto, Yasufumi Kaneda, Katsuto Tamai
    • Organizer
      The 49th European Society for Dermatology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16027
  • [Presentation] Single cell RNA- and ATAC-seq analyses in a murine model of dystrophic epidermolysis bullosa2019

    • Author(s)
      Takashi Shimbo, Sho Yamazaki, Tomomi Kitayama, Yuya Ouchi, Ryoma Yamamoto, Eiichi Takaki,Leena Bruckner-Tuderman, Jouni Uitto, Yasufumi Kaneda, Katsuto Tamai
    • Organizer
      第44回日本研究皮膚科学会
    • Data Source
      KAKENHI-PROJECT-18K16027
  • [Presentation] 網羅的遺伝子発現解析による末梢循環PDGFRα陽性間葉系幹細胞の性状解析2018

    • Author(s)
      新保敬史、佐々木英嗣、北山智美、西田真実、山崎翔、大内雄矢、山本竜馬、Edward Wijaya、菊池康、金田安史、玉井克人
    • Organizer
      第17回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-16H06951
  • [Presentation] HMGB1 ADMINISTRATION AMELIORATES CUTANEOUS AND NON-CUTANEOUS MANIFESTATIONS IN THE MOUSE MODEL FOR AN INHERITED CONNECTIVE TISSUE DISEASE, DYSTROPHIC EPIDERMOLYSIS BULLOSA2017

    • Author(s)
      Takashi Shimbo, Sho Yamazaki, Xin Wang, Yasushi Kikuchi, Leena Bruckner-Tuderman, Yasufumi Kaneda, Katsuto Tamai
    • Organizer
      The International Society for Stem Cell Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06951
  • [Presentation] Systemic delivery of HMGB1 ameliorates cutaneous and non-cutaneous manifestations in a dystrophic epidermolysis bullosa model mouse2017

    • Author(s)
      Takashi Shimbo, Sho Yamazaki, Xin Wang, Yasushi Kikuchi, Leena Bruckner-Tuderman, Yasufumi Kaneda, Katsuto Tamai
    • Organizer
      日本遺伝子細胞治療学会
    • Data Source
      KAKENHI-PROJECT-16H06951
  • [Presentation] Systemic HMGB1 administration ameliorates cutaneous and non-cutaneous manifestations in a dystrophic epidermolysis bullosa model mouse2017

    • Author(s)
      Takashi Shimbo, Sho Yamazaki, Xin Wang, Yasushi Kikuchi, Leena Bruckner-Tuderman, Yasufumi Kaneda,Katsuto Tamai
    • Organizer
      Society for Investigative Dermatology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06951
  • [Presentation] Comprehensive analysis on HMGB1-induced circulating cells during cutaneous tissue regeneration2017

    • Author(s)
      Takashi Shimbo, Mami Nishida,Tomomi Kitayama,Ryoma Yamamoto,Eiji Takaki,Yasushi Kikuchi,Yasufumi Kaneda, and Katsuto Tamai
    • Organizer
      The 47th European Society for Dermatology Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06951
  • [Presentation] 末梢循環間葉系幹細胞による組織再生制御2017

    • Author(s)
      新保 敬史
    • Organizer
      日本炎症再生医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H06951
  • [Presentation] Characterization of circulating stem/progenitor cells during fatal skin injury regeneration2017

    • Author(s)
      Takashi Shimbo, Eiji Sasaki, Tomomi Kitayama, Mami Nishida, Sho Yamazaki, Yuya Ouchi, Sachiko Yamaoka,Yasushi Kikuchi, Yasufumi Kaneda, Katsuto Tamai
    • Organizer
      日本研究皮膚科学会
    • Data Source
      KAKENHI-PROJECT-16H06951
  • 1.  Tamai Katsuto (20236730)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 2.  岩山 智明 (80757865)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  藤原 千春 (00755358)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  Endo Masayuki (30644794)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  藤井 誠 (10803760)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  佐賀 公太郎 (00563389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  谷口 歩 (10845225)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  今村 亮一 (40456976)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  阿部 豊文 (90750894)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  山中 和明 (10648017)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 11.  村上 伸也 (70239490)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  竹立 匡秀 (60452447)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TOMIMATSU Takuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  村山 正承
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  金田 安史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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